Reviewed, UniProtKB/Swiss-Prot P57008 (DHAS_NEIMA)

Names and origin

Protein names

Recommended name:
    Aspartate-semialdehyde dehydrogenase
      Short name=ASA dehydrogenase
      Short name=ASADH
    EC=1.2.1.11

Gene names

Name:	asd
Ordered Locus Names:	NMA0351

Organism

Neisseria meningitidis serogroup A [Complete proteome] [HAMAP]

Taxonomic identifier

65699 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 2/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the aspartate-semialdehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro NADP or NADPH binding Inferred from electronic annotation. Source: InterPro aspartate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Aspartate-semialdehyde dehydrogenase		PRO_0000141384
Sites
	Active site	135	1	Acyl-thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57008-1 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: B419F887BF39B0E8	FASTA	371	40,044
	10 20 30 40 50 60 MKVGFVGWRG MVGSVLMQRM KEENDFAHIP EAFFFTTSNV GGAAPDFGQA AKTLLDANDV 70 80 90 100 110 120 AELAKMDIIV TCQGGDYTKS VFQPLRDSGW NGYWVDAASS LRMKDDAIIV LDPVNRNVID 130 140 150 160 170 180 NGLKNGVKNY IGGNCTVSLM LMALGGLFQN DLVEWATSMT YQAASGAGAK NMRELISGMG 190 200 210 220 230 240 AIHAKVADEL ADPSSAILDI DRKVSDFLRS EDYPKANFGV PLAGSLIPWI DVDLGNGQSK 250 260 270 280 290 300 EEWKGGVETN KILGRSDNPT VIDGLCVRIG SMRCHSQALT LKLKKDLPVS EIEAILAGAN 310 320 330 340 350 360 DWVKVIPNEK EASIHELTPA KVTGTLSVPV GRIRKLEMGG EYISAFTVGD QLLWGAAEPL 370 RRVLRIVLGS L

References

[1]

"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491." Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S. , Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. Nature 404:502-506(2000) [PubMed: 10761919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z2491 / Serogroup A / Serotype 4A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL157959 Genomic DNA. Translation: CAM07651.1.
PIR	D82031.
RefSeq	YP_002341864.1.
3D structure databases
HSSP	HSSP built from PDB template 1BRM based on UniProtKB P00353.
SMR	P57008. Positions 1-369.
ModBase	Search...
Genome annotation databases
GeneID	906357.
GenomeReviews	Gene locus NMA0351 in contig AL157959_GR.
KEGG	nma:NMA0351.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P57008.
OMA	P57008. IDGLCVR.
Enzyme and pathway databases
BioCyc	NMEN122587:NMA0351-MON.
BRENDA	1.2.1.11. 292829.
Family and domain databases
InterPro	IPR000319. Asp-semialdehyde_DH_CS. IPR011534. Asp_ADH_proteob. IPR012080. Asp_semialdehyde_DH. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
PIRSF	PIRSF000148. ASA_dh. 1 hit.
TIGRFAMs	TIGR01745. asd_gamma. 1 hit.
PROSITE	PS01103. ASD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHAS_NEIMA

Accession

Primary (citable) accession number: P57008
Secondary accession number(s): A1IPI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)