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P57005

- SODC_NEIMA

UniProt

P57005 - SODC_NEIMA

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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 copper ion per subunit.By similarity
Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Copper; catalyticBy similarity
Metal bindingi81 – 811Copper; catalyticBy similarity
Metal bindingi104 – 1041Copper; catalyticBy similarity
Metal bindingi104 – 1041Zinc; structuralBy similarity
Metal bindingi113 – 1131Zinc; structuralBy similarity
Metal bindingi122 – 1221Zinc; structuralBy similarity
Metal bindingi125 – 1251Zinc; structuralBy similarity
Metal bindingi160 – 1601Copper; catalyticBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciNMEN122587:GI3Q-1469-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:sodC
Ordered Locus Names:NMA1617
OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Taxonomic identifieri122587 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000626: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 186164Superoxide dismutase [Cu-Zn]PRO_0000032833Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi86 ↔ 182By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi122587.NMA1617.

Structurei

Secondary structure

1
186
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 408Combined sources
Turni43 – 453Combined sources
Beta strandi48 – 5811Combined sources
Beta strandi61 – 688Combined sources
Beta strandi73 – 764Combined sources
Beta strandi78 – 847Combined sources
Beta strandi89 – 913Combined sources
Beta strandi94 – 963Combined sources
Helixi99 – 1013Combined sources
Beta strandi129 – 1313Combined sources
Beta strandi141 – 1433Combined sources
Helixi149 – 1524Combined sources
Beta strandi155 – 1628Combined sources
Beta strandi166 – 1716Combined sources
Helixi172 – 1754Combined sources
Beta strandi178 – 1858Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AQNX-ray1.40A/B/C23-186[»]
2AQPX-ray1.30A/B23-186[»]
2AQQX-ray1.65A/B/C23-186[»]
2AQTX-ray1.80A/B/C23-186[»]
ProteinModelPortaliP57005.
SMRiP57005. Positions 32-186.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57005.

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263449.
KOiK04565.
OMAiMAAGGHW.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57005-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNMKTLLALA VSAVCSVSVA QAHEHNTIPK GASIEVKVQQ LDPVNGNKDV
60 70 80 90 100
GTVTITESNY GLVFTPDLQG LSEGLHGFHI HENPSCEPKE KEGKLTAGLG
110 120 130 140 150
AGGHWDPKGA KQHGYPWQDD AHLGDLPALT VLHDGTATNP VLAPRLKHLD
160 170 180
DVRGHSIMIH TGGDNHSDHP APLGGGGPRM ACGVIK
Length:186
Mass (Da):19,550
Last modified:December 1, 2000 - v1
Checksum:i04C84AB87FC7522D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157959 Genomic DNA. Translation: CAM08755.1.
PIRiE81855.
RefSeqiYP_002342924.1. NC_003116.1.

Genome annotation databases

EnsemblBacteriaiCAM08755; CAM08755; NMA1617.
GeneIDi908006.
KEGGinma:NMA1617.
PATRICi20364347. VBINeiMen132687_1877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157959 Genomic DNA. Translation: CAM08755.1 .
PIRi E81855.
RefSeqi YP_002342924.1. NC_003116.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2AQN X-ray 1.40 A/B/C 23-186 [» ]
2AQP X-ray 1.30 A/B 23-186 [» ]
2AQQ X-ray 1.65 A/B/C 23-186 [» ]
2AQT X-ray 1.80 A/B/C 23-186 [» ]
ProteinModelPortali P57005.
SMRi P57005. Positions 32-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122587.NMA1617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM08755 ; CAM08755 ; NMA1617 .
GeneIDi 908006.
KEGGi nma:NMA1617.
PATRICi 20364347. VBINeiMen132687_1877.

Phylogenomic databases

eggNOGi COG2032.
HOGENOMi HOG000263449.
KOi K04565.
OMAi MAAGGHW.
OrthoDBi EOG6K13RS.

Enzyme and pathway databases

BioCyci NMEN122587:GI3Q-1469-MONOMER.

Miscellaneous databases

EvolutionaryTracei P57005.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Z2491.

Entry informationi

Entry nameiSODC_NEIMA
AccessioniPrimary (citable) accession number: P57005
Secondary accession number(s): A1ISJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3