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P57005

- SODC_NEIMA

UniProt

P57005 - SODC_NEIMA

Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 copper ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi79 – 791Copper; catalyticBy similarity
    Metal bindingi81 – 811Copper; catalyticBy similarity
    Metal bindingi104 – 1041Copper; catalyticBy similarity
    Metal bindingi104 – 1041Zinc; structuralBy similarity
    Metal bindingi113 – 1131Zinc; structuralBy similarity
    Metal bindingi122 – 1221Zinc; structuralBy similarity
    Metal bindingi125 – 1251Zinc; structuralBy similarity
    Metal bindingi160 – 1601Copper; catalyticBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciNMEN122587:GI3Q-1469-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
    Gene namesi
    Name:sodC
    Ordered Locus Names:NMA1617
    OrganismiNeisseria meningitidis serogroup A / serotype 4A (strain Z2491)
    Taxonomic identifieri122587 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000626: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 186164Superoxide dismutase [Cu-Zn]PRO_0000032833Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi86 ↔ 182By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi122587.NMA1617.

    Structurei

    Secondary structure

    1
    186
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 407
    Turni43 – 453
    Beta strandi48 – 5811
    Beta strandi61 – 688
    Beta strandi73 – 764
    Beta strandi78 – 847
    Beta strandi89 – 913
    Beta strandi94 – 963
    Helixi99 – 1013
    Beta strandi129 – 1313
    Beta strandi141 – 1433
    Helixi149 – 1524
    Beta strandi155 – 1628
    Beta strandi166 – 1716
    Helixi172 – 1754
    Beta strandi178 – 1858

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AQNX-ray1.40A/B/C23-186[»]
    2AQPX-ray1.30A/B23-186[»]
    2AQQX-ray1.65A/B/C23-186[»]
    2AQTX-ray1.80A/B/C23-186[»]
    ProteinModelPortaliP57005.
    SMRiP57005. Positions 32-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP57005.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Cu-Zn superoxide dismutase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2032.
    HOGENOMiHOG000263449.
    KOiK04565.
    OMAiMAAGGHW.
    OrthoDBiEOG6K13RS.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P57005-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNMKTLLALA VSAVCSVSVA QAHEHNTIPK GASIEVKVQQ LDPVNGNKDV    50
    GTVTITESNY GLVFTPDLQG LSEGLHGFHI HENPSCEPKE KEGKLTAGLG 100
    AGGHWDPKGA KQHGYPWQDD AHLGDLPALT VLHDGTATNP VLAPRLKHLD 150
    DVRGHSIMIH TGGDNHSDHP APLGGGGPRM ACGVIK 186
    Length:186
    Mass (Da):19,550
    Last modified:December 1, 2000 - v1
    Checksum:i04C84AB87FC7522D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157959 Genomic DNA. Translation: CAM08755.1.
    PIRiE81855.
    RefSeqiYP_002342924.1. NC_003116.1.

    Genome annotation databases

    EnsemblBacteriaiCAM08755; CAM08755; NMA1617.
    GeneIDi908006.
    KEGGinma:NMA1617.
    PATRICi20364347. VBINeiMen132687_1877.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157959 Genomic DNA. Translation: CAM08755.1 .
    PIRi E81855.
    RefSeqi YP_002342924.1. NC_003116.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AQN X-ray 1.40 A/B/C 23-186 [» ]
    2AQP X-ray 1.30 A/B 23-186 [» ]
    2AQQ X-ray 1.65 A/B/C 23-186 [» ]
    2AQT X-ray 1.80 A/B/C 23-186 [» ]
    ProteinModelPortali P57005.
    SMRi P57005. Positions 32-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 122587.NMA1617.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM08755 ; CAM08755 ; NMA1617 .
    GeneIDi 908006.
    KEGGi nma:NMA1617.
    PATRICi 20364347. VBINeiMen132687_1877.

    Phylogenomic databases

    eggNOGi COG2032.
    HOGENOMi HOG000263449.
    KOi K04565.
    OMAi MAAGGHW.
    OrthoDBi EOG6K13RS.

    Enzyme and pathway databases

    BioCyci NMEN122587:GI3Q-1469-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P57005.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Z2491.

    Entry informationi

    Entry nameiSODC_NEIMA
    AccessioniPrimary (citable) accession number: P57005
    Secondary accession number(s): A1ISJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3