P57002 (PGM_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucomutase
Short name=PGM
EC=5.4.2.2

Alternative name(s):
Glucose phosphomutase

Gene names

Name:	pgm
Ordered Locus Names:	NMA1001

Organism

Neisseria meningitidis serogroup A [Complete proteome] [HAMAP]

Taxonomic identifier

65699 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme participates in both the breakdown and synthesis of glucose.
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Phosphoglucomutase		PRO_0000147811
Sites
	Active site	103	1	Phosphoserine intermediate By similarity
	Metal binding	103	1	Magnesium; via phosphate group By similarity
	Metal binding	239	1	Magnesium By similarity
	Metal binding	241	1	Magnesium By similarity
	Metal binding	243	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57002 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 6A33983800CC6A42	FASTA	460	49,500
	10 20 30 40 50 60 MANIARDIFK AYDIRGIVGK TLTDDAAYLI GRAIAAKAAE KGMTRIALGR DGRLSGPELM 70 80 90 100 110 120 EHIQRGFTDS GIGVLNVGMV ATPMLYFAAI NECGGSGVMI TGSHNPPDYN GFKMMLGGDT 130 140 150 160 170 180 LAGEAIQELL AIVEKDGFVA ADKQGNVTEK DISGEYHNHI VGHIKLKRPM KIAIDAGNGV 190 200 210 220 230 240 GGAFAGKLYK GLGNEVTELF CDVDGTFPNH HPDPSKPKNL QDLIAALKNG DAEIGLAFDG 250 260 270 280 290 300 DADRLGVVTK DGNIIYPDRQ LMLFAQDVLN RNPGAKVIFD VKSTRLLAPW IKEHGGEAIM 310 320 330 340 350 360 EKTGHSFIKS AMKKTGALVA GEMSGHIFFK ERWFGFDDGL YAGARLLEIL SASDNPSEVL 370 380 390 400 410 420 NNLPQSISTP ELNIALPEGS NGHQVIDELA AKAEFEGATE IITIDGLRVE FPDGFGLMRA 430 440 450 460 SNTTPILVLR FEADTQAAIE RIQNQFKAVI ESNPNLIWPL

References

[1]

"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491." Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S. , Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. Nature 404:502-506(2000) [PubMed: 10761919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z2491 / Serogroup A / Serotype 4A.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL157959 Genomic DNA. Translation: CAM08223.1.
PIR	G81947.
RefSeq	YP_002342421.1. NC_003116.1.
3D structure databases
ProteinModelPortal	P57002.
SMR	P57002. Positions 5-452.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000000977; EBNEIP00000000977; EBNEIG00000000977.
GeneID	906977.
GenomeReviews	Gene locus NMA1001 in contig AL157959_GR.
KEGG	nma:NMA1001.
PATRIC	20362924. VBINeiMen132687_1171.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000021151.
HOGENOM	HBG644964.
OMA	EVGAYNQ.
ProtClustDB	CLSK877748.
Enzyme and pathway databases
BioCyc	NMEN122587:NMA1001-MONOMER.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K01835.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGM_NEIMA

Accession

Primary (citable) accession number: P57002
Secondary accession number(s): A1IR39

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program