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P56995 (TRPE_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anthranilate synthase component 1
EC=4.1.3.27
Alternative name(s):
Anthranilate synthase component I
Gene names
Name:trpE
Ordered Locus Names:NMB1021
OrganismNeisseria meningitidis serogroup B
Taxonomic identifier491 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Anthranilate synthase component 1
PRO_0000154104

Sequences

Sequence LengthMass (Da)Tools
P56995 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 815236B1334D122C

FASTA49154,702
        10         20         30         40         50         60 
MISKQEYQAQ AAQGYNRIPL VQELLADLDT PLSLYLKLAN RPYTYLLESV VGGERFGRYS 

        70         80         90        100        110        120 
FIGLPCSHYL KASGKHVDVY QNGEIVEQHD GNPLPFIEAF HNRFKTPEIP SLPRFTGGLV 

       130        140        150        160        170        180 
GYFGYETIYN FEHFAHRLKN TTKADPLGTP DILLMLSQEL AVIDNLSGKI HLVVYADPSQ 

       190        200        210        220        230        240 
PDGYERARER LEDIRTQLRQ SCAIPLSLGS KHTEAVSEFG EEPFKACVNK IKDYIFAGDC 

       250        260        270        280        290        300 
MQVVPSQRMS MEFTDSPLAL YRALRTLNPS PYLFYYDFGD FHIVGSSPEI LVRRERNDVI 

       310        320        330        340        350        360 
VRPIAGTRLR GKTPAEDLAN EQDLLSDAKE IAEHVMLIDL GRNDVGRISK TGEVKVTDKM 

       370        380        390        400        410        420 
VIEKYSHVMH IVSNVEGRLK DGMTNMDILA ATFPAGTLSG APKVRAMEII EEVEPSKRGI 

       430        440        450        460        470        480 
YGGAVGVWGF NNDMDLAIAI RTAVVKNNTL YVQSGAGVVA DSDPASEWQE TQNKARAVIH 

       490 
AAQMVQEGLD K

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002098 Genomic DNA. Translation: AAF41421.1.
PIRE81132.
RefSeqNP_274055.1. NC_003112.2.

3D structure databases

ProteinModelPortalP56995.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000009525; EBNEIP00000009145; EBNEIG00000009525.
GeneID903159.
GenomeReviewsGene locus NMB1021 in contig AE002098_GR.
KEGGnme:NMB1021.
NMPDRfig|122586.1.peg.989.
PATRIC20357577. VBINeiMen85645_1305.
TIGRNMB1021.

Phylogenomic databases

GeneTreeEBGT00050000020301.
HOGENOMHBG507440.
OMAPSQRMSM.
ProtClustDBPRK13565.

Enzyme and pathway databases

BioCycNMEN122586:NMB_1021-MONOMER.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I.
IPR006805. Anth_synth_I_N.
IPR005256. Anth_synth_I_PabB.
IPR015890. Chorismate-bd_C.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KOK01657.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMsTIGR00564. TrpE_most. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE_NEIMB
AccessionPrimary (citable) accession number: P56995
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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