P56991 (AROE_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	NMA2129

Organism

Neisseria meningitidis serogroup A [Complete proteome] [HAMAP]

Taxonomic identifier

65699 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000136019
Regions
	Nucleotide binding	132 – 136	5	NADP By similarity
Sites
	Active site	70	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	P56991 [UniParc]. Last modified December 1, 2000. Version 1. Checksum: 21026749E8757FB4	FASTA	271	28,853
	10 20 30 40 50 60 MTMHALPRYA VFGNPVAHSK SPQIHQQFAL QEGVDIEYER ICADIGGFAQ AVSTFFETGG 70 80 90 100 110 120 CGANVTVPFK QEAFHLADEH SERALAAGAV NTLIFLKNGK LRGDNTDGIG LANDITQVKN 130 140 150 160 170 180 IAIEGKTILL LGAGGAVRGV IPVLKEHRPA RIVIANRTRA KAEELAQLFG IEAVPMADVN 190 200 210 220 230 240 GGFDIIINGT SGGLNGQIPD IPPDIFQNCA LAYDMVYGCA AKPFLDFARQ SGAKKTADGL 250 260 270 GMLVGQAAAS YALWRGFTPD IRPVIEYMKA L

References

[1]

"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491." Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S. , Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. Nature 404:502-506(2000) [PubMed: 10761919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z2491 / Serogroup A / Serotype 4A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL157959 Genomic DNA. Translation: CAM09226.1.
PIR	F81784.
RefSeq	YP_002343378.1. NC_003116.1.
3D structure databases
ProteinModelPortal	P56991.
SMR	P56991. Positions 7-269.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000000152; EBNEIP00000000152; EBNEIG00000000152.
GeneID	907318.
GenomeReviews	Gene locus NMA2129 in contig AL157959_GR.
KEGG	nma:NMA2129.
PATRIC	20365768. VBINeiMen132687_2574.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000020137.
HOGENOM	HBG553408.
OMA	YERICAD.
ProtClustDB	CLSK877516.
Enzyme and pathway databases
BioCyc	NMEN122587:NMA2129-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_NEIMA

Accession

Primary (citable) accession number: P56991
Secondary accession number(s): A1ITV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program