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Protein

Divisome-associated membrane protein Blr

Gene

blr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cell division machinery, which is probably involved in the stabilization of the divisome under certain stress conditions.1 Publication

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cellular response to cell envelope stress Source: EcoCyc
  • response to antibiotic Source: EcoCyc

Keywordsi

Biological processAntibiotic resistance, Cell cycle, Cell division, Stress response

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1561.

Names & Taxonomyi

Protein namesi
Recommended name:
Divisome-associated membrane protein Blr
Alternative name(s):
Beta-lactam resistance protein
Gene namesi
Name:blr
Ordered Locus Names:b4409, JW5963
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14389. blr.

Subcellular locationi

  • Cell inner membrane 2 Publications; Single-pass membrane protein 2 Publications

  • Note: Localizes to the division septum. Localization requires FtsQ and FtsN.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3CytoplasmicSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 41PeriplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • integral component of membrane Source: EcoCyc
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Inactivation increases the susceptibility of bacteria to a number of antibiotics that inhibit peptidoglycan biosynthesis. Increases the susceptibility to cycloserine, bacitracin, and a wide spectrum of beta-lactam antibiotics. Does not affect susceptibility to fosfomycin, valinomycin, tetracycline, chloramphenicol, gentamicin or quinolones.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649431 – 41Divisome-associated membrane protein BlrAdd BLAST41

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PaxDbiP56976.
PRIDEiP56976.

Interactioni

Subunit structurei

Interacts with FtsL and several other divisomal proteins, including FtsI, FtsK, FtsN, FtsQ, FtsW and YmgF.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4259631. 432 interactors.
IntActiP56976. 8 interactors.
STRINGi511145.b4409.

Structurei

3D structure databases

ProteinModelPortaliP56976.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106C6R. Bacteria.
ENOG410Y1ZA. LUCA.
HOGENOMiHOG000294500.

Sequencei

Sequence statusi: Complete.

P56976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MNRLIELTGW IVLVVSVILL GVASHIDNYQ PPEQSASVQH K
Length:41
Mass (Da):4,556
Last modified:December 1, 2000 - v1
Checksum:iD384EBB01276D46B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219227 Genomic DNA. Translation: AAF82191.1.
U00096 Genomic DNA. Translation: AAT48132.1.
AP009048 Genomic DNA. Translation: BAE76483.1.
RefSeqiWP_001300888.1. NZ_LN832404.1.
YP_025303.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48132; AAT48132; b4409.
BAE76483; BAE76483; BAE76483.
GeneIDi2847682.
KEGGiecj:JW5963.
eco:b4409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219227 Genomic DNA. Translation: AAF82191.1.
U00096 Genomic DNA. Translation: AAT48132.1.
AP009048 Genomic DNA. Translation: BAE76483.1.
RefSeqiWP_001300888.1. NZ_LN832404.1.
YP_025303.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP56976.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259631. 432 interactors.
IntActiP56976. 8 interactors.
STRINGi511145.b4409.

Proteomic databases

PaxDbiP56976.
PRIDEiP56976.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48132; AAT48132; b4409.
BAE76483; BAE76483; BAE76483.
GeneIDi2847682.
KEGGiecj:JW5963.
eco:b4409.

Organism-specific databases

EcoGeneiEG14389. blr.

Phylogenomic databases

eggNOGiENOG4106C6R. Bacteria.
ENOG410Y1ZA. LUCA.
HOGENOMiHOG000294500.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1561.

Miscellaneous databases

PROiP56976.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiBLR_ECOLI
AccessioniPrimary (citable) accession number: P56976
Secondary accession number(s): Q2MB73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 15, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.