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Protein

Alpha-conotoxin CnIA

Gene
N/A
Organism
Conus consors (Singed cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (PubMed:10320362, PubMed:28238803). CnIA and CnIB block muscular nAChR alpha-1/gamma and alpha-1/delta subunits (PubMed:10320362).2 Publications

Miscellaneous

Found in injectable (milked) (IV) venom.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin CnIA
Cleaved into the following 2 chains:
Alternative name(s):
[Hyp7]-CnIK
OrganismiConus consors (Singed cone)
Taxonomic identifieri101297 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1558. CnIA.
594. CnIB.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000041982422 – 471 PublicationAdd BLAST26
PeptideiPRO_000041982548 – 62Alpha-conotoxin CnIKAdd BLAST15
PeptideiPRO_000003487149 – 62Alpha-conotoxin CnIAAdd BLAST14
PeptideiPRO_000003487251 – 62Alpha-conotoxin CnIBAdd BLAST12

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 561 Publication
Disulfide bondi52 ↔ 621 Publication
Modified residuei544-hydroxyproline; in CnIK; partial1 Publication1
Modified residuei62Cysteine amide2 Publications1

Keywords - PTMi

Amidation, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

Secondary structure

164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi54 – 56Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B45NMR-A49-62[»]
SMRiP56973.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56973.

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha3/5 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
IPR018072. Conotoxin_a-typ_CS.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.
PROSITEiView protein in PROSITE
PS60014. ALPHA_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTVF LLVVLTTTVV SFPSDSASDG RDDEAKDERS DIYESKRNGR
60
CCHPACGKYY SCGR
Length:64
Mass (Da):7,192
Last modified:October 31, 2012 - v2
Checksum:iDAF703CA33783812
GO

Mass spectrometryi

Molecular mass is 1541.58 Da from positions 49 - 62. Determined by ESI. CnIA.1 Publication
Molecular mass is 1328.47 Da from positions 51 - 62. Determined by ESI. CnIB.1 Publication
Molecular mass is 1655.65 Da from positions 48 - 62. Determined by ESI. CnIK.1 Publication
Molecular mass is 1671.63 Da from positions 48 - 62. Determined by ESI. [Hyp]CnIK.1 Publication

Sequence databases

PIRiA58963.

Similar proteinsi

Entry informationi

Entry nameiCA1A_CONCN
AccessioniPrimary (citable) accession number: P56973
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 31, 2012
Last modified: November 22, 2017
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families