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Protein

Geranylgeranyl pyrophosphate synthase

Gene

GGPS1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.

Catalytic activityi

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: farnesyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (FDPS), Geranylgeranyl pyrophosphate synthase (GGPS1)
This subpathway is part of the pathway farnesyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, the pathway farnesyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Pathwayi: geranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (FDPS), Geranylgeranyl pyrophosphate synthase (GGPS1)
This subpathway is part of the pathway geranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate, the pathway geranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Pathwayi: geranylgeranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Geranylgeranyl pyrophosphate synthase (GGPS1)
This subpathway is part of the pathway geranylgeranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate, the pathway geranylgeranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25Isopentenyl diphosphateBy similarity1
Binding sitei28Isopentenyl diphosphateBy similarity1
Binding sitei57Isopentenyl diphosphateBy similarity1
Metal bindingi64Magnesium 1By similarity1
Metal bindingi64Magnesium 2By similarity1
Metal bindingi68Magnesium 1By similarity1
Metal bindingi68Magnesium 2By similarity1
Binding sitei73Dimethylallyl diphosphateBy similarity1
Binding sitei74Isopentenyl diphosphateBy similarity1
Binding sitei151Dimethylallyl diphosphateBy similarity1
Binding sitei152Dimethylallyl diphosphateBy similarity1
Binding sitei185Dimethylallyl diphosphateBy similarity1
Metal bindingi188Magnesium 3By similarity1
Binding sitei202Dimethylallyl diphosphateBy similarity1
Binding sitei212Dimethylallyl diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processIsoprene biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-191273 Cholesterol biosynthesis
UniPathwayiUPA00259; UER00368
UPA00260; UER00369
UPA00389; UER00564

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl pyrophosphate synthase (EC:2.5.1.-)
Short name:
GGPP synthase
Short name:
GGPPSase
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase (EC:2.5.1.1)
Farnesyl diphosphate synthase
Farnesyltranstransferase (EC:2.5.1.29)
Geranylgeranyl diphosphate synthase
Geranyltranstransferase (EC:2.5.1.10)
Gene namesi
Name:GGPS1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Organism-specific databases

VGNCiVGNC:29343 GGPS1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239611 – 300Geranylgeranyl pyrophosphate synthaseAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP56966
PRIDEiP56966

Expressioni

Gene expression databases

BgeeiENSBTAG00000013068

Interactioni

Subunit structurei

Homohexamer; trimer of homodimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017376

Structurei

3D structure databases

ProteinModelPortaliP56966
SMRiP56966
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

eggNOGiKOG0777 Eukaryota
COG0142 LUCA
GeneTreeiENSGT00390000010417
HOGENOMiHOG000169461
HOVERGENiHBG051729
InParanoidiP56966
KOiK00804
OMAiFYSKAFF
OrthoDBiEOG091G0AO6
TreeFamiTF300101

Family and domain databases

Gene3Di1.10.600.101 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR000092 Polyprenyl_synt
IPR033749 Polyprenyl_synt_CS
PfamiView protein in Pfam
PF00348 polyprenyl_synt, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
PROSITEiView protein in PROSITE
PS00723 POLYPRENYL_SYNTHASE_1, 1 hit
PS00444 POLYPRENYL_SYNTHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P56966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII
60 70 80 90 100
EVTEMLHNAS LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL
110 120 130 140 150
EKVLTLNHPD AVKLFTRQLL ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ
160 170 180 190 200
KTGGLFGLAV GLMQLFSDYK EDLKPLLDTL GLFFQIRDDY ANLHSKEYSE
210 220 230 240 250
NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVHY
260 270 280 290 300
LENVGSFEYT RNTLKELESK AYKQIDARGG NPELVALIKH LSKMFKEENE
Length:300
Mass (Da):34,900
Last modified:April 3, 2007 - v2
Checksum:iFF6606F42CB9AE81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120313 mRNA Translation: AAI20314.1
RefSeqiNP_001073269.1, NM_001079801.1
XP_010818738.1, XM_010820436.1
UniGeneiBt.71777

Genome annotation databases

EnsembliENSBTAT00000017376; ENSBTAP00000017376; ENSBTAG00000013068
GeneIDi780882
KEGGibta:780882

Similar proteinsi

Entry informationi

Entry nameiGGPPS_BOVIN
AccessioniPrimary (citable) accession number: P56966
Secondary accession number(s): Q0VC78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome