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Protein

Geranylgeranyl pyrophosphate synthase

Gene

GGPS1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.

Catalytic activityi

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: farnesyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (FDPS), Geranylgeranyl pyrophosphate synthase (GGPS1)
This subpathway is part of the pathway farnesyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, the pathway farnesyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Pathwayi: geranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (FDPS), Geranylgeranyl pyrophosphate synthase (GGPS1)
This subpathway is part of the pathway geranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate, the pathway geranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Pathwayi: geranylgeranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Geranylgeranyl pyrophosphate synthase (GGPS1)
This subpathway is part of the pathway geranylgeranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate, the pathway geranylgeranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25Isopentenyl diphosphateBy similarity1
Binding sitei28Isopentenyl diphosphateBy similarity1
Binding sitei57Isopentenyl diphosphateBy similarity1
Metal bindingi64Magnesium 1By similarity1
Metal bindingi64Magnesium 2By similarity1
Metal bindingi68Magnesium 1By similarity1
Metal bindingi68Magnesium 2By similarity1
Binding sitei73Dimethylallyl diphosphateBy similarity1
Binding sitei74Isopentenyl diphosphateBy similarity1
Binding sitei151Dimethylallyl diphosphateBy similarity1
Binding sitei152Dimethylallyl diphosphateBy similarity1
Binding sitei185Dimethylallyl diphosphateBy similarity1
Metal bindingi188Magnesium 3By similarity1
Binding sitei202Dimethylallyl diphosphateBy similarity1
Binding sitei212Dimethylallyl diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-191273. Cholesterol biosynthesis.
R-BTA-2426168. Activation of gene expression by SREBF (SREBP).
UniPathwayiUPA00259; UER00368.
UPA00260; UER00369.
UPA00389; UER00564.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl pyrophosphate synthase (EC:2.5.1.-)
Short name:
GGPP synthase
Short name:
GGPPSase
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase (EC:2.5.1.1)
Farnesyl diphosphate synthase
Farnesyltranstransferase (EC:2.5.1.29)
Geranylgeranyl diphosphate synthase
Geranyltranstransferase (EC:2.5.1.10)
Gene namesi
Name:GGPS1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239611 – 300Geranylgeranyl pyrophosphate synthaseAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP56966.
PRIDEiP56966.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013068.

Interactioni

Subunit structurei

Homohexamer; trimer of homodimers.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017376.

Structurei

3D structure databases

ProteinModelPortaliP56966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

eggNOGiKOG0777. Eukaryota.
COG0142. LUCA.
GeneTreeiENSGT00390000010417.
HOGENOMiHOG000169461.
HOVERGENiHBG051729.
InParanoidiP56966.
KOiK00804.
OMAiHWLNVPE.
OrthoDBiEOG091G0AO6.
TreeFamiTF300101.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR033749. Polyprenyl_synt_CS.
[Graphical view]
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII
60 70 80 90 100
EVTEMLHNAS LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL
110 120 130 140 150
EKVLTLNHPD AVKLFTRQLL ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ
160 170 180 190 200
KTGGLFGLAV GLMQLFSDYK EDLKPLLDTL GLFFQIRDDY ANLHSKEYSE
210 220 230 240 250
NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVHY
260 270 280 290 300
LENVGSFEYT RNTLKELESK AYKQIDARGG NPELVALIKH LSKMFKEENE
Length:300
Mass (Da):34,900
Last modified:April 3, 2007 - v2
Checksum:iFF6606F42CB9AE81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120313 mRNA. Translation: AAI20314.1.
RefSeqiNP_001073269.1. NM_001079801.1.
XP_010818738.1. XM_010820436.1.
UniGeneiBt.71777.

Genome annotation databases

EnsembliENSBTAT00000017376; ENSBTAP00000017376; ENSBTAG00000013068.
GeneIDi780882.
KEGGibta:780882.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC120313 mRNA. Translation: AAI20314.1.
RefSeqiNP_001073269.1. NM_001079801.1.
XP_010818738.1. XM_010820436.1.
UniGeneiBt.71777.

3D structure databases

ProteinModelPortaliP56966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017376.

Proteomic databases

PaxDbiP56966.
PRIDEiP56966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017376; ENSBTAP00000017376; ENSBTAG00000013068.
GeneIDi780882.
KEGGibta:780882.

Organism-specific databases

CTDi9453.

Phylogenomic databases

eggNOGiKOG0777. Eukaryota.
COG0142. LUCA.
GeneTreeiENSGT00390000010417.
HOGENOMiHOG000169461.
HOVERGENiHBG051729.
InParanoidiP56966.
KOiK00804.
OMAiHWLNVPE.
OrthoDBiEOG091G0AO6.
TreeFamiTF300101.

Enzyme and pathway databases

UniPathwayiUPA00259; UER00368.
UPA00260; UER00369.
UPA00389; UER00564.
ReactomeiR-BTA-191273. Cholesterol biosynthesis.
R-BTA-2426168. Activation of gene expression by SREBF (SREBP).

Gene expression databases

BgeeiENSBTAG00000013068.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR033749. Polyprenyl_synt_CS.
[Graphical view]
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGGPPS_BOVIN
AccessioniPrimary (citable) accession number: P56966
Secondary accession number(s): Q0VC78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.