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Protein

Syntaxin-17

Gene

STX17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).3 Publications

GO - Molecular functioni

  • protein kinase binding Source: Ensembl
  • protein phosphatase binding Source: UniProtKB
  • SNAP receptor activity Source: UniProtKB
  • SNARE binding Source: UniProtKB

GO - Biological processi

  • autophagosome maturation Source: UniProtKB
  • autophagosome membrane docking Source: GO_Central
  • endoplasmic reticulum-Golgi intermediate compartment organization Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • exocytosis Source: GO_Central
  • Golgi organization Source: UniProtKB
  • intracellular protein transport Source: GO_Central
  • protein localization to phagophore assembly site Source: MGI
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central

Keywordsi

Biological processAutophagy, ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-171 Publication
Gene namesi
Name:STX17Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136874.10
HGNCiHGNC:11432 STX17
MIMi604204 gene
neXtProtiNX_P56962

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 228CytoplasmicSequence analysisAdd BLAST227
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 254LumenalSequence analysis5
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 302CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi244G → L: Alters localization to the autophagosome; when associated with Leu-248. 1 Publication1
Mutagenesisi248G → L: Alters localization to the autophagosome; when associated with Leu-244. 1 Publication1
Mutagenesisi264G → L: Alters localization to the autophagosome; when associated with Leu-268. 1 Publication1
Mutagenesisi268G → L: Alters localization to the autophagosome; when associated with Leu-264. 1 Publication1
Mutagenesisi299 – 300KK → AA: Localizes to the Golgi instead of the endoplasmic reticulum. 1 Publication2

Organism-specific databases

DisGeNETi55014
OpenTargetsiENSG00000136874
PharmGKBiPA36232

Polymorphism and mutation databases

BioMutaiSTX17
DMDMi212286190

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002102282 – 302Syntaxin-17Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei41N6-acetyllysineCombined sources1
Modified residuei157Phosphotyrosine; by ABL1By similarity1
Modified residuei289PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2; regulates exit from the endoplasmic reticulum (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP56962
MaxQBiP56962
PaxDbiP56962
PeptideAtlasiP56962
PRIDEiP56962
ProteomicsDBi56962

PTM databases

iPTMnetiP56962
PhosphoSitePlusiP56962

Expressioni

Gene expression databases

BgeeiENSG00000136874
CleanExiHS_STX17
ExpressionAtlasiP56962 baseline and differential
GenevisibleiP56962 HS

Organism-specific databases

HPAiHPA001204

Interactioni

Subunit structurei

Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome (PubMed:23217709, PubMed:25686604). Interacts with VAMP7 and VTI1B (PubMed:23217709). Probably interacts with BET1, SCFD1 and SEC22B (By similarity). Interacts with PTPN2 and ABL1; involved in STX17 phosphorylation (PubMed:23006999). Interacts with COPB1 (By similarity). Interacts with TMED9 and TMED10; the interaction is direct (PubMed:21545355). Interacts with ATG14 (PubMed:25686604).By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein kinase binding Source: Ensembl
  • protein phosphatase binding Source: UniProtKB
  • SNAP receptor activity Source: UniProtKB
  • SNARE binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120346, 12 interactors
DIPiDIP-47297N
IntActiP56962, 32 interactors
MINTiP56962
STRINGi9606.ENSP00000259400

Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi173 – 195Combined sources23
Helixi197 – 226Combined sources30

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WY4X-ray1.40B170-227[»]
ProteinModelPortaliP56962
SMRiP56962
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 224t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni229 – 275Necessary and sufficient for localization to autophagosome1 PublicationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili53 – 123Sequence analysisAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi299 – 302Endoplasmic reticulum retention signalSequence analysis4

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811 Eukaryota
COG5325 LUCA
GeneTreeiENSGT00390000013283
HOGENOMiHOG000006905
HOVERGENiHBG055257
InParanoidiP56962
KOiK08491
OMAiFNVAIPH
OrthoDBiEOG091G127M
PhylomeDBiP56962
TreeFamiTF323947

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR028676 STX17
IPR006012 Syntaxin/epimorphin_CS
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF139 PTHR19957:SF139, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDEEKVKL RRLEPAIQKF IKIVIPTDLE RLRKHQINIE KYQRCRIWDK
60 70 80 90 100
LHEEHINAGR TVQQLRSNIR EIEKLCLKVR KDDLVLLKRM IDPVKEEASA
110 120 130 140 150
ATAEFLQLHL ESVEELKKQF NDEETLLQPP LTRSMTVGGA FHTTEAEASS
160 170 180 190 200
QSLTQIYALP EIPQDQNAAE SWETLEADLI ELSQLVTDFS LLVNSQQEKI
210 220 230 240 250
DSIADHVNSA AVNVEEGTKN LGKAAKYKLA ALPVAGALIG GMVGGPIGLL
260 270 280 290 300
AGFKVAGIAA ALGGGVLGFT GGKLIQRKKQ KMMEKLTSSC PDLPSQTDKK

CS
Length:302
Mass (Da):33,403
Last modified:July 22, 2008 - v2
Checksum:i51AD5427EFBAC541
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28D → N in BAA91311 (PubMed:14702039).Curated1
Sequence conflicti172W → R in BAA91311 (PubMed:14702039).Curated1
Sequence conflicti252G → C in BAA91311 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000658 mRNA Translation: BAA91311.1
AL358937 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58920.1
BC101564 mRNA Translation: AAI01565.1
BC101566 mRNA Translation: AAI01567.1
CCDSiCCDS6745.1
RefSeqiNP_060389.2, NM_017919.2
XP_011517122.1, XM_011518820.2
XP_011517123.1, XM_011518821.2
UniGeneiHs.704031

Genome annotation databases

EnsembliENST00000259400; ENSP00000259400; ENSG00000136874
ENST00000525640; ENSP00000435981; ENSG00000136874
ENST00000534052; ENSP00000433484; ENSG00000136874
GeneIDi55014
KEGGihsa:55014
UCSCiuc004bal.5 human

Similar proteinsi

Entry informationi

Entry nameiSTX17_HUMAN
AccessioniPrimary (citable) accession number: P56962
Secondary accession number(s): Q4VXC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 22, 2008
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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