SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P56960

- EXOSX_MOUSE

UniProt

P56960 - EXOSX_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Exosome component 10
Gene
Exosc10, Pmscl2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity By similarity. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA By similarity.

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-KW
  3. exoribonuclease activity Source: Ensembl
  4. nucleotide binding Source: InterPro

GO - Biological processi

  1. CUT catabolic process Source: Ensembl
  2. dosage compensation by inactivation of X chromosome Source: MGI
  3. histone mRNA catabolic process Source: UniProtKB
  4. maturation of 5.8S rRNA Source: Ensembl
  5. nuclear polyadenylation-dependent rRNA catabolic process Source: Ensembl
  6. nuclear retention of unspliced pre-mRNA at the site of transcription Source: Ensembl
  7. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Nonsense-mediated mRNA decay, rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome component 10 (EC:3.1.13.-)
Alternative name(s):
Autoantigen PM/Scl 2 homolog
Polymyositis/scleroderma autoantigen 2 homolog
Gene namesi
Name:Exosc10
Synonyms:Pmscl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1355322. Exosc10.

Subcellular locationi

Cytoplasm By similarity. Nucleusnucleolus By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. exosome (RNase complex) Source: UniProtKB
  3. nuclear exosome (RNase complex) Source: InterPro
  4. nucleolus Source: UniProtKB
  5. transcriptionally active chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Exosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Exosome component 10
PRO_0000087134Add
BLAST

Proteomic databases

MaxQBiP56960.
PaxDbiP56960.
PRIDEiP56960.

PTM databases

PhosphoSiteiP56960.

Expressioni

Gene expression databases

ArrayExpressiP56960.
BgeeiP56960.
CleanExiMM_EXOSC10.
GenevestigatoriP56960.

Interactioni

Subunit structurei

Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Interacts with C1D and MPHOSPH6 By similarity. Interacts with ALYREF/THOC4 By similarity.

Protein-protein interaction databases

BioGridi206151. 1 interaction.
IntActiP56960. 1 interaction.
MINTiMINT-4094804.

Structurei

3D structure databases

ProteinModelPortaliP56960.
SMRiP56960. Positions 179-595.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini503 – 58381HRDC
Add
BLAST

Sequence similaritiesi

Contains 1 HRDC domain.

Phylogenomic databases

eggNOGiCOG0349.
GeneTreeiENSGT00390000015408.
HOGENOMiHOG000001579.
HOVERGENiHBG051524.
InParanoidiB1ARY9.
KOiK12591.
OMAiGNKSMSF.
OrthoDBiEOG7Z3F3S.
TreeFamiTF105991.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR012588. Exosome-assoc_fac_Rrp6_N.
IPR010997. HRDC-like.
IPR002121. HRDC_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01612. DNA_pol_A_exo1. 1 hit.
PF00570. HRDC. 1 hit.
PF08066. PMC2NT. 1 hit.
[Graphical view]
SMARTiSM00474. 35EXOc. 1 hit.
SM00341. HRDC. 1 hit.
[Graphical view]
SUPFAMiSSF47819. SSF47819. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50967. HRDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56960-1 [UniParc]FASTAAdd to Basket

« Hide

MAPPSPREHQ SAPATSATKP DAEMVLPGFP DADSFVKFAL GSVVAVTKAS    50
GGLPQFGDEY DFYRSFPAFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR 100
SKVTELEDKF DLLVDTNDVI LERVGMLLDE ASGVNKHQQP VLPAGLQVPK 150
TIVSSWNRKA GEYGKKAKSE TFRLLHAKNI VRPQLRFREK IDNSNTPFLP 200
KIFVKPNARK PLPLALSKER RERPQDRPED LDVPPALADF IHQQRTQQVE 250
QDMFAHPYQY ELDHFTPPQS VLQRPKPQLY RAVGETPCHL VSSLDELVEL 300
NEKLLGCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFIV DTLELRSDMY 350
ILNESLTDPA IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLAR 400
HSLDHLLRLY CGVESNKQYQ LADWRIRPLP EEMLSYARDD THYLLYIYDR 450
MRLELWERGN HQPVQLQVVW QRSRDICLKK FVKPIFTDES YLELYRKQKK 500
HLNSQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI AEELPKEPQG 550
IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSENAAGV RKSGPLPSAE 600
RLENDLFGPH DCSHAPPDNY QNTSTDGTLP LQKQPSLFTE GKEETSVDAG 650
CLLATAVITL FSEPNTEEGG KTPLTVAQKK AQNIMQSFEN PFRMFLPSLE 700
HKAHISQAAK FDPSSKIYEI SNRWKLASQV QVQKEPKEAT KKKVAEQTAA 750
REEAKEEAAA GVLEQAIPVR QQAALENATK KRERATSDLR TIEQKQEKKR 800
LKSSKKAKDP DPPGKDFSPY DYSQSDFRAF AGDSKSKPSS QFDPNKLAPS 850
GKKGVGAKKC KQSVGNKSMS FAVGKSDRGF RHNWPKR 887
Length:887
Mass (Da):100,942
Last modified:July 27, 2011 - v2
Checksum:i173164944163620C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti792 – 7921I → V in AAF01779. 1 Publication
Sequence conflicti792 – 7921I → V in AAF01781. 1 Publication
Sequence conflicti860 – 8601C → F in AAF01779. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF091392 mRNA. Translation: AAF01779.1.
AF091505
, AF091506, AF092074, AF092075, AF092076, AF092077, AF092078, AF092079, AF092080, AF092081, AF092082, AF092083 Genomic DNA. Translation: AAF01781.1.
AL606969, AL713995 Genomic DNA. Translation: CAM21195.1.
AL713995, AL606969 Genomic DNA. Translation: CAM23945.1.
CCDSiCCDS18939.1.
RefSeqiNP_057908.2. NM_016699.2.
UniGeneiMm.266635.

Genome annotation databases

EnsembliENSMUST00000017408; ENSMUSP00000017408; ENSMUSG00000017264.
GeneIDi50912.
KEGGimmu:50912.
UCSCiuc008vut.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF091392 mRNA. Translation: AAF01779.1 .
AF091505
, AF091506 , AF092074 , AF092075 , AF092076 , AF092077 , AF092078 , AF092079 , AF092080 , AF092081 , AF092082 , AF092083 Genomic DNA. Translation: AAF01781.1 .
AL606969 , AL713995 Genomic DNA. Translation: CAM21195.1 .
AL713995 , AL606969 Genomic DNA. Translation: CAM23945.1 .
CCDSi CCDS18939.1.
RefSeqi NP_057908.2. NM_016699.2.
UniGenei Mm.266635.

3D structure databases

ProteinModelPortali P56960.
SMRi P56960. Positions 179-595.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206151. 1 interaction.
IntActi P56960. 1 interaction.
MINTi MINT-4094804.

PTM databases

PhosphoSitei P56960.

Proteomic databases

MaxQBi P56960.
PaxDbi P56960.
PRIDEi P56960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000017408 ; ENSMUSP00000017408 ; ENSMUSG00000017264 .
GeneIDi 50912.
KEGGi mmu:50912.
UCSCi uc008vut.2. mouse.

Organism-specific databases

CTDi 5394.
MGIi MGI:1355322. Exosc10.

Phylogenomic databases

eggNOGi COG0349.
GeneTreei ENSGT00390000015408.
HOGENOMi HOG000001579.
HOVERGENi HBG051524.
InParanoidi B1ARY9.
KOi K12591.
OMAi GNKSMSF.
OrthoDBi EOG7Z3F3S.
TreeFami TF105991.

Miscellaneous databases

ChiTaRSi EXOSC10. mouse.
NextBioi 307899.
PROi P56960.
SOURCEi Search...

Gene expression databases

ArrayExpressi P56960.
Bgeei P56960.
CleanExi MM_EXOSC10.
Genevestigatori P56960.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
InterProi IPR002562. 3'-5'_exonuclease_dom.
IPR012588. Exosome-assoc_fac_Rrp6_N.
IPR010997. HRDC-like.
IPR002121. HRDC_dom.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF01612. DNA_pol_A_exo1. 1 hit.
PF00570. HRDC. 1 hit.
PF08066. PMC2NT. 1 hit.
[Graphical view ]
SMARTi SM00474. 35EXOc. 1 hit.
SM00341. HRDC. 1 hit.
[Graphical view ]
SUPFAMi SSF47819. SSF47819. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEi PS50967. HRDC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and localization of mouse Pmscl1 and Pmscl2 genes."
    Bliskovski V., Liddell R., Ramsay E.S., Miller M.J., Mock B.A.
    Genomics 64:106-110(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvJ and BALB/c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 395-400, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiEXOSX_MOUSE
AccessioniPrimary (citable) accession number: P56960
Secondary accession number(s): B1ARY9, Q9QYS8, Q9R0B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi