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P56960

- EXOSX_MOUSE

UniProt

P56960 - EXOSX_MOUSE

Protein

Exosome component 10

Gene

Exosc10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity By similarity. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA By similarity.By similarity

    GO - Molecular functioni

    1. 3'-5' exonuclease activity Source: InterPro
    2. exoribonuclease activity Source: Ensembl
    3. nucleotide binding Source: InterPro
    4. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. CUT catabolic process Source: Ensembl
    2. dosage compensation by inactivation of X chromosome Source: MGI
    3. histone mRNA catabolic process Source: UniProtKB
    4. maturation of 5.8S rRNA Source: Ensembl
    5. nuclear polyadenylation-dependent rRNA catabolic process Source: Ensembl
    6. nuclear retention of unspliced pre-mRNA at the site of transcription Source: Ensembl
    7. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    Nonsense-mediated mRNA decay, rRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exosome component 10 (EC:3.1.13.-)
    Alternative name(s):
    Autoantigen PM/Scl 2 homolog
    Polymyositis/scleroderma autoantigen 2 homolog
    Gene namesi
    Name:Exosc10
    Synonyms:Pmscl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1355322. Exosc10.

    Subcellular locationi

    Cytoplasm By similarity. Nucleusnucleolus By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. exosome (RNase complex) Source: UniProtKB
    3. nuclear exosome (RNase complex) Source: InterPro
    4. nucleolus Source: UniProtKB
    5. transcriptionally active chromatin Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Exosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 887887Exosome component 10PRO_0000087134Add
    BLAST

    Proteomic databases

    MaxQBiP56960.
    PaxDbiP56960.
    PRIDEiP56960.

    PTM databases

    PhosphoSiteiP56960.

    Expressioni

    Gene expression databases

    ArrayExpressiP56960.
    BgeeiP56960.
    CleanExiMM_EXOSC10.
    GenevestigatoriP56960.

    Interactioni

    Subunit structurei

    Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Interacts with C1D and MPHOSPH6 By similarity. Interacts with ALYREF/THOC4 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi206151. 1 interaction.
    IntActiP56960. 1 interaction.
    MINTiMINT-4094804.

    Structurei

    3D structure databases

    ProteinModelPortaliP56960.
    SMRiP56960. Positions 179-595.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini503 – 58381HRDCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HRDC domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0349.
    GeneTreeiENSGT00390000015408.
    HOGENOMiHOG000001579.
    HOVERGENiHBG051524.
    InParanoidiB1ARY9.
    KOiK12591.
    OMAiGNKSMSF.
    OrthoDBiEOG7Z3F3S.
    TreeFamiTF105991.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    InterProiIPR002562. 3'-5'_exonuclease_dom.
    IPR012588. Exosome-assoc_fac_Rrp6_N.
    IPR010997. HRDC-like.
    IPR002121. HRDC_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF01612. DNA_pol_A_exo1. 1 hit.
    PF00570. HRDC. 1 hit.
    PF08066. PMC2NT. 1 hit.
    [Graphical view]
    SMARTiSM00474. 35EXOc. 1 hit.
    SM00341. HRDC. 1 hit.
    [Graphical view]
    SUPFAMiSSF47819. SSF47819. 1 hit.
    SSF53098. SSF53098. 1 hit.
    PROSITEiPS50967. HRDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56960-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPPSPREHQ SAPATSATKP DAEMVLPGFP DADSFVKFAL GSVVAVTKAS    50
    GGLPQFGDEY DFYRSFPAFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR 100
    SKVTELEDKF DLLVDTNDVI LERVGMLLDE ASGVNKHQQP VLPAGLQVPK 150
    TIVSSWNRKA GEYGKKAKSE TFRLLHAKNI VRPQLRFREK IDNSNTPFLP 200
    KIFVKPNARK PLPLALSKER RERPQDRPED LDVPPALADF IHQQRTQQVE 250
    QDMFAHPYQY ELDHFTPPQS VLQRPKPQLY RAVGETPCHL VSSLDELVEL 300
    NEKLLGCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFIV DTLELRSDMY 350
    ILNESLTDPA IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLAR 400
    HSLDHLLRLY CGVESNKQYQ LADWRIRPLP EEMLSYARDD THYLLYIYDR 450
    MRLELWERGN HQPVQLQVVW QRSRDICLKK FVKPIFTDES YLELYRKQKK 500
    HLNSQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI AEELPKEPQG 550
    IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSENAAGV RKSGPLPSAE 600
    RLENDLFGPH DCSHAPPDNY QNTSTDGTLP LQKQPSLFTE GKEETSVDAG 650
    CLLATAVITL FSEPNTEEGG KTPLTVAQKK AQNIMQSFEN PFRMFLPSLE 700
    HKAHISQAAK FDPSSKIYEI SNRWKLASQV QVQKEPKEAT KKKVAEQTAA 750
    REEAKEEAAA GVLEQAIPVR QQAALENATK KRERATSDLR TIEQKQEKKR 800
    LKSSKKAKDP DPPGKDFSPY DYSQSDFRAF AGDSKSKPSS QFDPNKLAPS 850
    GKKGVGAKKC KQSVGNKSMS FAVGKSDRGF RHNWPKR 887
    Length:887
    Mass (Da):100,942
    Last modified:July 27, 2011 - v2
    Checksum:i173164944163620C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti792 – 7921I → V in AAF01779. (PubMed:10708524)Curated
    Sequence conflicti792 – 7921I → V in AAF01781. (PubMed:10708524)Curated
    Sequence conflicti860 – 8601C → F in AAF01779. (PubMed:10708524)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF091392 mRNA. Translation: AAF01779.1.
    AF091505
    , AF091506, AF092074, AF092075, AF092076, AF092077, AF092078, AF092079, AF092080, AF092081, AF092082, AF092083 Genomic DNA. Translation: AAF01781.1.
    AL606969, AL713995 Genomic DNA. Translation: CAM21195.1.
    AL713995, AL606969 Genomic DNA. Translation: CAM23945.1.
    CCDSiCCDS18939.1.
    RefSeqiNP_057908.2. NM_016699.2.
    UniGeneiMm.266635.

    Genome annotation databases

    EnsembliENSMUST00000017408; ENSMUSP00000017408; ENSMUSG00000017264.
    GeneIDi50912.
    KEGGimmu:50912.
    UCSCiuc008vut.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF091392 mRNA. Translation: AAF01779.1 .
    AF091505
    , AF091506 , AF092074 , AF092075 , AF092076 , AF092077 , AF092078 , AF092079 , AF092080 , AF092081 , AF092082 , AF092083 Genomic DNA. Translation: AAF01781.1 .
    AL606969 , AL713995 Genomic DNA. Translation: CAM21195.1 .
    AL713995 , AL606969 Genomic DNA. Translation: CAM23945.1 .
    CCDSi CCDS18939.1.
    RefSeqi NP_057908.2. NM_016699.2.
    UniGenei Mm.266635.

    3D structure databases

    ProteinModelPortali P56960.
    SMRi P56960. Positions 179-595.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206151. 1 interaction.
    IntActi P56960. 1 interaction.
    MINTi MINT-4094804.

    PTM databases

    PhosphoSitei P56960.

    Proteomic databases

    MaxQBi P56960.
    PaxDbi P56960.
    PRIDEi P56960.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017408 ; ENSMUSP00000017408 ; ENSMUSG00000017264 .
    GeneIDi 50912.
    KEGGi mmu:50912.
    UCSCi uc008vut.2. mouse.

    Organism-specific databases

    CTDi 5394.
    MGIi MGI:1355322. Exosc10.

    Phylogenomic databases

    eggNOGi COG0349.
    GeneTreei ENSGT00390000015408.
    HOGENOMi HOG000001579.
    HOVERGENi HBG051524.
    InParanoidi B1ARY9.
    KOi K12591.
    OMAi GNKSMSF.
    OrthoDBi EOG7Z3F3S.
    TreeFami TF105991.

    Miscellaneous databases

    ChiTaRSi EXOSC10. mouse.
    NextBioi 307899.
    PROi P56960.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56960.
    Bgeei P56960.
    CleanExi MM_EXOSC10.
    Genevestigatori P56960.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    InterProi IPR002562. 3'-5'_exonuclease_dom.
    IPR012588. Exosome-assoc_fac_Rrp6_N.
    IPR010997. HRDC-like.
    IPR002121. HRDC_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF01612. DNA_pol_A_exo1. 1 hit.
    PF00570. HRDC. 1 hit.
    PF08066. PMC2NT. 1 hit.
    [Graphical view ]
    SMARTi SM00474. 35EXOc. 1 hit.
    SM00341. HRDC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47819. SSF47819. 1 hit.
    SSF53098. SSF53098. 1 hit.
    PROSITEi PS50967. HRDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and localization of mouse Pmscl1 and Pmscl2 genes."
      Bliskovski V., Liddell R., Ramsay E.S., Miller M.J., Mock B.A.
      Genomics 64:106-110(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/SvJ and BALB/c.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 395-400, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiEXOSX_MOUSE
    AccessioniPrimary (citable) accession number: P56960
    Secondary accession number(s): B1ARY9, Q9QYS8, Q9R0B1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3