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P56959

- FUS_MOUSE

UniProt

P56959 - FUS_MOUSE

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Protein
RNA-binding protein FUS
Gene
Fus
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri415 – 44632RanBP2-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein FUS
Alternative name(s):
Protein pigpen
Gene namesi
Name:Fus
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1353633. Fus.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518RNA-binding protein FUS
PRO_0000081592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei217 – 2171Omega-N-methylated arginine By similarity
Modified residuei219 – 2191Omega-N-methylated arginine By similarity
Modified residuei235 – 2351Asymmetric dimethylarginine By similarity
Modified residuei237 – 2371Asymmetric dimethylarginine By similarity
Modified residuei241 – 2411Asymmetric dimethylarginine By similarity
Modified residuei244 – 2441Asymmetric dimethylarginine By similarity
Modified residuei252 – 2521Asymmetric dimethylarginine By similarity
Modified residuei270 – 2701Phosphoserine By similarity
Modified residuei279 – 2791Phosphothreonine By similarity
Modified residuei370 – 3701Asymmetric dimethylarginine By similarity
Modified residuei376 – 3761Asymmetric dimethylarginine By similarity
Modified residuei379 – 3791Asymmetric dimethylarginine By similarity
Modified residuei381 – 3811Asymmetric dimethylarginine By similarity
Modified residuei387 – 3871Asymmetric dimethylarginine By similarity
Modified residuei400 – 4001Asymmetric dimethylarginine By similarity
Modified residuei466 – 4661Asymmetric dimethylarginine By similarity
Modified residuei468 – 4681Asymmetric dimethylarginine By similarity
Modified residuei473 – 4731Asymmetric dimethylarginine By similarity
Modified residuei477 – 4771Asymmetric dimethylarginine By similarity
Modified residuei479 – 4791Asymmetric dimethylarginine By similarity
Modified residuei483 – 4831Asymmetric dimethylarginine By similarity
Modified residuei487 – 4871Asymmetric dimethylarginine By similarity
Modified residuei490 – 4901Asymmetric dimethylarginine By similarity
Modified residuei495 – 4951Asymmetric dimethylarginine By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP56959.
PaxDbiP56959.
PRIDEiP56959.

PTM databases

PhosphoSiteiP56959.

Expressioni

Gene expression databases

ArrayExpressiP56959.
BgeeiP56959.
GenevestigatoriP56959.

Interactioni

Subunit structurei

Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts with OTUB1 and SARNP By similarity.

Protein-protein interaction databases

BioGridi231475. 7 interactions.
IntActiP56959. 4 interactions.
MINTiMINT-136330.

Structurei

3D structure databases

ProteinModelPortaliP56959.
SMRiP56959. Positions 271-368.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini278 – 36487RRM
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 167167Gln/Gly/Ser/Tyr-rich
Add
BLAST
Compositional biasi168 – 26598Gly-rich
Add
BLAST
Compositional biasi364 – 518155Arg/Gly-rich
Add
BLAST

Sequence similaritiesi

Belongs to the RRM TET family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG240581.
HOGENOMiHOG000038010.
HOVERGENiHBG094940.
InParanoidiP56959.
KOiK13098.
OMAiNQPYGQQ.
OrthoDBiEOG7DZ8N7.
PhylomeDBiP56959.
TreeFamiTF322599.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56959-1 [UniParc]FASTAAdd to Basket

« Hide

MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YGQSADTSGY    50
GQSSYGSSYG QTQNTGYGTQ SAPQGYGSTG GYGSSQSSQS SYGQQSSYPG 100
YGQQPAPSST SGSYGGSSQS SSYGQPQSGG YGQQSGYGGQ QQSYGQQQSS 150
YNPPQGYGQQ NQYNSSSGGG GGGGGGNYGQ DQSSMSGGGG GGGYGNQDQS 200
GGGGGGYGGG QQDRGGRGRG GGGGYNRSSG GYEPRGRGGG RGGRGGMGGS 250
DRGGFNKFGG PRDQGSRHDS EQDNSDNNTI FVQGLGENVT IESVADYFKQ 300
IGIIKTNKKT GQPMINLYTD RETGKLKGEA TVSFDDPPSA KAAIDWFDGK 350
EFSGNPIKVS FATRRADFNR GGGNGRGGRG RGGPMGRGGY GGGGSGGGGR 400
GGFPSGGGGG GGQQRAGDWK CPNPTCENMN FSWRNECNQC KAPKPDGPGG 450
GPGGSHMGGN YGDDRRGRGG YDRGGYRGRG GDRGGFRGGR GGGDRGGFGP 500
GKMDSRGEHR QDRRERPY 518
Length:518
Mass (Da):52,673
Last modified:December 1, 2000 - v1
Checksum:iE06F231BFEED78D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF224264 mRNA. Translation: AAF70602.1.
CCDSiCCDS21886.1.
RefSeqiNP_631888.1. NM_139149.2.
UniGeneiMm.277680.

Genome annotation databases

EnsembliENSMUST00000106251; ENSMUSP00000101858; ENSMUSG00000030795.
GeneIDi233908.
KEGGimmu:233908.
UCSCiuc009jxo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF224264 mRNA. Translation: AAF70602.1 .
CCDSi CCDS21886.1.
RefSeqi NP_631888.1. NM_139149.2.
UniGenei Mm.277680.

3D structure databases

ProteinModelPortali P56959.
SMRi P56959. Positions 271-368.
ModBasei Search...

Protein-protein interaction databases

BioGridi 231475. 7 interactions.
IntActi P56959. 4 interactions.
MINTi MINT-136330.

PTM databases

PhosphoSitei P56959.

Proteomic databases

MaxQBi P56959.
PaxDbi P56959.
PRIDEi P56959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000106251 ; ENSMUSP00000101858 ; ENSMUSG00000030795 .
GeneIDi 233908.
KEGGi mmu:233908.
UCSCi uc009jxo.1. mouse.

Organism-specific databases

CTDi 2521.
MGIi MGI:1353633. Fus.

Phylogenomic databases

eggNOGi NOG240581.
HOGENOMi HOG000038010.
HOVERGENi HBG094940.
InParanoidi P56959.
KOi K13098.
OMAi NQPYGQQ.
OrthoDBi EOG7DZ8N7.
PhylomeDBi P56959.
TreeFami TF322599.

Miscellaneous databases

ChiTaRSi FUS. mouse.
NextBioi 381951.
PROi P56959.
SOURCEi Search...

Gene expression databases

ArrayExpressi P56959.
Bgeei P56959.
Genevestigatori P56959.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view ]
Pfami PF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis."
    Alappat S.R., Zhang M., Zhao X., Alliegro M.A., Alliegro M.C., Burdsal C.A.
    Dev. Dyn. 228:59-71(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFUS_MOUSE
AccessioniPrimary (citable) accession number: P56959
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi