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Protein

RNA-binding protein FUS

Gene

Fus

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri415 – 446RanBP2-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein FUS
Alternative name(s):
Protein pigpen
Gene namesi
Name:Fus
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1353633. Fus.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • dendritic spine head Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: MGI
  • perikaryon Source: Ensembl
  • perinuclear region of cytoplasm Source: Ensembl
  • polysome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815921 – 518RNA-binding protein FUSAdd BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei217Omega-N-methylarginine; alternateBy similarity1
Modified residuei217Omega-N-methylated arginine; alternateBy similarity1
Modified residuei219Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei219Omega-N-methylarginine; alternateBy similarity1
Modified residuei219Omega-N-methylated arginine; alternateBy similarity1
Modified residuei235Asymmetric dimethylarginineBy similarity1
Modified residuei237Asymmetric dimethylarginineBy similarity1
Modified residuei241Asymmetric dimethylarginineBy similarity1
Modified residuei244Asymmetric dimethylarginineBy similarity1
Modified residuei252Asymmetric dimethylarginineBy similarity1
Modified residuei270PhosphoserineBy similarity1
Modified residuei279PhosphothreonineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Modified residuei370Asymmetric dimethylarginineBy similarity1
Modified residuei376Asymmetric dimethylarginineBy similarity1
Modified residuei379Asymmetric dimethylarginineBy similarity1
Modified residuei381Asymmetric dimethylarginineBy similarity1
Modified residuei387Asymmetric dimethylarginineCombined sources1
Modified residuei400Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei400Omega-N-methylarginine; alternateCombined sources1
Modified residuei466Asymmetric dimethylarginineBy similarity1
Modified residuei468Asymmetric dimethylarginineBy similarity1
Modified residuei473Asymmetric dimethylarginineBy similarity1
Modified residuei477Asymmetric dimethylarginineBy similarity1
Modified residuei479Asymmetric dimethylarginineBy similarity1
Modified residuei483Asymmetric dimethylarginineBy similarity1
Modified residuei487Asymmetric dimethylarginineBy similarity1
Modified residuei490Asymmetric dimethylarginineBy similarity1
Modified residuei495Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei495Omega-N-methylarginine; alternateBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP56959.
PaxDbiP56959.
PeptideAtlasiP56959.
PRIDEiP56959.

PTM databases

iPTMnetiP56959.
PhosphoSitePlusiP56959.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030795.
ExpressionAtlasiP56959. baseline and differential.
GenevisibleiP56959. MM.

Interactioni

Subunit structurei

Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts with OTUB1 and SARNP (By similarity).By similarity

Protein-protein interaction databases

BioGridi231475. 52 interactors.
IntActiP56959. 48 interactors.
MINTiMINT-136330.
STRINGi10090.ENSMUSP00000101858.

Structurei

3D structure databases

ProteinModelPortaliP56959.
SMRiP56959.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini278 – 364RRMPROSITE-ProRule annotationAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 167Gln/Gly/Ser/Tyr-richAdd BLAST167
Compositional biasi168 – 265Gly-richAdd BLAST98
Compositional biasi364 – 518Arg/Gly-richAdd BLAST155

Sequence similaritiesi

Belongs to the RRM TET family.Curated
Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri415 – 446RanBP2-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IP58. Eukaryota.
ENOG4111GEG. LUCA.
GeneTreeiENSGT00530000063105.
HOGENOMiHOG000038010.
HOVERGENiHBG094940.
InParanoidiP56959.
KOiK13098.
OMAiYGQTQNS.
OrthoDBiEOG091G0U8W.
PhylomeDBiP56959.
TreeFamiTF322599.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF90209. SSF90209. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YGQSADTSGY
60 70 80 90 100
GQSSYGSSYG QTQNTGYGTQ SAPQGYGSTG GYGSSQSSQS SYGQQSSYPG
110 120 130 140 150
YGQQPAPSST SGSYGGSSQS SSYGQPQSGG YGQQSGYGGQ QQSYGQQQSS
160 170 180 190 200
YNPPQGYGQQ NQYNSSSGGG GGGGGGNYGQ DQSSMSGGGG GGGYGNQDQS
210 220 230 240 250
GGGGGGYGGG QQDRGGRGRG GGGGYNRSSG GYEPRGRGGG RGGRGGMGGS
260 270 280 290 300
DRGGFNKFGG PRDQGSRHDS EQDNSDNNTI FVQGLGENVT IESVADYFKQ
310 320 330 340 350
IGIIKTNKKT GQPMINLYTD RETGKLKGEA TVSFDDPPSA KAAIDWFDGK
360 370 380 390 400
EFSGNPIKVS FATRRADFNR GGGNGRGGRG RGGPMGRGGY GGGGSGGGGR
410 420 430 440 450
GGFPSGGGGG GGQQRAGDWK CPNPTCENMN FSWRNECNQC KAPKPDGPGG
460 470 480 490 500
GPGGSHMGGN YGDDRRGRGG YDRGGYRGRG GDRGGFRGGR GGGDRGGFGP
510
GKMDSRGEHR QDRRERPY
Length:518
Mass (Da):52,673
Last modified:December 1, 2000 - v1
Checksum:iE06F231BFEED78D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224264 mRNA. Translation: AAF70602.1.
CCDSiCCDS21886.1.
RefSeqiNP_631888.1. NM_139149.2.
UniGeneiMm.277680.

Genome annotation databases

EnsembliENSMUST00000106251; ENSMUSP00000101858; ENSMUSG00000030795.
GeneIDi233908.
KEGGimmu:233908.
UCSCiuc009jxo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224264 mRNA. Translation: AAF70602.1.
CCDSiCCDS21886.1.
RefSeqiNP_631888.1. NM_139149.2.
UniGeneiMm.277680.

3D structure databases

ProteinModelPortaliP56959.
SMRiP56959.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231475. 52 interactors.
IntActiP56959. 48 interactors.
MINTiMINT-136330.
STRINGi10090.ENSMUSP00000101858.

PTM databases

iPTMnetiP56959.
PhosphoSitePlusiP56959.

Proteomic databases

EPDiP56959.
PaxDbiP56959.
PeptideAtlasiP56959.
PRIDEiP56959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106251; ENSMUSP00000101858; ENSMUSG00000030795.
GeneIDi233908.
KEGGimmu:233908.
UCSCiuc009jxo.1. mouse.

Organism-specific databases

CTDi2521.
MGIiMGI:1353633. Fus.

Phylogenomic databases

eggNOGiENOG410IP58. Eukaryota.
ENOG4111GEG. LUCA.
GeneTreeiENSGT00530000063105.
HOGENOMiHOG000038010.
HOVERGENiHBG094940.
InParanoidiP56959.
KOiK13098.
OMAiYGQTQNS.
OrthoDBiEOG091G0U8W.
PhylomeDBiP56959.
TreeFamiTF322599.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiFus. mouse.
PROiP56959.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030795.
ExpressionAtlasiP56959. baseline and differential.
GenevisibleiP56959. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF90209. SSF90209. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUS_MOUSE
AccessioniPrimary (citable) accession number: P56959
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.