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Protein

RNA-binding protein FUS

Gene

Fus

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri415 – 446RanBP2-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein FUS
Alternative name(s):
Protein pigpen
Gene namesi
Name:Fus
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1353633 Fus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815921 – 518RNA-binding protein FUSAdd BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei217Omega-N-methylarginine; alternateBy similarity1
Modified residuei217Omega-N-methylated arginine; alternateBy similarity1
Modified residuei219Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei219Omega-N-methylarginine; alternateBy similarity1
Modified residuei219Omega-N-methylated arginine; alternateBy similarity1
Modified residuei235Asymmetric dimethylarginineBy similarity1
Modified residuei237Asymmetric dimethylarginineBy similarity1
Modified residuei241Asymmetric dimethylarginineBy similarity1
Modified residuei244Asymmetric dimethylarginineBy similarity1
Modified residuei252Asymmetric dimethylarginineBy similarity1
Modified residuei270PhosphoserineBy similarity1
Modified residuei279PhosphothreonineBy similarity1
Cross-linki327Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei333PhosphoserineBy similarity1
Modified residuei370Asymmetric dimethylarginineBy similarity1
Modified residuei376Asymmetric dimethylarginineBy similarity1
Modified residuei379Asymmetric dimethylarginineBy similarity1
Modified residuei381Asymmetric dimethylarginineBy similarity1
Modified residuei387Asymmetric dimethylarginineCombined sources1
Modified residuei400Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei400Omega-N-methylarginine; alternateCombined sources1
Modified residuei466Asymmetric dimethylarginineBy similarity1
Modified residuei468Asymmetric dimethylarginineBy similarity1
Modified residuei473Asymmetric dimethylarginineBy similarity1
Modified residuei477Asymmetric dimethylarginineBy similarity1
Modified residuei479Asymmetric dimethylarginineBy similarity1
Modified residuei483Asymmetric dimethylarginineBy similarity1
Modified residuei487Asymmetric dimethylarginineBy similarity1
Modified residuei490Asymmetric dimethylarginineBy similarity1
Modified residuei495Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei495Omega-N-methylarginine; alternateBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP56959
PaxDbiP56959
PeptideAtlasiP56959
PRIDEiP56959

PTM databases

iPTMnetiP56959
PhosphoSitePlusiP56959

Expressioni

Gene expression databases

BgeeiENSMUSG00000030795
ExpressionAtlasiP56959 baseline and differential
GenevisibleiP56959 MM

Interactioni

Subunit structurei

Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP. Interacts with LRSAM1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231475, 55 interactors
IntActiP56959, 50 interactors
MINTiP56959
STRINGi10090.ENSMUSP00000101858

Structurei

3D structure databases

ProteinModelPortaliP56959
SMRiP56959
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini278 – 364RRMPROSITE-ProRule annotationAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 167Gln/Gly/Ser/Tyr-richAdd BLAST167
Compositional biasi168 – 265Gly-richAdd BLAST98
Compositional biasi364 – 518Arg/Gly-richAdd BLAST155

Sequence similaritiesi

Belongs to the RRM TET family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri415 – 446RanBP2-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IP58 Eukaryota
ENOG4111GEG LUCA
GeneTreeiENSGT00530000063105
HOGENOMiHOG000038010
HOVERGENiHBG094940
InParanoidiP56959
KOiK13098
OMAiDSYNKGP
OrthoDBiEOG091G0U8W
PhylomeDBiP56959
TreeFamiTF322599

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034459 FUS
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034870 TET_fam
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PANTHERiPTHR23238 PTHR23238, 1 hit
PTHR23238:SF5 PTHR23238:SF5, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF00641 zf-RanBP, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P56959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YGQSADTSGY
60 70 80 90 100
GQSSYGSSYG QTQNTGYGTQ SAPQGYGSTG GYGSSQSSQS SYGQQSSYPG
110 120 130 140 150
YGQQPAPSST SGSYGGSSQS SSYGQPQSGG YGQQSGYGGQ QQSYGQQQSS
160 170 180 190 200
YNPPQGYGQQ NQYNSSSGGG GGGGGGNYGQ DQSSMSGGGG GGGYGNQDQS
210 220 230 240 250
GGGGGGYGGG QQDRGGRGRG GGGGYNRSSG GYEPRGRGGG RGGRGGMGGS
260 270 280 290 300
DRGGFNKFGG PRDQGSRHDS EQDNSDNNTI FVQGLGENVT IESVADYFKQ
310 320 330 340 350
IGIIKTNKKT GQPMINLYTD RETGKLKGEA TVSFDDPPSA KAAIDWFDGK
360 370 380 390 400
EFSGNPIKVS FATRRADFNR GGGNGRGGRG RGGPMGRGGY GGGGSGGGGR
410 420 430 440 450
GGFPSGGGGG GGQQRAGDWK CPNPTCENMN FSWRNECNQC KAPKPDGPGG
460 470 480 490 500
GPGGSHMGGN YGDDRRGRGG YDRGGYRGRG GDRGGFRGGR GGGDRGGFGP
510
GKMDSRGEHR QDRRERPY
Length:518
Mass (Da):52,673
Last modified:December 1, 2000 - v1
Checksum:iE06F231BFEED78D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224264 mRNA Translation: AAF70602.1
CCDSiCCDS21886.1
RefSeqiNP_631888.1, NM_139149.2
UniGeneiMm.277680

Genome annotation databases

EnsembliENSMUST00000106251; ENSMUSP00000101858; ENSMUSG00000030795
GeneIDi233908
KEGGimmu:233908
UCSCiuc009jxo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFUS_MOUSE
AccessioniPrimary (citable) accession number: P56959
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health