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Protein

RNA-binding protein FUS

Gene

Fus

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri415 – 44632RanBP2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_307866. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein FUS
Alternative name(s):
Protein pigpen
Gene namesi
Name:Fus
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1353633. Fus.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • dendritic spine head Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: MGI
  • perikaryon Source: Ensembl
  • perinuclear region of cytoplasm Source: Ensembl
  • polysome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518RNA-binding protein FUSPRO_0000081592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei217 – 2171Omega-N-methylated arginineBy similarity
Modified residuei219 – 2191Omega-N-methylated arginineBy similarity
Modified residuei235 – 2351Asymmetric dimethylarginineBy similarity
Modified residuei237 – 2371Asymmetric dimethylarginineBy similarity
Modified residuei241 – 2411Asymmetric dimethylarginineBy similarity
Modified residuei244 – 2441Asymmetric dimethylarginineBy similarity
Modified residuei252 – 2521Asymmetric dimethylarginineBy similarity
Modified residuei270 – 2701PhosphoserineBy similarity
Modified residuei279 – 2791PhosphothreonineBy similarity
Modified residuei370 – 3701Asymmetric dimethylarginineBy similarity
Modified residuei376 – 3761Asymmetric dimethylarginineBy similarity
Modified residuei379 – 3791Asymmetric dimethylarginineBy similarity
Modified residuei381 – 3811Asymmetric dimethylarginineBy similarity
Modified residuei387 – 3871Asymmetric dimethylarginineBy similarity
Modified residuei400 – 4001Asymmetric dimethylarginineBy similarity
Modified residuei466 – 4661Asymmetric dimethylarginineBy similarity
Modified residuei468 – 4681Asymmetric dimethylarginineBy similarity
Modified residuei473 – 4731Asymmetric dimethylarginineBy similarity
Modified residuei477 – 4771Asymmetric dimethylarginineBy similarity
Modified residuei479 – 4791Asymmetric dimethylarginineBy similarity
Modified residuei483 – 4831Asymmetric dimethylarginineBy similarity
Modified residuei487 – 4871Asymmetric dimethylarginineBy similarity
Modified residuei490 – 4901Asymmetric dimethylarginineBy similarity
Modified residuei495 – 4951Asymmetric dimethylarginineBy similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP56959.
PaxDbiP56959.
PRIDEiP56959.

PTM databases

PhosphoSiteiP56959.

Expressioni

Gene expression databases

BgeeiP56959.
ExpressionAtlasiP56959. baseline and differential.
GenevisibleiP56959. MM.

Interactioni

Subunit structurei

Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts with OTUB1 and SARNP (By similarity).By similarity

Protein-protein interaction databases

BioGridi231475. 7 interactions.
IntActiP56959. 4 interactions.
MINTiMINT-136330.
STRINGi10090.ENSMUSP00000101858.

Structurei

3D structure databases

ProteinModelPortaliP56959.
SMRiP56959. Positions 271-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini278 – 36487RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 167167Gln/Gly/Ser/Tyr-richAdd
BLAST
Compositional biasi168 – 26598Gly-richAdd
BLAST
Compositional biasi364 – 518155Arg/Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRM TET family.Curated
Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri415 – 44632RanBP2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG240581.
GeneTreeiENSGT00530000063105.
HOGENOMiHOG000038010.
HOVERGENiHBG094940.
InParanoidiP56959.
KOiK13098.
OMAiNQPYGQQ.
OrthoDBiEOG7DZ8N7.
PhylomeDBiP56959.
TreeFamiTF322599.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YGQSADTSGY
60 70 80 90 100
GQSSYGSSYG QTQNTGYGTQ SAPQGYGSTG GYGSSQSSQS SYGQQSSYPG
110 120 130 140 150
YGQQPAPSST SGSYGGSSQS SSYGQPQSGG YGQQSGYGGQ QQSYGQQQSS
160 170 180 190 200
YNPPQGYGQQ NQYNSSSGGG GGGGGGNYGQ DQSSMSGGGG GGGYGNQDQS
210 220 230 240 250
GGGGGGYGGG QQDRGGRGRG GGGGYNRSSG GYEPRGRGGG RGGRGGMGGS
260 270 280 290 300
DRGGFNKFGG PRDQGSRHDS EQDNSDNNTI FVQGLGENVT IESVADYFKQ
310 320 330 340 350
IGIIKTNKKT GQPMINLYTD RETGKLKGEA TVSFDDPPSA KAAIDWFDGK
360 370 380 390 400
EFSGNPIKVS FATRRADFNR GGGNGRGGRG RGGPMGRGGY GGGGSGGGGR
410 420 430 440 450
GGFPSGGGGG GGQQRAGDWK CPNPTCENMN FSWRNECNQC KAPKPDGPGG
460 470 480 490 500
GPGGSHMGGN YGDDRRGRGG YDRGGYRGRG GDRGGFRGGR GGGDRGGFGP
510
GKMDSRGEHR QDRRERPY
Length:518
Mass (Da):52,673
Last modified:December 1, 2000 - v1
Checksum:iE06F231BFEED78D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224264 mRNA. Translation: AAF70602.1.
CCDSiCCDS21886.1.
RefSeqiNP_631888.1. NM_139149.2.
UniGeneiMm.277680.

Genome annotation databases

EnsembliENSMUST00000106251; ENSMUSP00000101858; ENSMUSG00000030795.
GeneIDi233908.
KEGGimmu:233908.
UCSCiuc009jxo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF224264 mRNA. Translation: AAF70602.1.
CCDSiCCDS21886.1.
RefSeqiNP_631888.1. NM_139149.2.
UniGeneiMm.277680.

3D structure databases

ProteinModelPortaliP56959.
SMRiP56959. Positions 271-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231475. 7 interactions.
IntActiP56959. 4 interactions.
MINTiMINT-136330.
STRINGi10090.ENSMUSP00000101858.

PTM databases

PhosphoSiteiP56959.

Proteomic databases

MaxQBiP56959.
PaxDbiP56959.
PRIDEiP56959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106251; ENSMUSP00000101858; ENSMUSG00000030795.
GeneIDi233908.
KEGGimmu:233908.
UCSCiuc009jxo.1. mouse.

Organism-specific databases

CTDi2521.
MGIiMGI:1353633. Fus.

Phylogenomic databases

eggNOGiNOG240581.
GeneTreeiENSGT00530000063105.
HOGENOMiHOG000038010.
HOVERGENiHBG094940.
InParanoidiP56959.
KOiK13098.
OMAiNQPYGQQ.
OrthoDBiEOG7DZ8N7.
PhylomeDBiP56959.
TreeFamiTF322599.

Enzyme and pathway databases

ReactomeiREACT_307866. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiFus. mouse.
NextBioi381951.
PROiP56959.
SOURCEiSearch...

Gene expression databases

BgeeiP56959.
ExpressionAtlasiP56959. baseline and differential.
GenevisibleiP56959. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis."
    Alappat S.R., Zhang M., Zhao X., Alliegro M.A., Alliegro M.C., Burdsal C.A.
    Dev. Dyn. 228:59-71(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFUS_MOUSE
AccessioniPrimary (citable) accession number: P56959
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 22, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.