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P56959 (FUS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-binding protein FUS
Alternative name(s):
Protein pigpen
Gene names
Name:Fus
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity By similarity.

Subunit structure

Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts with OTUB1 and SARNP By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the RRM TET family.

Contains 1 RanBP2-type zinc finger.

Contains 1 RRM (RNA recognition motif) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518RNA-binding protein FUS
PRO_0000081592

Regions

Domain278 – 36487RRM
Zinc finger415 – 44632RanBP2-type
Compositional bias1 – 167167Gln/Gly/Ser/Tyr-rich
Compositional bias168 – 26598Gly-rich
Compositional bias364 – 518155Arg/Gly-rich

Amino acid modifications

Modified residue2171Omega-N-methylated arginine By similarity
Modified residue2191Omega-N-methylated arginine By similarity
Modified residue2351Asymmetric dimethylarginine By similarity
Modified residue2371Asymmetric dimethylarginine By similarity
Modified residue2411Asymmetric dimethylarginine By similarity
Modified residue2441Asymmetric dimethylarginine By similarity
Modified residue2521Asymmetric dimethylarginine By similarity
Modified residue2701Phosphoserine By similarity
Modified residue2791Phosphothreonine By similarity
Modified residue3701Asymmetric dimethylarginine By similarity
Modified residue3761Asymmetric dimethylarginine By similarity
Modified residue3791Asymmetric dimethylarginine By similarity
Modified residue3811Asymmetric dimethylarginine By similarity
Modified residue3871Asymmetric dimethylarginine By similarity
Modified residue4001Asymmetric dimethylarginine By similarity
Modified residue4661Asymmetric dimethylarginine By similarity
Modified residue4681Asymmetric dimethylarginine By similarity
Modified residue4731Asymmetric dimethylarginine By similarity
Modified residue4771Asymmetric dimethylarginine By similarity
Modified residue4791Asymmetric dimethylarginine By similarity
Modified residue4831Asymmetric dimethylarginine By similarity
Modified residue4871Asymmetric dimethylarginine By similarity
Modified residue4901Asymmetric dimethylarginine By similarity
Modified residue4951Asymmetric dimethylarginine By similarity

Sequences

Sequence LengthMass (Da)Tools
P56959 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: E06F231BFEED78D6

FASTA51852,673
        10         20         30         40         50         60 
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YGQSADTSGY GQSSYGSSYG 

        70         80         90        100        110        120 
QTQNTGYGTQ SAPQGYGSTG GYGSSQSSQS SYGQQSSYPG YGQQPAPSST SGSYGGSSQS 

       130        140        150        160        170        180 
SSYGQPQSGG YGQQSGYGGQ QQSYGQQQSS YNPPQGYGQQ NQYNSSSGGG GGGGGGNYGQ 

       190        200        210        220        230        240 
DQSSMSGGGG GGGYGNQDQS GGGGGGYGGG QQDRGGRGRG GGGGYNRSSG GYEPRGRGGG 

       250        260        270        280        290        300 
RGGRGGMGGS DRGGFNKFGG PRDQGSRHDS EQDNSDNNTI FVQGLGENVT IESVADYFKQ 

       310        320        330        340        350        360 
IGIIKTNKKT GQPMINLYTD RETGKLKGEA TVSFDDPPSA KAAIDWFDGK EFSGNPIKVS 

       370        380        390        400        410        420 
FATRRADFNR GGGNGRGGRG RGGPMGRGGY GGGGSGGGGR GGFPSGGGGG GGQQRAGDWK 

       430        440        450        460        470        480 
CPNPTCENMN FSWRNECNQC KAPKPDGPGG GPGGSHMGGN YGDDRRGRGG YDRGGYRGRG 

       490        500        510 
GDRGGFRGGR GGGDRGGFGP GKMDSRGEHR QDRRERPY 

« Hide

References

[1]"Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis."
Alappat S.R., Zhang M., Zhao X., Alliegro M.A., Alliegro M.C., Burdsal C.A.
Dev. Dyn. 228:59-71(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF224264 mRNA. Translation: AAF70602.1.
RefSeqNP_631888.1. NM_139149.2.
UniGeneMm.277680.

3D structure databases

ProteinModelPortalP56959.
SMRP56959. Positions 271-368, 411-448.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid231475. 6 interactions.
IntActP56959. 4 interactions.
MINTMINT-136330.

PTM databases

PhosphoSiteP56959.

Proteomic databases

PaxDbP56959.
PRIDEP56959.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000106251; ENSMUSP00000101858; ENSMUSG00000030795.
GeneID233908.
KEGGmmu:233908.
UCSCuc009jxo.1. mouse.

Organism-specific databases

CTD2521.
MGIMGI:1353633. Fus.

Phylogenomic databases

eggNOGNOG240581.
HOGENOMHOG000038010.
HOVERGENHBG094940.
InParanoidP56959.
KOK13098.
OMANQPYGQQ.
OrthoDBEOG7DZ8N7.
PhylomeDBP56959.
TreeFamTF322599.

Gene expression databases

ArrayExpressP56959.
BgeeP56959.
GenevestigatorP56959.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamPF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
PROSITEPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFUS. mouse.
NextBio381951.
PROP56959.
SOURCESearch...

Entry information

Entry nameFUS_MOUSE
AccessionPrimary (citable) accession number: P56959
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot