Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P56959

- FUS_MOUSE

UniProt

P56959 - FUS_MOUSE

Protein

RNA-binding protein FUS

Gene

Fus

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Dec 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri415 – 44632RanBP2-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. RNA binding Source: UniProtKB-KW
    4. zinc ion binding Source: InterPro

    Keywords - Ligandi

    DNA-binding, Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-binding protein FUS
    Alternative name(s):
    Protein pigpen
    Gene namesi
    Name:Fus
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1353633. Fus.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518RNA-binding protein FUSPRO_0000081592Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei217 – 2171Omega-N-methylated arginineBy similarity
    Modified residuei219 – 2191Omega-N-methylated arginineBy similarity
    Modified residuei235 – 2351Asymmetric dimethylarginineBy similarity
    Modified residuei237 – 2371Asymmetric dimethylarginineBy similarity
    Modified residuei241 – 2411Asymmetric dimethylarginineBy similarity
    Modified residuei244 – 2441Asymmetric dimethylarginineBy similarity
    Modified residuei252 – 2521Asymmetric dimethylarginineBy similarity
    Modified residuei270 – 2701PhosphoserineBy similarity
    Modified residuei279 – 2791PhosphothreonineBy similarity
    Modified residuei370 – 3701Asymmetric dimethylarginineBy similarity
    Modified residuei376 – 3761Asymmetric dimethylarginineBy similarity
    Modified residuei379 – 3791Asymmetric dimethylarginineBy similarity
    Modified residuei381 – 3811Asymmetric dimethylarginineBy similarity
    Modified residuei387 – 3871Asymmetric dimethylarginineBy similarity
    Modified residuei400 – 4001Asymmetric dimethylarginineBy similarity
    Modified residuei466 – 4661Asymmetric dimethylarginineBy similarity
    Modified residuei468 – 4681Asymmetric dimethylarginineBy similarity
    Modified residuei473 – 4731Asymmetric dimethylarginineBy similarity
    Modified residuei477 – 4771Asymmetric dimethylarginineBy similarity
    Modified residuei479 – 4791Asymmetric dimethylarginineBy similarity
    Modified residuei483 – 4831Asymmetric dimethylarginineBy similarity
    Modified residuei487 – 4871Asymmetric dimethylarginineBy similarity
    Modified residuei490 – 4901Asymmetric dimethylarginineBy similarity
    Modified residuei495 – 4951Asymmetric dimethylarginineBy similarity

    Keywords - PTMi

    Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiP56959.
    PaxDbiP56959.
    PRIDEiP56959.

    PTM databases

    PhosphoSiteiP56959.

    Expressioni

    Gene expression databases

    ArrayExpressiP56959.
    BgeeiP56959.
    GenevestigatoriP56959.

    Interactioni

    Subunit structurei

    Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts with OTUB1 and SARNP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi231475. 7 interactions.
    IntActiP56959. 4 interactions.
    MINTiMINT-136330.

    Structurei

    3D structure databases

    ProteinModelPortaliP56959.
    SMRiP56959. Positions 271-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini278 – 36487RRMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 167167Gln/Gly/Ser/Tyr-richAdd
    BLAST
    Compositional biasi168 – 26598Gly-richAdd
    BLAST
    Compositional biasi364 – 518155Arg/Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRM TET family.Curated
    Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri415 – 44632RanBP2-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG240581.
    HOGENOMiHOG000038010.
    HOVERGENiHBG094940.
    InParanoidiP56959.
    KOiK13098.
    OMAiNQPYGQQ.
    OrthoDBiEOG7DZ8N7.
    PhylomeDBiP56959.
    TreeFamiTF322599.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    4.10.1060.10. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR001876. Znf_RanBP2.
    [Graphical view]
    PfamiPF00076. RRM_1. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    SM00547. ZnF_RBZ. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56959-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YGQSADTSGY    50
    GQSSYGSSYG QTQNTGYGTQ SAPQGYGSTG GYGSSQSSQS SYGQQSSYPG 100
    YGQQPAPSST SGSYGGSSQS SSYGQPQSGG YGQQSGYGGQ QQSYGQQQSS 150
    YNPPQGYGQQ NQYNSSSGGG GGGGGGNYGQ DQSSMSGGGG GGGYGNQDQS 200
    GGGGGGYGGG QQDRGGRGRG GGGGYNRSSG GYEPRGRGGG RGGRGGMGGS 250
    DRGGFNKFGG PRDQGSRHDS EQDNSDNNTI FVQGLGENVT IESVADYFKQ 300
    IGIIKTNKKT GQPMINLYTD RETGKLKGEA TVSFDDPPSA KAAIDWFDGK 350
    EFSGNPIKVS FATRRADFNR GGGNGRGGRG RGGPMGRGGY GGGGSGGGGR 400
    GGFPSGGGGG GGQQRAGDWK CPNPTCENMN FSWRNECNQC KAPKPDGPGG 450
    GPGGSHMGGN YGDDRRGRGG YDRGGYRGRG GDRGGFRGGR GGGDRGGFGP 500
    GKMDSRGEHR QDRRERPY 518
    Length:518
    Mass (Da):52,673
    Last modified:December 1, 2000 - v1
    Checksum:iE06F231BFEED78D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF224264 mRNA. Translation: AAF70602.1.
    CCDSiCCDS21886.1.
    RefSeqiNP_631888.1. NM_139149.2.
    UniGeneiMm.277680.

    Genome annotation databases

    EnsembliENSMUST00000106251; ENSMUSP00000101858; ENSMUSG00000030795.
    GeneIDi233908.
    KEGGimmu:233908.
    UCSCiuc009jxo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF224264 mRNA. Translation: AAF70602.1 .
    CCDSi CCDS21886.1.
    RefSeqi NP_631888.1. NM_139149.2.
    UniGenei Mm.277680.

    3D structure databases

    ProteinModelPortali P56959.
    SMRi P56959. Positions 271-368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 231475. 7 interactions.
    IntActi P56959. 4 interactions.
    MINTi MINT-136330.

    PTM databases

    PhosphoSitei P56959.

    Proteomic databases

    MaxQBi P56959.
    PaxDbi P56959.
    PRIDEi P56959.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000106251 ; ENSMUSP00000101858 ; ENSMUSG00000030795 .
    GeneIDi 233908.
    KEGGi mmu:233908.
    UCSCi uc009jxo.1. mouse.

    Organism-specific databases

    CTDi 2521.
    MGIi MGI:1353633. Fus.

    Phylogenomic databases

    eggNOGi NOG240581.
    HOGENOMi HOG000038010.
    HOVERGENi HBG094940.
    InParanoidi P56959.
    KOi K13098.
    OMAi NQPYGQQ.
    OrthoDBi EOG7DZ8N7.
    PhylomeDBi P56959.
    TreeFami TF322599.

    Miscellaneous databases

    ChiTaRSi FUS. mouse.
    NextBioi 381951.
    PROi P56959.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56959.
    Bgeei P56959.
    Genevestigatori P56959.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    4.10.1060.10. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR001876. Znf_RanBP2.
    [Graphical view ]
    Pfami PF00076. RRM_1. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    SM00547. ZnF_RBZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis."
      Alappat S.R., Zhang M., Zhao X., Alliegro M.A., Alliegro M.C., Burdsal C.A.
      Dev. Dyn. 228:59-71(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiFUS_MOUSE
    AccessioniPrimary (citable) accession number: P56959
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3