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P56958 (RNB_HHV1M) Reviewed, UniProtKB/Swiss-Prot

Last modified June 26, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-binding protein
Alternative name(s):
Vmw21
Gene names
Name:US11
OrganismHuman herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifier10307 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in the inhibition of immune response by interacting with and inhibiting host PKR/EIF2AK2 thereby preventing the interferon-induced shut down of protein synthesis following viral infection. May also participate in nuclear egress of viral particles through interactions with host NCL and regulation of the viral UL34 mRNA By similarity.

Subunit structure

Associates with RNA derived from the 60S ribosomal subunits. Seems to form large heterogeneous polymers of up to 200 identical subunits in the cytoplasm By similarity.

Subcellular location

Host nucleushost nucleolus By similarity. Host cytoplasm By similarity. Note: Following infection, it is released into the cell cytoplasm By similarity.

Domain

The N-terminal tetrapeptide may be responsible for virion incorporation By similarity.

The C-terminal half, rich in Arg and Pro residues, seems to be responsible for the RNA-binding activity, and for the association with ribosomes and the localization to the nucleolus. This region may adopt a poly-L-proline II helix secondary structure By similarity.

Post-translational modification

May be phosphorylated on Ser residues by host kinases By similarity.

Sequence similarities

Belongs to the simplex virus US11 protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 161161RNA-binding protein
PRO_0000115741

Regions

Repeat85 – 9061
Repeat91 – 9662
Repeat97 – 10263
Repeat103 – 10864
Repeat109 – 11465
Repeat115 – 12066
Repeat121 – 12667
Repeat127 – 13268
Repeat133 – 13869
Repeat139 – 144610
Repeat145 – 150611
Repeat151 – 156612
Region85 – 1567212 X 6 AA approximate tandem repeats

Sequences

Sequence LengthMass (Da)Tools
P56958 [UniParc].

Last modified December 1, 2000. Version 1.
Checksum: 1CF68615474462FF

FASTA16117,745
        10         20         30         40         50         60 
MSQTQPPAPV GPGDPDVYLK GVPSAGMHPR GVHAPRGHPR MISGPPQRGD NDQAAGQCGD 

        70         80         90        100        110        120 
SGLLRVGADT TISKPSEAVR PPTIPRTPRV PREPRVPRPP REPREPRVPR ASRDPRVPRD 

       130        140        150        160 
PRDPRQPRSP REPRSPREPR PPREPRTPRT TREPRTARGA V 

« Hide

References

[1]Diaz J.-J.
Submitted (JUN-2000) to UniProtKB
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR020124. Herpes_US11_RNA-bd_N.
[Graphical view]
ProDomPD028529. Herpes_US11_RNA-bd_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameRNB_HHV1M
AccessionPrimary (citable) accession number: P56958
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: June 26, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families