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P56958

- RNB_HHV1M

UniProt

P56958 - RNB_HHV1M

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Protein
RNA-binding protein
Gene
US11
Organism
Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in the inhibition of immune response by interacting with and inhibiting host PKR/EIF2AK2 thereby preventing the interferon-induced shut down of protein synthesis following viral infection. May also participate in nuclear egress of viral particles through interactions with host NCL and regulation of the viral UL34 mRNA By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host PKR activity Source: UniProtKB-KW
  2. suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host PKR by virus, Viral immunoevasion

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein
Alternative name(s):
Vmw21
Gene namesi
Name:US11
OrganismiHuman herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10307 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Host nucleushost nucleolus By similarity. Host cytoplasm By similarity
Note: Following infection, it is released into the cell cytoplasm By similarity.

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. host cell nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161RNA-binding protein
PRO_0000115741Add
BLAST

Post-translational modificationi

May be phosphorylated on Ser residues by host kinases By similarity.

Keywords - PTMi

Phosphoprotein

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Associates with RNA derived from the 60S ribosomal subunits. Seems to form large heterogeneous polymers of up to 200 identical subunits in the cytoplasm By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati85 – 9061
Repeati91 – 9662
Repeati97 – 10263
Repeati103 – 10864
Repeati109 – 11465
Repeati115 – 12066
Repeati121 – 12667
Repeati127 – 13268
Repeati133 – 13869
Repeati139 – 144610
Repeati145 – 150611
Repeati151 – 156612

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 1567212 X 6 AA approximate tandem repeats
Add
BLAST

Domaini

The N-terminal tetrapeptide may be responsible for virion incorporation By similarity.
The C-terminal half, rich in Arg and Pro residues, seems to be responsible for the RNA-binding activity, and for the association with ribosomes and the localization to the nucleolus. This region may adopt a poly-L-proline II helix secondary structure By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR020124. Herpes_US11_RNA-bd_N.
[Graphical view]
ProDomiPD028529. Herpes_US11_RNA-bd_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P56958-1 [UniParc]FASTAAdd to Basket

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MSQTQPPAPV GPGDPDVYLK GVPSAGMHPR GVHAPRGHPR MISGPPQRGD    50
NDQAAGQCGD SGLLRVGADT TISKPSEAVR PPTIPRTPRV PREPRVPRPP 100
REPREPRVPR ASRDPRVPRD PRDPRQPRSP REPRSPREPR PPREPRTPRT 150
TREPRTARGA V 161
Length:161
Mass (Da):17,745
Last modified:December 1, 2000 - v1
Checksum:i1CF68615474462FF
GO

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR020124. Herpes_US11_RNA-bd_N.
[Graphical view ]
ProDomi PD028529. Herpes_US11_RNA-bd_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Diaz J.-J.
    Submitted (JUN-2000) to UniProtKB
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiRNB_HHV1M
AccessioniPrimary (citable) accession number: P56958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: June 26, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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