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P56958

- RNB_HHV1M

UniProt

P56958 - RNB_HHV1M

Protein

RNA-binding protein

Gene

US11

Organism
Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Plays a role in the inhibition of immune response by interacting with and inhibiting host PKR/EIF2AK2 thereby preventing the interferon-induced shut down of protein synthesis following viral infection. May also participate in nuclear egress of viral particles through interactions with host NCL and regulation of the viral UL34 mRNA By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host PKR activity Source: UniProtKB-KW
    2. suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host PKR by virus, Viral immunoevasion

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-binding protein
    Alternative name(s):
    Vmw21
    Gene namesi
    Name:US11
    OrganismiHuman herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10307 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Host nucleushost nucleolus By similarity. Host cytoplasm By similarity
    Note: Following infection, it is released into the cell cytoplasm.By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. host cell nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161RNA-binding proteinPRO_0000115741Add
    BLAST

    Post-translational modificationi

    May be phosphorylated on Ser residues by host kinases.By similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Associates with RNA derived from the 60S ribosomal subunits. Seems to form large heterogeneous polymers of up to 200 identical subunits in the cytoplasm By similarity.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati85 – 9061
    Repeati91 – 9662
    Repeati97 – 10263
    Repeati103 – 10864
    Repeati109 – 11465
    Repeati115 – 12066
    Repeati121 – 12667
    Repeati127 – 13268
    Repeati133 – 13869
    Repeati139 – 144610
    Repeati145 – 150611
    Repeati151 – 156612

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni85 – 1567212 X 6 AA approximate tandem repeatsAdd
    BLAST

    Domaini

    The N-terminal tetrapeptide may be responsible for virion incorporation.By similarity
    The C-terminal half, rich in Arg and Pro residues, seems to be responsible for the RNA-binding activity, and for the association with ribosomes and the localization to the nucleolus. This region may adopt a poly-L-proline II helix secondary structure By similarity.By similarity

    Sequence similaritiesi

    Belongs to the simplex virus US11 protein family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR020124. Herpes_US11_RNA-bd_N.
    [Graphical view]
    ProDomiPD028529. Herpes_US11_RNA-bd_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P56958-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQTQPPAPV GPGDPDVYLK GVPSAGMHPR GVHAPRGHPR MISGPPQRGD    50
    NDQAAGQCGD SGLLRVGADT TISKPSEAVR PPTIPRTPRV PREPRVPRPP 100
    REPREPRVPR ASRDPRVPRD PRDPRQPRSP REPRSPREPR PPREPRTPRT 150
    TREPRTARGA V 161
    Length:161
    Mass (Da):17,745
    Last modified:December 1, 2000 - v1
    Checksum:i1CF68615474462FF
    GO

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR020124. Herpes_US11_RNA-bd_N.
    [Graphical view ]
    ProDomi PD028529. Herpes_US11_RNA-bd_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Diaz J.-J.
      Submitted (JUN-2000) to UniProtKB
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiRNB_HHV1M
    AccessioniPrimary (citable) accession number: P56958
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3