Reviewed, UniProtKB/Swiss-Prot P56954 (MQO_CAMJE)

Names and origin

Protein names

Recommended name:
    Probable malate:quinone oxidoreductase
    EC=1.1.99.16
Alternative name(s):
    Malate dehydrogenase [acceptor]
    MQO

Gene names

Name:	mqo
Ordered Locus Names:	Cj0393c

Organism

Campylobacter jejuni [Complete proteome] [HAMAP]

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes oxidation of malate to oxaloacetate in the citric acid cycle. Donates electrons to quinones of the electron transfer chain By similarity.
Catalytic activity	(S)-malate + acceptor = oxaloacetate + reduced acceptor. HAMAP MF_00212
Cofactor	FAD. The FAD is tightly bound By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	malate dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Probable malate:quinone oxidoreductase HAMAP MF_00212		PRO_0000128708

Sequences

	Sequence		Length	Mass (Da)
	P56954-1 [UniParc]. Last modified May 30, 2000. Version 1. Checksum: 66D54F010F30A025	FASTA	448	50,586
	10 20 30 40 50 60 MSQQEFDVLV IGAGISGAAL FYELARYTNI KNIALIEKYN TAATLNSKGT SNSQTIHCGD 70 80 90 100 110 120 IETNYTLEKA RKVKRTADMI VKYGLMQNAQ NNFMFSHQKM ALAVGDIECD YMKKRYEEFK 130 140 150 160 170 180 ELYPYIKFFD KAKIKQIEPK VVLGEDCNQD RPENICAMGV ESGEVFTTVD FGKMSINLIE 190 200 210 220 230 240 QAQKQNKNTF VAFNQEIIHI EKKDDIFILK TSNHQEYHAK SVVVNAGAHS LYLAHKMNLG 250 260 270 280 290 300 MDKSCWPVAG SFYLTKQKLL NGKVYMVQNP KLPFAALHGD PDLLADMNTR FGPTALVIPK 310 320 330 340 350 360 LERYHGLKSV PEFFEALKLD KTVLKVTFNM FKDATIRNYI FYNYLFELPF VDKSLFVKDA 370 380 390 400 410 420 KKIVPSLKAS DIYYAKGFGG VRPQVIDKTK GELMLGEASI TETPGIIFNM TPSPGATSCL 430 440 GNAERDAKLV CNYLGMEFNE DKFSSELL

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL111168 Genomic DNA. Translation: CAL34543.1.
PIR	G81382.
RefSeq	YP_002343830.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	904716.
GenomeReviews	Gene locus Cj0393c in contig AL111168_GR.
KEGG	cje:Cj0393c.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P56954.
OMA	P56954. FELERFY.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ0393C-MON.
BRENDA	1.1.99.16. 255835.
Family and domain databases
HAMAP	MF_00212. [Tree]
InterPro	IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MQO_CAMJE

Accession

Primary (citable) accession number: P56954
Secondary accession number(s): Q0PBB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)