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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes oxidation of malate to oxaloacetate in the citric acid cycle. Donates electrons to quinones of the electron transfer chain (By similarity).By similarity

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.

Cofactori

FADBy similarityNote: The FAD is tightly bound.By similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-361-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductase (EC:1.1.5.4)
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene namesi
Name:mqo
Ordered Locus Names:Cj0393c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001287081 – 448Probable malate:quinone oxidoreductaseAdd BLAST448

Proteomic databases

PaxDbiP56954.

Interactioni

Protein-protein interaction databases

STRINGi192222.Cj0393c.

Structurei

3D structure databases

ProteinModelPortaliP56954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.Curated

Phylogenomic databases

eggNOGiENOG4107RSR. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000102104.
KOiK00116.
OMAiDMGEAKI.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00212. MQO. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR006231. MQO.
PfamiView protein in Pfam
PF06039. Mqo. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

P56954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQEFDVLV IGAGISGAAL FYELARYTNI KNIALIEKYN TAATLNSKGT
60 70 80 90 100
SNSQTIHCGD IETNYTLEKA RKVKRTADMI VKYGLMQNAQ NNFMFSHQKM
110 120 130 140 150
ALAVGDIECD YMKKRYEEFK ELYPYIKFFD KAKIKQIEPK VVLGEDCNQD
160 170 180 190 200
RPENICAMGV ESGEVFTTVD FGKMSINLIE QAQKQNKNTF VAFNQEIIHI
210 220 230 240 250
EKKDDIFILK TSNHQEYHAK SVVVNAGAHS LYLAHKMNLG MDKSCWPVAG
260 270 280 290 300
SFYLTKQKLL NGKVYMVQNP KLPFAALHGD PDLLADMNTR FGPTALVIPK
310 320 330 340 350
LERYHGLKSV PEFFEALKLD KTVLKVTFNM FKDATIRNYI FYNYLFELPF
360 370 380 390 400
VDKSLFVKDA KKIVPSLKAS DIYYAKGFGG VRPQVIDKTK GELMLGEASI
410 420 430 440
TETPGIIFNM TPSPGATSCL GNAERDAKLV CNYLGMEFNE DKFSSELL
Length:448
Mass (Da):50,586
Last modified:May 30, 2000 - v1
Checksum:i66D54F010F30A025
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34543.1.
PIRiG81382.
RefSeqiWP_002854402.1. NC_002163.1.
YP_002343830.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34543; CAL34543; Cj0393c.
GeneIDi904716.
KEGGicje:Cj0393c.
PATRICifig|192222.6.peg.384.

Similar proteinsi

Entry informationi

Entry nameiMQO_CAMJE
AccessioniPrimary (citable) accession number: P56954
Secondary accession number(s): Q0PBB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families