##gff-version 3 P56945 UniProtKB Chain 1 870 . . . ID=PRO_0000064854;Note=Breast cancer anti-estrogen resistance protein 1 P56945 UniProtKB Domain 3 65 . . . Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 P56945 UniProtKB Region 70 156 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P56945 UniProtKB Region 115 416 . . . Note=Substrate for kinases;Ontology_term=ECO:0000250;evidence=ECO:0000250 P56945 UniProtKB Region 411 449 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P56945 UniProtKB Region 609 658 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P56945 UniProtKB Region 715 734 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P56945 UniProtKB Region 746 796 . . . Note=Divergent helix-loop-helix motif P56945 UniProtKB Motif 635 643 . . . Note=SH3-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255 P56945 UniProtKB Compositional bias 72 99 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P56945 UniProtKB Compositional bias 100 156 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P56945 UniProtKB Compositional bias 427 445 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P56945 UniProtKB Compositional bias 623 653 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P56945 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.7 P56945 UniProtKB Modified residue 128 128 . . . Note=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22710723;Dbxref=PMID:22710723 P56945 UniProtKB Modified residue 134 134 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 P56945 UniProtKB Modified residue 139 139 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:19454314,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19454314,PMID:20068231,PMID:23186163 P56945 UniProtKB Modified residue 234 234 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61140 P56945 UniProtKB Modified residue 249 249 . . . Note=Phosphotyrosine%3B by ABL1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63767 P56945 UniProtKB Modified residue 269 269 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 P56945 UniProtKB Modified residue 292 292 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 P56945 UniProtKB Modified residue 362 362 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61140 P56945 UniProtKB Modified residue 372 372 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61140 P56945 UniProtKB Modified residue 410 410 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61140 P56945 UniProtKB Modified residue 428 428 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21406692;Dbxref=PMID:21406692 P56945 UniProtKB Modified residue 437 437 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19454314;Dbxref=PMID:19454314 P56945 UniProtKB Modified residue 639 639 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:19454314,ECO:0007744|PubMed:23186163;Dbxref=PMID:19454314,PMID:23186163 P56945 UniProtKB Alternative sequence 1 4 . . . ID=VSP_043559;Note=In isoform 2. MNHL->MLTHRPQEAEQRGRTPGPSFEW;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P56945 UniProtKB Alternative sequence 1 4 . . . ID=VSP_046127;Note=In isoform 4. MNHL->MQGK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P56945 UniProtKB Alternative sequence 1 4 . . . ID=VSP_046748;Note=In isoform 5. MNHL->ME;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P56945 UniProtKB Alternative sequence 1 4 . . . ID=VSP_046749;Note=In isoform 6. MNHL->MPAKPFLSSVLLSWKVLDFSGPGPQGTGQPCSCGHWAEGQGGPPEPAGGP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P56945 UniProtKB Alternative sequence 1 4 . . . ID=VSP_046750;Note=In isoform 7. MNHL->MHCPGEAPLAAPRPTPKDPCLR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P56945 UniProtKB Alternative sequence 1 4 . . . ID=VSP_046751;Note=In isoform 8. MNHL->MSVP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P56945 UniProtKB Alternative sequence 64 211 . . . ID=VSP_046128;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P56945 UniProtKB Alternative sequence 304 304 . . . ID=VSP_045355;Note=In isoform 3. A->AVSKCQGNARARLRLWGVW;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 P56945 UniProtKB Natural variant 76 76 . . . ID=VAR_058970;Note=P->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10639512,ECO:0000269|PubMed:14702039,ECO:0000269|Ref.2,ECO:0000269|Ref.3;Dbxref=dbSNP:rs1035539,PMID:10639512,PMID:14702039 P56945 UniProtKB Natural variant 407 407 . . . ID=VAR_035798;Note=In a breast cancer sample%3B somatic mutation. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs144989936,PMID:16959974 P56945 UniProtKB Natural variant 491 491 . . . ID=VAR_057820;Note=R->L;Dbxref=dbSNP:rs16957558 P56945 UniProtKB Natural variant 558 558 . . . ID=VAR_057821;Note=H->R;Dbxref=dbSNP:rs16957552 P56945 UniProtKB Mutagenesis 787 787 . . . Note=Weakens interaction with SH2D3C. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22081014;Dbxref=PMID:22081014 P56945 UniProtKB Mutagenesis 794 794 . . . Note=Weakens interaction with SH2D3C. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22081014;Dbxref=PMID:22081014 P56945 UniProtKB Mutagenesis 797 797 . . . Note=Weakens interaction with SH2D3C. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22081014;Dbxref=PMID:22081014 P56945 UniProtKB Sequence conflict 63 63 . . . Note=L->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 236 236 . . . Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 254 254 . . . Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 349 349 . . . Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 363 363 . . . Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 385 385 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 428 428 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 471 471 . . . Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 600 600 . . . Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 700 700 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 714 714 . . . Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Sequence conflict 740 740 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P56945 UniProtKB Beta strand 5 12 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1WYX P56945 UniProtKB Beta strand 29 34 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1WYX P56945 UniProtKB Helix 37 39 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1WYX P56945 UniProtKB Beta strand 43 48 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1WYX P56945 UniProtKB Beta strand 51 56 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1WYX P56945 UniProtKB Helix 57 59 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1WYX P56945 UniProtKB Beta strand 60 68 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1WYX P56945 UniProtKB Helix 740 770 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3T6G P56945 UniProtKB Helix 775 801 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3T6G P56945 UniProtKB Helix 806 835 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3T6G P56945 UniProtKB Helix 840 870 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3T6G