Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-keto-steroid reductase

Gene

HSD17B7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the reduction of the keto group on the C-3 of sterols.1 Publication

Catalytic activityi

A 3-beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH.
17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Pathwayi: estrogen biosynthesis

This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

Pathwayi: zymosterol biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes zymosterol from lanosterol.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Lanosterol 14-alpha demethylase (CYP51A1)
  2. no protein annotated in this organism
  3. Methylsterol monooxygenase 1 (MSMO1)
  4. Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)
  5. 3-keto-steroid reductase (HSD17B7)
  6. no protein annotated in this organism
This subpathway is part of the pathway zymosterol biosynthesis, which is itself part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes zymosterol from lanosterol, the pathway zymosterol biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171SubstrateBy similarity1
Active sitei193Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15NADSequence analysis8

GO - Molecular functioni

  • 3-keto sterol reductase activity Source: Reactome
  • estradiol 17-beta-dehydrogenase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS05604-MONOMER
BRENDAi1.1.1.270 2681
ReactomeiR-HSA-191273 Cholesterol biosynthesis
SABIO-RKiP56937
UniPathwayiUPA00769
UPA00770; UER00758

Chemistry databases

SwissLipidsiSLP:000001214

Names & Taxonomyi

Protein namesi
Recommended name:
3-keto-steroid reductase (EC:1.1.1.270)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 7
Short name:
17-beta-HSD 7
Estradiol 17-beta-dehydrogenase 7 (EC:1.1.1.62)
Short chain dehydrogenase/reductase family 37C member 1
Gene namesi
Name:HSD17B7
Synonyms:SDR37C1
ORF Names:UNQ2563/PRO6243
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000132196.13
HGNCiHGNC:5215 HSD17B7
MIMi606756 gene
neXtProtiNX_P56937

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 229ExtracellularSequence analysisAdd BLAST229
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 341CytoplasmicSequence analysisAdd BLAST91

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51478
OpenTargetsiENSG00000132196
PharmGKBiPA29483

Chemistry databases

ChEMBLiCHEMBL5999
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiHSD17B7
DMDMi8134404

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545861 – 3413-keto-steroid reductaseAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP56937
MaxQBiP56937
PaxDbiP56937
PeptideAtlasiP56937
PRIDEiP56937
ProteomicsDBi56957
56958 [P56937-2]
56959 [P56937-3]

PTM databases

iPTMnetiP56937
PhosphoSitePlusiP56937

Expressioni

Tissue specificityi

Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells.

Gene expression databases

BgeeiENSG00000132196
CleanExiHS_HSD17B7
ExpressionAtlasiP56937 baseline and differential
GenevisibleiP56937 HS

Organism-specific databases

HPAiHPA047496

Interactioni

Protein-protein interaction databases

BioGridi119563, 18 interactors
IntActiP56937, 5 interactors
STRINGi9606.ENSP00000254521

Chemistry databases

BindingDBiP56937

Structurei

3D structure databases

ProteinModelPortaliP56937
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1478 Eukaryota
ENOG410XPNE LUCA
GeneTreeiENSGT00390000013340
HOGENOMiHOG000253921
HOVERGENiHBG058236
InParanoidiP56937
KOiK13373
OMAiHPGIFTS
OrthoDBiEOG091G0BR9
PhylomeDBiP56937
TreeFamiTF105433

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56937-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRKVVLITGA SSGIGLALCK RLLAEDDELH LCLACRNMSK AEAVCAALLA
60 70 80 90 100
SHPTAEVTIV QVDVSNLQSV FRASKELKQR FQRLDCIYLN AGIMPNPQLN
110 120 130 140 150
IKALFFGLFS RKVIHMFSTA EGLLTQGDKI TADGLQEVFE TNVFGHFILI
160 170 180 190 200
RELEPLLCHS DNPSQLIWTS SRSARKSNFS LEDFQHSKGK EPYSSSKYAT
210 220 230 240 250
DLLSVALNRN FNQQGLYSNV ACPGTALTNL TYGILPPFIW TLLMPAILLL
260 270 280 290 300
RFFANAFTLT PYNGTEALVW LFHQKPESLN PLIKYLSATT GFGRNYIMTQ
310 320 330 340
KMDLDEDTAE KFYQKLLELE KHIRVTIQKT DNQARLSGSC L
Length:341
Mass (Da):38,206
Last modified:May 30, 2000 - v1
Checksum:iFE4892B2602F549B
GO
Isoform 2 (identifier: P56937-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-119: Missing.

Show »
Length:333
Mass (Da):37,262
Checksum:i187F2F8818D93869
GO
Isoform 3 (identifier: P56937-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-249: Missing.

Show »
Length:306
Mass (Da):34,476
Checksum:i61F696BEDA3B9EAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52 – 53HP → PT in AAF14537 (PubMed:10544267).Curated2
Sequence conflicti61Q → P in AAF14537 (PubMed:10544267).Curated1
Sequence conflicti86C → R in CAC88111 (PubMed:12732193).Curated1
Sequence conflicti105F → L in CAC88111 (PubMed:12732193).Curated1
Sequence conflicti135L → F in AAP97275 (Ref. 4) Curated1
Sequence conflicti273 – 276HQKP → PPKA in AAP97275 (Ref. 4) Curated4
Sequence conflicti288 – 295ATTGFGRN → GTTALEEI in AAP97275 (Ref. 4) Curated8

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006029112 – 119Missing in isoform 2. 1 Publication8
Alternative sequenceiVSP_012766215 – 249Missing in isoform 3. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098786 mRNA Translation: AAF09266.2
AF162767
, AF162759, AF162760, AF162761, AF162762, AF162763, AF162764, AF162765, AF162766 Genomic DNA Translation: AAF14537.1
AJ249179 mRNA Translation: CAC20418.1
AJ250550
, AJ250551, AJ250552, AJ250553, AJ250554, AJ250555, AJ250556, AJ250557, AJ250558 Genomic DNA Translation: CAC88111.1
AF145023 mRNA Translation: AAP97275.1
AY358962 mRNA Translation: AAQ89321.1
AK290741 mRNA Translation: BAF83430.1
BT007075 mRNA Translation: AAP35738.1
AL392003, AL445197 Genomic DNA Translation: CAI13457.1
AL445197, AL392003 Genomic DNA Translation: CAI15947.1
CH471067 Genomic DNA Translation: EAW90716.1
BC007068 mRNA Translation: AAH07068.1
BC065246 mRNA Translation: AAH65246.1
CCDSiCCDS1242.1 [P56937-1]
RefSeqiNP_001291441.1, NM_001304512.1
NP_001291442.1, NM_001304513.1
NP_057455.1, NM_016371.3 [P56937-1]
UniGeneiHs.492925

Genome annotation databases

EnsembliENST00000254521; ENSP00000254521; ENSG00000132196 [P56937-1]
GeneIDi51478
KEGGihsa:51478
UCSCiuc001gci.4 human [P56937-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDHB7_HUMAN
AccessioniPrimary (citable) accession number: P56937
Secondary accession number(s): Q5T246
, Q7Z4V9, Q8WWS2, Q9UF00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 20, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health