Reviewed, UniProtKB/Swiss-Prot P56932 (2ABD_RAT)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
      Short name=PP2A, subunit B, B-delta isoform
Alternative name(s):
    PP2A, subunit B, B55-delta isoform
    PP2A, subunit B, PR55-delta isoform
    PP2A, subunit B, R2-delta isoform

Gene names

Name:

Ppp2r2d

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Subunit structure	PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Subcellular location	Cytoplasm.
Tissue specificity	Widely expressed with high levels in brain, heart, placenta, skeletal muscle, testis, thymus and spleen.
Sequence similarities	Belongs to the phosphatase 2A regulatory subunit B family. Contains 7 WD repeats.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat WD repeat
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Ref.1 Traceable author statement. Source: RGD nucleoplasm Inferred from Experiment. Source: Reactome protein phosphatase type 2A complex Inferred from electronic annotation. Source: InterPro
Molecular function	phosphatidate phosphatase activity Inferred from Experiment. Source: Reactome protein phosphatase type 2A regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform		PRO_0000071435
Regions
	Repeat	32 – 71	40	WD 1
	Repeat	97 – 138	42	WD 2
	Repeat	181 – 219	39	WD 3
	Repeat	230 – 270	41	WD 4
	Repeat	289 – 327	39	WD 5
	Repeat	344 – 385	42	WD 6
	Repeat	420 – 452	33	WD 7
	Compositional bias	3 – 8	6	Poly-Gly
Experimental info
	Sequence conflict	330	1	H → Q in AAH81720. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P56932-1 [UniParc]. Last modified May 30, 2000. Version 1. Checksum: 733E80A93A5BC2BB	FASTA	453	51,982
	10 20 30 40 50 60 MAGAGGGGCP TGGNDFQWCF SQVKGAVDED VAEADIISTV EFNYSGDLLA TGDKGGRVVI 70 80 90 100 110 120 FQREQENKGR AHSRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAHFLLST 130 140 150 160 170 180 NDKTIKLWKI SERDKRAEGY NLKDEDGRLR DPFRITALRV PILKPMDLMV EASPRRIFAN 190 200 210 220 230 240 AHTYHINSIS VNSDHETYLS ADDLRINLWH LEITDRSFNI VDIKPANMEE LTEVITAAEF 250 260 270 280 290 300 HPHQCNVFVY SSSKGTIRLC DMRSSALCDR HAKFFEEPED PSSRSFFSEI ISSISDVKFS 310 320 330 340 350 360 HSGRYMMTRD YLSVKVWDLN MEGRPVETHH VHEYLRSKLC SLYENDCIFD KFECCWNGSD 370 380 390 400 410 420 SAIMTGSYNN FFRMFDRNTR RDVTLEASRE NSKPRASLKP RKVCSGGKRK KDEISVDSLD 430 440 450 FNKKILHTAW HPMESIIAVA ATNNLYIFQD KIN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A." Strack S., Chang D., Zaucha J.A., Colbran R.J., Wadzinski B.E. FEBS Lett. 460:462-466(1999) [PubMed: 10556517] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF180350 mRNA. Translation: AAF08536.1. BC081720 mRNA. Translation: AAH81720.1.
IPI	IPI00197077.
RefSeq	NP_653347.2.
UniGene	Rn.116122
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P56932.
Proteomic databases
PRIDE	P56932.
Genome annotation databases
Ensembl	ENSRNOT00000023139; ENSRNOP00000023139; ENSRNOG00000016940; Rattus norvegicus. [Genome view]
GeneID	246255.
KEGG	rno:246255.
UCSC	NM_144746. rat.
Organism-specific databases
CTD	246255.
RGD	708356. Ppp2r2d.
Phylogenomic databases
HOVERGEN	P56932.
Gene expression databases
ArrayExpress	P56932.
Genevestigator	P56932.
GermOnline	ENSRNOG00000016940. Rattus norvegicus.
Family and domain databases
InterPro	IPR019578. PP2A_Bsu_A/B_central-region. IPR000009. PP2A_PR55. IPR018067. PP2A_PR55_CS. IPR019573. PP2A_suB_N. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PANTHER	PTHR11871. Pp2A_PR55. 1 hit.
Pfam	PF10586. PP2A_B_N. 1 hit. PF10594. PP2A_B_subs_rcg. 1 hit. [Graphical view]
PIRSF	PIRSF037309. PP2A_PR55. 1 hit.
PRINTS	PR00600. PP2APR55.
SMART	SM00320. WD40. 7 hits. [Graphical view]
PROSITE	PS01024. PR55_1. 1 hit. PS01025. PR55_2. 1 hit. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	623603.

Entry information

Entry name

2ABD_RAT

Accession

Primary (citable) accession number: P56932
Secondary accession number(s): Q66HR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	October 13, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)