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Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68L-glutamineUniRule annotation1
Binding sitei213L-glutamineUniRule annotation1
Binding sitei232ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 38ATPUniRule annotation3
Nucleotide bindingi42 – 48ATPUniRule annotation7
Nucleotide bindingi264 – 265ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligaseUniRule annotation (EC:6.1.1.18UniRule annotation)
Alternative name(s):
Glutaminyl-tRNA synthetaseUniRule annotation
Short name:
GlnRSUniRule annotation
Gene namesi
Name:glnSUniRule annotation
Ordered Locus Names:NMB1560
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958391 – 562Glutamine--tRNA ligaseAdd BLAST562

Proteomic databases

PaxDbiP56927.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi122586.NMB1560.

Structurei

3D structure databases

ProteinModelPortaliP56927.
SMRiP56927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 45"HIGH" regionUniRule annotationAdd BLAST11
Motifi271 – 275"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105CX6. Bacteria.
COG0008. LUCA.
HOGENOMiHOG000259232.
KOiK01886.
OMAiVTHSICT.
OrthoDBiPOG091H00G9.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 3 hits.
HAMAPiMF_00126. Gln_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

P56927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNKDQFADN HFIRTIIEED LESGKHTAVQ TRFPPEPNGY LHIGHAKSIC
60 70 80 90 100
LNFGLAYIYD GLCNLRFDDT NPEKENDEYV NAIKEDVEWL GFHWAGEPRF
110 120 130 140 150
ASNYFDQLYD YAVGLIKDGK AYVDDLTPEE MREYRGTLTE AGKNSPYRDR
160 170 180 190 200
SVEENLDLFT RMKNGEFPDG SKTLRLKIDM ASGNINMRDP VIYRIRRAHH
210 220 230 240 250
HNTGDKWCIY PMYDYTHCIS DAIEGITHSL CTLEFEAHRP LYDCVLDNIP
260 270 280 290 300
APHATRPRQY EFSRLELLYT ITSKRKLNQL VVEKHVSGWD DPRMPTISGM
310 320 330 340 350
RRRGYTPEGL RLFAKRAGIS KSENIVDMSV LEGAIREELE NSAPRLMAVL
360 370 380 390 400
NPLKVTLTNF ETGRTQSRRA AFHPNHEEMG EREVPISQTI YIEADDFAEN
410 420 430 440 450
PPKGFKRLIP GGEVRLRHGY VIKCDEVVKD EAGNVVELKC SIDHDTLGKN
460 470 480 490 500
PEGRKVKGVI HWVSAEHAAE IKVRLYDRLF TVERPDAVRG EDGEYLPFTD
510 520 530 540 550
FLNPESVKEI TAYAEPAAKD LPAESRWQFE RIGYFVTDRK DHGKDTPVFN
560
RTVTLKDSWQ PK
Length:562
Mass (Da):64,650
Last modified:May 30, 2000 - v1
Checksum:i52F3C71FA22DE36D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA. Translation: AAF41914.1.
PIRiE81069.
RefSeqiNP_274567.2. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF41914; AAF41914; NMB1560.
GeneIDi904126.
KEGGinme:NMB1560.
PATRICifig|122586.8.peg.2007.

Similar proteinsi

Entry informationi

Entry nameiSYQ_NEIMB
AccessioniPrimary (citable) accession number: P56927
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: August 30, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families