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Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei311ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14055.
BRENDAi6.1.1.18. 1856.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligase (EC:6.1.1.18)
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name:
GlnRS
Gene namesi
Name:glnS
Ordered Locus Names:DR_2611
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958321 – 852Glutamine--tRNA ligaseAdd BLAST852

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi243230.DR_2611.

Structurei

Secondary structure

1852
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi51 – 61Combined sources11
Beta strandi69 – 72Combined sources4
Beta strandi76 – 78Combined sources3
Helixi82 – 84Combined sources3
Helixi85 – 97Combined sources13
Beta strandi101 – 106Combined sources6
Turni111 – 113Combined sources3
Helixi116 – 129Combined sources14
Beta strandi137 – 139Combined sources3
Helixi140 – 143Combined sources4
Helixi144 – 156Combined sources13
Beta strandi159 – 163Combined sources5
Helixi167 – 174Combined sources8
Turni185 – 188Combined sources4
Helixi191 – 202Combined sources12
Beta strandi212 – 215Combined sources4
Helixi224 – 226Combined sources3
Beta strandi230 – 234Combined sources5
Turni240 – 242Combined sources3
Beta strandi247 – 250Combined sources4
Helixi252 – 263Combined sources12
Beta strandi266 – 271Combined sources6
Helixi272 – 274Combined sources3
Turni275 – 277Combined sources3
Helixi278 – 287Combined sources10
Beta strandi295 – 299Combined sources5
Beta strandi302 – 304Combined sources3
Helixi311 – 319Combined sources9
Beta strandi322 – 325Combined sources4
Beta strandi331 – 333Combined sources3
Helixi334 – 340Combined sources7
Helixi344 – 353Combined sources10
Beta strandi361 – 363Combined sources3
Helixi365 – 377Combined sources13
Beta strandi385 – 394Combined sources10
Beta strandi401 – 408Combined sources8
Helixi410 – 414Combined sources5
Beta strandi424 – 426Combined sources3
Helixi431 – 433Combined sources3
Beta strandi435 – 440Combined sources6
Beta strandi442 – 447Combined sources6
Helixi448 – 450Combined sources3
Beta strandi467 – 470Combined sources4
Turni471 – 473Combined sources3
Beta strandi474 – 483Combined sources10
Beta strandi489 – 496Combined sources8
Turni512 – 514Combined sources3
Beta strandi516 – 523Combined sources8
Beta strandi526 – 530Combined sources5
Helixi566 – 569Combined sources4
Beta strandi574 – 582Combined sources9
Helixi584 – 588Combined sources5
Beta strandi594 – 597Combined sources4
Turni598 – 600Combined sources3
Beta strandi601 – 605Combined sources5
Helixi607 – 611Combined sources5
Beta strandi621 – 626Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HZ7X-ray2.30A2-852[»]
ProteinModelPortaliP56926.
SMRiP56926.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56926.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 635Glutaminyl-tRNA synthetaseAdd BLAST635
Regioni636 – 852GatB-likeAdd BLAST217

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi74 – 84"HIGH" regionAdd BLAST11
Motifi308 – 312"KMSKS" region5

Sequence similaritiesi

In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.Curated
In the C-terminal section; belongs to the GatB/GatE family.Curated

Phylogenomic databases

eggNOGiENOG4105CX6. Bacteria.
COG0008. LUCA.
COG0064. LUCA.
HOGENOMiHOG000259232.
InParanoidiP56926.
KOiK01886.
OMAiDIAVYEN.
OrthoDBiPOG091H00G9.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPiMF_00126. Gln_tRNA_synth. 1 hit.
InterProiIPR018027. Asn/Gln_amidotransferase.
IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02637. GatB_Yqey. 1 hit.
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SMARTiSM00845. GatB_Yqey. 1 hit.
[Graphical view]
SUPFAMiSSF50715. SSF50715. 2 hits.
SSF89095. SSF89095. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.

Sequencei

Sequence statusi: Complete.

P56926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAFGWEQDR GAPFSGRSPR ILTRMTDAPR PTAGADAPAR PPAAPLVAPN
60 70 80 90 100
FITEIIERDL EAGKYPRVVT RFPPDPSGYA HLGHVFASLL DFNTARQYGG
110 120 130 140 150
QFNLRMDDTN PELARQEYVD SIADDLKWLG LDWGEHFYYA SDYFDRYYAY
160 170 180 190 200
AEQLIRQGDA YVESVSPEEL SRLRGNATTP GTPSPYRDRS VEENLDLLRR
210 220 230 240 250
MKAGEFADGE HVLRAKIDLT APNMKLRDPV LYRIVNKPHF RTSDEWHIYP
260 270 280 290 300
AYDFEHPLQD AIEGVTHSMC SLEFVDNRAI YDWLMEKLNF DPRPHQYEFG
310 320 330 340 350
RRGLEYTITS KRKLRELVQA GRVSGWDDPR MPTLRAQRRL GVTPEAVRAF
360 370 380 390 400
AAQIGVSRTN RTVDIAVYEN AVRDDLNHRA PRVMAVLDPV KVTLTNLDGE
410 420 430 440 450
KTLSLPYWPH DVVRDSPDGL VGMPGGGRVA PEEAVRDVPL TRELYIERDD
460 470 480 490 500
FSPAPPKGFK RLTPGGTVRL RGAGIIRADD FGTDEAGQVT HIRATLLGED
510 520 530 540 550
AKAAGVIHWV SAERALPAEF RLYDRLFRVP HPEGENADVE DDSAGPAEHE
560 570 580 590 600
AEPGAGQETA PVSQGFMRYL TPDSLRVLRG YVEPSVAGDP ADTRYQFERQ
610 620 630 640 650
GYFWRDPVEL ERVDSREDAL VFGRIITLKD TWGKQGGGTQ QKAEGKKRPS
660 670 680 690 700
TKGRGPDEVR GEGSSSPAKA HAPKAQPLTP EQDAEFTRLL GLGASEGDAR
710 720 730 740 750
TIARDPALLA FVGGAAPGDT FAQVASWTVN ELVAGLRAGE VKVRAADLAP
760 770 780 790 800
LAEGVASGQL SARIAREALA RAAASGDAPL TIIEREGLNA GLSAEALQQV
810 820 830 840 850
VAQVIAANPD KAEAYRGGKT ALLGFFTGQV MRATAGKADP QALAAALKDA

LA
Length:852
Mass (Da):93,471
Last modified:May 30, 2000 - v1
Checksum:i82911AA229D25F79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF12148.1.
PIRiA75253.
RefSeqiNP_296330.1. NC_001263.1.
WP_010889235.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF12148; AAF12148; DR_2611.
GeneIDi1798434.
KEGGidra:DR_2611.
PATRICi21632975. VBIDeiRad64572_2858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF12148.1.
PIRiA75253.
RefSeqiNP_296330.1. NC_001263.1.
WP_010889235.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HZ7X-ray2.30A2-852[»]
ProteinModelPortaliP56926.
SMRiP56926.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_2611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF12148; AAF12148; DR_2611.
GeneIDi1798434.
KEGGidra:DR_2611.
PATRICi21632975. VBIDeiRad64572_2858.

Phylogenomic databases

eggNOGiENOG4105CX6. Bacteria.
COG0008. LUCA.
COG0064. LUCA.
HOGENOMiHOG000259232.
InParanoidiP56926.
KOiK01886.
OMAiDIAVYEN.
OrthoDBiPOG091H00G9.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14055.
BRENDAi6.1.1.18. 1856.

Miscellaneous databases

EvolutionaryTraceiP56926.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPiMF_00126. Gln_tRNA_synth. 1 hit.
InterProiIPR018027. Asn/Gln_amidotransferase.
IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02637. GatB_Yqey. 1 hit.
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SMARTiSM00845. GatB_Yqey. 1 hit.
[Graphical view]
SUPFAMiSSF50715. SSF50715. 2 hits.
SSF89095. SSF89095. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSYQ_DEIRA
AccessioniPrimary (citable) accession number: P56926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.