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P56926

- SYQ_DEIRA

UniProt

P56926 - SYQ_DEIRA

Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei311 – 3111ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro
    3. glutamine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutaminyl-tRNA aminoacylation Source: InterPro
    2. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-2666-MONOMER.
    MetaCyc:MONOMER-14055.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--tRNA ligase (EC:6.1.1.18)
    Alternative name(s):
    Glutaminyl-tRNA synthetase
    Short name:
    GlnRS
    Gene namesi
    Name:glnS
    Ordered Locus Names:DR_2611
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 852852Glutamine--tRNA ligasePRO_0000195832Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi243230.DR_2611.

    Structurei

    Secondary structure

    1
    852
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi51 – 6111
    Beta strandi69 – 724
    Beta strandi76 – 783
    Helixi82 – 843
    Helixi85 – 9713
    Beta strandi101 – 1066
    Turni111 – 1133
    Helixi116 – 12914
    Beta strandi137 – 1393
    Helixi140 – 1434
    Helixi144 – 15613
    Beta strandi159 – 1635
    Helixi167 – 1748
    Turni185 – 1884
    Helixi191 – 20212
    Beta strandi212 – 2154
    Helixi224 – 2263
    Beta strandi230 – 2345
    Turni240 – 2423
    Beta strandi247 – 2504
    Helixi252 – 26312
    Beta strandi266 – 2716
    Helixi272 – 2743
    Turni275 – 2773
    Helixi278 – 28710
    Beta strandi295 – 2995
    Beta strandi302 – 3043
    Helixi311 – 3199
    Beta strandi322 – 3254
    Beta strandi331 – 3333
    Helixi334 – 3407
    Helixi344 – 35310
    Beta strandi361 – 3633
    Helixi365 – 37713
    Beta strandi385 – 39410
    Beta strandi401 – 4088
    Helixi410 – 4145
    Beta strandi424 – 4263
    Helixi431 – 4333
    Beta strandi435 – 4406
    Beta strandi442 – 4476
    Helixi448 – 4503
    Beta strandi467 – 4704
    Turni471 – 4733
    Beta strandi474 – 48310
    Beta strandi489 – 4968
    Turni512 – 5143
    Beta strandi516 – 5238
    Beta strandi526 – 5305
    Helixi566 – 5694
    Beta strandi574 – 5829
    Helixi584 – 5885
    Beta strandi594 – 5974
    Turni598 – 6003
    Beta strandi601 – 6055
    Helixi607 – 6115
    Beta strandi621 – 6266

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HZ7X-ray2.30A2-852[»]
    ProteinModelPortaliP56926.
    SMRiP56926. Positions 43-632.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP56926.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 635635Glutaminyl-tRNA synthetaseAdd
    BLAST
    Regioni636 – 852217GatB-likeAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi74 – 8411"HIGH" regionAdd
    BLAST
    Motifi308 – 3125"KMSKS" region

    Sequence similaritiesi

    In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.Curated
    In the C-terminal section; belongs to the GatB/GatE family.Curated

    Phylogenomic databases

    eggNOGiCOG0064.
    HOGENOMiHOG000259232.
    KOiK01886.
    OMAiHAGDKWF.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    HAMAPiMF_00126. Gln_tRNA_synth.
    InterProiIPR018027. Asn/Gln_amidotransferase.
    IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
    IPR004514. Gln-tRNA-synth.
    IPR022861. Gln_tRNA_ligase_bac.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF02637. GatB_Yqey. 1 hit.
    PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SMARTiSM00845. GatB_Yqey. 1 hit.
    [Graphical view]
    SUPFAMiSSF50715. SSF50715. 2 hits.
    SSF89095. SSF89095. 1 hit.
    TIGRFAMsiTIGR00440. glnS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56926-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAFGWEQDR GAPFSGRSPR ILTRMTDAPR PTAGADAPAR PPAAPLVAPN    50
    FITEIIERDL EAGKYPRVVT RFPPDPSGYA HLGHVFASLL DFNTARQYGG 100
    QFNLRMDDTN PELARQEYVD SIADDLKWLG LDWGEHFYYA SDYFDRYYAY 150
    AEQLIRQGDA YVESVSPEEL SRLRGNATTP GTPSPYRDRS VEENLDLLRR 200
    MKAGEFADGE HVLRAKIDLT APNMKLRDPV LYRIVNKPHF RTSDEWHIYP 250
    AYDFEHPLQD AIEGVTHSMC SLEFVDNRAI YDWLMEKLNF DPRPHQYEFG 300
    RRGLEYTITS KRKLRELVQA GRVSGWDDPR MPTLRAQRRL GVTPEAVRAF 350
    AAQIGVSRTN RTVDIAVYEN AVRDDLNHRA PRVMAVLDPV KVTLTNLDGE 400
    KTLSLPYWPH DVVRDSPDGL VGMPGGGRVA PEEAVRDVPL TRELYIERDD 450
    FSPAPPKGFK RLTPGGTVRL RGAGIIRADD FGTDEAGQVT HIRATLLGED 500
    AKAAGVIHWV SAERALPAEF RLYDRLFRVP HPEGENADVE DDSAGPAEHE 550
    AEPGAGQETA PVSQGFMRYL TPDSLRVLRG YVEPSVAGDP ADTRYQFERQ 600
    GYFWRDPVEL ERVDSREDAL VFGRIITLKD TWGKQGGGTQ QKAEGKKRPS 650
    TKGRGPDEVR GEGSSSPAKA HAPKAQPLTP EQDAEFTRLL GLGASEGDAR 700
    TIARDPALLA FVGGAAPGDT FAQVASWTVN ELVAGLRAGE VKVRAADLAP 750
    LAEGVASGQL SARIAREALA RAAASGDAPL TIIEREGLNA GLSAEALQQV 800
    VAQVIAANPD KAEAYRGGKT ALLGFFTGQV MRATAGKADP QALAAALKDA 850
    LA 852
    Length:852
    Mass (Da):93,471
    Last modified:May 30, 2000 - v1
    Checksum:i82911AA229D25F79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF12148.1.
    PIRiA75253.
    RefSeqiNP_296330.1. NC_001263.1.
    WP_010889235.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF12148; AAF12148; DR_2611.
    GeneIDi1798434.
    KEGGidra:DR_2611.
    PATRICi21632975. VBIDeiRad64572_2858.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF12148.1 .
    PIRi A75253.
    RefSeqi NP_296330.1. NC_001263.1.
    WP_010889235.1. NC_001263.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HZ7 X-ray 2.30 A 2-852 [» ]
    ProteinModelPortali P56926.
    SMRi P56926. Positions 43-632.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_2611.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF12148 ; AAF12148 ; DR_2611 .
    GeneIDi 1798434.
    KEGGi dra:DR_2611.
    PATRICi 21632975. VBIDeiRad64572_2858.

    Phylogenomic databases

    eggNOGi COG0064.
    HOGENOMi HOG000259232.
    KOi K01886.
    OMAi HAGDKWF.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-2666-MONOMER.
    MetaCyc:MONOMER-14055.

    Miscellaneous databases

    EvolutionaryTracei P56926.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    HAMAPi MF_00126. Gln_tRNA_synth.
    InterProi IPR018027. Asn/Gln_amidotransferase.
    IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
    IPR004514. Gln-tRNA-synth.
    IPR022861. Gln_tRNA_ligase_bac.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF02637. GatB_Yqey. 1 hit.
    PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SMARTi SM00845. GatB_Yqey. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50715. SSF50715. 2 hits.
    SSF89095. SSF89095. 1 hit.
    TIGRFAMsi TIGR00440. glnS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

    Entry informationi

    Entry nameiSYQ_DEIRA
    AccessioniPrimary (citable) accession number: P56926
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3