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P56926

- SYQ_DEIRA

UniProt

P56926 - SYQ_DEIRA

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Protein

Glutamine--tRNA ligase

Gene
glnS, DR_2611
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei311 – 3111ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro
  3. glutamine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutaminyl-tRNA aminoacylation Source: InterPro
  2. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2666-MONOMER.
MetaCyc:MONOMER-14055.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligase (EC:6.1.1.18)
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name:
GlnRS
Gene namesi
Name:glnS
Ordered Locus Names:DR_2611
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 852852Glutamine--tRNA ligaseUniRule annotationPRO_0000195832Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243230.DR_2611.

Structurei

Secondary structure

1
852
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi51 – 6111
Beta strandi69 – 724
Beta strandi76 – 783
Helixi82 – 843
Helixi85 – 9713
Beta strandi101 – 1066
Turni111 – 1133
Helixi116 – 12914
Beta strandi137 – 1393
Helixi140 – 1434
Helixi144 – 15613
Beta strandi159 – 1635
Helixi167 – 1748
Turni185 – 1884
Helixi191 – 20212
Beta strandi212 – 2154
Helixi224 – 2263
Beta strandi230 – 2345
Turni240 – 2423
Beta strandi247 – 2504
Helixi252 – 26312
Beta strandi266 – 2716
Helixi272 – 2743
Turni275 – 2773
Helixi278 – 28710
Beta strandi295 – 2995
Beta strandi302 – 3043
Helixi311 – 3199
Beta strandi322 – 3254
Beta strandi331 – 3333
Helixi334 – 3407
Helixi344 – 35310
Beta strandi361 – 3633
Helixi365 – 37713
Beta strandi385 – 39410
Beta strandi401 – 4088
Helixi410 – 4145
Beta strandi424 – 4263
Helixi431 – 4333
Beta strandi435 – 4406
Beta strandi442 – 4476
Helixi448 – 4503
Beta strandi467 – 4704
Turni471 – 4733
Beta strandi474 – 48310
Beta strandi489 – 4968
Turni512 – 5143
Beta strandi516 – 5238
Beta strandi526 – 5305
Helixi566 – 5694
Beta strandi574 – 5829
Helixi584 – 5885
Beta strandi594 – 5974
Turni598 – 6003
Beta strandi601 – 6055
Helixi607 – 6115
Beta strandi621 – 6266

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HZ7X-ray2.30A2-852[»]
ProteinModelPortaliP56926.
SMRiP56926. Positions 43-632.

Miscellaneous databases

EvolutionaryTraceiP56926.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 635635Glutaminyl-tRNA synthetaseUniRule annotationAdd
BLAST
Regioni636 – 852217GatB-likeUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi74 – 8411"HIGH" regionUniRule annotationAdd
BLAST
Motifi308 – 3125"KMSKS" regionUniRule annotation

Sequence similaritiesi

In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.
In the C-terminal section; belongs to the GatB/GatE family.

Phylogenomic databases

eggNOGiCOG0064.
HOGENOMiHOG000259232.
KOiK01886.
OMAiHAGDKWF.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPiMF_00126. Gln_tRNA_synth.
InterProiIPR018027. Asn/Gln_amidotransferase.
IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF02637. GatB_Yqey. 1 hit.
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SMARTiSM00845. GatB_Yqey. 1 hit.
[Graphical view]
SUPFAMiSSF50715. SSF50715. 2 hits.
SSF89095. SSF89095. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.

Sequencei

Sequence statusi: Complete.

P56926-1 [UniParc]FASTAAdd to Basket

« Hide

MGAFGWEQDR GAPFSGRSPR ILTRMTDAPR PTAGADAPAR PPAAPLVAPN    50
FITEIIERDL EAGKYPRVVT RFPPDPSGYA HLGHVFASLL DFNTARQYGG 100
QFNLRMDDTN PELARQEYVD SIADDLKWLG LDWGEHFYYA SDYFDRYYAY 150
AEQLIRQGDA YVESVSPEEL SRLRGNATTP GTPSPYRDRS VEENLDLLRR 200
MKAGEFADGE HVLRAKIDLT APNMKLRDPV LYRIVNKPHF RTSDEWHIYP 250
AYDFEHPLQD AIEGVTHSMC SLEFVDNRAI YDWLMEKLNF DPRPHQYEFG 300
RRGLEYTITS KRKLRELVQA GRVSGWDDPR MPTLRAQRRL GVTPEAVRAF 350
AAQIGVSRTN RTVDIAVYEN AVRDDLNHRA PRVMAVLDPV KVTLTNLDGE 400
KTLSLPYWPH DVVRDSPDGL VGMPGGGRVA PEEAVRDVPL TRELYIERDD 450
FSPAPPKGFK RLTPGGTVRL RGAGIIRADD FGTDEAGQVT HIRATLLGED 500
AKAAGVIHWV SAERALPAEF RLYDRLFRVP HPEGENADVE DDSAGPAEHE 550
AEPGAGQETA PVSQGFMRYL TPDSLRVLRG YVEPSVAGDP ADTRYQFERQ 600
GYFWRDPVEL ERVDSREDAL VFGRIITLKD TWGKQGGGTQ QKAEGKKRPS 650
TKGRGPDEVR GEGSSSPAKA HAPKAQPLTP EQDAEFTRLL GLGASEGDAR 700
TIARDPALLA FVGGAAPGDT FAQVASWTVN ELVAGLRAGE VKVRAADLAP 750
LAEGVASGQL SARIAREALA RAAASGDAPL TIIEREGLNA GLSAEALQQV 800
VAQVIAANPD KAEAYRGGKT ALLGFFTGQV MRATAGKADP QALAAALKDA 850
LA 852
Length:852
Mass (Da):93,471
Last modified:May 30, 2000 - v1
Checksum:i82911AA229D25F79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF12148.1.
PIRiA75253.
RefSeqiNP_296330.1. NC_001263.1.
WP_010889235.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF12148; AAF12148; DR_2611.
GeneIDi1798434.
KEGGidra:DR_2611.
PATRICi21632975. VBIDeiRad64572_2858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF12148.1 .
PIRi A75253.
RefSeqi NP_296330.1. NC_001263.1.
WP_010889235.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HZ7 X-ray 2.30 A 2-852 [» ]
ProteinModelPortali P56926.
SMRi P56926. Positions 43-632.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_2611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF12148 ; AAF12148 ; DR_2611 .
GeneIDi 1798434.
KEGGi dra:DR_2611.
PATRICi 21632975. VBIDeiRad64572_2858.

Phylogenomic databases

eggNOGi COG0064.
HOGENOMi HOG000259232.
KOi K01886.
OMAi HAGDKWF.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-2666-MONOMER.
MetaCyc:MONOMER-14055.

Miscellaneous databases

EvolutionaryTracei P56926.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPi MF_00126. Gln_tRNA_synth.
InterProi IPR018027. Asn/Gln_amidotransferase.
IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF02637. GatB_Yqey. 1 hit.
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SMARTi SM00845. GatB_Yqey. 1 hit.
[Graphical view ]
SUPFAMi SSF50715. SSF50715. 2 hits.
SSF89095. SSF89095. 1 hit.
TIGRFAMsi TIGR00440. glnS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiSYQ_DEIRA
AccessioniPrimary (citable) accession number: P56926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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