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P56926

- SYQ_DEIRA

UniProt

P56926 - SYQ_DEIRA

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Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei311 – 3111ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro
  3. glutamine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutaminyl-tRNA aminoacylation Source: InterPro
  2. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2666-MONOMER.
MetaCyc:MONOMER-14055.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligase (EC:6.1.1.18)
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name:
GlnRS
Gene namesi
Name:glnS
Ordered Locus Names:DR_2611
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 852852Glutamine--tRNA ligasePRO_0000195832Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi243230.DR_2611.

Structurei

Secondary structure

1
852
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi51 – 6111Combined sources
Beta strandi69 – 724Combined sources
Beta strandi76 – 783Combined sources
Helixi82 – 843Combined sources
Helixi85 – 9713Combined sources
Beta strandi101 – 1066Combined sources
Turni111 – 1133Combined sources
Helixi116 – 12914Combined sources
Beta strandi137 – 1393Combined sources
Helixi140 – 1434Combined sources
Helixi144 – 15613Combined sources
Beta strandi159 – 1635Combined sources
Helixi167 – 1748Combined sources
Turni185 – 1884Combined sources
Helixi191 – 20212Combined sources
Beta strandi212 – 2154Combined sources
Helixi224 – 2263Combined sources
Beta strandi230 – 2345Combined sources
Turni240 – 2423Combined sources
Beta strandi247 – 2504Combined sources
Helixi252 – 26312Combined sources
Beta strandi266 – 2716Combined sources
Helixi272 – 2743Combined sources
Turni275 – 2773Combined sources
Helixi278 – 28710Combined sources
Beta strandi295 – 2995Combined sources
Beta strandi302 – 3043Combined sources
Helixi311 – 3199Combined sources
Beta strandi322 – 3254Combined sources
Beta strandi331 – 3333Combined sources
Helixi334 – 3407Combined sources
Helixi344 – 35310Combined sources
Beta strandi361 – 3633Combined sources
Helixi365 – 37713Combined sources
Beta strandi385 – 39410Combined sources
Beta strandi401 – 4088Combined sources
Helixi410 – 4145Combined sources
Beta strandi424 – 4263Combined sources
Helixi431 – 4333Combined sources
Beta strandi435 – 4406Combined sources
Beta strandi442 – 4476Combined sources
Helixi448 – 4503Combined sources
Beta strandi467 – 4704Combined sources
Turni471 – 4733Combined sources
Beta strandi474 – 48310Combined sources
Beta strandi489 – 4968Combined sources
Turni512 – 5143Combined sources
Beta strandi516 – 5238Combined sources
Beta strandi526 – 5305Combined sources
Helixi566 – 5694Combined sources
Beta strandi574 – 5829Combined sources
Helixi584 – 5885Combined sources
Beta strandi594 – 5974Combined sources
Turni598 – 6003Combined sources
Beta strandi601 – 6055Combined sources
Helixi607 – 6115Combined sources
Beta strandi621 – 6266Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HZ7X-ray2.30A2-852[»]
ProteinModelPortaliP56926.
SMRiP56926. Positions 43-632.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56926.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 635635Glutaminyl-tRNA synthetaseAdd
BLAST
Regioni636 – 852217GatB-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi74 – 8411"HIGH" regionAdd
BLAST
Motifi308 – 3125"KMSKS" region

Sequence similaritiesi

In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.Curated
In the C-terminal section; belongs to the GatB/GatE family.Curated

Phylogenomic databases

eggNOGiCOG0064.
HOGENOMiHOG000259232.
InParanoidiP56926.
KOiK01886.
OMAiHAGDKWF.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPiMF_00126. Gln_tRNA_synth.
InterProiIPR018027. Asn/Gln_amidotransferase.
IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF02637. GatB_Yqey. 1 hit.
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SMARTiSM00845. GatB_Yqey. 1 hit.
[Graphical view]
SUPFAMiSSF50715. SSF50715. 2 hits.
SSF89095. SSF89095. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.

Sequencei

Sequence statusi: Complete.

P56926-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAFGWEQDR GAPFSGRSPR ILTRMTDAPR PTAGADAPAR PPAAPLVAPN
60 70 80 90 100
FITEIIERDL EAGKYPRVVT RFPPDPSGYA HLGHVFASLL DFNTARQYGG
110 120 130 140 150
QFNLRMDDTN PELARQEYVD SIADDLKWLG LDWGEHFYYA SDYFDRYYAY
160 170 180 190 200
AEQLIRQGDA YVESVSPEEL SRLRGNATTP GTPSPYRDRS VEENLDLLRR
210 220 230 240 250
MKAGEFADGE HVLRAKIDLT APNMKLRDPV LYRIVNKPHF RTSDEWHIYP
260 270 280 290 300
AYDFEHPLQD AIEGVTHSMC SLEFVDNRAI YDWLMEKLNF DPRPHQYEFG
310 320 330 340 350
RRGLEYTITS KRKLRELVQA GRVSGWDDPR MPTLRAQRRL GVTPEAVRAF
360 370 380 390 400
AAQIGVSRTN RTVDIAVYEN AVRDDLNHRA PRVMAVLDPV KVTLTNLDGE
410 420 430 440 450
KTLSLPYWPH DVVRDSPDGL VGMPGGGRVA PEEAVRDVPL TRELYIERDD
460 470 480 490 500
FSPAPPKGFK RLTPGGTVRL RGAGIIRADD FGTDEAGQVT HIRATLLGED
510 520 530 540 550
AKAAGVIHWV SAERALPAEF RLYDRLFRVP HPEGENADVE DDSAGPAEHE
560 570 580 590 600
AEPGAGQETA PVSQGFMRYL TPDSLRVLRG YVEPSVAGDP ADTRYQFERQ
610 620 630 640 650
GYFWRDPVEL ERVDSREDAL VFGRIITLKD TWGKQGGGTQ QKAEGKKRPS
660 670 680 690 700
TKGRGPDEVR GEGSSSPAKA HAPKAQPLTP EQDAEFTRLL GLGASEGDAR
710 720 730 740 750
TIARDPALLA FVGGAAPGDT FAQVASWTVN ELVAGLRAGE VKVRAADLAP
760 770 780 790 800
LAEGVASGQL SARIAREALA RAAASGDAPL TIIEREGLNA GLSAEALQQV
810 820 830 840 850
VAQVIAANPD KAEAYRGGKT ALLGFFTGQV MRATAGKADP QALAAALKDA

LA
Length:852
Mass (Da):93,471
Last modified:May 30, 2000 - v1
Checksum:i82911AA229D25F79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF12148.1.
PIRiA75253.
RefSeqiNP_296330.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF12148; AAF12148; DR_2611.
GeneIDi1798434.
KEGGidra:DR_2611.
PATRICi21632975. VBIDeiRad64572_2858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF12148.1 .
PIRi A75253.
RefSeqi NP_296330.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HZ7 X-ray 2.30 A 2-852 [» ]
ProteinModelPortali P56926.
SMRi P56926. Positions 43-632.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_2611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF12148 ; AAF12148 ; DR_2611 .
GeneIDi 1798434.
KEGGi dra:DR_2611.
PATRICi 21632975. VBIDeiRad64572_2858.

Phylogenomic databases

eggNOGi COG0064.
HOGENOMi HOG000259232.
InParanoidi P56926.
KOi K01886.
OMAi HAGDKWF.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-2666-MONOMER.
MetaCyc:MONOMER-14055.

Miscellaneous databases

EvolutionaryTracei P56926.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPi MF_00126. Gln_tRNA_synth.
InterProi IPR018027. Asn/Gln_amidotransferase.
IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF02637. GatB_Yqey. 1 hit.
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SMARTi SM00845. GatB_Yqey. 1 hit.
[Graphical view ]
SUPFAMi SSF50715. SSF50715. 2 hits.
SSF89095. SSF89095. 1 hit.
TIGRFAMsi TIGR00440. glnS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiSYQ_DEIRA
AccessioniPrimary (citable) accession number: P56926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3