P56915 (GSC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein goosecoid

Gene names

Name:

GSC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dorsal/ventral neural tube patterning Inferred from electronic annotation. Source: Compara embryonic skeletal system morphogenesis Inferred from electronic annotation. Source: Compara forebrain development Inferred from electronic annotation. Source: Compara gastrulation Non-traceable author statement Ref.1. Source: UniProtKB middle ear morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB muscle organ morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara signal transduction involved in regulation of gene expression Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Non-traceable author statement. Source: UniProtKB RNA polymerase II repressing transcription factor binding Inferred from sequence or structural similarity. Source: BHF-UCL sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 257

257

Homeobox protein goosecoid

PRO_0000048885

Regions

DNA binding

160 – 219

60

Homeobox

Experimental info

Sequence conflict

26 – 28

3

AHS → RT Ref.1

Sequence conflict

45 – 47

3

Missing Ref.1

Sequence conflict

65

1

Missing Ref.1

Sequence conflict

74

1

S → T Ref.1

Secondary structure

1

.

.

.

.

.

.

.

257

Helix Strand Turn

Details...

Helix

169 – 181

13

Helix

187 – 196

10

Helix

201 – 217

17

Sequences

	Sequence		Length	Mass (Da)
	P56915 [UniParc]. Last modified March 15, 2005. Version 2. Checksum: BA2A56144F921407	FASTA	257	28,150
	10 20 30 40 50 60 MPASMFSIDN ILAARPRCKD SVLPVAHSAA APVVFPALHG DSLYGASGGA SSDYGAFYPR 70 80 90 100 110 120 PVAPGGAGLP AAVSGSRLGY NNYFYGQLHV QAAPVGPACC GAVPPLGAQQ CSCVPTPPGY 130 140 150 160 170 180 EGPGSVLVSP VPHQMLPYMN VGTLSRTELQ LLNQLHCRRK RRHRTIFTDE QLEALENLFQ 190 200 210 220 230 240 ETKYPDVGTR EQLARKVHLR EEKVEVWFKN RRAKWRRQKR SSSEESENAE KWNKTSSSKA 250 SPEKREEEGK SDLDSDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1." Blum M., De Robertis E.M., Kojis T., Heinzmann C., Klisak I., Geissert D., Sparkes R.S. Genomics 21:388-393(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leukocyte.
[2]	"Cloning and expression pattern, DNA binding study of two novel human Hox genes." Guo J.H., Chen S., Chen L., Yu L. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone.
[4]	"Solution structure of the homeobox domain of homeobox protein goosecoid." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 161-217.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY177407 mRNA. Translation: AAO18645.1.
BC063580 mRNA. Translation: AAH63580.1.

IPI

IPI00011923.

PIR

A54677.

RefSeq

NP_776248.1. NM_173849.2.

UniGene

Hs.440438.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DMU	NMR	-	A	161-217	[»]

ProteinModelPortal

P56915.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000238558.

PTM databases

PhosphoSite

P56915.

Polymorphism databases

DMDM

61252078.

Proteomic databases

PaxDb

P56915.

PRIDE

P56915.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000238558; ENSP00000238558; ENSG00000133937.

GeneID

145258.

KEGG

hsa:145258.

UCSC

uc001ydu.3. human.

Organism-specific databases

CTD

145258.

GeneCards

GC14M095234.

HGNC

HGNC:4612. GSC.

MIM

138890. gene.

neXtProt

NX_P56915.

PharmGKB

PA29004.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG247162.

HOGENOM

HOG000112823.

HOVERGEN

HBG005921.

InParanoid

P56915.

KO

K09324.

OMA

PVGPSCC.

OrthoDB

EOG46Q6T9.

PhylomeDB

P56915.

Enzyme and pathway databases

Pathway_Interaction_DB

smad2_3nuclearpathway. Regulation of nuclear SMAD2/3 signaling.

Gene expression databases

Bgee

P56915.

CleanEx

HS_GSC.

Genevestigator

P56915.

GermOnline

ENSG00000133937. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.60. 1 hit.

InterPro

IPR017970. Homeobox_CS.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
[Graphical view]

Pfam

PF00046. Homeobox. 1 hit.
[Graphical view]

SMART

SM00389. HOX. 1 hit.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.

PROSITE

PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P56915.

GenomeRNAi

145258.

NextBio

85059.

SOURCE

Search...

Entry information

Entry name

GSC_HUMAN

Accession

Primary (citable) accession number: P56915
Secondary accession number(s): Q86YR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	March 15, 2005
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.