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P56915 (GSC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein goosecoid
Gene names
Name:GSC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the paired homeobox family. Bicoid subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdorsal/ventral neural tube patterning

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal system morphogenesis

Inferred from electronic annotation. Source: Ensembl

forebrain development

Inferred from electronic annotation. Source: Ensembl

gastrulation

Non-traceable author statement Ref.1. Source: UniProtKB

middle ear morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

muscle organ morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

signal transduction involved in regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionRNA polymerase II repressing transcription factor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

RNA polymerase II transcription factor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Homeobox protein goosecoid
PRO_0000048885

Regions

DNA binding160 – 21960Homeobox

Experimental info

Sequence conflict26 – 283AHS → RT Ref.1
Sequence conflict45 – 473Missing Ref.1
Sequence conflict651Missing Ref.1
Sequence conflict741S → T Ref.1

Secondary structure

....... 257
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P56915 [UniParc].

Last modified March 15, 2005. Version 2.
Checksum: BA2A56144F921407

FASTA25728,150
        10         20         30         40         50         60 
MPASMFSIDN ILAARPRCKD SVLPVAHSAA APVVFPALHG DSLYGASGGA SSDYGAFYPR 

        70         80         90        100        110        120 
PVAPGGAGLP AAVSGSRLGY NNYFYGQLHV QAAPVGPACC GAVPPLGAQQ CSCVPTPPGY 

       130        140        150        160        170        180 
EGPGSVLVSP VPHQMLPYMN VGTLSRTELQ LLNQLHCRRK RRHRTIFTDE QLEALENLFQ 

       190        200        210        220        230        240 
ETKYPDVGTR EQLARKVHLR EEKVEVWFKN RRAKWRRQKR SSSEESENAE KWNKTSSSKA 

       250 
SPEKREEEGK SDLDSDS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1."
Blum M., De Robertis E.M., Kojis T., Heinzmann C., Klisak I., Geissert D., Sparkes R.S.
Genomics 21:388-393(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leukocyte.
[2]"Cloning and expression pattern, DNA binding study of two novel human Hox genes."
Guo J.H., Chen S., Chen L., Yu L.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone.
[4]"Solution structure of the homeobox domain of homeobox protein goosecoid."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 161-217.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY177407 mRNA. Translation: AAO18645.1.
BC063580 mRNA. Translation: AAH63580.1.
CCDSCCDS9930.1.
PIRA54677.
RefSeqNP_776248.1. NM_173849.2.
UniGeneHs.440438.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DMUNMR-A161-217[»]
ProteinModelPortalP56915.
SMRP56915. Positions 161-222.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126899. 1 interaction.
STRING9606.ENSP00000238558.

PTM databases

PhosphoSiteP56915.

Polymorphism databases

DMDM61252078.

Proteomic databases

PaxDbP56915.
PRIDEP56915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000238558; ENSP00000238558; ENSG00000133937.
GeneID145258.
KEGGhsa:145258.
UCSCuc001ydu.3. human.

Organism-specific databases

CTD145258.
GeneCardsGC14M095234.
HGNCHGNC:4612. GSC.
MIM138890. gene.
neXtProtNX_P56915.
PharmGKBPA29004.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG247162.
HOGENOMHOG000112823.
HOVERGENHBG005921.
InParanoidP56915.
KOK09324.
OMAPVGPSCC.
OrthoDBEOG78SQKS.
PhylomeDBP56915.
TreeFamTF351613.

Gene expression databases

BgeeP56915.
CleanExHS_GSC.
GenevestigatorP56915.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP56915.
GeneWikiGSC_(gene).
GenomeRNAi145258.
NextBio85059.
PROP56915.
SOURCESearch...

Entry information

Entry nameGSC_HUMAN
AccessionPrimary (citable) accession number: P56915
Secondary accession number(s): Q86YR1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 15, 2005
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM