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P56904

- THID_RHIME

UniProt

P56904 - THID_RHIME

Protein

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene

thiD

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (02 Nov 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

    Catalytic activityi

    ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
    ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
    3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-4520-MONOMER.
    UniPathwayiUPA00060; UER00137.
    UPA00060; UER00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC:2.7.1.49, EC:2.7.4.7)
    Alternative name(s):
    Hydroxymethylpyrimidine kinase
    Short name:
    HMP kinase
    Hydroxymethylpyrimidine phosphate kinase
    Short name:
    HMP-P kinase
    Short name:
    HMP-phosphate kinase
    Short name:
    HMPP kinase
    Gene namesi
    Name:thiD
    Ordered Locus Names:RB1087
    ORF Names:SMb20962
    Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Plasmid pSymB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Hydroxymethylpyrimidine/phosphomethylpyrimidine kinasePRO_0000192025Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SM_b20962.

    Structurei

    3D structure databases

    ProteinModelPortaliP56904.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ThiD family.Curated

    Phylogenomic databases

    eggNOGiCOG0351.
    KOiK00941.
    OMAiTNHWAYS.
    OrthoDBiEOG6XWV53.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    InterProiIPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF08543. Phos_pyr_kin. 1 hit.
    [Graphical view]
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56904-1 [UniParc]FASTAAdd to Basket

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    MTAIALSIAG SDSGGGAGIQ ADLKTFSALG VYGASVITAI TAQNTRGVTA    50
    VEDVSAEIVS AQMDAVFSDL DVKAVKIGMV SRRETIAAIA DGLRRFGKRA 100
    VVDPVMVATS GDALLRPDAV AALIEELLPL ALVVTPNLAE AALMTGRAIA 150
    GDEAEMARQA EAIMRTGAHA VLVKGGHLKG QEATDLFFDG DTLVRLPAGR 200
    IETRNDHGTG CTLSAAIAAG LAKGVPLIEA VSAAKAYLHA AISAADRLEI 250
    GQGRGPVHHF HRWWKD 266
    Length:266
    Mass (Da):27,423
    Last modified:November 2, 2001 - v2
    Checksum:i803D0C58EB9A1830
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti98 – 992KR → RL in AAD46983. 1 PublicationCurated
    Sequence conflicti115 – 1151L → F in AAD46983. 1 PublicationCurated
    Sequence conflicti134 – 1341V → A in AAD46983. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070520 Genomic DNA. Translation: AAD46983.1.
    AL591985 Genomic DNA. Translation: CAC49487.1.
    Z22636 Genomic DNA. Translation: CAA80350.1. Sequence problems.
    PIRiG95977.
    S78110.
    RefSeqiNP_437627.1. NC_003078.1.

    Genome annotation databases

    EnsemblBacteriaiCAC49487; CAC49487; SM_b20962.
    GeneIDi1237418.
    KEGGisme:SM_b20962.
    PATRICi23638592. VBISinMel96828_6017.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070520 Genomic DNA. Translation: AAD46983.1 .
    AL591985 Genomic DNA. Translation: CAC49487.1 .
    Z22636 Genomic DNA. Translation: CAA80350.1 . Sequence problems.
    PIRi G95977.
    S78110.
    RefSeqi NP_437627.1. NC_003078.1.

    3D structure databases

    ProteinModelPortali P56904.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SM_b20962.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC49487 ; CAC49487 ; SM_b20962 .
    GeneIDi 1237418.
    KEGGi sme:SM_b20962.
    PATRICi 23638592. VBISinMel96828_6017.

    Phylogenomic databases

    eggNOGi COG0351.
    KOi K00941.
    OMAi TNHWAYS.
    OrthoDBi EOG6XWV53.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00137 .
    UPA00060 ; UER00138 .
    BioCyci SMEL266834:GJF6-4520-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    InterProi IPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF08543. Phos_pyr_kin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a DNA fragment related to salt tolerance in Sinorhizobium meliloti."
      Yang S., Chen X.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 042B.
    2. "The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing endosymbiont Sinorhizobium meliloti."
      Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P., Vorhoelter F.J., Hernandez-Lucas I., Becker A., Cowie A., Gouzy J., Golding B., Puehler A.
      Proc. Natl. Acad. Sci. U.S.A. 98:9889-9894(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    4. "Identification and analysis of the Rhizobium meliloti exoAMONP genes involved in exopolysaccharide biosynthesis and mapping of promoters located on the exoHKLAMONP fragment."
      Becker A., Kleickmann A., Keller M., Arnold W., Puehler A.
      Mol. Gen. Genet. 241:367-379(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 103-266.
      Strain: RCR2011 / SU47.

    Entry informationi

    Entry nameiTHID_RHIME
    AccessioniPrimary (citable) accession number: P56904
    Secondary accession number(s): Q52914
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 2, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3