Reviewed, UniProtKB/Swiss-Prot P56896 (NUOC2_RHIME)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit C 2
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit C 2
    NDH-1 subunit C 2

Gene names

Name:	nuoC2
Ordered Locus Names:	RA0832
ORF Names:	SMa1531

Encoded on

Plasmid pSymA (megaplasmid 1)

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD(+) + quinol.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	mitochondrial electron transport, NADH to ubiquinone Inferred from electronic annotation. Source: InterPro
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	NADH-quinone oxidoreductase subunit C 2		PRO_0000118675

Sequences

	Sequence		Length	Mass (Da)
	P56896-1 [UniParc]. Last modified May 30, 2000. Version 1. Checksum: 996133260B330F67	FASTA	182	20,893
	10 20 30 40 50 60 MTGERPVHLT AIIGSFGGAV ENLGAAHGIY AFAVPPEQIV EFCRFLKEHP ALEFDFLSDI 70 80 90 100 110 120 CGVDHYPETP RFETVYHLYS LKNKWRVRIK CRLGEPPHVP TVTGVWRTAN WHEREAWDMY 130 140 150 160 170 180 GIRFEGHPDL RRIYMWEGFE GFPQRKDFPL RGYKDKLNPF GAEGPPPTQP DLATNDIPQG GR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rhizobium meliloti carries two sets of nuo genes." Putnoky P., Jady B., Chellapilla K.P., Barta F., Kiss E. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 41.
[2]	"Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid." Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F., Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L., Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H. , Palm C., Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A., Long S.R. Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001) [PubMed: 11481432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ245399 Genomic DNA. Translation: CAB51631.1. AE006469 Genomic DNA. Translation: AAK65490.1.
PIR	H95365.
RefSeq	NP_436078.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1235868.
GenomeReviews	Gene locus RA0832 in contig AE006469_GR.
KEGG	sme:SMa1531.
NMPDR	fig|266834.1.peg.832.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P56896.
Enzyme and pathway databases
BioCyc	SMEL266834:SMA1531-MON.
Family and domain databases
InterPro	IPR010218. NADH_DH_csu. IPR001268. NADH_DHase_Ub_30kDa_su. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. Complex1_30K. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01961. NuoC_fam. 1 hit.
PROSITE	PS00542. COMPLEX1_30K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOC2_RHIME

Accession

Primary (citable) accession number: P56896

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	November 25, 2008
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)