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Protein

Fructose-1,6-bisphosphatase class 1

Gene

fbp

Organism
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Magnesium 1UniRule annotation
Metal bindingi110 – 1101Magnesium 1UniRule annotation
Metal bindingi110 – 1101Magnesium 2UniRule annotation
Metal bindingi112 – 1121Magnesium 1; via carbonyl oxygenUniRule annotation
Metal bindingi113 – 1131Magnesium 2UniRule annotation
Binding sitei205 – 2051SubstrateUniRule annotation
Metal bindingi277 – 2771Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSMED366394:GJAL-3981-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase class 1UniRule annotation (EC:3.1.3.11UniRule annotation)
Short name:
FBPase class 1UniRule annotation
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1UniRule annotation
Gene namesi
Name:fbpUniRule annotation
Synonyms:cbbF
Ordered Locus Names:Smed_3920
Encoded oniPlasmid pSMED010 Publication
OrganismiSinorhizobium medicae (strain WSM419) (Ensifer medicae)
Taxonomic identifieri366394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001108 Componenti: Plasmid pSMED01

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Fructose-1,6-bisphosphatase class 1PRO_0000200485Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP56886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 1164Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the FBPase class 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000191264.
KOiK03841.
OMAiTLDRTDN.
OrthoDBiPOG091H05DB.

Family and domain databases

CDDicd00354. FBPase. 1 hit.
HAMAPiMF_01855. FBPase_class1. 1 hit.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGATLEAYL ASCTTHGDEL SRDVAAVIQR LAKAALDIRK LVNQGALGTV
60 70 80 90 100
FNGMHSGSNT DGDVQKDLDI LCDDQFLSCL QGAPVACYAS EELENPVLLD
110 120 130 140 150
PAARLAVAID PLDGSSNIDN NISIGTIFSV LPAAKGPDVD PSQSFLQPGN
160 170 180 190 200
RQLAAGFFVY GPQTALVLSL GRGTEIFIFS SRLGCFVDAY KSVGIPDRAN
210 220 230 240 250
EFAINMSNYR HWEEAIRLYV DDCLAGSEGP RERDFNMRWI ASLVAEAYRI
260 270 280 290 300
LVRGGIFLYP ADSRKGYSHG RIRLVYEANP IAFIVENAGG SATTSVDRIL
310 320 330 340
DLVPESLHQR VPLVFGSRRE VARITRYHVD PNMIGERAPL FGKRGLFRA
Length:349
Mass (Da):37,999
Last modified:November 13, 2007 - v2
Checksum:i7031BBED2E887366
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431Q → H in AAF25375 (Ref. 1) Curated
Sequence conflicti175 – 1751E → D in AAF25375 (Ref. 1) Curated
Sequence conflicti322 – 3221A → G in AAF25375 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211846 Genomic DNA. Translation: AAF25375.1.
CP000739 Genomic DNA. Translation: ABR62730.1.
RefSeqiWP_011969552.1. NC_009620.1.
YP_001312663.1. NC_009620.1.

Genome annotation databases

EnsemblBacteriaiABR62730; ABR62730; Smed_3920.
GeneIDi5318705.
KEGGismd:Smed_3920.
PATRICi23613386. VBISinMed134228_0366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211846 Genomic DNA. Translation: AAF25375.1.
CP000739 Genomic DNA. Translation: ABR62730.1.
RefSeqiWP_011969552.1. NC_009620.1.
YP_001312663.1. NC_009620.1.

3D structure databases

ProteinModelPortaliP56886.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR62730; ABR62730; Smed_3920.
GeneIDi5318705.
KEGGismd:Smed_3920.
PATRICi23613386. VBISinMed134228_0366.

Phylogenomic databases

HOGENOMiHOG000191264.
KOiK03841.
OMAiTLDRTDN.
OrthoDBiPOG091H05DB.

Enzyme and pathway databases

UniPathwayiUPA00138.
BioCyciSMED366394:GJAL-3981-MONOMER.

Family and domain databases

CDDicd00354. FBPase. 1 hit.
HAMAPiMF_01855. FBPase_class1. 1 hit.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF16PA_SINMW
AccessioniPrimary (citable) accession number: P56886
Secondary accession number(s): A6UGF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 13, 2007
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.