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Protein

Claudin-20

Gene

CLDN20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-20
Gene namesi
Name:CLDN20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:2042. CLDN20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 118CytoplasmicSequence analysisAdd BLAST16
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 160ExtracellularSequence analysisAdd BLAST21
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 219CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi49861.
OpenTargetsiENSG00000171217.
PharmGKBiPA26568.

Polymorphism and mutation databases

BioMutaiCLDN20.
DMDMi7387580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447841 – 219Claudin-20Add BLAST219

Proteomic databases

PaxDbiP56880.
PRIDEiP56880.

Expressioni

Gene expression databases

BgeeiENSG00000171217.
CleanExiHS_CLDN20.
ExpressionAtlasiP56880. baseline and differential.
GenevisibleiP56880. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119070. 2 interactors.
STRINGi9606.ENSP00000356133.

Structurei

3D structure databases

ProteinModelPortaliP56880.
SMRiP56880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJXC. Eukaryota.
ENOG410XTF5. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56880.
KOiK06087.
OMAiCTLKYSI.
OrthoDBiEOG091G0MX2.
PhylomeDBiP56880.
TreeFamiTF331936.

Family and domain databases

InterProiView protein in InterPro
IPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PROSITEiView protein in PROSITE
PS01346. CLAUDIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P56880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAGLQLLA FILALSGVSG VLTATLLPNW KVNVDVDSNI ITAIVQLHGL
60 70 80 90 100
WMDCTWYSTG MFSCALKHSI LSLPIHVQAA RATMVLACVL SALGICTSTV
110 120 130 140 150
GMKCTRLGGD RETKSHASFA GGVCFMSAGI SSLISTVWYT KEIIANFLDL
160 170 180 190 200
TVPESNKHEP GGAIYIGFIS AMLLFISGMI FCTSCIKRNP EARLDPPTQQ
210
PISNTQLENN STHNLKDYV
Length:219
Mass (Da):23,515
Last modified:May 30, 2000 - v1
Checksum:iD2F5FAD2AAB66306
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139101 Genomic DNA. No translation available.
BC020838 mRNA. Translation: AAH20838.1.
CCDSiCCDS5249.1.
RefSeqiNP_001001346.1. NM_001001346.3.
XP_011534150.1. XM_011535848.2.
UniGeneiHs.567491.

Genome annotation databases

EnsembliENST00000367165; ENSP00000356133; ENSG00000171217.
GeneIDi49861.
KEGGihsa:49861.
UCSCiuc003qql.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCLD20_HUMAN
AccessioniPrimary (citable) accession number: P56880
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: April 12, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families