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Protein

Claudin-20

Gene

CLDN20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-20
Gene namesi
Name:CLDN20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:2042. CLDN20.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 8153ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11816CytoplasmicSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Topological domaini140 – 16021ExtracellularSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 21938CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26568.

Polymorphism and mutation databases

BioMutaiCLDN20.
DMDMi7387580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Claudin-20PRO_0000144784Add
BLAST

Proteomic databases

PaxDbiP56880.
PRIDEiP56880.

Expressioni

Gene expression databases

BgeeiENSG00000171217.
CleanExiHS_CLDN20.
GenevisibleiP56880. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119070. 2 interactions.
STRINGi9606.ENSP00000356133.

Structurei

3D structure databases

ProteinModelPortaliP56880.
SMRiP56880. Positions 4-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJXC. Eukaryota.
ENOG410XTF5. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56880.
KOiK06087.
OMAiCTLKYSI.
OrthoDBiEOG091G0MX2.
PhylomeDBiP56880.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAGLQLLA FILALSGVSG VLTATLLPNW KVNVDVDSNI ITAIVQLHGL
60 70 80 90 100
WMDCTWYSTG MFSCALKHSI LSLPIHVQAA RATMVLACVL SALGICTSTV
110 120 130 140 150
GMKCTRLGGD RETKSHASFA GGVCFMSAGI SSLISTVWYT KEIIANFLDL
160 170 180 190 200
TVPESNKHEP GGAIYIGFIS AMLLFISGMI FCTSCIKRNP EARLDPPTQQ
210
PISNTQLENN STHNLKDYV
Length:219
Mass (Da):23,515
Last modified:May 30, 2000 - v1
Checksum:iD2F5FAD2AAB66306
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139101 Genomic DNA. Translation: CAI20505.1.
BC020838 mRNA. Translation: AAH20838.1.
CCDSiCCDS5249.1.
RefSeqiNP_001001346.1. NM_001001346.3.
XP_011534150.1. XM_011535848.2.
UniGeneiHs.567491.

Genome annotation databases

EnsembliENST00000367165; ENSP00000356133; ENSG00000171217.
GeneIDi49861.
KEGGihsa:49861.
UCSCiuc003qql.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139101 Genomic DNA. Translation: CAI20505.1.
BC020838 mRNA. Translation: AAH20838.1.
CCDSiCCDS5249.1.
RefSeqiNP_001001346.1. NM_001001346.3.
XP_011534150.1. XM_011535848.2.
UniGeneiHs.567491.

3D structure databases

ProteinModelPortaliP56880.
SMRiP56880. Positions 4-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119070. 2 interactions.
STRINGi9606.ENSP00000356133.

Polymorphism and mutation databases

BioMutaiCLDN20.
DMDMi7387580.

Proteomic databases

PaxDbiP56880.
PRIDEiP56880.

Protocols and materials databases

DNASUi49861.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367165; ENSP00000356133; ENSG00000171217.
GeneIDi49861.
KEGGihsa:49861.
UCSCiuc003qql.2. human.

Organism-specific databases

CTDi49861.
GeneCardsiCLDN20.
HGNCiHGNC:2042. CLDN20.
neXtProtiNX_P56880.
PharmGKBiPA26568.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJXC. Eukaryota.
ENOG410XTF5. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56880.
KOiK06087.
OMAiCTLKYSI.
OrthoDBiEOG091G0MX2.
PhylomeDBiP56880.
TreeFamiTF331936.

Enzyme and pathway databases

ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN20.
GenomeRNAii49861.
PROiP56880.

Gene expression databases

BgeeiENSG00000171217.
CleanExiHS_CLDN20.
GenevisibleiP56880. HS.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD20_HUMAN
AccessioniPrimary (citable) accession number: P56880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.