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Protein

Probable peroxiredoxin

Gene

tsaA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peroxiredoxin (EC:1.11.1.15)
Alternative name(s):
26 kDa antigen
Thioredoxin reductase
Gene namesi
Name:tsaA
Ordered Locus Names:jhp_1471
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001351451 – 198Probable peroxiredoxinAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49Interchain (with C-169)
Disulfide bondi169Interchain (with C-49)

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP56876.

Interactioni

Subunit structurei

Decameric ring of 5 homodimers; disulfide-linked. The rings have an approximate diameter of 125 A and a central hole of 55 A.1 Publication

Protein-protein interaction databases

IntActiP56876. 1 interactor.
STRINGi85963.jhp1471.

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 15Combined sources5
Beta strandi21 – 26Combined sources6
Turni27 – 29Combined sources3
Beta strandi33 – 40Combined sources8
Helixi52 – 58Combined sources7
Helixi60 – 65Combined sources6
Beta strandi69 – 76Combined sources8
Helixi78 – 85Combined sources8
Helixi89 – 91Combined sources3
Beta strandi101 – 103Combined sources3
Helixi108 – 112Combined sources5
Turni118 – 120Combined sources3
Beta strandi124 – 130Combined sources7
Turni131 – 133Combined sources3
Beta strandi134 – 144Combined sources11
Helixi148 – 163Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZOFX-ray2.95A/B/C/D/E/F/G/H/I/J1-198[»]
ProteinModelPortaliP56876.
SMRiP56876.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56876.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 161ThioredoxinPROSITE-ProRule annotationAdd BLAST160

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105D3R. Bacteria.
COG0450. LUCA.
KOiK03386.
OMAiNWTPGEK.
OrthoDBiPOG091H026G.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVTKLAPDF KAPAVLGNNE VDEHFELSKN LGKNGVILFF WPKDFTFVCP
60 70 80 90 100
TEIIAFDKRV KDFHEKGFNV IGVSIDSEQV HFAWKNTPVE KGGIGQVSFP
110 120 130 140 150
MVADITKSIS RDYDVLFEEA IALRGAFLID KNMKVRHAVI NDLPLGRNAD
160 170 180 190
EMLRMVDALL HFEEHGEVCP AGWRKGDKGM KATHQGVAEY LKENSIKL
Length:198
Mass (Da):22,259
Last modified:May 30, 2000 - v1
Checksum:i3E6C18E6F06D52F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD07055.1.
PIRiH71801.
RefSeqiWP_000961648.1. NZ_CP011330.1.

Genome annotation databases

EnsemblBacteriaiAAD07055; AAD07055; jhp_1471.
KEGGihpj:jhp_1471.
PATRICi20607840. VBIHelPyl98156_1598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD07055.1.
PIRiH71801.
RefSeqiWP_000961648.1. NZ_CP011330.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZOFX-ray2.95A/B/C/D/E/F/G/H/I/J1-198[»]
ProteinModelPortaliP56876.
SMRiP56876.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56876. 1 interactor.
STRINGi85963.jhp1471.

Proteomic databases

PRIDEiP56876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07055; AAD07055; jhp_1471.
KEGGihpj:jhp_1471.
PATRICi20607840. VBIHelPyl98156_1598.

Phylogenomic databases

eggNOGiENOG4105D3R. Bacteria.
COG0450. LUCA.
KOiK03386.
OMAiNWTPGEK.
OrthoDBiPOG091H026G.

Miscellaneous databases

EvolutionaryTraceiP56876.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSAA_HELPJ
AccessioniPrimary (citable) accession number: P56876
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.