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Protein

Adenylyl-sulfate kinase

Gene

cysC

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of activated sulfate.By similarity

Catalytic activityi

ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes sulfite from sulfate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase (sat)
  2. Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051Phosphoserine intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2705-MONOMER.
UniPathwayiUPA00140; UER00205.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl-sulfate kinase (EC:2.7.1.25)
Alternative name(s):
APS kinase
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase
Gene namesi
Name:cysC
Ordered Locus Names:DR_A0014
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Adenylyl-sulfate kinasePRO_0000105908Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_A0014.

Structurei

3D structure databases

ProteinModelPortaliP56861.
SMRiP56861. Positions 23-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APS kinase family.Curated

Phylogenomic databases

eggNOGiENOG4107T1U. Bacteria.
COG0529. LUCA.
HOGENOMiHOG000228204.
InParanoidiP56861.
KOiK00860.
OMAiCRILDGD.
OrthoDBiPOG091H04O4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.

Sequencei

Sequence statusi: Complete.

P56861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASPSLPAS QGPLPQGERV NKAGRVVWFT GLSGAGKSTL ATALFEELSA
60 70 80 90 100
RGEAVELLDG DAVRENLSKG LGFSREDRDT NVRRIAFVAG LLAKHGVTVL
110 120 130 140 150
VSAISPYADT RREVLASLPN ALEVFVDAPL EVVTERDVKG LYLKALAGEI
160 170 180 190
PHFTGVSDPY EAPENPDLHL RTDRISVEDG VQQLLGRLSD DR
Length:192
Mass (Da):20,588
Last modified:May 30, 2000 - v1
Checksum:i5BBEC5EF95217947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001825 Genomic DNA. Translation: AAF12298.1.
PIRiB75594.
RefSeqiNP_285338.1. NC_001264.1.
WP_010889274.1. NC_001264.1.

Genome annotation databases

EnsemblBacteriaiAAF12298; AAF12298; DR_A0014.
GeneIDi1798178.
KEGGidra:DR_A0014.
PATRICi21633060. VBIDeiRad64572_2900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001825 Genomic DNA. Translation: AAF12298.1.
PIRiB75594.
RefSeqiNP_285338.1. NC_001264.1.
WP_010889274.1. NC_001264.1.

3D structure databases

ProteinModelPortaliP56861.
SMRiP56861. Positions 23-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_A0014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF12298; AAF12298; DR_A0014.
GeneIDi1798178.
KEGGidra:DR_A0014.
PATRICi21633060. VBIDeiRad64572_2900.

Phylogenomic databases

eggNOGiENOG4107T1U. Bacteria.
COG0529. LUCA.
HOGENOMiHOG000228204.
InParanoidiP56861.
KOiK00860.
OMAiCRILDGD.
OrthoDBiPOG091H04O4.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00205.
BioCyciDRAD243230:GH46-2705-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYSC_DEIRA
AccessioniPrimary (citable) accession number: P56861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.