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Protein

Probable adenylyl-sulfate kinase

Gene

cysC

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of activated sulfate.

Catalytic activityi

ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes sulfite from sulfate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase (sat)
  2. Probable adenylyl-sulfate kinase (cysC)
  3. no protein annotated in this organism
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Phosphoserine intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00140; UER00205.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable adenylyl-sulfate kinase (EC:2.7.1.25)
Alternative name(s):
APS kinase
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase
Gene namesi
Name:cysC
Ordered Locus Names:PYRAB11720
ORF Names:PAB0781
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 174174Probable adenylyl-sulfate kinasePRO_0000105930Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB0781.

Structurei

3D structure databases

ProteinModelPortaliP56858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APS kinase family.Curated

Phylogenomic databases

eggNOGiarCOG01040. Archaea.
COG0529. LUCA.
HOGENOMiHOG000228204.
KOiK00860.
OMAiNIKWHNL.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.

Sequencei

Sequence statusi: Complete.

P56858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGFTIWLTG PSGAGKTTLA VKLAKKLREM GYKVEILDGD TIRKTLYPNL
60 70 80 90 100
GFSKEAREMH NRIVIYMAKL LTRNGVIAIV SLISPYKRIR EYARKEIGRF
110 120 130 140 150
MEVYVYAPLE VRIKRDPKGL YAKAIRGEIR GLTGYDGVYE EPENPEVKVD
160 170
SSRMTPDEEA ELVIRKAKEL GYLP
Length:174
Mass (Da):19,829
Last modified:May 30, 2000 - v1
Checksum:i2BE71A04D4A46897
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248286 Genomic DNA. Translation: CAB50083.1.
HE613800 Genomic DNA. Translation: CCE70597.1.
PIRiF75097.
RefSeqiWP_010868289.1. NC_000868.1.

Genome annotation databases

EnsemblBacteriaiCAB50083; CAB50083; PAB0781.
GeneIDi1496543.
KEGGipab:PAB0781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248286 Genomic DNA. Translation: CAB50083.1.
HE613800 Genomic DNA. Translation: CCE70597.1.
PIRiF75097.
RefSeqiWP_010868289.1. NC_000868.1.

3D structure databases

ProteinModelPortaliP56858.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB0781.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB50083; CAB50083; PAB0781.
GeneIDi1496543.
KEGGipab:PAB0781.

Phylogenomic databases

eggNOGiarCOG01040. Archaea.
COG0529. LUCA.
HOGENOMiHOG000228204.
KOiK00860.
OMAiNIKWHNL.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00205.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYSC_PYRAB
AccessioniPrimary (citable) accession number: P56858
Secondary accession number(s): G8ZKF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.