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P56856

- CLD18_HUMAN

UniProt

P56856 - CLD18_HUMAN

Protein

Claudin-18

Gene

CLDN18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (30 May 2000)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB
    2. cell-cell junction organization Source: Reactome
    3. cell junction assembly Source: Reactome
    4. tight junction assembly Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-18
    Gene namesi
    Name:CLDN18
    ORF Names:UNQ778/PRO1572
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:2039. CLDN18.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26565.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Claudin-18PRO_0000144779Add
    BLAST

    Proteomic databases

    PaxDbiP56856.
    PRIDEiP56856.

    PTM databases

    PhosphoSiteiP56856.

    Expressioni

    Tissue specificityi

    Concentrated at the cell-cell borders of epithelial cells.

    Gene expression databases

    ArrayExpressiP56856.
    BgeeiP56856.
    CleanExiHS_CLDN18.
    GenevestigatoriP56856.

    Organism-specific databases

    HPAiCAB013010.
    CAB013243.
    HPA018446.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-48955N.
    STRINGi9606.ENSP00000183605.

    Structurei

    3D structure databases

    ProteinModelPortaliP56856.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini28 – 8053ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini102 – 12221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini144 – 17431ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini196 – 26166CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46146.
    HOGENOMiHOG000220937.
    HOVERGENiHBG102991.
    KOiK06087.
    OMAiHRTANYD.
    OrthoDBiEOG76HQ2T.
    PhylomeDBiP56856.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003928. Claudin18.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PTHR12002:SF9. PTHR12002:SF9. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01448. CLAUDIN18.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A1 (identifier: P56856-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTTTCQVVA FLLSILGLAG CIAATGMDMW STQDLYDNPV TSVFQYEGLW    50
    RSCVRQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG AIGLLVSIFA 100
    LKCIRIGSME DSAKANMTLT SGIMFIVSGL CAIAGVSVFA NMLVTNFWMS 150
    TANMYTGMGG MVQTVQTRYT FGAALFVGWV AGGLTLIGGV MMCIACRGLA 200
    PEETNYKAVS YHASGHSVAY KPGGFKASTG FGSNTKNKKI YDGGARTEDE 250
    VQSYPSKHDY V 261
    Length:261
    Mass (Da):27,856
    Last modified:May 30, 2000 - v1
    Checksum:i4362B590D3C2B387
    GO
    Isoform A2 (identifier: P56856-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-69: MSTTTCQVVA...FTECRPYFTI → MAVTACQGLG...FTECRGYFTL

    Show »
    Length:261
    Mass (Da):27,720
    Checksum:iDA519D1E57FDFCA7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti149 – 1491M → L.
    Corresponds to variant rs17204075 [ dbSNP | Ensembl ].
    VAR_033775

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6969MSTTT…PYFTI → MAVTACQGLGFVVSLIGIAG IIAATCMDQWSTQDLYNNPV TAVFNYQGLWRSCVRESSGF TECRGYFTL in isoform A2. CuratedVSP_001102Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF221069 mRNA. Translation: AAF26448.1.
    AF349452 mRNA. Translation: AAL15637.1.
    AY358479 mRNA. Translation: AAQ88843.1.
    CH471052 Genomic DNA. Translation: EAW79092.1.
    BC142708 mRNA. Translation: AAI42709.1.
    BC146668 mRNA. Translation: AAI46669.1.
    CCDSiCCDS3095.1. [P56856-1]
    CCDS33862.1. [P56856-2]
    RefSeqiNP_001002026.1. NM_001002026.2. [P56856-2]
    NP_057453.1. NM_016369.3. [P56856-1]
    UniGeneiHs.655324.

    Genome annotation databases

    EnsembliENST00000183605; ENSP00000183605; ENSG00000066405. [P56856-1]
    ENST00000343735; ENSP00000340939; ENSG00000066405. [P56856-2]
    GeneIDi51208.
    KEGGihsa:51208.
    UCSCiuc003ero.1. human. [P56856-2]
    uc003erp.1. human. [P56856-1]

    Polymorphism databases

    DMDMi7387578.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF221069 mRNA. Translation: AAF26448.1 .
    AF349452 mRNA. Translation: AAL15637.1 .
    AY358479 mRNA. Translation: AAQ88843.1 .
    CH471052 Genomic DNA. Translation: EAW79092.1 .
    BC142708 mRNA. Translation: AAI42709.1 .
    BC146668 mRNA. Translation: AAI46669.1 .
    CCDSi CCDS3095.1. [P56856-1 ]
    CCDS33862.1. [P56856-2 ]
    RefSeqi NP_001002026.1. NM_001002026.2. [P56856-2 ]
    NP_057453.1. NM_016369.3. [P56856-1 ]
    UniGenei Hs.655324.

    3D structure databases

    ProteinModelPortali P56856.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48955N.
    STRINGi 9606.ENSP00000183605.

    PTM databases

    PhosphoSitei P56856.

    Polymorphism databases

    DMDMi 7387578.

    Proteomic databases

    PaxDbi P56856.
    PRIDEi P56856.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000183605 ; ENSP00000183605 ; ENSG00000066405 . [P56856-1 ]
    ENST00000343735 ; ENSP00000340939 ; ENSG00000066405 . [P56856-2 ]
    GeneIDi 51208.
    KEGGi hsa:51208.
    UCSCi uc003ero.1. human. [P56856-2 ]
    uc003erp.1. human. [P56856-1 ]

    Organism-specific databases

    CTDi 51208.
    GeneCardsi GC03P137717.
    H-InvDB HIX0003711.
    HGNCi HGNC:2039. CLDN18.
    HPAi CAB013010.
    CAB013243.
    HPA018446.
    MIMi 609210. gene.
    neXtProti NX_P56856.
    PharmGKBi PA26565.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46146.
    HOGENOMi HOG000220937.
    HOVERGENi HBG102991.
    KOi K06087.
    OMAi HRTANYD.
    OrthoDBi EOG76HQ2T.
    PhylomeDBi P56856.
    TreeFami TF331936.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    GeneWikii CLDN18.
    GenomeRNAii 51208.
    NextBioi 54274.
    PROi P56856.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56856.
    Bgeei P56856.
    CleanExi HS_CLDN18.
    Genevestigatori P56856.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003928. Claudin18.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    PTHR12002:SF9. PTHR12002:SF9. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01448. CLAUDIN18.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing."
      Niimi T., Nagashima K., Ward J.M., Minoo P., Zimonjic D.B., Popescu N.C., Kimura S.
      Mol. Cell. Biol. 21:7380-7390(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1).

    Entry informationi

    Entry nameiCLD18_HUMAN
    AccessioniPrimary (citable) accession number: P56856
    Secondary accession number(s): A5PL21, Q96PH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3