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P56856 (CLD18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Claudin-18
Gene names
Name:CLDN18
ORF Names:UNQ778/PRO1572
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

Subcellular location

Cell junctiontight junction. Cell membrane; Multi-pass membrane protein.

Tissue specificity

Concentrated at the cell-cell borders of epithelial cells.

Sequence similarities

Belongs to the claudin family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A1 (identifier: P56856-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform A2 (identifier: P56856-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MSTTTCQVVA...FTECRPYFTI → MAVTACQGLG...FTECRGYFTL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Claudin-18
PRO_0000144779

Regions

Topological domain1 – 66Cytoplasmic Potential
Transmembrane7 – 2721Helical; Potential
Topological domain28 – 8053Extracellular Potential
Transmembrane81 – 10121Helical; Potential
Topological domain102 – 12221Cytoplasmic Potential
Transmembrane123 – 14321Helical; Potential
Topological domain144 – 17431Extracellular Potential
Transmembrane175 – 19521Helical; Potential
Topological domain196 – 26166Cytoplasmic Potential

Natural variations

Alternative sequence1 – 6969MSTTT…PYFTI → MAVTACQGLGFVVSLIGIAG IIAATCMDQWSTQDLYNNPV TAVFNYQGLWRSCVRESSGF TECRGYFTL in isoform A2.
VSP_001102
Natural variant1491M → L.
Corresponds to variant rs17204075 [ dbSNP | Ensembl ].
VAR_033775

Sequences

Sequence LengthMass (Da)Tools
Isoform A1 [UniParc].

Last modified May 30, 2000. Version 1.
Checksum: 4362B590D3C2B387

FASTA26127,856
        10         20         30         40         50         60 
MSTTTCQVVA FLLSILGLAG CIAATGMDMW STQDLYDNPV TSVFQYEGLW RSCVRQSSGF 

        70         80         90        100        110        120 
TECRPYFTIL GLPAMLQAVR ALMIVGIVLG AIGLLVSIFA LKCIRIGSME DSAKANMTLT 

       130        140        150        160        170        180 
SGIMFIVSGL CAIAGVSVFA NMLVTNFWMS TANMYTGMGG MVQTVQTRYT FGAALFVGWV 

       190        200        210        220        230        240 
AGGLTLIGGV MMCIACRGLA PEETNYKAVS YHASGHSVAY KPGGFKASTG FGSNTKNKKI 

       250        260 
YDGGARTEDE VQSYPSKHDY V 

« Hide

Isoform A2 [UniParc].

Checksum: DA519D1E57FDFCA7
Show »

FASTA26127,720

References

« Hide 'large scale' references
[1]"Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing."
Niimi T., Nagashima K., Ward J.M., Minoo P., Zimonjic D.B., Popescu N.C., Kimura S.
Mol. Cell. Biol. 21:7380-7390(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1).
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF221069 mRNA. Translation: AAF26448.1.
AF349452 mRNA. Translation: AAL15637.1.
AY358479 mRNA. Translation: AAQ88843.1.
CH471052 Genomic DNA. Translation: EAW79092.1.
BC142708 mRNA. Translation: AAI42709.1.
BC146668 mRNA. Translation: AAI46669.1.
CCDSCCDS3095.1. [P56856-1]
CCDS33862.1. [P56856-2]
RefSeqNP_001002026.1. NM_001002026.2. [P56856-2]
NP_057453.1. NM_016369.3. [P56856-1]
UniGeneHs.655324.

3D structure databases

ProteinModelPortalP56856.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-48955N.
STRING9606.ENSP00000183605.

PTM databases

PhosphoSiteP56856.

Polymorphism databases

DMDM7387578.

Proteomic databases

PaxDbP56856.
PRIDEP56856.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000183605; ENSP00000183605; ENSG00000066405. [P56856-1]
ENST00000343735; ENSP00000340939; ENSG00000066405. [P56856-2]
GeneID51208.
KEGGhsa:51208.
UCSCuc003ero.1. human. [P56856-2]
uc003erp.1. human. [P56856-1]

Organism-specific databases

CTD51208.
GeneCardsGC03P137717.
H-InvDBHIX0003711.
HGNCHGNC:2039. CLDN18.
HPACAB013010.
CAB013243.
HPA018446.
MIM609210. gene.
neXtProtNX_P56856.
PharmGKBPA26565.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46146.
HOGENOMHOG000220937.
HOVERGENHBG102991.
KOK06087.
OMAHRTANYD.
OrthoDBEOG76HQ2T.
PhylomeDBP56856.
TreeFamTF331936.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressP56856.
BgeeP56856.
CleanExHS_CLDN18.
GenevestigatorP56856.

Family and domain databases

InterProIPR006187. Claudin.
IPR003928. Claudin18.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF9. PTHR12002:SF9. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PR01448. CLAUDIN18.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCLDN18.
GenomeRNAi51208.
NextBio54274.
PROP56856.
SOURCESearch...

Entry information

Entry nameCLD18_HUMAN
AccessionPrimary (citable) accession number: P56856
Secondary accession number(s): A5PL21, Q96PH4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM