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Protein

Claudin-18

Gene

CLDN18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-18
Gene namesi
Name:CLDN18
ORF Names:UNQ778/PRO1572
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:2039. CLDN18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence Analysis
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Topological domaini28 – 8053ExtracellularSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Topological domaini102 – 12221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST
Topological domaini144 – 17431ExtracellularSequence AnalysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Topological domaini196 – 26166CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26565.

Polymorphism and mutation databases

BioMutaiCLDN18.
DMDMi7387578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Claudin-18PRO_0000144779Add
BLAST

Proteomic databases

PaxDbiP56856.
PRIDEiP56856.

PTM databases

PhosphoSiteiP56856.

Expressioni

Tissue specificityi

Concentrated at the cell-cell borders of epithelial cells.

Gene expression databases

BgeeiP56856.
CleanExiHS_CLDN18.
ExpressionAtlasiP56856. baseline and differential.
GenevisibleiP56856. HS.

Organism-specific databases

HPAiCAB013010.
CAB013243.
HPA018446.

Interactioni

Protein-protein interaction databases

DIPiDIP-48955N.
STRINGi9606.ENSP00000183605.

Structurei

3D structure databases

ProteinModelPortaliP56856.
SMRiP56856. Positions 7-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46146.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG102991.
InParanoidiP56856.
KOiK06087.
OMAiNRYTFGS.
OrthoDBiEOG76HQ2T.
PhylomeDBiP56856.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003928. Claudin18.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF9. PTHR12002:SF9. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01448. CLAUDIN18.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A1 (identifier: P56856-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTTTCQVVA FLLSILGLAG CIAATGMDMW STQDLYDNPV TSVFQYEGLW
60 70 80 90 100
RSCVRQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG AIGLLVSIFA
110 120 130 140 150
LKCIRIGSME DSAKANMTLT SGIMFIVSGL CAIAGVSVFA NMLVTNFWMS
160 170 180 190 200
TANMYTGMGG MVQTVQTRYT FGAALFVGWV AGGLTLIGGV MMCIACRGLA
210 220 230 240 250
PEETNYKAVS YHASGHSVAY KPGGFKASTG FGSNTKNKKI YDGGARTEDE
260
VQSYPSKHDY V
Length:261
Mass (Da):27,856
Last modified:May 30, 2000 - v1
Checksum:i4362B590D3C2B387
GO
Isoform A2 (identifier: P56856-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MSTTTCQVVA...FTECRPYFTI → MAVTACQGLG...FTECRGYFTL

Show »
Length:261
Mass (Da):27,720
Checksum:iDA519D1E57FDFCA7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491M → L.
Corresponds to variant rs17204075 [ dbSNP | Ensembl ].
VAR_033775

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6969MSTTT…PYFTI → MAVTACQGLGFVVSLIGIAG IIAATCMDQWSTQDLYNNPV TAVFNYQGLWRSCVRESSGF TECRGYFTL in isoform A2. CuratedVSP_001102Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221069 mRNA. Translation: AAF26448.1.
AF349452 mRNA. Translation: AAL15637.1.
AY358479 mRNA. Translation: AAQ88843.1.
CH471052 Genomic DNA. Translation: EAW79092.1.
BC142708 mRNA. Translation: AAI42709.1.
BC146668 mRNA. Translation: AAI46669.1.
CCDSiCCDS3095.1. [P56856-1]
CCDS33862.1. [P56856-2]
RefSeqiNP_001002026.1. NM_001002026.2. [P56856-2]
NP_057453.1. NM_016369.3. [P56856-1]
UniGeneiHs.655324.

Genome annotation databases

EnsembliENST00000183605; ENSP00000183605; ENSG00000066405.
ENST00000343735; ENSP00000340939; ENSG00000066405. [P56856-2]
GeneIDi51208.
KEGGihsa:51208.
UCSCiuc003ero.1. human. [P56856-2]
uc003erp.1. human. [P56856-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221069 mRNA. Translation: AAF26448.1.
AF349452 mRNA. Translation: AAL15637.1.
AY358479 mRNA. Translation: AAQ88843.1.
CH471052 Genomic DNA. Translation: EAW79092.1.
BC142708 mRNA. Translation: AAI42709.1.
BC146668 mRNA. Translation: AAI46669.1.
CCDSiCCDS3095.1. [P56856-1]
CCDS33862.1. [P56856-2]
RefSeqiNP_001002026.1. NM_001002026.2. [P56856-2]
NP_057453.1. NM_016369.3. [P56856-1]
UniGeneiHs.655324.

3D structure databases

ProteinModelPortaliP56856.
SMRiP56856. Positions 7-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48955N.
STRINGi9606.ENSP00000183605.

PTM databases

PhosphoSiteiP56856.

Polymorphism and mutation databases

BioMutaiCLDN18.
DMDMi7387578.

Proteomic databases

PaxDbiP56856.
PRIDEiP56856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000183605; ENSP00000183605; ENSG00000066405.
ENST00000343735; ENSP00000340939; ENSG00000066405. [P56856-2]
GeneIDi51208.
KEGGihsa:51208.
UCSCiuc003ero.1. human. [P56856-2]
uc003erp.1. human. [P56856-1]

Organism-specific databases

CTDi51208.
GeneCardsiGC03P137717.
H-InvDBHIX0003711.
HGNCiHGNC:2039. CLDN18.
HPAiCAB013010.
CAB013243.
HPA018446.
MIMi609210. gene.
neXtProtiNX_P56856.
PharmGKBiPA26565.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46146.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG102991.
InParanoidiP56856.
KOiK06087.
OMAiNRYTFGS.
OrthoDBiEOG76HQ2T.
PhylomeDBiP56856.
TreeFamiTF331936.

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Miscellaneous databases

ChiTaRSiCLDN18. human.
GeneWikiiCLDN18.
GenomeRNAii51208.
NextBioi54274.
PROiP56856.
SOURCEiSearch...

Gene expression databases

BgeeiP56856.
CleanExiHS_CLDN18.
ExpressionAtlasiP56856. baseline and differential.
GenevisibleiP56856. HS.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003928. Claudin18.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF9. PTHR12002:SF9. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01448. CLAUDIN18.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing."
    Niimi T., Nagashima K., Ward J.M., Minoo P., Zimonjic D.B., Popescu N.C., Kimura S.
    Mol. Cell. Biol. 21:7380-7390(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1).

Entry informationi

Entry nameiCLD18_HUMAN
AccessioniPrimary (citable) accession number: P56856
Secondary accession number(s): A5PL21, Q96PH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 22, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.