P56853TXHN2_GRAROKappa-theraphotoxin-Gr1bKappa-TRTX-Gr1bHanatoxin-2HaTx2Grammostola roseaChilean rose tarantulaGrammostola spatulataEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeTheraphosidaeGrammostolaAn inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula.PROTEIN SEQUENCEInhibitor of voltage-gated potassium channels. Inhibits Kv2.1/KCNB1 channels, by shifting activation of the channel to more depolarized voltages. The toxin binding sites may be situated on the S3-S4 extracellular linker of the channel. One, two, three or four toxin molecules may bind the Kv2.1/KCNB1 channel. May need to partition into the membrane in order to bind to the channel. Antibacterial activity is not observed.SecretedExpressed by the venom gland.The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.Belongs to the neurotoxin 10 (Hwtx-1) family. 09 (HaTx) subfamily.Direct protein sequencingDisulfide bondIon channel impairing toxinKnottinNeurotoxinPotassium channel impairing toxinSecretedToxinVoltage-gated potassium channel impairing toxinECRYLFGGCKTTADCCKHLGCKFRDKYCAWDFTFS
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