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P56853

- TXHN2_GRARO

UniProt

P56853 - TXHN2_GRARO

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Protein
Kappa-theraphotoxin-Gr1b
Gene
N/A
Organism
Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibitor of voltage-gated potassium channels. Inhibits Kv2.1/KCNB1 channels, by shifting activation of the channel to more depolarized voltages. The toxin binding sites may be situated on the S3-S4 extracellular linker of the channel. One, two, three or four toxin molecules may bind the Kv2.1/KCNB1 channel. May need to partition into the membrane in order to bind to the channel. Antibacterial activity is not observed.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei3 – 31May be involved in interaction with voltage sensor By similarity
Sitei22 – 221May be involved in interaction with voltage sensor By similarity
Sitei30 – 301Involved in active face By similarity

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-theraphotoxin-Gr1b
Short name:
Kappa-TRTX-Gr1b
Alternative name(s):
Hanatoxin-2
Short name:
HaTx2
OrganismiGrammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Taxonomic identifieri432528 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeTheraphosidaeGrammostola

Organism-specific databases

ArachnoServeriAS000343. kappa-theraphotoxin-Gr1b.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3535Kappa-theraphotoxin-Gr1b
PRO_0000045013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 16 By similarity
Disulfide bondi9 ↔ 21 By similarity
Disulfide bondi15 ↔ 28 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP56853.
SMRiP56853. Positions 1-35.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 63Involved in active face By similarity

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

Sequence similaritiesi

Belongs to the huwentoxin-1 family.

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR011696. Ion_channel_inhibitory.
[Graphical view]
PfamiPF07740. Toxin_12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56853-1 [UniParc]FASTAAdd to Basket

« Hide

ECRYLFGGCK TTADCCKHLG CKFRDKYCAW DFTFS                   35
Length:35
Mass (Da):4,105
Last modified:May 30, 2000 - v1
Checksum:i5601AC8A9B14C513
GO

Cross-referencesi

3D structure databases

ProteinModelPortali P56853.
SMRi P56853. Positions 1-35.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000343. kappa-theraphotoxin-Gr1b.

Family and domain databases

InterProi IPR011696. Ion_channel_inhibitory.
[Graphical view ]
Pfami PF07740. Toxin_12. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula."
    Swartz K.J., MacKinnon R.
    Neuron 15:941-949(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiTXHN2_GRARO
AccessioniPrimary (citable) accession number: P56853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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