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Protein

Epididymal secretory protein E3-beta

Gene

EDDM3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible function in sperm maturation.

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal secretory protein E3-beta
Alternative name(s):
Human epididymis-specific protein 3-beta
Short name:
HE3-beta
Gene namesi
Name:EDDM3B
Synonyms:FAM12B, HE3B
ORF Names:UNQ6412/PRO21187
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19223. EDDM3B.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181552.
PharmGKBiPA165478900.

Polymorphism and mutation databases

BioMutaiEDDM3B.
DMDMi14916988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002118926 – 147Epididymal secretory protein E3-betaAdd BLAST122

Proteomic databases

PaxDbiP56851.
PeptideAtlasiP56851.
PRIDEiP56851.

PTM databases

iPTMnetiP56851.
PhosphoSitePlusiP56851.

Expressioni

Tissue specificityi

Epididymis.

Gene expression databases

BgeeiENSG00000181552.
CleanExiHS_FAM12B.
ExpressionAtlasiP56851. baseline and differential.
GenevisibleiP56851. HS.

Organism-specific databases

HPAiHPA001323.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122100. 39 interactors.
IntActiP56851. 7 interactors.
STRINGi9606.ENSP00000314810.

Structurei

3D structure databases

ProteinModelPortaliP56851.
SMRiP56851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0SW. Eukaryota.
ENOG41115Q7. LUCA.
GeneTreeiENSGT00390000004706.
HOGENOMiHOG000112382.
HOVERGENiHBG018983.
InParanoidiP56851.
OMAiHKIEHIC.
OrthoDBiEOG091G0UBB.
PhylomeDBiP56851.
TreeFamiTF314795.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiView protein in InterPro
IPR029748. EDDM3B.
IPR023412. RNaseA_domain.
PANTHERiPTHR16788:SF3. PTHR16788:SF3. 1 hit.
PfamiView protein in Pfam
PF00074. RnaseA. 1 hit.
SMARTiView protein in SMART
SM00092. RNAse_Pc. 1 hit.
SUPFAMiSSF54076. SSF54076. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSLKIWGT LLALLCILCT LLVQSKEVSW REFMKQHYLS PSREFREYKC
60 70 80 90 100
DVLMRENEAL KDKSSHMFIY ISWYKIEHIC TSDNWMDRFR NAYVWVQNPL
110 120 130 140
KVLKCHQENS KNSYTESRSF NYIEFHCSMD GYVDSIEDLK MVEPIGN
Length:147
Mass (Da):17,584
Last modified:July 11, 2001 - v2
Checksum:i022367C7BA0C2708
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0389465L → V1 PublicationCorresponds to variant dbSNP:rs3827906Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76386 mRNA. Translation: CAC17141.1.
AY358865 mRNA. Translation: AAQ89224.1.
BC128030 mRNA. Translation: AAI28031.1.
CCDSiCCDS9557.1.
RefSeqiNP_071755.1. NM_022360.4.
UniGeneiHs.525202.

Genome annotation databases

EnsembliENST00000326783; ENSP00000314810; ENSG00000181552.
GeneIDi64184.
KEGGihsa:64184.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEP3B_HUMAN
AccessioniPrimary (citable) accession number: P56851
Secondary accession number(s): A0PK89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2001
Last modified: August 30, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot