Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-secretase 1

Gene

BACE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.2 Publications

Catalytic activityi

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.

Enzyme regulationi

Inhibited by RTN3 and RTN4.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93PROSITE-ProRule annotation1
Active sitei289PROSITE-ProRule annotation1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: UniProtKB
  • beta-amyloid binding Source: Alzheimers_University_of_Toronto
  • beta-aspartyl-peptidase activity Source: Reactome
  • enzyme binding Source: UniProtKB
  • peptidase activity Source: CACAO

GO - Biological processi

  • beta-amyloid metabolic process Source: UniProtKB
  • cellular protein metabolic process Source: Reactome
  • membrane protein ectodomain proteolysis Source: UniProtKB
  • protein catabolic process Source: GO_Central
  • proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000160610-MONOMER.
ZFISH:ENSG00000160610-MONOMER.
BRENDAi3.4.23.46. 2681.
ReactomeiR-HSA-977225. Amyloid fiber formation.
SABIO-RKP56817.
SIGNORiP56817.

Protein family/group databases

MEROPSiA01.004.
TCDBi8.A.32.1.1. the Beta-amyloid cleaving enzyme (bace1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-secretase 1 (EC:3.4.23.46)
Alternative name(s):
Aspartyl protease 2
Short name:
ASP2
Short name:
Asp 2
Beta-site amyloid precursor protein cleaving enzyme 1
Short name:
Beta-site APP cleaving enzyme 1
Memapsin-2
Membrane-associated aspartic protease 2
Gene namesi
Name:BACE1
Synonyms:BACE, KIAA1149
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:933. BACE1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 457ExtracellularSequence analysisAdd BLAST436
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 501CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

  • axon Source: Ensembl
  • cell surface Source: UniProtKB-SubCell
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum lumen Source: Reactome
  • endosome Source: UniProtKB
  • endosome membrane Source: Reactome
  • Golgi apparatus Source: UniProtKB
  • Golgi-associated vesicle lumen Source: Reactome
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • late endosome Source: UniProtKB
  • membrane raft Source: UniProtKB-SubCell
  • multivesicular body Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23621.
PharmGKBiPA25232.

Chemistry databases

ChEMBLiCHEMBL4822.
GuidetoPHARMACOLOGYi2330.

Polymorphism and mutation databases

BioMutaiBACE1.
DMDMi296434407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002593922 – 451 PublicationAdd BLAST24
ChainiPRO_000002594046 – 501Beta-secretase 1Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126N6-acetyllysine2 Publications1
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi216 ↔ 4201 Publication
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Modified residuei275N6-acetyllysine2 Publications1
Disulfide bondi278 ↔ 4431 Publication
Modified residuei279N6-acetyllysine2 Publications1
Modified residuei285N6-acetyllysine2 Publications1
Modified residuei299N6-acetyllysine2 Publications1
Modified residuei300N6-acetyllysine2 Publications1
Modified residuei307N6-acetyllysine2 Publications1
Disulfide bondi330 ↔ 3801 Publication
Glycosylationi354N-linked (GlcNAc...)Sequence analysis1
Lipidationi474S-palmitoyl cysteineBy similarity1
Lipidationi478S-palmitoyl cysteineBy similarity1
Lipidationi482S-palmitoyl cysteineBy similarity1
Lipidationi485S-palmitoyl cysteineBy similarity1
Modified residuei498PhosphoserineBy similarity1

Post-translational modificationi

N-Glycosylated.2 Publications
Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300 and Lys-307. Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein.2 Publications
Palmitoylation mediates lipid raft localization.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Zymogen

Proteomic databases

PaxDbiP56817.
PeptideAtlasiP56817.
PRIDEiP56817.

PTM databases

iPTMnetiP56817.
PhosphoSitePlusiP56817.
UniCarbKBiP56817.

Miscellaneous databases

PMAP-CutDBP56817.

Expressioni

Tissue specificityi

Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.2 Publications

Gene expression databases

BgeeiENSG00000186318.
CleanExiHS_BACE1.
ExpressionAtlasiP56817. baseline and differential.
GenevisibleiP56817. HS.

Organism-specific databases

HPAiCAB016358.

Interactioni

Subunit structurei

Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4. Interacts with SNX6. Interacts with PCSK9. Interacts with NAT8 and NAT8B.10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Clec4gQ8BNX12EBI-2433139,EBI-11176364From a different organism.
FLOT2Q142542EBI-2433139,EBI-348613

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117154. 16 interactors.
DIPiDIP-41388N.
IntActiP56817. 8 interactors.
MINTiMINT-242532.
STRINGi9606.ENSP00000318585.

Chemistry databases

BindingDBiP56817.

Structurei

Secondary structure

1501
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi61 – 63Combined sources3
Beta strandi67 – 70Combined sources4
Turni71 – 73Combined sources3
Beta strandi75 – 81Combined sources7
Turni82 – 85Combined sources4
Beta strandi86 – 93Combined sources8
Beta strandi99 – 102Combined sources4
Beta strandi109 – 111Combined sources3
Helixi115 – 117Combined sources3
Beta strandi122 – 131Combined sources10
Beta strandi132 – 134Combined sources3
Beta strandi136 – 147Combined sources12
Beta strandi149 – 151Combined sources3
Beta strandi155 – 168Combined sources14
Turni172 – 174Combined sources3
Beta strandi178 – 181Combined sources4
Helixi185 – 187Combined sources3
Beta strandi188 – 190Combined sources3
Helixi197 – 204Combined sources8
Beta strandi211 – 215Combined sources5
Helixi224 – 229Combined sources6
Beta strandi230 – 239Combined sources10
Helixi242 – 244Combined sources3
Beta strandi245 – 253Combined sources9
Turni257 – 260Combined sources4
Beta strandi264 – 269Combined sources6
Helixi278 – 282Combined sources5
Beta strandi286 – 288Combined sources3
Beta strandi294 – 298Combined sources5
Helixi299 – 312Combined sources14
Turni313 – 315Combined sources3
Helixi320 – 323Combined sources4
Beta strandi329 – 332Combined sources4
Turni333 – 335Combined sources3
Helixi338 – 340Combined sources3
Beta strandi344 – 349Combined sources6
Beta strandi355 – 361Combined sources7
Helixi363 – 366Combined sources4
Beta strandi367 – 369Combined sources3
Helixi373 – 375Combined sources3
Beta strandi378 – 383Combined sources6
Beta strandi385 – 390Combined sources6
Beta strandi392 – 394Combined sources3
Helixi396 – 399Combined sources4
Beta strandi402 – 407Combined sources6
Turni408 – 411Combined sources4
Beta strandi412 – 418Combined sources7
Beta strandi430 – 436Combined sources7
Helixi440 – 443Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FKNX-ray1.90A/B56-446[»]
1M4HX-ray2.10A/B56-446[»]
1PY1X-ray2.60E/F/G/H494-501[»]
1SGZX-ray2.00A/B/C/D58-446[»]
1TQFX-ray1.80A43-446[»]
1UJJX-ray2.60C490-501[»]
1UJKX-ray1.90C/D490-501[»]
1W50X-ray1.75A43-453[»]
1W51X-ray2.55A43-453[»]
1XN2X-ray1.90A/B/C/D58-446[»]
1XN3X-ray2.00A/B/C/D58-446[»]
1XS7X-ray2.80D58-446[»]
1YM2X-ray2.05A/B/C48-447[»]
1YM4X-ray2.25A/B/C48-453[»]
2B8LX-ray1.70A43-446[»]
2B8VX-ray1.80A43-446[»]
2F3EX-ray2.11A/B/C48-447[»]
2F3FX-ray2.30A/B/C48-447[»]
2FDPX-ray2.50A/B/C59-446[»]
2G94X-ray1.86A/B/C/D58-446[»]
2HIZX-ray2.50A/B/C14-453[»]
2HM1X-ray2.20A57-453[»]
2IQGX-ray1.70A57-453[»]
2IRZX-ray1.80A43-446[»]
2IS0X-ray2.20A43-446[»]
2NTRX-ray1.80A43-446[»]
2OAHX-ray1.80A43-446[»]
2OF0X-ray2.25A45-446[»]
2OHKX-ray2.20A45-446[»]
2OHLX-ray2.65A45-446[»]
2OHMX-ray2.70A45-446[»]
2OHNX-ray2.15A45-446[»]
2OHPX-ray2.25A45-446[»]
2OHQX-ray2.10A45-446[»]
2OHRX-ray2.25A45-446[»]
2OHSX-ray2.45A45-446[»]
2OHTX-ray2.30A45-446[»]
2OHUX-ray2.35A45-446[»]
2P4JX-ray2.50A/B/C/D58-446[»]
2P83X-ray2.50A/B/C14-446[»]
2P8HX-ray1.80A43-446[»]
2PH6X-ray2.00A43-446[»]
2PH8X-ray1.70A43-446[»]
2Q11X-ray2.40A/B/C59-446[»]
2Q15X-ray2.40A62-446[»]
2QK5X-ray2.20A/B55-447[»]
2QMDX-ray1.65A/B55-447[»]
2QMFX-ray1.75A/B55-447[»]
2QMGX-ray1.89A/B55-447[»]
2QP8X-ray1.50A/B55-447[»]
2QU2X-ray2.60A46-454[»]
2QU3X-ray2.00A46-454[»]
2QZKX-ray1.80A43-446[»]
2QZLX-ray1.80A43-446[»]
2VA5X-ray2.75A14-453[»]
2VA6X-ray2.50A14-453[»]
2VA7X-ray2.20A14-453[»]
2VIEX-ray1.90A61-452[»]
2VIJX-ray1.60A61-452[»]
2VIYX-ray1.82A61-452[»]
2VIZX-ray1.60A61-452[»]
2VJ6X-ray1.80A61-452[»]
2VJ7X-ray1.60A61-452[»]
2VJ9X-ray1.60A61-452[»]
2VKMX-ray2.05A/B/C/D58-446[»]
2VNMX-ray1.79A61-452[»]
2VNNX-ray1.87A61-452[»]
2WEZX-ray1.70A61-452[»]
2WF0X-ray1.60A61-452[»]
2WF1X-ray1.60A61-452[»]
2WF2X-ray1.80A61-452[»]
2WF3X-ray2.08A61-452[»]
2WF4X-ray1.80A61-452[»]
2WJOX-ray2.50A58-460[»]
2XFIX-ray1.73A61-452[»]
2XFJX-ray1.80A61-452[»]
2XFKX-ray1.80A61-452[»]
2ZDZX-ray2.00A46-454[»]
2ZE1X-ray2.20A46-454[»]
2ZHRX-ray2.50A/B45-454[»]
2ZHSX-ray2.70A45-454[»]
2ZHTX-ray2.35A45-454[»]
2ZHUX-ray2.40A45-454[»]
2ZHVX-ray1.85A45-454[»]
2ZJHX-ray2.60A43-446[»]
2ZJIX-ray2.30A43-446[»]
2ZJJX-ray2.20A43-446[»]
2ZJKX-ray3.00A/B/C43-446[»]
2ZJLX-ray2.10A43-446[»]
2ZJMX-ray1.90A43-446[»]
2ZJNX-ray2.70A43-446[»]
3BRAX-ray2.30A46-454[»]
3BUFX-ray2.30A46-454[»]
3BUGX-ray2.50A46-454[»]
3BUHX-ray2.30A46-454[»]
3CIBX-ray1.72A/B58-447[»]
3CICX-ray1.75A/B58-447[»]
3CIDX-ray1.80A/B58-447[»]
3CKPX-ray2.30A/B/C43-454[»]
3CKRX-ray2.70A/B/C43-454[»]
3DM6X-ray2.60A/B/C42-446[»]
3DUYX-ray1.97A/B/C48-447[»]
3DV1X-ray2.10A/B/C48-447[»]
3DV5X-ray2.10A/B/C48-447[»]
3EXOX-ray2.10A43-454[»]
3FKTX-ray1.90A43-446[»]
3H0BX-ray2.70A/B/C43-446[»]
3HVGX-ray2.26A/B/C46-453[»]
3HW1X-ray2.48A/B/C46-453[»]
3I25X-ray2.10A/B/C42-446[»]
3IGBX-ray2.24A46-454[»]
3IN3X-ray2.00A46-454[»]
3IN4X-ray2.30A46-454[»]
3INDX-ray2.25A46-454[»]
3INEX-ray2.00A46-454[»]
3INFX-ray1.85A46-454[»]
3INHX-ray1.80A46-454[»]
3IVHX-ray1.80A57-453[»]
3IVIX-ray2.20A/B/C57-453[»]
3IXJX-ray2.20A/B/C59-446[»]
3IXKX-ray2.50A/B/C42-446[»]
3K5CX-ray2.12A/B/C48-447[»]
3K5DX-ray2.90A/B/C48-453[»]
3K5FX-ray2.25A/B/C48-447[»]
3K5GX-ray2.00A/B/C48-447[»]
3KMXX-ray1.70A/B53-447[»]
3KMYX-ray1.90A/B53-447[»]
3KN0X-ray1.90A/B53-447[»]
3KYRX-ray2.60A/B/C42-446[»]
3L38X-ray2.10A46-454[»]
3L3AX-ray2.36A46-454[»]
3L58X-ray1.80A/B41-454[»]
3L59X-ray2.00A/B41-454[»]
3L5BX-ray1.80A/B41-454[»]
3L5CX-ray1.80A/B41-454[»]
3L5DX-ray1.75A/B41-454[»]
3L5EX-ray1.53A/B41-454[»]
3L5FX-ray1.70A/B41-454[»]
3LHGX-ray2.10A46-454[»]
3LNKX-ray1.80A/B53-447[»]
3LPIX-ray2.05A/B14-454[»]
3LPJX-ray1.79A/B14-454[»]
3LPKX-ray1.93A/B14-454[»]
3MSJX-ray1.80A/B/C43-453[»]
3MSKX-ray2.00A48-453[»]
3MSLX-ray2.40A48-453[»]
3N4LX-ray2.70A/B/C57-453[»]
3NSHX-ray2.20A/B/C57-453[»]
3OHFX-ray2.10A/B14-454[»]
3OHHX-ray2.01A/B14-454[»]
3OOZX-ray1.80A46-454[»]
3PI5X-ray2.40A/B/C48-447[»]
3QBHX-ray2.24A/B/C48-447[»]
3QI1X-ray2.30A57-453[»]
3R1GX-ray2.80B57-453[»]
3R2FX-ray2.53A/B/D/E14-454[»]
3RSVX-ray2.50A43-453[»]
3RSXX-ray2.48A43-453[»]
3RTHX-ray2.70A43-453[»]
3RTMX-ray2.76A43-453[»]
3RTNX-ray2.70A43-453[»]
3RU1X-ray2.30A43-453[»]
3RVIX-ray2.65A43-453[»]
3S2OX-ray2.60A48-453[»]
3S7LX-ray2.16A46-454[»]
3S7MX-ray2.20A46-454[»]
3SKFX-ray3.00A/B14-454[»]
3SKGX-ray2.88A/B/D/E14-454[»]
3TPJX-ray1.61A43-454[»]
3TPLX-ray2.50A/B/C43-454[»]
3TPPX-ray1.60A43-454[»]
3TPRX-ray2.55A43-454[»]
3U6AX-ray2.20A/B/C58-446[»]
3UDHX-ray1.70A58-453[»]
3UDJX-ray1.80A58-453[»]
3UDKX-ray2.51A58-453[»]
3UDMX-ray1.94A58-453[»]
3UDNX-ray2.19A58-453[»]
3UDPX-ray1.95A58-453[»]
3UDQX-ray2.73A58-453[»]
3UDRX-ray1.95A58-453[»]
3UDYX-ray2.00A58-453[»]
3UFLX-ray1.90A58-446[»]
3UQPX-ray1.77A43-454[»]
3UQRX-ray3.06A/B/C43-454[»]
3UQUX-ray1.70A43-454[»]
3UQWX-ray2.20A43-454[»]
3UQXX-ray1.70A43-454[»]
3VEUX-ray1.52A48-447[»]
3VF3X-ray1.48A48-447[»]
3VG1X-ray1.77A48-447[»]
3VV6X-ray2.05A43-454[»]
3VV7X-ray2.10A43-454[»]
3VV8X-ray2.50A43-454[»]
3WB4X-ray2.25A43-454[»]
3WB5X-ray2.50A43-454[»]
3ZMGX-ray1.74A46-454[»]
3ZOVX-ray2.10A46-454[»]
4ACUX-ray1.75A43-453[»]
4ACXX-ray2.00A43-453[»]
4AZYX-ray1.79A43-453[»]
4B00X-ray1.83A43-453[»]
4B05X-ray1.80A43-453[»]
4B0QX-ray1.87A62-445[»]
4B1CX-ray1.95A58-445[»]
4B1DX-ray1.95A58-445[»]
4B1EX-ray1.95A58-445[»]
4B70X-ray1.60A61-445[»]
4B72X-ray1.60A58-445[»]
4B77X-ray1.80A58-445[»]
4B78X-ray1.50A62-445[»]
4BEKX-ray2.39A46-454[»]
4BFDX-ray2.30A46-454[»]
4D83X-ray2.40A/B/C48-447[»]
4D85X-ray2.65A48-453[»]
4D88X-ray1.70A48-447[»]
4D89X-ray1.65A48-447[»]
4D8CX-ray2.07A/B/C48-447[»]
4DH6X-ray2.50A43-453[»]
4DI2X-ray2.00A/B/C43-453[»]
4DJUX-ray1.80A/B41-454[»]
4DJVX-ray1.73A/B41-454[»]
4DJWX-ray1.90A/B41-454[»]
4DJXX-ray1.50A/B41-454[»]
4DJYX-ray1.86A/B41-454[»]
4DPFX-ray1.80A57-446[»]
4DPIX-ray1.90A57-446[»]
4DUSX-ray2.50A43-453[»]
4DV9X-ray2.08A43-454[»]
4DVFX-ray1.80A/B43-454[»]
4EWOX-ray1.80A61-446[»]
4EXGX-ray1.80A61-446[»]
4FCOX-ray1.76A43-454[»]
4FGXX-ray1.59A43-454[»]
4FM7X-ray1.56A58-453[»]
4FM8X-ray1.90A58-453[»]
4FRIX-ray2.30A43-453[»]
4FRJX-ray1.95A43-453[»]
4FRKX-ray2.10A43-453[»]
4FRSX-ray1.70A/B53-447[»]
4FS4X-ray1.74A/B58-447[»]
4FSEX-ray2.65A/B/D/E14-454[»]
4FSLX-ray2.50A/B/D/E43-453[»]
4GIDX-ray2.00A/B/C/D59-446[»]
4GMIX-ray1.80A57-446[»]
4H1EX-ray1.90A/B41-454[»]
4H3FX-ray1.70A/B41-454[»]
4H3GX-ray1.85A/B41-454[»]
4H3IX-ray1.96A/B41-454[»]
4H3JX-ray1.60A/B41-454[»]
4HA5X-ray1.83A/B41-454[»]
4HZTX-ray1.80A57-453[»]
4I0DX-ray1.91A57-453[»]
4I0EX-ray1.70A57-453[»]
4I0FX-ray1.80A57-453[»]
4I0GX-ray1.78A57-453[»]
4I0HX-ray2.20A/B/C57-453[»]
4I0IX-ray2.20A/B/C57-453[»]
4I0JX-ray1.99A57-453[»]
4I0ZX-ray1.80A57-453[»]
4I10X-ray2.07A57-453[»]
4I11X-ray1.89A57-453[»]
4I12X-ray1.78A57-453[»]
4I1CX-ray2.00A57-453[»]
4IVSX-ray2.64A43-454[»]
4IVTX-ray1.60A43-454[»]
4J0PX-ray1.97A46-454[»]
4J0TX-ray2.05A46-454[»]
4J0VX-ray1.94A46-454[»]
4J0YX-ray1.77A46-454[»]
4J0ZX-ray2.13A46-454[»]
4J17X-ray1.81A46-454[»]
4J1CX-ray2.01A46-454[»]
4J1EX-ray1.78A46-454[»]
4J1FX-ray2.25A46-454[»]
4J1HX-ray2.20A46-454[»]
4J1IX-ray2.05A46-454[»]
4J1KX-ray2.18A46-454[»]
4JOOX-ray1.80A57-453[»]
4JP9X-ray1.80A57-453[»]
4JPCX-ray1.80A57-453[»]
4JPEX-ray1.80A57-453[»]
4K8SX-ray2.39A/B/C59-446[»]
4K9HX-ray2.29A/B/C59-446[»]
4KE0X-ray2.30A/B/C43-453[»]
4KE1X-ray1.91A43-453[»]
4L7GX-ray1.38A57-453[»]
4L7HX-ray1.85A57-453[»]
4L7JX-ray1.65A57-453[»]
4LC7X-ray1.70A57-453[»]
4LXAX-ray1.95A/B/C48-447[»]
4LXKX-ray2.05A/B/C48-447[»]
4LXMX-ray2.30A/B/C48-447[»]
4N00X-ray1.80A57-453[»]
4PZWX-ray1.80A57-453[»]
4PZXX-ray1.80A57-453[»]
4R5NX-ray1.80A57-453[»]
4R8YX-ray1.90A/B41-454[»]
4R91X-ray1.58A/B41-454[»]
4R92X-ray1.71A/B41-454[»]
4R93X-ray1.71A/B41-454[»]
4R95X-ray1.99A/B41-454[»]
4RCDX-ray1.90A43-453[»]
4RCEX-ray2.40A43-453[»]
4RCFX-ray1.78A43-453[»]
4RRNX-ray1.80A57-453[»]
4RROX-ray1.80A57-453[»]
4RRSX-ray1.80A57-453[»]
4TRWX-ray2.85A/B/C58-447[»]
4TRYX-ray2.75A/B/C60-447[»]
4TRZX-ray3.25A/B/C60-447[»]
4WTUX-ray1.85A43-453[»]
4WY1X-ray1.98A58-453[»]
4WY6X-ray2.10A46-454[»]
4X2LX-ray2.55A46-454[»]
4X7IX-ray1.77A/B14-454[»]
4XKXX-ray1.80A43-453[»]
4XXSX-ray1.86A46-454[»]
4YBIX-ray1.84A/B14-454[»]
4ZPEX-ray1.70A43-446[»]
4ZPFX-ray1.80A43-446[»]
4ZPGX-ray2.00A43-446[»]
4ZSMX-ray1.96A/B14-454[»]
4ZSPX-ray1.91A/B14-454[»]
4ZSQX-ray2.30A/B14-454[»]
4ZSRX-ray1.65A/B14-454[»]
5CLMX-ray2.61A46-446[»]
5DQCX-ray2.47A/B/C58-447[»]
5ENKX-ray2.11A14-454[»]
5ENMX-ray1.98A14-454[»]
5EZXX-ray1.90A57-446[»]
5EZZX-ray2.10A57-446[»]
5F00X-ray1.95A57-446[»]
5F01X-ray1.52A57-446[»]
5HD0X-ray1.65A/B41-454[»]
5HDUX-ray1.58A/B41-454[»]
5HDVX-ray1.71A/B41-454[»]
5HDXX-ray1.60A/B41-454[»]
5HDZX-ray1.49A/B41-454[»]
5HE4X-ray1.53A/B41-454[»]
5HE5X-ray1.55A/B41-454[»]
5HE7X-ray1.71A/B41-454[»]
5I3VX-ray1.62A43-453[»]
5I3WX-ray2.15A43-453[»]
5I3XX-ray1.85A43-453[»]
5I3YX-ray2.15A43-453[»]
5IE1X-ray2.30A43-453[»]
5KQFX-ray1.98A14-454[»]
5KR8X-ray2.12A14-454[»]
ProteinModelPortaliP56817.
SMRiP56817.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56817.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 416Peptidase A1PROSITE-ProRule annotationAdd BLAST342

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni479 – 501Interaction with RTN3Add BLAST23

Domaini

The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.1 Publication

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOVERGENiHBG059578.
InParanoidiP56817.
KOiK04521.
OrthoDBiEOG091G0CNK.
PhylomeDBiP56817.
TreeFamiTF329595.

Family and domain databases

CDDicd05473. beta_secretase_like. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR009119. BACE.
IPR009120. BACE1.
IPR033874. Memapsin-like.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF245. PTHR13683:SF245. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR01816. BACE1.
PR01815. BACEFAMILY.
PR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P56817-1) [UniParc]FASTAAdd to basket
Also known as: BACE-1A, BAC-501

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQALPWLLL WMGAGVLPAH GTQHGIRLPL RSGLGGAPLG LRLPRETDEE
60 70 80 90 100
PEEPGRRGSF VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA
110 120 130 140 150
VGAAPHPFLH RYYQRQLSST YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH
160 170 180 190 200
GPNVTVRANI AAITESDKFF INGSNWEGIL GLAYAEIARP DDSLEPFFDS
210 220 230 240 250
LVKQTHVPNL FSLQLCGAGF PLNQSEVLAS VGGSMIIGGI DHSLYTGSLW
260 270 280 290 300
YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK
310 320 330 340 350
VFEAAVKSIK AASSTEKFPD GFWLGEQLVC WQAGTTPWNI FPVISLYLMG
360 370 380 390 400
EVTNQSFRIT ILPQQYLRPV EDVATSQDDC YKFAISQSST GTVMGAVIME
410 420 430 440 450
GFYVVFDRAR KRIGFAVSAC HVHDEFRTAA VEGPFVTLDM EDCGYNIPQT
460 470 480 490 500
DESTLMTIAY VMAAICALFM LPLCLMVCQW CCLRCLRQQH DDFADDISLL

K
Length:501
Mass (Da):55,711
Last modified:May 18, 2010 - v2
Checksum:i377CE4C838C09F05
GO
Isoform B (identifier: P56817-2) [UniParc]FASTAAdd to basket
Also known as: BACE-1B, BACE-I-476

The sequence of this isoform differs from the canonical sequence as follows:
     190-214: Missing.

Show »
Length:476
Mass (Da):52,855
Checksum:i6C8C87F8B53FDF66
GO
Isoform C (identifier: P56817-3) [UniParc]FASTAAdd to basket
Also known as: BACE-1C, BACE-I-457

The sequence of this isoform differs from the canonical sequence as follows:
     146-189: Missing.

Show »
Length:457
Mass (Da):51,015
Checksum:iC794C9A9F43397A2
GO
Isoform D (identifier: P56817-4) [UniParc]FASTAAdd to basket
Also known as: BACE-1D, BACE-I-432

The sequence of this isoform differs from the canonical sequence as follows:
     146-189: Missing.
     190-214: Missing.

Show »
Length:432
Mass (Da):48,159
Checksum:i96FC81E6EC82A01B
GO
Isoform 5 (identifier: P56817-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MAQALPWLLLWMGAGVLPAH → MVPFIYLQAHFTLCSGWSST
     21-120: Missing.

Note: Gene prediction based on EST data.
Show »
Length:401
Mass (Da):44,964
Checksum:iA8D5B1112614B521
GO
Isoform 6 (identifier: P56817-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MAQALPWLLLWMGAGVLPAH → MVPFIYLQAHFTLCSGWSST
     21-120: Missing.
     190-214: Missing.

Note: Gene prediction based on EST data.
Show »
Length:376
Mass (Da):42,107
Checksum:i93E4D8C54F8E4716
GO

Sequence cautioni

The sequence BAA86463 differs from that shown. Reason: Frameshift at position 34.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060692265V → A.1 PublicationCorresponds to variant rs28989503dbSNPEnsembl.1
Natural variantiVAR_051509481C → R.12 PublicationsCorresponds to variant rs539765dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470921 – 20MAQAL…VLPAH → MVPFIYLQAHFTLCSGWSST in isoform 5 and isoform 6. CuratedAdd BLAST20
Alternative sequenceiVSP_04709321 – 120Missing in isoform 5 and isoform 6. CuratedAdd BLAST100
Alternative sequenceiVSP_005222146 – 189Missing in isoform C and isoform D. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_005223190 – 214Missing in isoform B, isoform D and isoform 6. 2 PublicationsAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190725 mRNA. Translation: AAF04142.1.
AF201468 mRNA. Translation: AAF18982.1.
AF200343 mRNA. Translation: AAF17079.1.
AF204943 mRNA. Translation: AAF26367.1.
AF338816 mRNA. Translation: AAK38374.1.
AF338817 mRNA. Translation: AAK38375.1.
AB050436 mRNA. Translation: BAB40931.1.
AB050437 mRNA. Translation: BAB40932.1.
AB050438 mRNA. Translation: BAB40933.1.
AB032975 mRNA. Translation: BAA86463.2. Frameshift.
DQ007053 Genomic DNA. Translation: AAY16982.1.
EF444940 Genomic DNA. Translation: ACA05927.1.
AP000892 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67313.1.
BC065492 mRNA. Translation: AAH65492.1.
AF200193 mRNA. Translation: AAF13715.1.
CCDSiCCDS44739.1. [P56817-2]
CCDS44740.1. [P56817-3]
CCDS44741.1. [P56817-4]
CCDS55786.1. [P56817-6]
CCDS55787.1. [P56817-5]
CCDS8383.1. [P56817-1]
PIRiA59090.
RefSeqiNP_001193978.1. NM_001207049.1.
NP_036236.1. NM_012104.4.
NP_620427.1. NM_138971.3.
NP_620428.1. NM_138972.3.
NP_620429.1. NM_138973.3.
UniGeneiHs.504003.

Genome annotation databases

EnsembliENST00000313005; ENSP00000318585; ENSG00000186318.
ENST00000392937; ENSP00000475405; ENSG00000186318.
ENST00000428381; ENSP00000402228; ENSG00000186318.
ENST00000445823; ENSP00000403685; ENSG00000186318.
ENST00000510630; ENSP00000422461; ENSG00000186318.
ENST00000513780; ENSP00000424536; ENSG00000186318.
GeneIDi23621.
KEGGihsa:23621.
UCSCiuc001pqw.4. human. [P56817-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190725 mRNA. Translation: AAF04142.1.
AF201468 mRNA. Translation: AAF18982.1.
AF200343 mRNA. Translation: AAF17079.1.
AF204943 mRNA. Translation: AAF26367.1.
AF338816 mRNA. Translation: AAK38374.1.
AF338817 mRNA. Translation: AAK38375.1.
AB050436 mRNA. Translation: BAB40931.1.
AB050437 mRNA. Translation: BAB40932.1.
AB050438 mRNA. Translation: BAB40933.1.
AB032975 mRNA. Translation: BAA86463.2. Frameshift.
DQ007053 Genomic DNA. Translation: AAY16982.1.
EF444940 Genomic DNA. Translation: ACA05927.1.
AP000892 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67313.1.
BC065492 mRNA. Translation: AAH65492.1.
AF200193 mRNA. Translation: AAF13715.1.
CCDSiCCDS44739.1. [P56817-2]
CCDS44740.1. [P56817-3]
CCDS44741.1. [P56817-4]
CCDS55786.1. [P56817-6]
CCDS55787.1. [P56817-5]
CCDS8383.1. [P56817-1]
PIRiA59090.
RefSeqiNP_001193978.1. NM_001207049.1.
NP_036236.1. NM_012104.4.
NP_620427.1. NM_138971.3.
NP_620428.1. NM_138972.3.
NP_620429.1. NM_138973.3.
UniGeneiHs.504003.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FKNX-ray1.90A/B56-446[»]
1M4HX-ray2.10A/B56-446[»]
1PY1X-ray2.60E/F/G/H494-501[»]
1SGZX-ray2.00A/B/C/D58-446[»]
1TQFX-ray1.80A43-446[»]
1UJJX-ray2.60C490-501[»]
1UJKX-ray1.90C/D490-501[»]
1W50X-ray1.75A43-453[»]
1W51X-ray2.55A43-453[»]
1XN2X-ray1.90A/B/C/D58-446[»]
1XN3X-ray2.00A/B/C/D58-446[»]
1XS7X-ray2.80D58-446[»]
1YM2X-ray2.05A/B/C48-447[»]
1YM4X-ray2.25A/B/C48-453[»]
2B8LX-ray1.70A43-446[»]
2B8VX-ray1.80A43-446[»]
2F3EX-ray2.11A/B/C48-447[»]
2F3FX-ray2.30A/B/C48-447[»]
2FDPX-ray2.50A/B/C59-446[»]
2G94X-ray1.86A/B/C/D58-446[»]
2HIZX-ray2.50A/B/C14-453[»]
2HM1X-ray2.20A57-453[»]
2IQGX-ray1.70A57-453[»]
2IRZX-ray1.80A43-446[»]
2IS0X-ray2.20A43-446[»]
2NTRX-ray1.80A43-446[»]
2OAHX-ray1.80A43-446[»]
2OF0X-ray2.25A45-446[»]
2OHKX-ray2.20A45-446[»]
2OHLX-ray2.65A45-446[»]
2OHMX-ray2.70A45-446[»]
2OHNX-ray2.15A45-446[»]
2OHPX-ray2.25A45-446[»]
2OHQX-ray2.10A45-446[»]
2OHRX-ray2.25A45-446[»]
2OHSX-ray2.45A45-446[»]
2OHTX-ray2.30A45-446[»]
2OHUX-ray2.35A45-446[»]
2P4JX-ray2.50A/B/C/D58-446[»]
2P83X-ray2.50A/B/C14-446[»]
2P8HX-ray1.80A43-446[»]
2PH6X-ray2.00A43-446[»]
2PH8X-ray1.70A43-446[»]
2Q11X-ray2.40A/B/C59-446[»]
2Q15X-ray2.40A62-446[»]
2QK5X-ray2.20A/B55-447[»]
2QMDX-ray1.65A/B55-447[»]
2QMFX-ray1.75A/B55-447[»]
2QMGX-ray1.89A/B55-447[»]
2QP8X-ray1.50A/B55-447[»]
2QU2X-ray2.60A46-454[»]
2QU3X-ray2.00A46-454[»]
2QZKX-ray1.80A43-446[»]
2QZLX-ray1.80A43-446[»]
2VA5X-ray2.75A14-453[»]
2VA6X-ray2.50A14-453[»]
2VA7X-ray2.20A14-453[»]
2VIEX-ray1.90A61-452[»]
2VIJX-ray1.60A61-452[»]
2VIYX-ray1.82A61-452[»]
2VIZX-ray1.60A61-452[»]
2VJ6X-ray1.80A61-452[»]
2VJ7X-ray1.60A61-452[»]
2VJ9X-ray1.60A61-452[»]
2VKMX-ray2.05A/B/C/D58-446[»]
2VNMX-ray1.79A61-452[»]
2VNNX-ray1.87A61-452[»]
2WEZX-ray1.70A61-452[»]
2WF0X-ray1.60A61-452[»]
2WF1X-ray1.60A61-452[»]
2WF2X-ray1.80A61-452[»]
2WF3X-ray2.08A61-452[»]
2WF4X-ray1.80A61-452[»]
2WJOX-ray2.50A58-460[»]
2XFIX-ray1.73A61-452[»]
2XFJX-ray1.80A61-452[»]
2XFKX-ray1.80A61-452[»]
2ZDZX-ray2.00A46-454[»]
2ZE1X-ray2.20A46-454[»]
2ZHRX-ray2.50A/B45-454[»]
2ZHSX-ray2.70A45-454[»]
2ZHTX-ray2.35A45-454[»]
2ZHUX-ray2.40A45-454[»]
2ZHVX-ray1.85A45-454[»]
2ZJHX-ray2.60A43-446[»]
2ZJIX-ray2.30A43-446[»]
2ZJJX-ray2.20A43-446[»]
2ZJKX-ray3.00A/B/C43-446[»]
2ZJLX-ray2.10A43-446[»]
2ZJMX-ray1.90A43-446[»]
2ZJNX-ray2.70A43-446[»]
3BRAX-ray2.30A46-454[»]
3BUFX-ray2.30A46-454[»]
3BUGX-ray2.50A46-454[»]
3BUHX-ray2.30A46-454[»]
3CIBX-ray1.72A/B58-447[»]
3CICX-ray1.75A/B58-447[»]
3CIDX-ray1.80A/B58-447[»]
3CKPX-ray2.30A/B/C43-454[»]
3CKRX-ray2.70A/B/C43-454[»]
3DM6X-ray2.60A/B/C42-446[»]
3DUYX-ray1.97A/B/C48-447[»]
3DV1X-ray2.10A/B/C48-447[»]
3DV5X-ray2.10A/B/C48-447[»]
3EXOX-ray2.10A43-454[»]
3FKTX-ray1.90A43-446[»]
3H0BX-ray2.70A/B/C43-446[»]
3HVGX-ray2.26A/B/C46-453[»]
3HW1X-ray2.48A/B/C46-453[»]
3I25X-ray2.10A/B/C42-446[»]
3IGBX-ray2.24A46-454[»]
3IN3X-ray2.00A46-454[»]
3IN4X-ray2.30A46-454[»]
3INDX-ray2.25A46-454[»]
3INEX-ray2.00A46-454[»]
3INFX-ray1.85A46-454[»]
3INHX-ray1.80A46-454[»]
3IVHX-ray1.80A57-453[»]
3IVIX-ray2.20A/B/C57-453[»]
3IXJX-ray2.20A/B/C59-446[»]
3IXKX-ray2.50A/B/C42-446[»]
3K5CX-ray2.12A/B/C48-447[»]
3K5DX-ray2.90A/B/C48-453[»]
3K5FX-ray2.25A/B/C48-447[»]
3K5GX-ray2.00A/B/C48-447[»]
3KMXX-ray1.70A/B53-447[»]
3KMYX-ray1.90A/B53-447[»]
3KN0X-ray1.90A/B53-447[»]
3KYRX-ray2.60A/B/C42-446[»]
3L38X-ray2.10A46-454[»]
3L3AX-ray2.36A46-454[»]
3L58X-ray1.80A/B41-454[»]
3L59X-ray2.00A/B41-454[»]
3L5BX-ray1.80A/B41-454[»]
3L5CX-ray1.80A/B41-454[»]
3L5DX-ray1.75A/B41-454[»]
3L5EX-ray1.53A/B41-454[»]
3L5FX-ray1.70A/B41-454[»]
3LHGX-ray2.10A46-454[»]
3LNKX-ray1.80A/B53-447[»]
3LPIX-ray2.05A/B14-454[»]
3LPJX-ray1.79A/B14-454[»]
3LPKX-ray1.93A/B14-454[»]
3MSJX-ray1.80A/B/C43-453[»]
3MSKX-ray2.00A48-453[»]
3MSLX-ray2.40A48-453[»]
3N4LX-ray2.70A/B/C57-453[»]
3NSHX-ray2.20A/B/C57-453[»]
3OHFX-ray2.10A/B14-454[»]
3OHHX-ray2.01A/B14-454[»]
3OOZX-ray1.80A46-454[»]
3PI5X-ray2.40A/B/C48-447[»]
3QBHX-ray2.24A/B/C48-447[»]
3QI1X-ray2.30A57-453[»]
3R1GX-ray2.80B57-453[»]
3R2FX-ray2.53A/B/D/E14-454[»]
3RSVX-ray2.50A43-453[»]
3RSXX-ray2.48A43-453[»]
3RTHX-ray2.70A43-453[»]
3RTMX-ray2.76A43-453[»]
3RTNX-ray2.70A43-453[»]
3RU1X-ray2.30A43-453[»]
3RVIX-ray2.65A43-453[»]
3S2OX-ray2.60A48-453[»]
3S7LX-ray2.16A46-454[»]
3S7MX-ray2.20A46-454[»]
3SKFX-ray3.00A/B14-454[»]
3SKGX-ray2.88A/B/D/E14-454[»]
3TPJX-ray1.61A43-454[»]
3TPLX-ray2.50A/B/C43-454[»]
3TPPX-ray1.60A43-454[»]
3TPRX-ray2.55A43-454[»]
3U6AX-ray2.20A/B/C58-446[»]
3UDHX-ray1.70A58-453[»]
3UDJX-ray1.80A58-453[»]
3UDKX-ray2.51A58-453[»]
3UDMX-ray1.94A58-453[»]
3UDNX-ray2.19A58-453[»]
3UDPX-ray1.95A58-453[»]
3UDQX-ray2.73A58-453[»]
3UDRX-ray1.95A58-453[»]
3UDYX-ray2.00A58-453[»]
3UFLX-ray1.90A58-446[»]
3UQPX-ray1.77A43-454[»]
3UQRX-ray3.06A/B/C43-454[»]
3UQUX-ray1.70A43-454[»]
3UQWX-ray2.20A43-454[»]
3UQXX-ray1.70A43-454[»]
3VEUX-ray1.52A48-447[»]
3VF3X-ray1.48A48-447[»]
3VG1X-ray1.77A48-447[»]
3VV6X-ray2.05A43-454[»]
3VV7X-ray2.10A43-454[»]
3VV8X-ray2.50A43-454[»]
3WB4X-ray2.25A43-454[»]
3WB5X-ray2.50A43-454[»]
3ZMGX-ray1.74A46-454[»]
3ZOVX-ray2.10A46-454[»]
4ACUX-ray1.75A43-453[»]
4ACXX-ray2.00A43-453[»]
4AZYX-ray1.79A43-453[»]
4B00X-ray1.83A43-453[»]
4B05X-ray1.80A43-453[»]
4B0QX-ray1.87A62-445[»]
4B1CX-ray1.95A58-445[»]
4B1DX-ray1.95A58-445[»]
4B1EX-ray1.95A58-445[»]
4B70X-ray1.60A61-445[»]
4B72X-ray1.60A58-445[»]
4B77X-ray1.80A58-445[»]
4B78X-ray1.50A62-445[»]
4BEKX-ray2.39A46-454[»]
4BFDX-ray2.30A46-454[»]
4D83X-ray2.40A/B/C48-447[»]
4D85X-ray2.65A48-453[»]
4D88X-ray1.70A48-447[»]
4D89X-ray1.65A48-447[»]
4D8CX-ray2.07A/B/C48-447[»]
4DH6X-ray2.50A43-453[»]
4DI2X-ray2.00A/B/C43-453[»]
4DJUX-ray1.80A/B41-454[»]
4DJVX-ray1.73A/B41-454[»]
4DJWX-ray1.90A/B41-454[»]
4DJXX-ray1.50A/B41-454[»]
4DJYX-ray1.86A/B41-454[»]
4DPFX-ray1.80A57-446[»]
4DPIX-ray1.90A57-446[»]
4DUSX-ray2.50A43-453[»]
4DV9X-ray2.08A43-454[»]
4DVFX-ray1.80A/B43-454[»]
4EWOX-ray1.80A61-446[»]
4EXGX-ray1.80A61-446[»]
4FCOX-ray1.76A43-454[»]
4FGXX-ray1.59A43-454[»]
4FM7X-ray1.56A58-453[»]
4FM8X-ray1.90A58-453[»]
4FRIX-ray2.30A43-453[»]
4FRJX-ray1.95A43-453[»]
4FRKX-ray2.10A43-453[»]
4FRSX-ray1.70A/B53-447[»]
4FS4X-ray1.74A/B58-447[»]
4FSEX-ray2.65A/B/D/E14-454[»]
4FSLX-ray2.50A/B/D/E43-453[»]
4GIDX-ray2.00A/B/C/D59-446[»]
4GMIX-ray1.80A57-446[»]
4H1EX-ray1.90A/B41-454[»]
4H3FX-ray1.70A/B41-454[»]
4H3GX-ray1.85A/B41-454[»]
4H3IX-ray1.96A/B41-454[»]
4H3JX-ray1.60A/B41-454[»]
4HA5X-ray1.83A/B41-454[»]
4HZTX-ray1.80A57-453[»]
4I0DX-ray1.91A57-453[»]
4I0EX-ray1.70A57-453[»]
4I0FX-ray1.80A57-453[»]
4I0GX-ray1.78A57-453[»]
4I0HX-ray2.20A/B/C57-453[»]
4I0IX-ray2.20A/B/C57-453[»]
4I0JX-ray1.99A57-453[»]
4I0ZX-ray1.80A57-453[»]
4I10X-ray2.07A57-453[»]
4I11X-ray1.89A57-453[»]
4I12X-ray1.78A57-453[»]
4I1CX-ray2.00A57-453[»]
4IVSX-ray2.64A43-454[»]
4IVTX-ray1.60A43-454[»]
4J0PX-ray1.97A46-454[»]
4J0TX-ray2.05A46-454[»]
4J0VX-ray1.94A46-454[»]
4J0YX-ray1.77A46-454[»]
4J0ZX-ray2.13A46-454[»]
4J17X-ray1.81A46-454[»]
4J1CX-ray2.01A46-454[»]
4J1EX-ray1.78A46-454[»]
4J1FX-ray2.25A46-454[»]
4J1HX-ray2.20A46-454[»]
4J1IX-ray2.05A46-454[»]
4J1KX-ray2.18A46-454[»]
4JOOX-ray1.80A57-453[»]
4JP9X-ray1.80A57-453[»]
4JPCX-ray1.80A57-453[»]
4JPEX-ray1.80A57-453[»]
4K8SX-ray2.39A/B/C59-446[»]
4K9HX-ray2.29A/B/C59-446[»]
4KE0X-ray2.30A/B/C43-453[»]
4KE1X-ray1.91A43-453[»]
4L7GX-ray1.38A57-453[»]
4L7HX-ray1.85A57-453[»]
4L7JX-ray1.65A57-453[»]
4LC7X-ray1.70A57-453[»]
4LXAX-ray1.95A/B/C48-447[»]
4LXKX-ray2.05A/B/C48-447[»]
4LXMX-ray2.30A/B/C48-447[»]
4N00X-ray1.80A57-453[»]
4PZWX-ray1.80A57-453[»]
4PZXX-ray1.80A57-453[»]
4R5NX-ray1.80A57-453[»]
4R8YX-ray1.90A/B41-454[»]
4R91X-ray1.58A/B41-454[»]
4R92X-ray1.71A/B41-454[»]
4R93X-ray1.71A/B41-454[»]
4R95X-ray1.99A/B41-454[»]
4RCDX-ray1.90A43-453[»]
4RCEX-ray2.40A43-453[»]
4RCFX-ray1.78A43-453[»]
4RRNX-ray1.80A57-453[»]
4RROX-ray1.80A57-453[»]
4RRSX-ray1.80A57-453[»]
4TRWX-ray2.85A/B/C58-447[»]
4TRYX-ray2.75A/B/C60-447[»]
4TRZX-ray3.25A/B/C60-447[»]
4WTUX-ray1.85A43-453[»]
4WY1X-ray1.98A58-453[»]
4WY6X-ray2.10A46-454[»]
4X2LX-ray2.55A46-454[»]
4X7IX-ray1.77A/B14-454[»]
4XKXX-ray1.80A43-453[»]
4XXSX-ray1.86A46-454[»]
4YBIX-ray1.84A/B14-454[»]
4ZPEX-ray1.70A43-446[»]
4ZPFX-ray1.80A43-446[»]
4ZPGX-ray2.00A43-446[»]
4ZSMX-ray1.96A/B14-454[»]
4ZSPX-ray1.91A/B14-454[»]
4ZSQX-ray2.30A/B14-454[»]
4ZSRX-ray1.65A/B14-454[»]
5CLMX-ray2.61A46-446[»]
5DQCX-ray2.47A/B/C58-447[»]
5ENKX-ray2.11A14-454[»]
5ENMX-ray1.98A14-454[»]
5EZXX-ray1.90A57-446[»]
5EZZX-ray2.10A57-446[»]
5F00X-ray1.95A57-446[»]
5F01X-ray1.52A57-446[»]
5HD0X-ray1.65A/B41-454[»]
5HDUX-ray1.58A/B41-454[»]
5HDVX-ray1.71A/B41-454[»]
5HDXX-ray1.60A/B41-454[»]
5HDZX-ray1.49A/B41-454[»]
5HE4X-ray1.53A/B41-454[»]
5HE5X-ray1.55A/B41-454[»]
5HE7X-ray1.71A/B41-454[»]
5I3VX-ray1.62A43-453[»]
5I3WX-ray2.15A43-453[»]
5I3XX-ray1.85A43-453[»]
5I3YX-ray2.15A43-453[»]
5IE1X-ray2.30A43-453[»]
5KQFX-ray1.98A14-454[»]
5KR8X-ray2.12A14-454[»]
ProteinModelPortaliP56817.
SMRiP56817.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117154. 16 interactors.
DIPiDIP-41388N.
IntActiP56817. 8 interactors.
MINTiMINT-242532.
STRINGi9606.ENSP00000318585.

Chemistry databases

BindingDBiP56817.
ChEMBLiCHEMBL4822.
GuidetoPHARMACOLOGYi2330.

Protein family/group databases

MEROPSiA01.004.
TCDBi8.A.32.1.1. the Beta-amyloid cleaving enzyme (bace1) family.

PTM databases

iPTMnetiP56817.
PhosphoSitePlusiP56817.
UniCarbKBiP56817.

Polymorphism and mutation databases

BioMutaiBACE1.
DMDMi296434407.

Proteomic databases

PaxDbiP56817.
PeptideAtlasiP56817.
PRIDEiP56817.

Protocols and materials databases

DNASUi23621.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313005; ENSP00000318585; ENSG00000186318.
ENST00000392937; ENSP00000475405; ENSG00000186318.
ENST00000428381; ENSP00000402228; ENSG00000186318.
ENST00000445823; ENSP00000403685; ENSG00000186318.
ENST00000510630; ENSP00000422461; ENSG00000186318.
ENST00000513780; ENSP00000424536; ENSG00000186318.
GeneIDi23621.
KEGGihsa:23621.
UCSCiuc001pqw.4. human. [P56817-1]

Organism-specific databases

CTDi23621.
DisGeNETi23621.
GeneCardsiBACE1.
HGNCiHGNC:933. BACE1.
HPAiCAB016358.
MIMi604252. gene.
neXtProtiNX_P56817.
PharmGKBiPA25232.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOVERGENiHBG059578.
InParanoidiP56817.
KOiK04521.
OrthoDBiEOG091G0CNK.
PhylomeDBiP56817.
TreeFamiTF329595.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000160610-MONOMER.
ZFISH:ENSG00000160610-MONOMER.
BRENDAi3.4.23.46. 2681.
ReactomeiR-HSA-977225. Amyloid fiber formation.
SABIO-RKP56817.
SIGNORiP56817.

Miscellaneous databases

EvolutionaryTraceiP56817.
GeneWikiiBeta-secretase_1.
GenomeRNAii23621.
PMAP-CutDBP56817.
PROiP56817.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186318.
CleanExiHS_BACE1.
ExpressionAtlasiP56817. baseline and differential.
GenevisibleiP56817. HS.

Family and domain databases

CDDicd05473. beta_secretase_like. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR009119. BACE.
IPR009120. BACE1.
IPR033874. Memapsin-like.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF245. PTHR13683:SF245. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR01816. BACE1.
PR01815. BACEFAMILY.
PR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBACE1_HUMAN
AccessioniPrimary (citable) accession number: P56817
Secondary accession number(s): A0M8W7
, B0YIU9, E9PE65, H7BXJ9, Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5, Q9ULS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 187 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.