Reviewed, UniProtKB/Swiss-Prot P56810 (PORA_METTH)

Names and origin

Protein names

Recommended name:
    Pyruvate synthase subunit porA
    EC=1.2.7.1
Alternative name(s):
    Pyruvate oxidoreductase alpha chain
      Short name=POR
    Pyruvic-ferredoxin oxidoreductase subunit alpha

Gene names

Name:	porA
Ordered Locus Names:	MTH_1739

Organism

Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro pyruvate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 383	382	Pyruvate synthase subunit porA		PRO_0000099897

Sequences

	Sequence		Length	Mass (Da)
	P56810-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 586DFD585247BF1E	FASTA	383	42,448
	10 20 30 40 50 60 MVLKVISANQ AVAEAAKLAK PKVIPVYPIT PQTSISEYLA KFVADGELKA EYIRVESEHS 70 80 90 100 110 120 AMSACVGASG AGVRVFTATS SQGLALMHEI VYAAAGLRNP IVMANANRAL SAPLSIWNDQ 130 140 150 160 170 180 QDSIAERDSG WMQIYVESGQ EALDSVLLSY RVSEDRDVLL PSMVCLDGFI LTHTVEPVDI 190 200 210 220 230 240 PSQEDVDSFL PEFQPQVMLD PDEPMSLGTF TDPDYYMEAR YEVEKAMERS RKIIERACRE 250 260 270 280 290 300 FSEMFGREYG LVEEYRCEDA EIILVAMGSV CSTLREVIDE LRDKGKAVGL LKVRVHRPFP 310 320 330 340 350 360 AEEIKSAVRN ASKVAVLDKN ITFSVGGALY TEISALLRDR EVYGFIVGLG GRDITPAHIE 370 380 EIVRRTENPE RSVTWIGLKE ESE

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000666 Genomic DNA. Translation: AAB86209.1.
PIR	E69099.
RefSeq	NP_276849.1.
3D structure databases
HSSP	HSSP built from PDB template 1KEK based on UniProtKB P94692.
ModBase	Search...
Protein-protein interaction databases
STRING	P56810.
Genome annotation databases
GeneID	1470824.
GenomeReviews	Gene locus MTH_1739 in contig AE000666_GR.
KEGG	mth:MTH1739.
NMPDR	fig|187420.1.peg.1704.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P56810.
OMA	DAGWLQI.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH1739-MON.
BRENDA	1.2.7.1. 270.
Family and domain databases
InterPro	IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N. IPR015941. Transketolase-like_C. IPR005476. Transketolase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF01855. POR_N. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PORA_METTH

Accession

Primary (citable) accession number: P56810

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)