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P56750 (CLD17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Claudin-17
Gene names
Name:CLDN17
ORF Names:UNQ758/PRO1489
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

Subcellular location

Cell junctiontight junction. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the claudin family.

Sequence caution

The sequence AAQ88461.1 differs from that shown. Reason: Frameshift at position 31.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Claudin-17
PRO_0000144777

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821Helical; Potential
Topological domain29 – 8153Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 12422Cytoplasmic Potential
Transmembrane125 – 14521Helical; Potential
Topological domain146 – 16419Extracellular Potential
Transmembrane165 – 18521Helical; Potential
Topological domain186 – 22439Cytoplasmic Potential

Natural variations

Natural variant821A → T.
Corresponds to variant rs35531957 [ dbSNP | Ensembl ].
VAR_033774

Sequences

Sequence LengthMass (Da)Tools
P56750 [UniParc].

Last modified May 30, 2000. Version 1.
Checksum: 1833ED3178B7F63A

FASTA22424,603
        10         20         30         40         50         60 
MAFYPLQIAG LVLGFLGMVG TLATTLLPQW RVSAFVGSNI IVFERLWEGL WMNCIRQARV 

        70         80         90        100        110        120 
RLQCKFYSSL LALPPALETA RALMCVAVAL SLIALLIGIC GMKQVQCTGS NERAKAYLLG 

       130        140        150        160        170        180 
TSGVLFILTG IFVLIPVSWT ANIIIRDFYN PAIHIGQKRE LGAALFLGWA SAAVLFIGGG 

       190        200        210        220 
LLCGFCCCNR KKQGYRYPVP GYRVPHTDKR RNTTMLSKTS TSYV 

« Hide

References

« Hide 'large scale' references
[1]Keen T.J., Inglehearn C.F.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250712 Genomic DNA. Translation: CAB60616.1.
AY358094 mRNA. Translation: AAQ88461.1. Frameshift.
AP001707 Genomic DNA. Translation: BAA95566.1.
BC101503 mRNA. Translation: AAI01504.1.
BC101505 mRNA. Translation: AAI01506.1.
RefSeqNP_036263.1. NM_012131.2.
UniGeneHs.258589.

3D structure databases

ProteinModelPortalP56750.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117667. 1 interaction.
STRING9606.ENSP00000286808.

PTM databases

PhosphoSiteP56750.

Polymorphism databases

DMDM6685309.

Proteomic databases

PRIDEP56750.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000286808; ENSP00000286808; ENSG00000156282.
GeneID26285.
KEGGhsa:26285.
UCSCuc011acv.2. human.

Organism-specific databases

CTD26285.
GeneCardsGC21M031537.
HGNCHGNC:2038. CLDN17.
HPACAB034279.
neXtProtNX_P56750.
PharmGKBPA26564.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39944.
HOGENOMHOG000220937.
HOVERGENHBG000643.
InParanoidP56750.
KOK06087.
OMAARALMCV.
OrthoDBEOG76HQ2T.
PhylomeDBP56750.
TreeFamTF331936.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

BgeeP56750.
CleanExHS_CLDN17.
GenevestigatorP56750.

Family and domain databases

InterProIPR006187. Claudin.
IPR003556. Claudin14.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PR01385. CLAUDIN14.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCLDN17.
GenomeRNAi26285.
NextBio48613.
PROP56750.

Entry information

Entry nameCLD17_HUMAN
AccessionPrimary (citable) accession number: P56750
Secondary accession number(s): Q3MJB5, Q6UY37
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM