Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P56750

- CLD17_HUMAN

UniProt

P56750 - CLD17_HUMAN

Protein

Claudin-17

Gene

CLDN17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (30 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB
    2. cell-cell junction organization Source: Reactome
    3. cell junction assembly Source: Reactome
    4. tight junction assembly Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-17
    Gene namesi
    Name:CLDN17
    ORF Names:UNQ758/PRO1489
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:2038. CLDN17.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB
    3. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26564.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Claudin-17PRO_0000144777Add
    BLAST

    Proteomic databases

    PRIDEiP56750.

    PTM databases

    PhosphoSiteiP56750.

    Expressioni

    Gene expression databases

    BgeeiP56750.
    CleanExiHS_CLDN17.
    GenevestigatoriP56750.

    Organism-specific databases

    HPAiCAB034279.

    Interactioni

    Protein-protein interaction databases

    BioGridi117667. 1 interaction.
    STRINGi9606.ENSP00000286808.

    Structurei

    3D structure databases

    ProteinModelPortaliP56750.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini29 – 8153ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 12422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini146 – 16419ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini186 – 22439CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39944.
    HOGENOMiHOG000220937.
    HOVERGENiHBG000643.
    InParanoidiP56750.
    KOiK06087.
    OMAiARALMCV.
    OrthoDBiEOG76HQ2T.
    PhylomeDBiP56750.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003556. Claudin14.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01385. CLAUDIN14.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56750-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFYPLQIAG LVLGFLGMVG TLATTLLPQW RVSAFVGSNI IVFERLWEGL    50
    WMNCIRQARV RLQCKFYSSL LALPPALETA RALMCVAVAL SLIALLIGIC 100
    GMKQVQCTGS NERAKAYLLG TSGVLFILTG IFVLIPVSWT ANIIIRDFYN 150
    PAIHIGQKRE LGAALFLGWA SAAVLFIGGG LLCGFCCCNR KKQGYRYPVP 200
    GYRVPHTDKR RNTTMLSKTS TSYV 224
    Length:224
    Mass (Da):24,603
    Last modified:May 30, 2000 - v1
    Checksum:i1833ED3178B7F63A
    GO

    Sequence cautioni

    The sequence AAQ88461.1 differs from that shown. Reason: Frameshift at position 31.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821A → T.
    Corresponds to variant rs35531957 [ dbSNP | Ensembl ].
    VAR_033774

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250712 Genomic DNA. Translation: CAB60616.1.
    AY358094 mRNA. Translation: AAQ88461.1. Frameshift.
    AP001707 Genomic DNA. Translation: BAA95566.1.
    BC101503 mRNA. Translation: AAI01504.1.
    BC101505 mRNA. Translation: AAI01506.1.
    CCDSiCCDS13586.1.
    RefSeqiNP_036263.1. NM_012131.2.
    UniGeneiHs.258589.

    Genome annotation databases

    EnsembliENST00000286808; ENSP00000286808; ENSG00000156282.
    GeneIDi26285.
    KEGGihsa:26285.
    UCSCiuc011acv.2. human.

    Polymorphism databases

    DMDMi6685309.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250712 Genomic DNA. Translation: CAB60616.1 .
    AY358094 mRNA. Translation: AAQ88461.1 . Frameshift.
    AP001707 Genomic DNA. Translation: BAA95566.1 .
    BC101503 mRNA. Translation: AAI01504.1 .
    BC101505 mRNA. Translation: AAI01506.1 .
    CCDSi CCDS13586.1.
    RefSeqi NP_036263.1. NM_012131.2.
    UniGenei Hs.258589.

    3D structure databases

    ProteinModelPortali P56750.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117667. 1 interaction.
    STRINGi 9606.ENSP00000286808.

    PTM databases

    PhosphoSitei P56750.

    Polymorphism databases

    DMDMi 6685309.

    Proteomic databases

    PRIDEi P56750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286808 ; ENSP00000286808 ; ENSG00000156282 .
    GeneIDi 26285.
    KEGGi hsa:26285.
    UCSCi uc011acv.2. human.

    Organism-specific databases

    CTDi 26285.
    GeneCardsi GC21M031537.
    HGNCi HGNC:2038. CLDN17.
    HPAi CAB034279.
    neXtProti NX_P56750.
    PharmGKBi PA26564.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39944.
    HOGENOMi HOG000220937.
    HOVERGENi HBG000643.
    InParanoidi P56750.
    KOi K06087.
    OMAi ARALMCV.
    OrthoDBi EOG76HQ2T.
    PhylomeDBi P56750.
    TreeFami TF331936.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    GeneWikii CLDN17.
    GenomeRNAii 26285.
    NextBioi 48613.
    PROi P56750.

    Gene expression databases

    Bgeei P56750.
    CleanExi HS_CLDN17.
    Genevestigatori P56750.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003556. Claudin14.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01385. CLAUDIN14.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Keen T.J., Inglehearn C.F.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCLD17_HUMAN
    AccessioniPrimary (citable) accession number: P56750
    Secondary accession number(s): Q3MJB5, Q6UY37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3