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Protein

Claudin-17

Gene

CLDN17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  2. cell-cell junction organization Source: Reactome
  3. cell junction assembly Source: Reactome
  4. tight junction assembly Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-17
Gene namesi
Name:CLDN17
ORF Names:UNQ758/PRO1489
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:2038. CLDN17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence Analysis
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Topological domaini29 – 8153ExtracellularSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 12422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Topological domaini146 – 16419ExtracellularSequence AnalysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Topological domaini186 – 22439CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
  3. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Claudin-17PRO_0000144777Add
BLAST

Proteomic databases

PRIDEiP56750.

PTM databases

PhosphoSiteiP56750.

Expressioni

Gene expression databases

BgeeiP56750.
CleanExiHS_CLDN17.
GenevestigatoriP56750.

Interactioni

Protein-protein interaction databases

BioGridi117667. 1 interaction.
STRINGi9606.ENSP00000286808.

Structurei

3D structure databases

ProteinModelPortaliP56750.
SMRiP56750. Positions 30-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39944.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56750.
KOiK06087.
OMAiWTANIII.
OrthoDBiEOG76HQ2T.
PhylomeDBiP56750.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFYPLQIAG LVLGFLGMVG TLATTLLPQW RVSAFVGSNI IVFERLWEGL
60 70 80 90 100
WMNCIRQARV RLQCKFYSSL LALPPALETA RALMCVAVAL SLIALLIGIC
110 120 130 140 150
GMKQVQCTGS NERAKAYLLG TSGVLFILTG IFVLIPVSWT ANIIIRDFYN
160 170 180 190 200
PAIHIGQKRE LGAALFLGWA SAAVLFIGGG LLCGFCCCNR KKQGYRYPVP
210 220
GYRVPHTDKR RNTTMLSKTS TSYV
Length:224
Mass (Da):24,603
Last modified:May 30, 2000 - v1
Checksum:i1833ED3178B7F63A
GO

Sequence cautioni

The sequence AAQ88461.1 differs from that shown. Reason: Frameshift at position 31. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821A → T.
Corresponds to variant rs35531957 [ dbSNP | Ensembl ].
VAR_033774

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250712 Genomic DNA. Translation: CAB60616.1.
AY358094 mRNA. Translation: AAQ88461.1. Frameshift.
AP001707 Genomic DNA. Translation: BAA95566.1.
BC101503 mRNA. Translation: AAI01504.1.
BC101505 mRNA. Translation: AAI01506.1.
CCDSiCCDS13586.1.
RefSeqiNP_036263.1. NM_012131.2.
UniGeneiHs.258589.

Genome annotation databases

EnsembliENST00000286808; ENSP00000286808; ENSG00000156282.
GeneIDi26285.
KEGGihsa:26285.
UCSCiuc011acv.2. human.

Polymorphism databases

DMDMi6685309.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250712 Genomic DNA. Translation: CAB60616.1.
AY358094 mRNA. Translation: AAQ88461.1. Frameshift.
AP001707 Genomic DNA. Translation: BAA95566.1.
BC101503 mRNA. Translation: AAI01504.1.
BC101505 mRNA. Translation: AAI01506.1.
CCDSiCCDS13586.1.
RefSeqiNP_036263.1. NM_012131.2.
UniGeneiHs.258589.

3D structure databases

ProteinModelPortaliP56750.
SMRiP56750. Positions 30-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117667. 1 interaction.
STRINGi9606.ENSP00000286808.

PTM databases

PhosphoSiteiP56750.

Polymorphism databases

DMDMi6685309.

Proteomic databases

PRIDEiP56750.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286808; ENSP00000286808; ENSG00000156282.
GeneIDi26285.
KEGGihsa:26285.
UCSCiuc011acv.2. human.

Organism-specific databases

CTDi26285.
GeneCardsiGC21M031537.
HGNCiHGNC:2038. CLDN17.
neXtProtiNX_P56750.
PharmGKBiPA26564.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39944.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56750.
KOiK06087.
OMAiWTANIII.
OrthoDBiEOG76HQ2T.
PhylomeDBiP56750.
TreeFamiTF331936.

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN17.
GenomeRNAii26285.
NextBioi48613.
PROiP56750.

Gene expression databases

BgeeiP56750.
CleanExiHS_CLDN17.
GenevestigatoriP56750.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Keen T.J., Inglehearn C.F.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCLD17_HUMAN
AccessioniPrimary (citable) accession number: P56750
Secondary accession number(s): Q3MJB5, Q6UY37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: March 4, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.