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Protein

Claudin-12

Gene

CLDN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157224-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-12
Gene namesi
Name:CLDN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:2034. CLDN12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 87ExtracellularSequence analysisAdd BLAST56
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 135CytoplasmicSequence analysisAdd BLAST27
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 174ExtracellularSequence analysisAdd BLAST18
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 244CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi9069.
OpenTargetsiENSG00000157224.
PharmGKBiPA26560.

Polymorphism and mutation databases

BioMutaiCLDN12.
DMDMi6685308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447651 – 244Claudin-12Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei228PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP56749.
MaxQBiP56749.
PaxDbiP56749.
PeptideAtlasiP56749.
PRIDEiP56749.

PTM databases

iPTMnetiP56749.
PhosphoSitePlusiP56749.

Expressioni

Gene expression databases

BgeeiENSG00000157224.
CleanExiHS_CLDN12.
ExpressionAtlasiP56749. baseline and differential.
GenevisibleiP56749. HS.

Organism-specific databases

HPAiHPA026945.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114527. 5 interactors.
IntActiP56749. 3 interactors.
MINTiMINT-1396055.
STRINGi9606.ENSP00000287916.

Structurei

3D structure databases

ProteinModelPortaliP56749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE44. Eukaryota.
ENOG410ZR1K. LUCA.
GeneTreeiENSGT00400000022250.
HOGENOMiHOG000036050.
HOVERGENiHBG050986.
InParanoidiP56749.
OMAiFYNTHLN.
OrthoDBiEOG091G0E18.
PhylomeDBiP56749.
TreeFamiTF331972.

Family and domain databases

InterProiIPR013287. Claudin12.
IPR017974. Claudin_CS.
[Graphical view]
PRINTSiPR01872. CLAUDIN12.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCRDVHAAT VLSFLCGIAS VAGLFAGTLL PNWRKLRLIT FNRNEKNLTV
60 70 80 90 100
YTGLWVKCAR YDGSSDCLMY DTTWYSSVDQ LDLRVLQFAL PLSMLIAMGA
110 120 130 140 150
LLLCLIGMCN TAFRSSVPNI KLAKCLVNSA GCHLVAGLLF FLAGTVSLSP
160 170 180 190 200
SIWVIFYNIH LNKKFEPVFS FDYAVYVTIA SAGGLFMTSL ILFIWYCTCK
210 220 230 240
SLPSPFWQPL YSHPPSMHTY SQPYSARSRL SAIEIDIPVV SHTT
Length:244
Mass (Da):27,110
Last modified:May 30, 2000 - v1
Checksum:i0547A9D76392CB5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250713 Genomic DNA. Translation: CAB60617.1.
AL136770 mRNA. Translation: CAB66704.1.
AC006153 Genomic DNA. Translation: AAP22363.1.
CH236949 Genomic DNA. Translation: EAL24163.1.
CH471091 Genomic DNA. Translation: EAW76876.1.
CH471091 Genomic DNA. Translation: EAW76877.1.
BC036754 mRNA. Translation: AAH36754.1.
BC068532 mRNA. Translation: AAH68532.1.
CCDSiCCDS5618.1.
RefSeqiNP_001172001.1. NM_001185072.2.
NP_001172002.1. NM_001185073.2.
NP_036261.1. NM_012129.4.
UniGeneiHs.731917.

Genome annotation databases

EnsembliENST00000287916; ENSP00000287916; ENSG00000157224.
ENST00000394605; ENSP00000378103; ENSG00000157224.
ENST00000496677; ENSP00000419053; ENSG00000157224.
GeneIDi9069.
KEGGihsa:9069.
UCSCiuc003ukr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250713 Genomic DNA. Translation: CAB60617.1.
AL136770 mRNA. Translation: CAB66704.1.
AC006153 Genomic DNA. Translation: AAP22363.1.
CH236949 Genomic DNA. Translation: EAL24163.1.
CH471091 Genomic DNA. Translation: EAW76876.1.
CH471091 Genomic DNA. Translation: EAW76877.1.
BC036754 mRNA. Translation: AAH36754.1.
BC068532 mRNA. Translation: AAH68532.1.
CCDSiCCDS5618.1.
RefSeqiNP_001172001.1. NM_001185072.2.
NP_001172002.1. NM_001185073.2.
NP_036261.1. NM_012129.4.
UniGeneiHs.731917.

3D structure databases

ProteinModelPortaliP56749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114527. 5 interactors.
IntActiP56749. 3 interactors.
MINTiMINT-1396055.
STRINGi9606.ENSP00000287916.

PTM databases

iPTMnetiP56749.
PhosphoSitePlusiP56749.

Polymorphism and mutation databases

BioMutaiCLDN12.
DMDMi6685308.

Proteomic databases

EPDiP56749.
MaxQBiP56749.
PaxDbiP56749.
PeptideAtlasiP56749.
PRIDEiP56749.

Protocols and materials databases

DNASUi9069.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287916; ENSP00000287916; ENSG00000157224.
ENST00000394605; ENSP00000378103; ENSG00000157224.
ENST00000496677; ENSP00000419053; ENSG00000157224.
GeneIDi9069.
KEGGihsa:9069.
UCSCiuc003ukr.4. human.

Organism-specific databases

CTDi9069.
DisGeNETi9069.
GeneCardsiCLDN12.
HGNCiHGNC:2034. CLDN12.
HPAiHPA026945.
MIMi611232. gene.
neXtProtiNX_P56749.
OpenTargetsiENSG00000157224.
PharmGKBiPA26560.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE44. Eukaryota.
ENOG410ZR1K. LUCA.
GeneTreeiENSGT00400000022250.
HOGENOMiHOG000036050.
HOVERGENiHBG050986.
InParanoidiP56749.
OMAiFYNTHLN.
OrthoDBiEOG091G0E18.
PhylomeDBiP56749.
TreeFamiTF331972.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157224-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN12.
GenomeRNAii9069.
PROiP56749.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157224.
CleanExiHS_CLDN12.
ExpressionAtlasiP56749. baseline and differential.
GenevisibleiP56749. HS.

Family and domain databases

InterProiIPR013287. Claudin12.
IPR017974. Claudin_CS.
[Graphical view]
PRINTSiPR01872. CLAUDIN12.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD12_HUMAN
AccessioniPrimary (citable) accession number: P56749
Secondary accession number(s): D6W5Q4, Q7LDZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.