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Protein

Claudin-12

Gene

CLDN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-12
Gene namesi
Name:CLDN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:2034. CLDN12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Topological domaini32 – 8756ExtracellularSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Topological domaini109 – 13527CytoplasmicSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST
Topological domaini157 – 17418ExtracellularSequence analysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Topological domaini196 – 24449CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26560.

Polymorphism and mutation databases

BioMutaiCLDN12.
DMDMi6685308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Claudin-12PRO_0000144765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP56749.
PaxDbiP56749.
PRIDEiP56749.

PTM databases

iPTMnetiP56749.
PhosphoSiteiP56749.

Expressioni

Gene expression databases

BgeeiP56749.
CleanExiHS_CLDN12.
ExpressionAtlasiP56749. baseline and differential.
GenevisibleiP56749. HS.

Organism-specific databases

HPAiHPA026945.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114527. 5 interactions.
IntActiP56749. 3 interactions.
MINTiMINT-1396055.
STRINGi9606.ENSP00000287916.

Structurei

3D structure databases

ProteinModelPortaliP56749.
SMRiP56749. Positions 7-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE44. Eukaryota.
ENOG410ZR1K. LUCA.
GeneTreeiENSGT00400000022250.
HOGENOMiHOG000036050.
HOVERGENiHBG050986.
InParanoidiP56749.
OMAiFYNTHLN.
OrthoDBiEOG7ZSHTQ.
PhylomeDBiP56749.
TreeFamiTF331972.

Family and domain databases

InterProiIPR013287. Claudin12.
IPR017974. Claudin_CS.
[Graphical view]
PRINTSiPR01872. CLAUDIN12.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCRDVHAAT VLSFLCGIAS VAGLFAGTLL PNWRKLRLIT FNRNEKNLTV
60 70 80 90 100
YTGLWVKCAR YDGSSDCLMY DTTWYSSVDQ LDLRVLQFAL PLSMLIAMGA
110 120 130 140 150
LLLCLIGMCN TAFRSSVPNI KLAKCLVNSA GCHLVAGLLF FLAGTVSLSP
160 170 180 190 200
SIWVIFYNIH LNKKFEPVFS FDYAVYVTIA SAGGLFMTSL ILFIWYCTCK
210 220 230 240
SLPSPFWQPL YSHPPSMHTY SQPYSARSRL SAIEIDIPVV SHTT
Length:244
Mass (Da):27,110
Last modified:May 30, 2000 - v1
Checksum:i0547A9D76392CB5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250713 Genomic DNA. Translation: CAB60617.1.
AL136770 mRNA. Translation: CAB66704.1.
AC006153 Genomic DNA. Translation: AAP22363.1.
CH236949 Genomic DNA. Translation: EAL24163.1.
CH471091 Genomic DNA. Translation: EAW76876.1.
CH471091 Genomic DNA. Translation: EAW76877.1.
BC036754 mRNA. Translation: AAH36754.1.
BC068532 mRNA. Translation: AAH68532.1.
CCDSiCCDS5618.1.
RefSeqiNP_001172001.1. NM_001185072.2.
NP_001172002.1. NM_001185073.2.
NP_036261.1. NM_012129.4.
UniGeneiHs.731917.

Genome annotation databases

EnsembliENST00000287916; ENSP00000287916; ENSG00000157224.
ENST00000394605; ENSP00000378103; ENSG00000157224.
ENST00000496677; ENSP00000419053; ENSG00000157224.
GeneIDi9069.
KEGGihsa:9069.
UCSCiuc003ukr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250713 Genomic DNA. Translation: CAB60617.1.
AL136770 mRNA. Translation: CAB66704.1.
AC006153 Genomic DNA. Translation: AAP22363.1.
CH236949 Genomic DNA. Translation: EAL24163.1.
CH471091 Genomic DNA. Translation: EAW76876.1.
CH471091 Genomic DNA. Translation: EAW76877.1.
BC036754 mRNA. Translation: AAH36754.1.
BC068532 mRNA. Translation: AAH68532.1.
CCDSiCCDS5618.1.
RefSeqiNP_001172001.1. NM_001185072.2.
NP_001172002.1. NM_001185073.2.
NP_036261.1. NM_012129.4.
UniGeneiHs.731917.

3D structure databases

ProteinModelPortaliP56749.
SMRiP56749. Positions 7-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114527. 5 interactions.
IntActiP56749. 3 interactions.
MINTiMINT-1396055.
STRINGi9606.ENSP00000287916.

PTM databases

iPTMnetiP56749.
PhosphoSiteiP56749.

Polymorphism and mutation databases

BioMutaiCLDN12.
DMDMi6685308.

Proteomic databases

MaxQBiP56749.
PaxDbiP56749.
PRIDEiP56749.

Protocols and materials databases

DNASUi9069.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287916; ENSP00000287916; ENSG00000157224.
ENST00000394605; ENSP00000378103; ENSG00000157224.
ENST00000496677; ENSP00000419053; ENSG00000157224.
GeneIDi9069.
KEGGihsa:9069.
UCSCiuc003ukr.4. human.

Organism-specific databases

CTDi9069.
GeneCardsiCLDN12.
HGNCiHGNC:2034. CLDN12.
HPAiHPA026945.
MIMi611232. gene.
neXtProtiNX_P56749.
PharmGKBiPA26560.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE44. Eukaryota.
ENOG410ZR1K. LUCA.
GeneTreeiENSGT00400000022250.
HOGENOMiHOG000036050.
HOVERGENiHBG050986.
InParanoidiP56749.
OMAiFYNTHLN.
OrthoDBiEOG7ZSHTQ.
PhylomeDBiP56749.
TreeFamiTF331972.

Enzyme and pathway databases

ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN12.
GenomeRNAii9069.
NextBioi33981.
PROiP56749.
SOURCEiSearch...

Gene expression databases

BgeeiP56749.
CleanExiHS_CLDN12.
ExpressionAtlasiP56749. baseline and differential.
GenevisibleiP56749. HS.

Family and domain databases

InterProiIPR013287. Claudin12.
IPR017974. Claudin_CS.
[Graphical view]
PRINTSiPR01872. CLAUDIN12.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Keen T.J., Inglehearn C.F.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCLD12_HUMAN
AccessioniPrimary (citable) accession number: P56749
Secondary accession number(s): D6W5Q4, Q7LDZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: March 16, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.