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Protein

Claudin-8

Gene

CLDN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156284-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Protein family/group databases

TCDBi1.H.1.1.7. the claudin tight junction (claudin1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-8
Gene namesi
Name:CLDN8
ORF Names:UNQ779/PRO1573
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:2050. CLDN8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 117CytoplasmicSequence analysisAdd BLAST15
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 166ExtracellularSequence analysisAdd BLAST28
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 225CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

  • apicolateral plasma membrane Source: Ensembl
  • basolateral plasma membrane Source: Ensembl
  • bicellular tight junction Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi9073.
OpenTargetsiENSG00000156284.
PharmGKBiPA26576.

Polymorphism and mutation databases

BioMutaiCLDN8.
DMDMi6685307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447531 – 225Claudin-8Add BLAST225

Proteomic databases

PaxDbiP56748.
PeptideAtlasiP56748.
PRIDEiP56748.

PTM databases

iPTMnetiP56748.
PhosphoSitePlusiP56748.

Expressioni

Tissue specificityi

Expressed in the epididymis, mainly in the caput segment.1 Publication

Gene expression databases

BgeeiENSG00000156284.
CleanExiHS_CLDN8.
ExpressionAtlasiP56748. baseline and differential.
GenevisibleiP56748. HS.

Organism-specific databases

HPAiHPA060605.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-10215641,EBI-749265
SYNE4Q8N2053EBI-10215641,EBI-7131783

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114530. 4 interactors.
IntActiP56748. 3 interactors.
STRINGi9606.ENSP00000286809.

Structurei

3D structure databases

ProteinModelPortaliP56748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 225Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJK4. Eukaryota.
ENOG410YQQY. LUCA.
GeneTreeiENSGT00760000118928.
HOVERGENiHBG000643.
InParanoidiP56748.
KOiK06087.
OMAiKCTRCTG.
OrthoDBiEOG091G0MX2.
PhylomeDBiP56748.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003926. Claudin8.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF24. PTHR12002:SF24. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATHALEIAG LFLGGVGMVG TVAVTVMPQW RVSAFIENNI VVFENFWEGL
60 70 80 90 100
WMNCVRQANI RMQCKIYDSL LALSPDLQAA RGLMCAASVM SFLAFMMAIL
110 120 130 140 150
GMKCTRCTGD NEKVKAHILL TAGIIFIITG MVVLIPVSWV ANAIIRDFYN
160 170 180 190 200
SIVNVAQKRE LGEALYLGWT TALVLIVGGA LFCCVFCCNE KSSSYRYSIP
210 220
SHRTTQKSYH TGKKSPSVYS RSQYV
Length:225
Mass (Da):24,845
Last modified:May 30, 2000 - v1
Checksum:iF7920E8E71682473
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170T → A in BAD97232 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04873925T → A.Corresponds to variant rs1557294dbSNPEnsembl.1
Natural variantiVAR_024417129T → A.Corresponds to variant rs685967dbSNPEnsembl.1
Natural variantiVAR_020387151S → P.1 PublicationCorresponds to variant rs686364dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250711 Genomic DNA. Translation: CAB60615.1.
AY358707 mRNA. Translation: AAQ89070.1.
AK223512 mRNA. Translation: BAD97232.1.
AP001707 Genomic DNA. Translation: BAA95567.1.
CH471079 Genomic DNA. Translation: EAX09901.1.
CH471079 Genomic DNA. Translation: EAX09902.1.
BC020866 mRNA. Translation: AAH20866.1.
BC058004 mRNA. Translation: AAH58004.1.
CCDSiCCDS13587.1.
RefSeqiNP_955360.1. NM_199328.2.
UniGeneiHs.162209.

Genome annotation databases

EnsembliENST00000399899; ENSP00000382783; ENSG00000156284.
GeneIDi9073.
KEGGihsa:9073.
UCSCiuc002ynu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250711 Genomic DNA. Translation: CAB60615.1.
AY358707 mRNA. Translation: AAQ89070.1.
AK223512 mRNA. Translation: BAD97232.1.
AP001707 Genomic DNA. Translation: BAA95567.1.
CH471079 Genomic DNA. Translation: EAX09901.1.
CH471079 Genomic DNA. Translation: EAX09902.1.
BC020866 mRNA. Translation: AAH20866.1.
BC058004 mRNA. Translation: AAH58004.1.
CCDSiCCDS13587.1.
RefSeqiNP_955360.1. NM_199328.2.
UniGeneiHs.162209.

3D structure databases

ProteinModelPortaliP56748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114530. 4 interactors.
IntActiP56748. 3 interactors.
STRINGi9606.ENSP00000286809.

Protein family/group databases

TCDBi1.H.1.1.7. the claudin tight junction (claudin1) family.

PTM databases

iPTMnetiP56748.
PhosphoSitePlusiP56748.

Polymorphism and mutation databases

BioMutaiCLDN8.
DMDMi6685307.

Proteomic databases

PaxDbiP56748.
PeptideAtlasiP56748.
PRIDEiP56748.

Protocols and materials databases

DNASUi9073.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399899; ENSP00000382783; ENSG00000156284.
GeneIDi9073.
KEGGihsa:9073.
UCSCiuc002ynu.3. human.

Organism-specific databases

CTDi9073.
DisGeNETi9073.
GeneCardsiCLDN8.
HGNCiHGNC:2050. CLDN8.
HPAiHPA060605.
MIMi611231. gene.
neXtProtiNX_P56748.
OpenTargetsiENSG00000156284.
PharmGKBiPA26576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJK4. Eukaryota.
ENOG410YQQY. LUCA.
GeneTreeiENSGT00760000118928.
HOVERGENiHBG000643.
InParanoidiP56748.
KOiK06087.
OMAiKCTRCTG.
OrthoDBiEOG091G0MX2.
PhylomeDBiP56748.
TreeFamiTF331936.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156284-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN8.
GenomeRNAii9073.
PROiP56748.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156284.
CleanExiHS_CLDN8.
ExpressionAtlasiP56748. baseline and differential.
GenevisibleiP56748. HS.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003926. Claudin8.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF24. PTHR12002:SF24. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD8_HUMAN
AccessioniPrimary (citable) accession number: P56748
Secondary accession number(s): D3DSE3, Q53EX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.