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P56748

- CLD8_HUMAN

UniProt

P56748 - CLD8_HUMAN

Protein

Claudin-8

Gene

CLDN8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (30 May 2000)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Protein family/group databases

    TCDBi1.H.1.1.7. the claudin tight junction (claudin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-8
    Gene namesi
    Name:CLDN8
    ORF Names:UNQ779/PRO1573
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:2050. CLDN8.

    Subcellular locationi

    Cell junctiontight junction. Cell membrane; Multi-pass membrane protein
    Note: Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB
    4. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26576.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225Claudin-8PRO_0000144753Add
    BLAST

    Proteomic databases

    PaxDbiP56748.
    PRIDEiP56748.

    PTM databases

    PhosphoSiteiP56748.

    Expressioni

    Tissue specificityi

    Expressed in the epididymis, mainly in the caput segment.1 Publication

    Gene expression databases

    BgeeiP56748.
    CleanExiHS_CLDN8.
    GenevestigatoriP56748.

    Organism-specific databases

    HPAiHPA060605.

    Interactioni

    Subunit structurei

    Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.By similarity

    Protein-protein interaction databases

    BioGridi114530. 1 interaction.
    STRINGi9606.ENSP00000286809.

    Structurei

    3D structure databases

    ProteinModelPortaliP56748.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini29 – 8153ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini139 – 16628ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini188 – 22538CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni224 – 2252Interactions with TJP1, TJP2 and TJP3By similarity

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40590.
    HOVERGENiHBG000643.
    InParanoidiP56748.
    KOiK06087.
    OMAiKCTRCTG.
    OrthoDBiEOG76HQ2T.
    PhylomeDBiP56748.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003926. Claudin8.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01446. CLAUDIN8.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56748-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATHALEIAG LFLGGVGMVG TVAVTVMPQW RVSAFIENNI VVFENFWEGL    50
    WMNCVRQANI RMQCKIYDSL LALSPDLQAA RGLMCAASVM SFLAFMMAIL 100
    GMKCTRCTGD NEKVKAHILL TAGIIFIITG MVVLIPVSWV ANAIIRDFYN 150
    SIVNVAQKRE LGEALYLGWT TALVLIVGGA LFCCVFCCNE KSSSYRYSIP 200
    SHRTTQKSYH TGKKSPSVYS RSQYV 225
    Length:225
    Mass (Da):24,845
    Last modified:May 30, 2000 - v1
    Checksum:iF7920E8E71682473
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti170 – 1701T → A in BAD97232. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251T → A.
    Corresponds to variant rs1557294 [ dbSNP | Ensembl ].
    VAR_048739
    Natural varianti129 – 1291T → A.
    Corresponds to variant rs685967 [ dbSNP | Ensembl ].
    VAR_024417
    Natural varianti151 – 1511S → P.1 Publication
    Corresponds to variant rs686364 [ dbSNP | Ensembl ].
    VAR_020387

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250711 Genomic DNA. Translation: CAB60615.1.
    AY358707 mRNA. Translation: AAQ89070.1.
    AK223512 mRNA. Translation: BAD97232.1.
    AP001707 Genomic DNA. Translation: BAA95567.1.
    CH471079 Genomic DNA. Translation: EAX09901.1.
    CH471079 Genomic DNA. Translation: EAX09902.1.
    BC020866 mRNA. Translation: AAH20866.1.
    BC058004 mRNA. Translation: AAH58004.1.
    CCDSiCCDS13587.1.
    RefSeqiNP_955360.1. NM_199328.2.
    UniGeneiHs.162209.

    Genome annotation databases

    EnsembliENST00000399899; ENSP00000382783; ENSG00000156284.
    GeneIDi9073.
    KEGGihsa:9073.
    UCSCiuc002ynu.2. human.

    Polymorphism databases

    DMDMi6685307.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250711 Genomic DNA. Translation: CAB60615.1 .
    AY358707 mRNA. Translation: AAQ89070.1 .
    AK223512 mRNA. Translation: BAD97232.1 .
    AP001707 Genomic DNA. Translation: BAA95567.1 .
    CH471079 Genomic DNA. Translation: EAX09901.1 .
    CH471079 Genomic DNA. Translation: EAX09902.1 .
    BC020866 mRNA. Translation: AAH20866.1 .
    BC058004 mRNA. Translation: AAH58004.1 .
    CCDSi CCDS13587.1.
    RefSeqi NP_955360.1. NM_199328.2.
    UniGenei Hs.162209.

    3D structure databases

    ProteinModelPortali P56748.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114530. 1 interaction.
    STRINGi 9606.ENSP00000286809.

    Protein family/group databases

    TCDBi 1.H.1.1.7. the claudin tight junction (claudin) family.

    PTM databases

    PhosphoSitei P56748.

    Polymorphism databases

    DMDMi 6685307.

    Proteomic databases

    PaxDbi P56748.
    PRIDEi P56748.

    Protocols and materials databases

    DNASUi 9073.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399899 ; ENSP00000382783 ; ENSG00000156284 .
    GeneIDi 9073.
    KEGGi hsa:9073.
    UCSCi uc002ynu.2. human.

    Organism-specific databases

    CTDi 9073.
    GeneCardsi GC21M031586.
    HGNCi HGNC:2050. CLDN8.
    HPAi HPA060605.
    MIMi 611231. gene.
    neXtProti NX_P56748.
    PharmGKBi PA26576.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40590.
    HOVERGENi HBG000643.
    InParanoidi P56748.
    KOi K06087.
    OMAi KCTRCTG.
    OrthoDBi EOG76HQ2T.
    PhylomeDBi P56748.
    TreeFami TF331936.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    GeneWikii CLDN8.
    GenomeRNAii 9073.
    NextBioi 33997.
    PROi P56748.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56748.
    CleanExi HS_CLDN8.
    Genevestigatori P56748.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003926. Claudin8.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01446. CLAUDIN8.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Keen T.J., Inglehearn C.F.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-151.
      Tissue: Colon.
    4. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    7. "Gene expression profiling and its relevance to the blood-epididymal barrier in the human epididymis."
      Dube E., Chan P.T.K., Hermo L., Cyr D.G.
      Biol. Reprod. 76:1034-1044(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. Cited for: MISCELLANEOUS.

    Entry informationi

    Entry nameiCLD8_HUMAN
    AccessioniPrimary (citable) accession number: P56748
    Secondary accession number(s): D3DSE3, Q53EX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3