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P56747

- CLD6_HUMAN

UniProt

P56747 - CLD6_HUMAN

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Protein

Claudin-6

Gene
CLDN6, UNQ757/PRO1488
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space By similarity. May act as a coreceptor for HCV entry into hepatic cells.

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. calcium-independent cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-6
Alternative name(s):
Skullin
Gene namesi
Name:CLDN6
ORF Names:UNQ757/PRO1488
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:2048. CLDN6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2821Helical; Reviewed predictionAdd
BLAST
Topological domaini29 – 8153Extracellular Reviewed predictionAdd
BLAST
Transmembranei82 – 10221Helical; Reviewed predictionAdd
BLAST
Topological domaini103 – 11614Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei117 – 13721Helical; Reviewed predictionAdd
BLAST
Topological domaini138 – 16023Extracellular Reviewed predictionAdd
BLAST
Transmembranei161 – 18121Helical; Reviewed predictionAdd
BLAST
Topological domaini182 – 22039Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26574.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Claudin-6PRO_0000144748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011Phosphoserine1 Publication
Modified residuei203 – 2031Phosphoserine1 Publication
Modified residuei208 – 2081Phosphoserine1 Publication
Modified residuei212 – 2121Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP56747.
PaxDbiP56747.
PRIDEiP56747.

PTM databases

PhosphoSiteiP56747.

Expressioni

Tissue specificityi

Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.

Gene expression databases

ArrayExpressiP56747.
BgeeiP56747.
CleanExiHS_CLDN6.
GenevestigatoriP56747.

Organism-specific databases

HPAiHPA007322.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 By similarity.

Protein-protein interaction databases

BioGridi114531. 1 interaction.
STRINGi9606.ENSP00000328674.

Structurei

3D structure databases

ProteinModelPortaliP56747.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2202Interactions with TJP1, TJP2 and TJP3 By similarity

Sequence similaritiesi

Belongs to the claudin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45113.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56747.
KOiK06087.
OMAiCPENIST.
OrthoDBiEOG79KPGQ.
PhylomeDBiP56747.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003925. Claudin6.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF41. PTHR12002:SF41. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01445. CLAUDIN6.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56747-1 [UniParc]FASTAAdd to Basket

« Hide

MASAGMQILG VVLTLLGWVN GLVSCALPMW KVTAFIGNSI VVAQVVWEGL    50
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLV ALFGLLVYLA 100
GAKCTTCVEE KDSKARLVLT SGIVFVISGV LTLIPVCWTA HAIIRDFYNP 150
LVAEAQKREL GASLYLGWAA SGLLLLGGGL LCCTCPSGGS QGPSHYMARY 200
STSAPAISRG PSEYPTKNYV 220
Length:220
Mass (Da):23,292
Last modified:March 7, 2006 - v2
Checksum:iD80AECB5681502AA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti143 – 1431I → V.4 Publications
Corresponds to variant rs2257295 [ dbSNP | Ensembl ].
VAR_017151

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249735 Genomic DNA. Translation: CAB56533.1.
AF125306 mRNA. Translation: AAK02013.1.
AY358480 mRNA. Translation: AAQ88844.1.
BT007399 mRNA. Translation: AAP36063.1.
AK075329 mRNA. Translation: BAG52111.1.
CH471112 Genomic DNA. Translation: EAW85431.1.
CH471112 Genomic DNA. Translation: EAW85432.1.
BC008934 mRNA. Translation: AAH08934.1.
CCDSiCCDS10488.1.
RefSeqiNP_067018.2. NM_021195.4.
UniGeneiHs.533779.

Genome annotation databases

EnsembliENST00000328796; ENSP00000328674; ENSG00000184697.
ENST00000396925; ENSP00000380131; ENSG00000184697.
GeneIDi9074.
KEGGihsa:9074.
UCSCiuc002csu.4. human.

Polymorphism databases

DMDMi90183180.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249735 Genomic DNA. Translation: CAB56533.1 .
AF125306 mRNA. Translation: AAK02013.1 .
AY358480 mRNA. Translation: AAQ88844.1 .
BT007399 mRNA. Translation: AAP36063.1 .
AK075329 mRNA. Translation: BAG52111.1 .
CH471112 Genomic DNA. Translation: EAW85431.1 .
CH471112 Genomic DNA. Translation: EAW85432.1 .
BC008934 mRNA. Translation: AAH08934.1 .
CCDSi CCDS10488.1.
RefSeqi NP_067018.2. NM_021195.4.
UniGenei Hs.533779.

3D structure databases

ProteinModelPortali P56747.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114531. 1 interaction.
STRINGi 9606.ENSP00000328674.

PTM databases

PhosphoSitei P56747.

Polymorphism databases

DMDMi 90183180.

Proteomic databases

MaxQBi P56747.
PaxDbi P56747.
PRIDEi P56747.

Protocols and materials databases

DNASUi 9074.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328796 ; ENSP00000328674 ; ENSG00000184697 .
ENST00000396925 ; ENSP00000380131 ; ENSG00000184697 .
GeneIDi 9074.
KEGGi hsa:9074.
UCSCi uc002csu.4. human.

Organism-specific databases

CTDi 9074.
GeneCardsi GC16M003064.
HGNCi HGNC:2048. CLDN6.
HPAi HPA007322.
MIMi 615798. gene.
neXtProti NX_P56747.
PharmGKBi PA26574.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45113.
HOGENOMi HOG000220937.
HOVERGENi HBG000643.
InParanoidi P56747.
KOi K06087.
OMAi CPENIST.
OrthoDBi EOG79KPGQ.
PhylomeDBi P56747.
TreeFami TF331936.

Enzyme and pathway databases

Reactomei REACT_19373. Tight junction interactions.

Miscellaneous databases

GeneWikii CLDN6.
GenomeRNAii 9074.
NextBioi 34001.
PROi P56747.
SOURCEi Search...

Gene expression databases

ArrayExpressi P56747.
Bgeei P56747.
CleanExi HS_CLDN6.
Genevestigatori P56747.

Family and domain databases

InterProi IPR006187. Claudin.
IPR003925. Claudin6.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view ]
PANTHERi PTHR12002. PTHR12002. 1 hit.
PTHR12002:SF41. PTHR12002:SF41. 1 hit.
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01077. CLAUDIN.
PR01445. CLAUDIN6.
PROSITEi PS01346. CLAUDIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Keen T.J., Inglehearn C.F.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-143.
  2. "Skullin: a novel membrane molecule marks formation of epithelium."
    Troy T., Wisco V., Turksen K.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-143.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-143.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-143.
    Tissue: Placenta.
  8. "Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus."
    Zheng A., Yuan F., Li Y., Zhu F., Hou P., Li J., Song X., Ding M., Deng H.
    J. Virol. 81:12465-12471(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION AS CORECEPTOR FOR HCV.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; SER-203; SER-208 AND SER-212, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLD6_HUMAN
AccessioniPrimary (citable) accession number: P56747
Secondary accession number(s): B3KQP9, D3DUA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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