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P56747 (CLD6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Claudin-6
Alternative name(s):
Skullin
Gene names
Name:CLDN6
ORF Names:UNQ757/PRO1488
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space By similarity.

Subunit structure

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 By similarity.

Subcellular location

Cell junctiontight junction By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the claudin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Claudin-6
PRO_0000144748

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821Helical; Potential
Topological domain29 – 8153Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 11614Cytoplasmic Potential
Transmembrane117 – 13721Helical; Potential
Topological domain138 – 16023Extracellular Potential
Transmembrane161 – 18121Helical; Potential
Topological domain182 – 22039Cytoplasmic Potential
Region219 – 2202Interactions with TJP1, TJP2 and TJP3 By similarity

Amino acid modifications

Modified residue2011Phosphoserine Ref.9
Modified residue2031Phosphoserine Ref.9
Modified residue2081Phosphoserine Ref.9
Modified residue2121Phosphoserine Ref.9

Natural variations

Natural variant1431I → V. Ref.1 Ref.2 Ref.5 Ref.7
Corresponds to variant rs2257295 [ dbSNP | Ensembl ].
VAR_017151

Sequences

Sequence LengthMass (Da)Tools
P56747 [UniParc].

Last modified March 7, 2006. Version 2.
Checksum: D80AECB5681502AA

FASTA22023,292
        10         20         30         40         50         60 
MASAGMQILG VVLTLLGWVN GLVSCALPMW KVTAFIGNSI VVAQVVWEGL WMSCVVQSTG 

        70         80         90        100        110        120 
QMQCKVYDSL LALPQDLQAA RALCVIALLV ALFGLLVYLA GAKCTTCVEE KDSKARLVLT 

       130        140        150        160        170        180 
SGIVFVISGV LTLIPVCWTA HAIIRDFYNP LVAEAQKREL GASLYLGWAA SGLLLLGGGL 

       190        200        210        220 
LCCTCPSGGS QGPSHYMARY STSAPAISRG PSEYPTKNYV 

« Hide

References

« Hide 'large scale' references
[1]Keen T.J., Inglehearn C.F.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-143.
[2]"Skullin: a novel membrane molecule marks formation of epithelium."
Troy T., Wisco V., Turksen K.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-143.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-143.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-143.
Tissue: Placenta.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; SER-203; SER-208 AND SER-212, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ249735 Genomic DNA. Translation: CAB56533.1.
AF125306 mRNA. Translation: AAK02013.1.
AY358480 mRNA. Translation: AAQ88844.1.
BT007399 mRNA. Translation: AAP36063.1.
AK075329 mRNA. Translation: BAG52111.1.
CH471112 Genomic DNA. Translation: EAW85431.1.
CH471112 Genomic DNA. Translation: EAW85432.1.
BC008934 mRNA. Translation: AAH08934.1.
RefSeqNP_067018.2. NM_021195.4.
UniGeneHs.533779.

3D structure databases

ProteinModelPortalP56747.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114531. 1 interaction.
STRING9606.ENSP00000328674.

PTM databases

PhosphoSiteP56747.

Polymorphism databases

DMDM90183180.

Proteomic databases

PaxDbP56747.
PRIDEP56747.

Protocols and materials databases

DNASU9074.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328796; ENSP00000328674; ENSG00000184697.
ENST00000396925; ENSP00000380131; ENSG00000184697.
GeneID9074.
KEGGhsa:9074.
UCSCuc002csu.4. human.

Organism-specific databases

CTD9074.
GeneCardsGC16M003064.
HGNCHGNC:2048. CLDN6.
HPAHPA007322.
neXtProtNX_P56747.
PharmGKBPA26574.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45113.
HOGENOMHOG000220937.
HOVERGENHBG000643.
InParanoidP56747.
KOK06087.
OMARGPSEYP.
OrthoDBEOG79KPGQ.
PhylomeDBP56747.
TreeFamTF331936.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressP56747.
BgeeP56747.
CleanExHS_CLDN6.
GenevestigatorP56747.

Family and domain databases

InterProIPR006187. Claudin.
IPR003925. Claudin6.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF41. PTHR12002:SF41. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PR01445. CLAUDIN6.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCLDN6.
GenomeRNAi9074.
NextBio34001.
PROP56747.

Entry information

Entry nameCLD6_HUMAN
AccessionPrimary (citable) accession number: P56747
Secondary accession number(s): B3KQP9, D3DUA5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 7, 2006
Last modified: March 19, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM