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Protein

Claudin-6

Gene

CLDN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.2 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: InterPro
  • virus receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-6
Alternative name(s):
Skullin
Gene namesi
Name:CLDN6
ORF Names:UNQ757/PRO1488
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2048. CLDN6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 116CytoplasmicSequence analysisAdd BLAST14
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 160ExtracellularSequence analysisAdd BLAST23
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 220CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi9074.
OpenTargetsiENSG00000184697.
PharmGKBiPA26574.

Polymorphism and mutation databases

BioMutaiCLDN6.
DMDMi90183180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447481 – 220Claudin-6Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei201PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei219PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP56747.
MaxQBiP56747.
PaxDbiP56747.
PeptideAtlasiP56747.
PRIDEiP56747.

PTM databases

iPTMnetiP56747.
PhosphoSitePlusiP56747.

Expressioni

Tissue specificityi

Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.1 Publication

Gene expression databases

BgeeiENSG00000184697.
CleanExiHS_CLDN6.
ExpressionAtlasiP56747. baseline and differential.
GenevisibleiP56747. HS.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1, CD81 and OCLN (PubMed:20375010).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114531. 1 interactor.
IntActiP56747. 1 interactor.
STRINGi9606.ENSP00000328674.

Structurei

3D structure databases

ProteinModelPortaliP56747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 220Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56747.
KOiK06087.
OMAiGSSHYMA.
OrthoDBiEOG091G0MMR.
PhylomeDBiP56747.
TreeFamiTF331936.

Family and domain databases

InterProiView protein in InterPro
IPR006187. Claudin.
IPR003925. Claudin6.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF136. PTHR12002:SF136. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01445. CLAUDIN6.
PROSITEiView protein in PROSITE
PS01346. CLAUDIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P56747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAGMQILG VVLTLLGWVN GLVSCALPMW KVTAFIGNSI VVAQVVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLV ALFGLLVYLA
110 120 130 140 150
GAKCTTCVEE KDSKARLVLT SGIVFVISGV LTLIPVCWTA HAIIRDFYNP
160 170 180 190 200
LVAEAQKREL GASLYLGWAA SGLLLLGGGL LCCTCPSGGS QGPSHYMARY
210 220
STSAPAISRG PSEYPTKNYV
Length:220
Mass (Da):23,292
Last modified:March 7, 2006 - v2
Checksum:iD80AECB5681502AA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017151143I → V4 PublicationsCorresponds to variant dbSNP:rs2257295Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249735 Genomic DNA. Translation: CAB56533.1.
AF125306 mRNA. Translation: AAK02013.1.
AY358480 mRNA. Translation: AAQ88844.1.
BT007399 mRNA. Translation: AAP36063.1.
AK075329 mRNA. Translation: BAG52111.1.
CH471112 Genomic DNA. Translation: EAW85431.1.
CH471112 Genomic DNA. Translation: EAW85432.1.
BC008934 mRNA. Translation: AAH08934.1.
CCDSiCCDS10488.1.
RefSeqiNP_067018.2. NM_021195.4.
UniGeneiHs.533779.

Genome annotation databases

EnsembliENST00000328796; ENSP00000328674; ENSG00000184697.
ENST00000396925; ENSP00000380131; ENSG00000184697.
GeneIDi9074.
KEGGihsa:9074.
UCSCiuc002csu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCLD6_HUMAN
AccessioniPrimary (citable) accession number: P56747
Secondary accession number(s): B3KQP9, D3DUA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 7, 2006
Last modified: August 30, 2017
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families