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P56747

- CLD6_HUMAN

UniProt

P56747 - CLD6_HUMAN

Protein

Claudin-6

Gene

CLDN6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space By similarity. May act as a coreceptor for HCV entry into hepatic cells.By similarity1 Publication

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB

    Keywords - Biological processi

    Host-virus interaction

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-6
    Alternative name(s):
    Skullin
    Gene namesi
    Name:CLDN6
    ORF Names:UNQ757/PRO1488
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:2048. CLDN6.

    Subcellular locationi

    Cell junctiontight junction By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26574.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Claudin-6PRO_0000144748Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei201 – 2011Phosphoserine1 Publication
    Modified residuei203 – 2031Phosphoserine1 Publication
    Modified residuei208 – 2081Phosphoserine1 Publication
    Modified residuei212 – 2121Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP56747.
    PaxDbiP56747.
    PRIDEiP56747.

    PTM databases

    PhosphoSiteiP56747.

    Expressioni

    Tissue specificityi

    Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.1 Publication

    Gene expression databases

    ArrayExpressiP56747.
    BgeeiP56747.
    CleanExiHS_CLDN6.
    GenevestigatoriP56747.

    Organism-specific databases

    HPAiHPA007322.

    Interactioni

    Subunit structurei

    Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.By similarity

    Protein-protein interaction databases

    BioGridi114531. 1 interaction.
    STRINGi9606.ENSP00000328674.

    Structurei

    3D structure databases

    ProteinModelPortaliP56747.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini29 – 8153ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini138 – 16023ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini182 – 22039CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni219 – 2202Interactions with TJP1, TJP2 and TJP3By similarity

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45113.
    HOGENOMiHOG000220937.
    HOVERGENiHBG000643.
    InParanoidiP56747.
    KOiK06087.
    OMAiCPENIST.
    OrthoDBiEOG79KPGQ.
    PhylomeDBiP56747.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003925. Claudin6.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PTHR12002:SF41. PTHR12002:SF41. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01445. CLAUDIN6.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56747-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAGMQILG VVLTLLGWVN GLVSCALPMW KVTAFIGNSI VVAQVVWEGL    50
    WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLV ALFGLLVYLA 100
    GAKCTTCVEE KDSKARLVLT SGIVFVISGV LTLIPVCWTA HAIIRDFYNP 150
    LVAEAQKREL GASLYLGWAA SGLLLLGGGL LCCTCPSGGS QGPSHYMARY 200
    STSAPAISRG PSEYPTKNYV 220
    Length:220
    Mass (Da):23,292
    Last modified:March 7, 2006 - v2
    Checksum:iD80AECB5681502AA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti143 – 1431I → V.4 Publications
    Corresponds to variant rs2257295 [ dbSNP | Ensembl ].
    VAR_017151

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249735 Genomic DNA. Translation: CAB56533.1.
    AF125306 mRNA. Translation: AAK02013.1.
    AY358480 mRNA. Translation: AAQ88844.1.
    BT007399 mRNA. Translation: AAP36063.1.
    AK075329 mRNA. Translation: BAG52111.1.
    CH471112 Genomic DNA. Translation: EAW85431.1.
    CH471112 Genomic DNA. Translation: EAW85432.1.
    BC008934 mRNA. Translation: AAH08934.1.
    CCDSiCCDS10488.1.
    RefSeqiNP_067018.2. NM_021195.4.
    UniGeneiHs.533779.

    Genome annotation databases

    EnsembliENST00000328796; ENSP00000328674; ENSG00000184697.
    ENST00000396925; ENSP00000380131; ENSG00000184697.
    GeneIDi9074.
    KEGGihsa:9074.
    UCSCiuc002csu.4. human.

    Polymorphism databases

    DMDMi90183180.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249735 Genomic DNA. Translation: CAB56533.1 .
    AF125306 mRNA. Translation: AAK02013.1 .
    AY358480 mRNA. Translation: AAQ88844.1 .
    BT007399 mRNA. Translation: AAP36063.1 .
    AK075329 mRNA. Translation: BAG52111.1 .
    CH471112 Genomic DNA. Translation: EAW85431.1 .
    CH471112 Genomic DNA. Translation: EAW85432.1 .
    BC008934 mRNA. Translation: AAH08934.1 .
    CCDSi CCDS10488.1.
    RefSeqi NP_067018.2. NM_021195.4.
    UniGenei Hs.533779.

    3D structure databases

    ProteinModelPortali P56747.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114531. 1 interaction.
    STRINGi 9606.ENSP00000328674.

    PTM databases

    PhosphoSitei P56747.

    Polymorphism databases

    DMDMi 90183180.

    Proteomic databases

    MaxQBi P56747.
    PaxDbi P56747.
    PRIDEi P56747.

    Protocols and materials databases

    DNASUi 9074.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328796 ; ENSP00000328674 ; ENSG00000184697 .
    ENST00000396925 ; ENSP00000380131 ; ENSG00000184697 .
    GeneIDi 9074.
    KEGGi hsa:9074.
    UCSCi uc002csu.4. human.

    Organism-specific databases

    CTDi 9074.
    GeneCardsi GC16M003064.
    HGNCi HGNC:2048. CLDN6.
    HPAi HPA007322.
    MIMi 615798. gene.
    neXtProti NX_P56747.
    PharmGKBi PA26574.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45113.
    HOGENOMi HOG000220937.
    HOVERGENi HBG000643.
    InParanoidi P56747.
    KOi K06087.
    OMAi CPENIST.
    OrthoDBi EOG79KPGQ.
    PhylomeDBi P56747.
    TreeFami TF331936.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    GeneWikii CLDN6.
    GenomeRNAii 9074.
    NextBioi 34001.
    PROi P56747.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56747.
    Bgeei P56747.
    CleanExi HS_CLDN6.
    Genevestigatori P56747.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003925. Claudin6.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    PTHR12002:SF41. PTHR12002:SF41. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01445. CLAUDIN6.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Keen T.J., Inglehearn C.F.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-143.
    2. "Skullin: a novel membrane molecule marks formation of epithelium."
      Troy T., Wisco V., Turksen K.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-143.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-143.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-143.
      Tissue: Placenta.
    8. "Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus."
      Zheng A., Yuan F., Li Y., Zhu F., Hou P., Li J., Song X., Ding M., Deng H.
      J. Virol. 81:12465-12471(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION AS CORECEPTOR FOR HCV.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; SER-203; SER-208 AND SER-212, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCLD6_HUMAN
    AccessioniPrimary (citable) accession number: P56747
    Secondary accession number(s): B3KQP9, D3DUA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3