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P56746

- CLD15_HUMAN

UniProt

P56746 - CLD15_HUMAN

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Protein

Claudin-15

Gene

CLDN15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na+, Li+ and K+ ions, but selects against Cl- ions. Plays an important role in paracellular Na+ transport in the intestine and in Na+ homeostasis. Required for normal Na+-dependent intestinal nutrient uptake.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei55 – 551Important for Na(+)-selective paracellular ion transport
Sitei64 – 641Important for Na(+)-selective paracellular ion transport
Sitei68 – 681Important for the formation of tight-junction strand-like structuresBy similarity

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. calcium-independent cell-cell adhesion Source: UniProtKB
  2. cell-cell junction organization Source: Reactome
  3. cell junction assembly Source: Reactome
  4. ion transport Source: UniProtKB-KW
  5. tight junction assembly Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Protein family/group databases

TCDBi1.H.1.1.9. the claudin tight junction (claudin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-15
Gene namesi
Name:CLDN15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:2036. CLDN15.

Subcellular locationi

Cell junctiontight junction. Cell membrane; Multi-pass membrane protein
Note: Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lateral plasma membrane Source: Ensembl
  3. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi46 – 461E → K: No effect on charge selectivity for paracellular ion transport. 1 Publication
Mutagenesisi55 – 551D → R: Reverses the charge selectivity for paracellular ion transport, favoring Cl(-) transport. 1 Publication
Mutagenesisi64 – 641E → K: Impairs the charge selectivity for paracellular ion transport, favoring Cl(-) transport. 1 Publication

Organism-specific databases

PharmGKBiPA26562.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Claudin-15PRO_0000144771Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 62By similarity

Post-translational modificationi

Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP56746.
PRIDEiP56746.

PTM databases

PhosphoSiteiP56746.

Expressioni

Tissue specificityi

Detected in colon (at protein level).1 Publication

Gene expression databases

BgeeiP56746.
CleanExiHS_CLDN15.
ExpressionAtlasiP56746. baseline and differential.
GenevestigatoriP56746.

Organism-specific databases

HPAiHPA053199.

Interactioni

Subunit structurei

Can form linear homooligomers in the membrane, giving rise to tight junction strand-like structures.

Protein-protein interaction databases

BioGridi117296. 1 interaction.
IntActiP56746. 1 interaction.
STRINGi9606.ENSP00000308870.

Structurei

3D structure databases

ProteinModelPortaliP56746.
SMRiP56746. Positions 1-181.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11CytoplasmicBy similarity
Topological domaini25 – 7450ExtracellularBy similarityAdd
BLAST
Topological domaini100 – 11516CytoplasmicBy similarityAdd
BLAST
Topological domaini141 – 15919ExtracellularBy similarityAdd
BLAST
Topological domaini183 – 22846CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2423HelicalBy similarityAdd
BLAST
Transmembranei75 – 9925HelicalBy similarityAdd
BLAST
Transmembranei116 – 14025HelicalBy similarityAdd
BLAST
Transmembranei160 – 18223HelicalBy similarityAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni146 – 1472Important for the formation of tight-junction strand-like structuresBy similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46136.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56746.
KOiK06087.
OMAiIFENLWY.
OrthoDBiEOG76HQ2T.
PhylomeDBiP56746.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR008094. Claudin15.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01718. CLAUDIN15.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56746-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMAVETFGF FMATVGLLML GVTLPNSYWR VSTVHGNVIT TNTIFENLWF
60 70 80 90 100
SCATDSLGVY NCWEFPSMLA LSGYIQACRA LMITAILLGF LGLLLGIAGL
110 120 130 140 150
RCTNIGGLEL SRKAKLAATA GALHILAGIC GMVAISWYAF NITRDFFDPL
160 170 180 190 200
YPGTKYELGP ALYLGWSASL ISILGGLCLC SACCCGSDED PAASARRPYQ
210 220
APVSVMPVAT SDQEGDSSFG KYGRNAYV
Length:228
Mass (Da):24,356
Last modified:May 30, 2000 - v1
Checksum:iD502E2CD9116F4B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ245738 mRNA. Translation: CAB52587.1.
AK056103 mRNA. Translation: BAG51627.1.
CH471197 Genomic DNA. Translation: EAW50211.1.
CCDSiCCDS5717.1.
RefSeqiNP_001172009.1. NM_001185080.1.
NP_055158.1. NM_014343.2.
UniGeneiHs.38738.

Genome annotation databases

EnsembliENST00000308344; ENSP00000308870; ENSG00000106404.
ENST00000401528; ENSP00000385300; ENSG00000106404.
GeneIDi24146.
KEGGihsa:24146.
UCSCiuc003uyg.2. human.

Polymorphism databases

DMDMi6685306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ245738 mRNA. Translation: CAB52587.1 .
AK056103 mRNA. Translation: BAG51627.1 .
CH471197 Genomic DNA. Translation: EAW50211.1 .
CCDSi CCDS5717.1.
RefSeqi NP_001172009.1. NM_001185080.1.
NP_055158.1. NM_014343.2.
UniGenei Hs.38738.

3D structure databases

ProteinModelPortali P56746.
SMRi P56746. Positions 1-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117296. 1 interaction.
IntActi P56746. 1 interaction.
STRINGi 9606.ENSP00000308870.

Protein family/group databases

TCDBi 1.H.1.1.9. the claudin tight junction (claudin) family.

PTM databases

PhosphoSitei P56746.

Polymorphism databases

DMDMi 6685306.

Proteomic databases

PaxDbi P56746.
PRIDEi P56746.

Protocols and materials databases

DNASUi 24146.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308344 ; ENSP00000308870 ; ENSG00000106404 .
ENST00000401528 ; ENSP00000385300 ; ENSG00000106404 .
GeneIDi 24146.
KEGGi hsa:24146.
UCSCi uc003uyg.2. human.

Organism-specific databases

CTDi 24146.
GeneCardsi GC07M100875.
HGNCi HGNC:2036. CLDN15.
HPAi HPA053199.
MIMi 615778. gene.
neXtProti NX_P56746.
PharmGKBi PA26562.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46136.
GeneTreei ENSGT00760000119222.
HOGENOMi HOG000220937.
HOVERGENi HBG000643.
InParanoidi P56746.
KOi K06087.
OMAi IFENLWY.
OrthoDBi EOG76HQ2T.
PhylomeDBi P56746.
TreeFami TF331936.

Enzyme and pathway databases

Reactomei REACT_19373. Tight junction interactions.

Miscellaneous databases

GeneWikii CLDN15.
GenomeRNAii 24146.
NextBioi 46839.
PROi P56746.
SOURCEi Search...

Gene expression databases

Bgeei P56746.
CleanExi HS_CLDN15.
ExpressionAtlasi P56746. baseline and differential.
Genevestigatori P56746.

Family and domain databases

InterProi IPR006187. Claudin.
IPR008094. Claudin15.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view ]
PANTHERi PTHR12002. PTHR12002. 1 hit.
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01077. CLAUDIN.
PR01718. CLAUDIN15.
PROSITEi PS01346. CLAUDIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Keen T.J., Inglehearn C.F.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Claudins create charge-selective channels in the paracellular pathway between epithelial cells."
    Colegio O.R., Van Itallie C.M., McCrea H.J., Rahner C., Anderson J.M.
    Am. J. Physiol. 283:C142-C142(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF GLU-46; ASP-55 AND GLU-64.
  5. "Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins."
    Van Itallie C.M., Fanning A.S., Anderson J.M.
    Am. J. Physiol. 285:F1078-F1078(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCLD15_HUMAN
AccessioniPrimary (citable) accession number: P56746
Secondary accession number(s): B3KPB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3