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Protein

Claudin-15

Gene

CLDN15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na+, Li+ and K+ ions, but selects against Cl- ions. Plays an important role in paracellular Na+ transport in the intestine and in Na+ homeostasis. Required for normal Na+-dependent intestinal nutrient uptake.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei55Important for Na(+)-selective paracellular ion transport1
Sitei64Important for Na(+)-selective paracellular ion transport1
Sitei68Important for the formation of tight-junction strand-like structuresBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106404-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Protein family/group databases

TCDBi1.H.1.1.9. the claudin tight junction (claudin1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-15
Gene namesi
Name:CLDN15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:2036. CLDN15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicBy similarity1
Transmembranei2 – 24HelicalBy similarityAdd BLAST23
Topological domaini25 – 74ExtracellularBy similarityAdd BLAST50
Transmembranei75 – 99HelicalBy similarityAdd BLAST25
Topological domaini100 – 115CytoplasmicBy similarityAdd BLAST16
Transmembranei116 – 140HelicalBy similarityAdd BLAST25
Topological domaini141 – 159ExtracellularBy similarityAdd BLAST19
Transmembranei160 – 182HelicalBy similarityAdd BLAST23
Topological domaini183 – 228CytoplasmicBy similarityAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi46E → K: No effect on charge selectivity for paracellular ion transport. 1 Publication1
Mutagenesisi55D → R: Reverses the charge selectivity for paracellular ion transport, favoring Cl(-) transport. 1 Publication1
Mutagenesisi64E → K: Impairs the charge selectivity for paracellular ion transport, favoring Cl(-) transport. 1 Publication1

Organism-specific databases

DisGeNETi24146.
OpenTargetsiENSG00000106404.
PharmGKBiPA26562.

Polymorphism and mutation databases

BioMutaiCLDN15.
DMDMi6685306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447711 – 228Claudin-15Add BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 62By similarity
Modified residuei111PhosphoserineCombined sources1
Modified residuei211PhosphoserineBy similarity1
Modified residuei218PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP56746.
PeptideAtlasiP56746.
PRIDEiP56746.

PTM databases

iPTMnetiP56746.
PhosphoSitePlusiP56746.

Expressioni

Tissue specificityi

Detected in colon (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000106404.
CleanExiHS_CLDN15.
ExpressionAtlasiP56746. baseline and differential.
GenevisibleiP56746. HS.

Interactioni

Subunit structurei

Can form linear homooligomers in the membrane, giving rise to tight junction strand-like structures.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117296. 1 interactor.
IntActiP56746. 1 interactor.
STRINGi9606.ENSP00000308870.

Structurei

3D structure databases

ProteinModelPortaliP56746.
SMRiP56746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni146 – 147Important for the formation of tight-junction strand-like structuresBy similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKVT. Eukaryota.
ENOG410YHAD. LUCA.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56746.
KOiK06087.
OMAiIFENLWY.
OrthoDBiEOG091G0MX2.
PhylomeDBiP56746.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR008094. Claudin15.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01718. CLAUDIN15.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMAVETFGF FMATVGLLML GVTLPNSYWR VSTVHGNVIT TNTIFENLWF
60 70 80 90 100
SCATDSLGVY NCWEFPSMLA LSGYIQACRA LMITAILLGF LGLLLGIAGL
110 120 130 140 150
RCTNIGGLEL SRKAKLAATA GALHILAGIC GMVAISWYAF NITRDFFDPL
160 170 180 190 200
YPGTKYELGP ALYLGWSASL ISILGGLCLC SACCCGSDED PAASARRPYQ
210 220
APVSVMPVAT SDQEGDSSFG KYGRNAYV
Length:228
Mass (Da):24,356
Last modified:May 30, 2000 - v1
Checksum:iD502E2CD9116F4B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245738 mRNA. Translation: CAB52587.1.
AK056103 mRNA. Translation: BAG51627.1.
CH471197 Genomic DNA. Translation: EAW50211.1.
CCDSiCCDS5717.1.
RefSeqiNP_001172009.1. NM_001185080.1.
NP_055158.1. NM_014343.2.
UniGeneiHs.38738.

Genome annotation databases

EnsembliENST00000308344; ENSP00000308870; ENSG00000106404.
ENST00000401528; ENSP00000385300; ENSG00000106404.
GeneIDi24146.
KEGGihsa:24146.
UCSCiuc003uyg.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245738 mRNA. Translation: CAB52587.1.
AK056103 mRNA. Translation: BAG51627.1.
CH471197 Genomic DNA. Translation: EAW50211.1.
CCDSiCCDS5717.1.
RefSeqiNP_001172009.1. NM_001185080.1.
NP_055158.1. NM_014343.2.
UniGeneiHs.38738.

3D structure databases

ProteinModelPortaliP56746.
SMRiP56746.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117296. 1 interactor.
IntActiP56746. 1 interactor.
STRINGi9606.ENSP00000308870.

Protein family/group databases

TCDBi1.H.1.1.9. the claudin tight junction (claudin1) family.

PTM databases

iPTMnetiP56746.
PhosphoSitePlusiP56746.

Polymorphism and mutation databases

BioMutaiCLDN15.
DMDMi6685306.

Proteomic databases

PaxDbiP56746.
PeptideAtlasiP56746.
PRIDEiP56746.

Protocols and materials databases

DNASUi24146.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308344; ENSP00000308870; ENSG00000106404.
ENST00000401528; ENSP00000385300; ENSG00000106404.
GeneIDi24146.
KEGGihsa:24146.
UCSCiuc003uyg.2. human.

Organism-specific databases

CTDi24146.
DisGeNETi24146.
GeneCardsiCLDN15.
HGNCiHGNC:2036. CLDN15.
MIMi615778. gene.
neXtProtiNX_P56746.
OpenTargetsiENSG00000106404.
PharmGKBiPA26562.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKVT. Eukaryota.
ENOG410YHAD. LUCA.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56746.
KOiK06087.
OMAiIFENLWY.
OrthoDBiEOG091G0MX2.
PhylomeDBiP56746.
TreeFamiTF331936.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106404-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN15.
GenomeRNAii24146.
PROiP56746.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106404.
CleanExiHS_CLDN15.
ExpressionAtlasiP56746. baseline and differential.
GenevisibleiP56746. HS.

Family and domain databases

InterProiIPR006187. Claudin.
IPR008094. Claudin15.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01718. CLAUDIN15.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD15_HUMAN
AccessioniPrimary (citable) accession number: P56746
Secondary accession number(s): B3KPB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.