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P56745 (CLD1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Claudin-1
Gene names
Name:Cldn1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

Subunit structure

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL By similarity.

Subcellular location

Cell junction › tight junction By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the claudin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Claudin-1
PRO_0000144731

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821Helical; Potential
Topological domain29 – 8153Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 11513Cytoplasmic Potential
Transmembrane116 – 13621Helical; Potential
Topological domain137 – 16327Extracellular Potential
Transmembrane164 – 18421Helical; Potential
Topological domain185 – 21127Cytoplasmic Potential
Region210 – 2112Interactions with TJP1, TJP2, TJP3 and INADL By similarity

Amino acid modifications

Modified residue2051Phosphoserine By similarity
Modified residue2061Phosphoserine By similarity

Natural variations

Natural variant231V → D. Ref.1

Experimental info

Sequence conflict1331T → I in AAF04850. Ref.1
Sequence conflict1551V → I in AAH61992. Ref.2
Sequence conflict2061S → T in AAH61992. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P56745 [UniParc].

Last modified March 29, 2005. Version 2.
Checksum: 5B123CE46C110D97

FASTA21122,843
        10         20         30         40         50         60 
MANAGLQLLG FILASLGWIG SIVSTALPQW KIYSYAGDNI VTAQAIYEGL WMSCVSQSTG 

        70         80         90        100        110        120 
QIQCKVFDSL LNLNSTLQAT RALMVIGILL GLIAIFVSTI GMKCMRCLED DEVQKMWMAV 

       130        140        150        160        170        180 
IGGIIFVISG LATLVATAWY GNRIVQEFYD PMTPVNARYE FGQALFTGWA AASLCLLGGA 

       190        200        210 
LLSCSCPRKT TSYPTPRPYP KPTPSSGKDY V

« Hide

References

« Hide 'large scale' references
[1]"Claudin-1 is not restricted to tight junctions in the rat epididymis."
Gregory M., Dufresne J., Hermo L., Cyr D.
Endocrinology 142:854-863(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-23.
Strain: Sprague-Dawley.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF195500 mRNA. Translation: AAF04850.1.
BC061992 mRNA. Translation: AAH61992.1.
IPIIPI00195286.
RefSeqNP_113887.2. NM_031699.2.
UniGeneRn.24293.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000002640.

PTM databases

PhosphoSiteP56745.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000002640; ENSRNOP00000002640; ENSRNOG00000001926.
GeneID65129.
KEGGrno:65129.
UCSCRGD:68422. rat.

Organism-specific databases

CTD9076.
RGD68422. Cldn1.

Phylogenomic databases

eggNOGNOG47316.
GeneTreeENSGT00700000104133.
HOGENOMHOG000220937.
HOVERGENHBG000643.
InParanoidP56745.
KOK06087.
OMAIYEGLWM.
OrthoDBEOG4G7C0B.

Gene expression databases

GenevestigatorP56745.
GermOnlineENSRNOG00000001926. Rattus norvegicus.

Family and domain databases

InterProIPR006187. Claudin.
IPR003548. Claudin1.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF29. PTHR12002:SF29. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PR01377. CLAUDIN1.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio613923.

Entry information

Entry nameCLD1_RAT
AccessionPrimary (citable) accession number: P56745
Secondary accession number(s): Q6P6V9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: April 3, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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