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P56745

- CLD1_RAT

UniProt

P56745 - CLD1_RAT

Protein

Claudin-1

Gene

Cldn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions By similarity.By similarity

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB
    2. cell-cell junction organization Source: Ensembl
    3. establishment of skin barrier Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-1
    Gene namesi
    Name:Cldn1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 11

    Organism-specific databases

    RGDi68422. Cldn1.

    Subcellular locationi

    Cell junctiontight junction 1 Publication. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. integral component of plasma membrane Source: UniProtKB
    3. lateral plasma membrane Source: RGD
    4. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Claudin-1PRO_0000144731Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 64By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP56745.

    PTM databases

    PhosphoSiteiP56745.

    Expressioni

    Tissue specificityi

    Detected in epididymis (at protein level). Detected in testis and epididymis.1 Publication

    Gene expression databases

    GenevestigatoriP56745.

    Interactioni

    Subunit structurei

    Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000002640.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicBy similarity
    Topological domaini29 – 8153ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini137 – 16327ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini185 – 21127CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni210 – 2112Interactions with TJP1, TJP2, TJP3 and INADLBy similarity

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47316.
    GeneTreeiENSGT00740000115004.
    HOGENOMiHOG000220937.
    HOVERGENiHBG000643.
    InParanoidiP56745.
    KOiK06087.
    OMAiIYEGLWM.
    OrthoDBiEOG76HQ2T.
    PhylomeDBiP56745.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003548. Claudin1.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01377. CLAUDIN1.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56745-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANAGLQLLG FILASLGWIG SIVSTALPQW KIYSYAGDNI VTAQAIYEGL    50
    WMSCVSQSTG QIQCKVFDSL LNLNSTLQAT RALMVIGILL GLIAIFVSTI 100
    GMKCMRCLED DEVQKMWMAV IGGIIFVISG LATLVATAWY GNRIVQEFYD 150
    PMTPVNARYE FGQALFTGWA AASLCLLGGA LLSCSCPRKT TSYPTPRPYP 200
    KPTPSSGKDY V 211
    Length:211
    Mass (Da):22,843
    Last modified:March 29, 2005 - v2
    Checksum:i5B123CE46C110D97
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti133 – 1331T → I in AAF04850. (PubMed:11159859)Curated
    Sequence conflicti155 – 1551V → I in AAH61992. (PubMed:15489334)Curated
    Sequence conflicti206 – 2061S → T in AAH61992. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231V → D.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF195500 mRNA. Translation: AAF04850.1.
    BC061992 mRNA. Translation: AAH61992.1.
    RefSeqiNP_113887.2. NM_031699.2.
    XP_006248589.1. XM_006248527.1.
    UniGeneiRn.24293.

    Genome annotation databases

    EnsembliENSRNOT00000002640; ENSRNOP00000002640; ENSRNOG00000001926.
    GeneIDi65129.
    KEGGirno:65129.
    UCSCiRGD:68422. rat.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF195500 mRNA. Translation: AAF04850.1 .
    BC061992 mRNA. Translation: AAH61992.1 .
    RefSeqi NP_113887.2. NM_031699.2.
    XP_006248589.1. XM_006248527.1.
    UniGenei Rn.24293.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000002640.

    PTM databases

    PhosphoSitei P56745.

    Proteomic databases

    PRIDEi P56745.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002640 ; ENSRNOP00000002640 ; ENSRNOG00000001926 .
    GeneIDi 65129.
    KEGGi rno:65129.
    UCSCi RGD:68422. rat.

    Organism-specific databases

    CTDi 9076.
    RGDi 68422. Cldn1.

    Phylogenomic databases

    eggNOGi NOG47316.
    GeneTreei ENSGT00740000115004.
    HOGENOMi HOG000220937.
    HOVERGENi HBG000643.
    InParanoidi P56745.
    KOi K06087.
    OMAi IYEGLWM.
    OrthoDBi EOG76HQ2T.
    PhylomeDBi P56745.
    TreeFami TF331936.

    Miscellaneous databases

    NextBioi 613923.
    PROi P56745.

    Gene expression databases

    Genevestigatori P56745.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003548. Claudin1.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01377. CLAUDIN1.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Claudin-1 is not restricted to tight junctions in the rat epididymis."
      Gregory M., Dufresne J., Hermo L., Cyr D.
      Endocrinology 142:854-863(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-23, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiCLD1_RAT
    AccessioniPrimary (citable) accession number: P56745
    Secondary accession number(s): Q6P6V9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3