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P56745

- CLD1_RAT

UniProt

P56745 - CLD1_RAT

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Protein
Claudin-1
Gene
Cldn1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions By similarity.

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. calcium-independent cell-cell adhesion Source: UniProtKB
  2. cell-cell junction organization Source: Ensembl
  3. establishment of skin barrier Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-1
Gene namesi
Name:Cldn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 11

Organism-specific databases

RGDi68422. Cldn1.

Subcellular locationi

Cell junctiontight junction. Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic By similarity
Transmembranei8 – 2821Helical; Reviewed prediction
Add
BLAST
Topological domaini29 – 8153Extracellular Reviewed prediction
Add
BLAST
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Topological domaini103 – 11513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei116 – 13621Helical; Reviewed prediction
Add
BLAST
Topological domaini137 – 16327Extracellular Reviewed prediction
Add
BLAST
Transmembranei164 – 18421Helical; Reviewed prediction
Add
BLAST
Topological domaini185 – 21127Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. integral component of plasma membrane Source: UniProtKB
  3. lateral plasma membrane Source: RGD
  4. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Claudin-1
PRO_0000144731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 64 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP56745.

PTM databases

PhosphoSiteiP56745.

Expressioni

Tissue specificityi

Detected in epididymis (at protein level). Detected in testis and epididymis.1 Publication

Gene expression databases

GenevestigatoriP56745.

Interactioni

Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002640.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 2112Interactions with TJP1, TJP2, TJP3 and INADL By similarity

Sequence similaritiesi

Belongs to the claudin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47316.
GeneTreeiENSGT00740000115004.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiP56745.
KOiK06087.
OMAiIYEGLWM.
OrthoDBiEOG76HQ2T.
PhylomeDBiP56745.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003548. Claudin1.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01377. CLAUDIN1.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56745-1 [UniParc]FASTAAdd to Basket

« Hide

MANAGLQLLG FILASLGWIG SIVSTALPQW KIYSYAGDNI VTAQAIYEGL    50
WMSCVSQSTG QIQCKVFDSL LNLNSTLQAT RALMVIGILL GLIAIFVSTI 100
GMKCMRCLED DEVQKMWMAV IGGIIFVISG LATLVATAWY GNRIVQEFYD 150
PMTPVNARYE FGQALFTGWA AASLCLLGGA LLSCSCPRKT TSYPTPRPYP 200
KPTPSSGKDY V 211
Length:211
Mass (Da):22,843
Last modified:March 29, 2005 - v2
Checksum:i5B123CE46C110D97
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231V → D.1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331T → I in AAF04850. 1 Publication
Sequence conflicti155 – 1551V → I in AAH61992. 1 Publication
Sequence conflicti206 – 2061S → T in AAH61992. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF195500 mRNA. Translation: AAF04850.1.
BC061992 mRNA. Translation: AAH61992.1.
RefSeqiNP_113887.2. NM_031699.2.
XP_006248589.1. XM_006248527.1.
UniGeneiRn.24293.

Genome annotation databases

EnsembliENSRNOT00000002640; ENSRNOP00000002640; ENSRNOG00000001926.
GeneIDi65129.
KEGGirno:65129.
UCSCiRGD:68422. rat.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF195500 mRNA. Translation: AAF04850.1 .
BC061992 mRNA. Translation: AAH61992.1 .
RefSeqi NP_113887.2. NM_031699.2.
XP_006248589.1. XM_006248527.1.
UniGenei Rn.24293.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000002640.

PTM databases

PhosphoSitei P56745.

Proteomic databases

PRIDEi P56745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000002640 ; ENSRNOP00000002640 ; ENSRNOG00000001926 .
GeneIDi 65129.
KEGGi rno:65129.
UCSCi RGD:68422. rat.

Organism-specific databases

CTDi 9076.
RGDi 68422. Cldn1.

Phylogenomic databases

eggNOGi NOG47316.
GeneTreei ENSGT00740000115004.
HOGENOMi HOG000220937.
HOVERGENi HBG000643.
InParanoidi P56745.
KOi K06087.
OMAi IYEGLWM.
OrthoDBi EOG76HQ2T.
PhylomeDBi P56745.
TreeFami TF331936.

Miscellaneous databases

NextBioi 613923.
PROi P56745.

Gene expression databases

Genevestigatori P56745.

Family and domain databases

InterProi IPR006187. Claudin.
IPR003548. Claudin1.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view ]
PANTHERi PTHR12002. PTHR12002. 1 hit.
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01077. CLAUDIN.
PR01377. CLAUDIN1.
PROSITEi PS01346. CLAUDIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Claudin-1 is not restricted to tight junctions in the rat epididymis."
    Gregory M., Dufresne J., Hermo L., Cyr D.
    Endocrinology 142:854-863(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-23, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiCLD1_RAT
AccessioniPrimary (citable) accession number: P56745
Secondary accession number(s): Q6P6V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: September 3, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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