Reviewed,
UniProtKB/Swiss-Prot P56742 (OXLA_CROAT)
Last modified
June 16, 2009.
Version 40.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: L-amino-acid oxidase Short name=LAAO Short name=LAO EC=1.4.3.2 Alternative name(s): Apoxin-1 Apoxin I |
| Organism | Crotalus atrox (Western diamondback rattlesnake) |
| Taxonomic identifier | 8730 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Viperidae › Crotalinae › Crotalus |
Protein attributes
| Sequence length | 516 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids. Inhibits platelet aggregation By similarity. Has an antibacterial activity. Has an ability to induce hemorrhage and apoptosis. |
| Catalytic activity | An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2. |
| Cofactor | FAD. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Tissue specificity | Expressed by the venom gland. |
| Post-translational modification | Glycosylated By similarity. |
| Sequence similarities | Belongs to the flavin monoamine oxidase family. FIG1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis Blood coagulation |
| Cellular component | Secreted |
| Domain | Signal |
| Ligand | FAD Flavoprotein |
| Molecular function | Antibiotic Antimicrobial Oxidoreductase Toxin |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | apoptosis Inferred from electronic annotation. Source: UniProtKB-KW blood coagulationInferred from electronic annotation. Source: UniProtKB-KW defense response to bacteriumInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW pathogenesisInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | L-amino-acid oxidase activity Inferred from electronic annotation. Source: EC electron carrier activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | Ref.2 | ||||||||
| Chain | 19 – 516 | 498 | L-amino-acid oxidase | PRO_0000099870 | |||||||
Regions | |||||||||||
| Nucleotide binding | 105 – 106 | 2 | FAD By similarity | ||||||||
| Nucleotide binding | 484 – 487 | 4 | FAD By similarity | ||||||||
Sites | |||||||||||
| Binding site | 81 | 1 | FAD By similarity | ||||||||
| Binding site | 89 | 1 | FAD By similarity | ||||||||
| Binding site | 106 | 1 | Substrate By similarity | ||||||||
| Binding site | 239 | 1 | Substrate By similarity | ||||||||
| Binding site | 279 | 1 | FAD; via amide nitrogen and carbonyl oxygen By similarity | ||||||||
| Binding site | 390 | 1 | Substrate By similarity | ||||||||
| Binding site | 475 | 1 | FAD By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 379 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 28 ↔ 189 | By similarity | |||||||||
| Disulfide bond | 349 ↔ 430 | By similarity | |||||||||
Sequences
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References
| [1] | "Molecular cloning and its expression of Apoxin 1, an apoptosis inducing protein having L-amino acid oxidase activity from western diamondback rattlesnake venom." Torii S., Mashima T., Naito M., Haga N., Yamane K., Yamamoto K., Fox J.W., Tsuruo T. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland. |
| [2] | "Apoxin I, a novel apoptosis-inducing factor with L-amino acid oxidase activity purified from Western diamondback rattlesnake venom." Torii S., Naito M., Tsuruo T. J. Biol. Chem. 272:9539-9542(1997) [PubMed: 9083096] [Abstract] Cited for: PROTEIN SEQUENCE OF 19-38, FUNCTION. Tissue: Venom. |
Cross-references
Sequence databases | |
|---|---|
| AF093248 mRNA. Translation: AAD45200.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1F8R based on UniProtKB P81382. |
| SMR | P56742. Positions 22-504. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P56742. |
Enzyme and pathway databases | |
| BRENDA | 1.4.3.2. 18621. |
Family and domain databases | |
| InterPro | IPR002937. Amino_oxidase. [Graphical view] |
| Pfam | PF01593. Amino_oxidase. 1 hit. [Graphical view] |
| ProDom | PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Entry information
| Entry name | OXLA_CROAT | ||||||||
| Accession | Primary (citable) accession number: P56742 Secondary accession number(s): Q9PWC9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Tox-Prot (Toxin Annotation Project) | ||||||||

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