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P56740

- FOLB_STAAU

UniProt

P56740 - FOLB_STAAU

Protein

Dihydroneopterin aldolase

Gene

folB

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

    Catalytic activityi

    2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.

    Pathwayi

    GO - Molecular functioni

    1. dihydroneopterin aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Folate biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00077; UER00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroneopterin aldolase (EC:4.1.2.25)
    Short name:
    DHNA
    Gene namesi
    Name:folB
    OrganismiStaphylococcus aureus
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 121121Dihydroneopterin aldolasePRO_0000168283Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer. Four molecules assemble into a ring, and two rings come together to give a cylinder with a hole of at least 13 a diameter.

    Structurei

    Secondary structure

    1
    121
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 1411
    Beta strandi17 – 193
    Helixi20 – 256
    Beta strandi27 – 3711
    Helixi40 – 456
    Helixi48 – 503
    Helixi54 – 6512
    Beta strandi66 – 683
    Helixi73 – 8715
    Beta strandi91 – 10212
    Beta strandi112 – 1198

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1DHNX-ray1.65A1-121[»]
    1RRIX-ray2.00A1-121[»]
    1RRWX-ray2.21A1-121[»]
    1RRYX-ray2.70A1-121[»]
    1RS2X-ray2.31A1-121[»]
    1RS4X-ray2.70A1-121[»]
    1RSDX-ray2.50A1-121[»]
    1RSIX-ray2.20A1-121[»]
    1U68X-ray2.40A1-121[»]
    2DHNX-ray2.20A1-121[»]
    2NM2X-ray1.70A/B/C/D1-121[»]
    2NM3X-ray1.68A1-121[»]
    ProteinModelPortaliP56740.
    SMRiP56740. Positions 1-121.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP56740.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHNA family.Curated

    Phylogenomic databases

    eggNOGiCOG1539.

    Family and domain databases

    InterProiIPR006156. Dihydroneopterin_aldolase.
    IPR006157. FolB_dom.
    [Graphical view]
    PfamiPF02152. FolB. 1 hit.
    [Graphical view]
    SMARTiSM00905. FolB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00525. folB. 1 hit.
    TIGR00526. folB_dom. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56740-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDTIFLKGM RFYGYHGALS AENEIGQIFK VDVTLKVDLS EAGRTDNVID    50
    TVHYGEVFEE VKSIMEGKAV NLLEHLAERI ANRINSQYNR VMETKVRITK 100
    ENPPIPGHYD GVGIEIVREN K 121
    Length:121
    Mass (Da):13,751
    Last modified:May 30, 2000 - v1
    Checksum:i55B267FB69CA3D8D
    GO

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1DHN X-ray 1.65 A 1-121 [» ]
    1RRI X-ray 2.00 A 1-121 [» ]
    1RRW X-ray 2.21 A 1-121 [» ]
    1RRY X-ray 2.70 A 1-121 [» ]
    1RS2 X-ray 2.31 A 1-121 [» ]
    1RS4 X-ray 2.70 A 1-121 [» ]
    1RSD X-ray 2.50 A 1-121 [» ]
    1RSI X-ray 2.20 A 1-121 [» ]
    1U68 X-ray 2.40 A 1-121 [» ]
    2DHN X-ray 2.20 A 1-121 [» ]
    2NM2 X-ray 1.70 A/B/C/D 1-121 [» ]
    2NM3 X-ray 1.68 A 1-121 [» ]
    ProteinModelPortali P56740.
    SMRi P56740. Positions 1-121.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1539.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00154 .

    Miscellaneous databases

    EvolutionaryTracei P56740.

    Family and domain databases

    InterProi IPR006156. Dihydroneopterin_aldolase.
    IPR006157. FolB_dom.
    [Graphical view ]
    Pfami PF02152. FolB. 1 hit.
    [Graphical view ]
    SMARTi SM00905. FolB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00525. folB. 1 hit.
    TIGR00526. folB_dom. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus."
      Hennig M., D'Arcy A., Hampele I.C., Page M.G., Oefner C., Dale G.E.
      Nat. Struct. Biol. 5:357-362(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
      Strain: ATCC 25923 / DSM 1104 / Seattle 1945 / FO 14462 / JCM 2413.

    Entry informationi

    Entry nameiFOLB_STAAU
    AccessioniPrimary (citable) accession number: P56740
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3