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Protein

Orexin receptor type 2

Gene

Hcrtr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • neuropeptide receptor activity Source: GO_Central
  • orexin receptor activity Source: RGD
  • peptide hormone binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 2
Short name:
Ox-2-R
Short name:
Ox2-R
Short name:
Ox2R
Alternative name(s):
Hypocretin receptor type 2
Gene namesi
Name:Hcrtr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2788. Hcrtr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularSequence analysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini76 – 8813CytoplasmicSequence analysisAdd
BLAST
Transmembranei89 – 11022Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini111 – 12717ExtracellularSequence analysisAdd
BLAST
Transmembranei128 – 15023Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini151 – 17222CytoplasmicSequence analysisAdd
BLAST
Transmembranei173 – 19321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini194 – 22431ExtracellularSequence analysisAdd
BLAST
Transmembranei225 – 24723Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini248 – 30457CytoplasmicSequence analysisAdd
BLAST
Transmembranei305 – 32723Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini328 – 34215ExtracellularSequence analysisAdd
BLAST
Transmembranei343 – 36624Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini367 – 46094CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1275216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Orexin receptor type 2PRO_0000069992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP56719.
PRIDEiP56719.

PTM databases

PhosphoSiteiP56719.

Expressioni

Tissue specificityi

Expressed in the brain in the cerebral cortex, septal nuclei, hippocampus, medial thalamic groups, dorsal and median raphe nuclei, and many hypothalamic nuclei including the tuberomammillary nucleus, dorsomedial hypothalamus, paraventricular hypothalamic nucleus, and ventral premammillary nucleus. Not detected in the spleen, lung, liver, skeletal muscle, kidney and testis. Orexin receptor mRNA expression has also been reported in the adrenal gland, enteric nervous system, and pancreas.

Gene expression databases

GenevisibleiP56719. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015824.

Chemistry

BindingDBiP56719.

Structurei

3D structure databases

ProteinModelPortaliP56719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiP56719.
KOiK04239.
OMAiNSIVVIW.
OrthoDBiEOG7CG72H.
PhylomeDBiP56719.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTKLEDSL PRRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP
60 70 80 90 100
KEYEWVLIAG YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD
110 120 130 140 150
VLVTITCLPA TLVVDITETW FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL
160 170 180 190 200
DRWYAICHPL MFKSTAKRAR NSIVVIWIVS CIIMIPQAIV MERSSMLPGL
210 220 230 240 250
ANKTTLFTVC DERWGGEVYP KMYHICFFLV TYMAPLCLMV LAYLQIFRKL
260 270 280 290 300
WCRQIPGTSS VVQRKWKQPQ PVSQPRGSGQ QSKARISAVA AEIKQIRARR
310 320 330 340 350
KTARMLMVVL LVFAICYLPI SILNVLKRVF GMFTHTEDRE TVYAWFTFSH
360 370 380 390 400
WLVYANSAAN PIIYNFLSGK FREEFKAAFS CCLGVHRRQG DRLARGRTST
410 420 430 440 450
ESRKSLTTQI SNFDNVSKLS EHVALTSIST LPAANGAGPL QNWYLQQGVP
460
SSLLSTWLEV
Length:460
Mass (Da):52,489
Last modified:May 30, 2000 - v1
Checksum:i3B44E3D82F8B85D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041246 mRNA. Translation: AAC40042.1.
RefSeqiNP_037206.1. NM_013074.1.
UniGeneiRn.9893.

Genome annotation databases

EnsembliENSRNOT00000015824; ENSRNOP00000015824; ENSRNOG00000011251.
GeneIDi25605.
KEGGirno:25605.
UCSCiRGD:2788. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041246 mRNA. Translation: AAC40042.1.
RefSeqiNP_037206.1. NM_013074.1.
UniGeneiRn.9893.

3D structure databases

ProteinModelPortaliP56719.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015824.

Chemistry

BindingDBiP56719.
ChEMBLiCHEMBL1275216.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP56719.

Proteomic databases

PaxDbiP56719.
PRIDEiP56719.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015824; ENSRNOP00000015824; ENSRNOG00000011251.
GeneIDi25605.
KEGGirno:25605.
UCSCiRGD:2788. rat.

Organism-specific databases

CTDi3062.
RGDi2788. Hcrtr2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiP56719.
KOiK04239.
OMAiNSIVVIW.
OrthoDBiEOG7CG72H.
PhylomeDBiP56719.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-RNO-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP56719.

Gene expression databases

GenevisibleiP56719. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Hypocretin/orexin, sleep and narcolepsy."
    Hungs M., Mignot E.
    Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  3. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
    Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
    Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiOX2R_RAT
AccessioniPrimary (citable) accession number: P56719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.