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Protein

Orexin receptor type 1

Gene

Hcrtr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei36Important for responses to orexinBy similarity1
Binding sitei318AgonistBy similarity1

GO - Molecular functioni

  • neuropeptide receptor activity Source: GO_Central
  • orexin receptor activity Source: RGD
  • peptide hormone binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 1
Short name:
Ox-1-R
Short name:
Ox1-R
Short name:
Ox1R
Alternative name(s):
Hypocretin receptor type 1
Gene namesi
Name:Hcrtr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2787. Hcrtr1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularBy similarityAdd BLAST46
Transmembranei47 – 67Helical; Name=1By similarityAdd BLAST21
Topological domaini68 – 82CytoplasmicBy similarityAdd BLAST15
Transmembranei83 – 105Helical; Name=2By similarityAdd BLAST23
Topological domaini106 – 119ExtracellularBy similarityAdd BLAST14
Transmembranei120 – 140Helical; Name=3By similarityAdd BLAST21
Topological domaini141 – 160CytoplasmicBy similarityAdd BLAST20
Transmembranei161 – 182Helical; Name=4By similarityAdd BLAST22
Topological domaini183 – 213ExtracellularBy similarityAdd BLAST31
Transmembranei214 – 235Helical; Name=5By similarityAdd BLAST22
Topological domaini236 – 298CytoplasmicBy similarityAdd BLAST63
Transmembranei299 – 321Helical; Name=6By similarityAdd BLAST23
Topological domaini322 – 336ExtracellularBy similarityAdd BLAST15
Transmembranei337 – 360Helical; Name=7By similarityAdd BLAST24
Topological domaini361 – 416CytoplasmicBy similarityAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075232.
GuidetoPHARMACOLOGYi321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699871 – 416Orexin receptor type 1Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi119 ↔ 202By similarity
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP56718.
PRIDEiP56718.

PTM databases

PhosphoSitePlusiP56718.

Expressioni

Tissue specificityi

Highly expressed in the brain in the prefrontal cortex, hippocampus, paraventricular thalamus, ventromedial hypothalamus, arcuate nucleus, dorsal raphe nucleus, and locus coeruleus. Not detected in the spleen, lung, liver, skeletal muscle, kidney and testis. Orexin receptor mRNA expression has also been reported in the adrenal gland, enteric nervous system, and pancreas.1 Publication

Inductioni

By nutritional state, up-regulated by fasting.1 Publication

Gene expression databases

BgeeiENSRNOG00000013838.
GenevisibleiP56718. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018674.

Chemistry databases

BindingDBiP56718.

Structurei

3D structure databases

ProteinModelPortaliP56718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 41Required for response to orexin-ABy similarityAdd BLAST16

Domaini

The N-terminal region is required for orexin signaling.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiP56718.
KOiK04238.
OMAiMEYSSVL.
OrthoDBiEOG091G0ZDG.
PhylomeDBiP56718.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSATPGAQ PGVPTSSGEP FHLPPDYEDE FLRYLWRDYL YPKQYEWVLI
60 70 80 90 100
AAYVAVFLIA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL
110 120 130 140 150
PASLLVDITE SWLFGHALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH
160 170 180 190 200
PLLFKSTARR ARGSILGIWA VSLAVMVPQA AVMECSSVLP ELANRTRLFS
210 220 230 240 250
VCDERWADEL YPKIYHSCFF FVTYLAPLGL MGMAYFQIFR KLWGPQIPGT
260 270 280 290 300
TSALVRNWKR PSEQLEAQHQ GLCTEPQPRA RAFLAEVKQM RARRKTAKML
310 320 330 340 350
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN
360 370 380 390 400
SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPSSSARHKS LSLQSRCSVS
410
KVSEHVVLTT VTTVLS
Length:416
Mass (Da):46,800
Last modified:May 30, 2000 - v1
Checksum:i774DE7A22EA05D18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041244 mRNA. Translation: AAC40041.1.
RefSeqiNP_037196.1. NM_013064.1.
UniGeneiRn.88262.

Genome annotation databases

EnsembliENSRNOT00000018674; ENSRNOP00000018674; ENSRNOG00000013838.
GeneIDi25593.
KEGGirno:25593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041244 mRNA. Translation: AAC40041.1.
RefSeqiNP_037196.1. NM_013064.1.
UniGeneiRn.88262.

3D structure databases

ProteinModelPortaliP56718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018674.

Chemistry databases

BindingDBiP56718.
ChEMBLiCHEMBL1075232.
GuidetoPHARMACOLOGYi321.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP56718.

Proteomic databases

PaxDbiP56718.
PRIDEiP56718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018674; ENSRNOP00000018674; ENSRNOG00000013838.
GeneIDi25593.
KEGGirno:25593.

Organism-specific databases

CTDi3061.
RGDi2787. Hcrtr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiP56718.
KOiK04238.
OMAiMEYSSVL.
OrthoDBiEOG091G0ZDG.
PhylomeDBiP56718.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-RNO-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP56718.

Gene expression databases

BgeeiENSRNOG00000013838.
GenevisibleiP56718. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOX1R_RAT
AccessioniPrimary (citable) accession number: P56718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.