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Protein

Orexin-A

Gene

HCRT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity).By similarity

GO - Biological processi

  1. feeding behavior Source: InterPro
  2. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_287476. G alpha (q) signalling events.
REACT_290593. Orexin and neuropeptides FF and QRFP bind to their respective receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin-A
Alternative name(s):
Hypocretin-1
Short name:
Hcrt1
Gene namesi
Name:HCRT
Synonyms:OX, PPOX
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

  1. Rough endoplasmic reticulum By similarity
  2. Cytoplasmic vesicle By similarity
  3. Cell junctionsynapse By similarity

  4. Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  3. perinuclear region of cytoplasm Source: Ensembl
  4. rough endoplasmic reticulum Source: UniProtKB-SubCell
  5. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3333Orexin-APRO_0000044769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Pyrrolidone carboxylic acidBy similarity
Disulfide bondi6 ↔ 12By similarity
Disulfide bondi7 ↔ 14By similarity
Modified residuei33 – 331Leucine amideBy similarity

Keywords - PTMi

Amidation, Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Gene expression databases

ExpressionAtlasiP56717. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000875.

Structurei

3D structure databases

SMRiP56717. Positions 1-33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.Curated

Phylogenomic databases

eggNOGiNOG70925.

Family and domain databases

InterProiIPR001704. Orexin.
[Graphical view]
PANTHERiPTHR15173:SF2. PTHR15173:SF2. 1 hit.
PfamiPF02072. Orexin. 1 hit.
[Graphical view]
PRINTSiPR01091. OREXINPP.

Sequencei

Sequence statusi: Complete.

P56717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
QPLPDCCRQK TCSCRLYELL HGAGNHAAGI LTL
Length:33
Mass (Da):3,583
Last modified:May 30, 2000 - v1
Checksum:i8C16A02AA7CBFBD5
GO

Sequence databases

UniGeneiBt.13040.

Cross-referencesi

Web resourcesi

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Sequence databases

UniGeneiBt.13040.

3D structure databases

SMRiP56717. Positions 1-33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG70925.

Enzyme and pathway databases

ReactomeiREACT_287476. G alpha (q) signalling events.
REACT_290593. Orexin and neuropeptides FF and QRFP bind to their respective receptors.

Gene expression databases

ExpressionAtlasiP56717. baseline.

Family and domain databases

InterProiIPR001704. Orexin.
[Graphical view]
PANTHERiPTHR15173:SF2. PTHR15173:SF2. 1 hit.
PfamiPF02072. Orexin. 1 hit.
[Graphical view]
PRINTSiPR01091. OREXINPP.
ProtoNetiSearch...

Publicationsi

  1. Cited for: PROTEIN SEQUENCE.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiOREX_BOVIN
AccessioniPrimary (citable) accession number: P56717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: April 1, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.