P56717 (OREX_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Orexin-A

Alternative name(s):
Hypocretin-1
Short name=Hcrt1

Gene names

Name:	HCRT
Synonyms:	OX, PPOX

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	33 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity By similarity.
Subcellular location	Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junction › synapse By similarity. Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses By similarity.
Sequence similarities	Belongs to the orexin family.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Endoplasmic reticulum Synapse
Molecular function	Neuropeptide
PTM	Amidation Disulfide bond Pyrrolidone carboxylic acid
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	feeding behavior Inferred from electronic annotation. Source: InterPro neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasmic membrane-bounded vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara rough endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 33	33	Orexin-A		PRO_0000044769
Amino acid modifications
	Modified residue	1	1	Pyrrolidone carboxylic acid By similarity
	Modified residue	33	1	Leucine amide By similarity
	Disulfide bond	6 ↔ 12		By similarity
	Disulfide bond	7 ↔ 14		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56717 [UniParc]. Last modified May 30, 2000. Version 1. Checksum: 8C16A02AA7CBFBD5	FASTA	33	3,583
	10 20 30 QPLPDCCRQK TCSCRLYELL HGAGNHAAGI LTL

References

[1]

"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.-S., Terrett J.A. , Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Cell 92:573-585(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Hypothalamus.

Web resources

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Cross-references

Sequence databases
IPI	IPI00695657.
UniGene	Bt.13040.
3D structure databases
ProteinModelPortal	P56717.
SMR	P56717. Positions 1-33.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000000875.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG70925.
InParanoid	P56717.
OrthoDB	EOG408N9S.
Gene expression databases
ArrayExpress	P56717.
Family and domain databases
InterPro	IPR001704. Orexin. [Graphical view]
PANTHER	PTHR15173. PTHR15173. 1 hit.
Pfam	PF02072. Orexin. 1 hit. [Graphical view]
PRINTS	PR01091. OREXINPP.
ProtoNet	Search...

Entry information

Entry name

OREX_BOVIN

Accession

Primary (citable) accession number: P56717

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program