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P56717

- OREX_BOVIN

UniProt

P56717 - OREX_BOVIN

Protein

Orexin-A

Gene

HCRT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity By similarity.By similarity

    GO - Biological processi

    1. feeding behavior Source: InterPro
    2. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_205260. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
    REACT_209521. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orexin-A
    Alternative name(s):
    Hypocretin-1
    Short name:
    Hcrt1
    Gene namesi
    Name:HCRT
    Synonyms:OX, PPOX
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Rough endoplasmic reticulum By similarity. Cytoplasmic vesicle By similarity. Cell junctionsynapse By similarity
    Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    3. perinuclear region of cytoplasm Source: Ensembl
    4. rough endoplasmic reticulum Source: UniProtKB-SubCell
    5. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3333Orexin-APRO_0000044769Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi6 ↔ 12By similarity
    Disulfide bondi7 ↔ 14By similarity
    Modified residuei33 – 331Leucine amideBy similarity

    Keywords - PTMi

    Amidation, Disulfide bond, Pyrrolidone carboxylic acid

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000000875.

    Structurei

    3D structure databases

    ProteinModelPortaliP56717.
    SMRiP56717. Positions 1-33.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the orexin family.Curated

    Phylogenomic databases

    eggNOGiNOG70925.
    InParanoidiP56717.

    Family and domain databases

    InterProiIPR001704. Orexin.
    [Graphical view]
    PANTHERiPTHR15173. PTHR15173. 1 hit.
    PfamiPF02072. Orexin. 1 hit.
    [Graphical view]
    PRINTSiPR01091. OREXINPP.

    Sequencei

    Sequence statusi: Complete.

    P56717-1 [UniParc]FASTAAdd to Basket

    « Hide

    QPLPDCCRQK TCSCRLYELL HGAGNHAAGI LTL                     33
    Length:33
    Mass (Da):3,583
    Last modified:May 30, 2000 - v1
    Checksum:i8C16A02AA7CBFBD5
    GO

    Sequence databases

    UniGeneiBt.13040.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Qui dort dine - Issue 15 of October 2001

    Sequence databases

    UniGenei Bt.13040.

    3D structure databases

    ProteinModelPortali P56717.
    SMRi P56717. Positions 1-33.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000000875.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG70925.
    InParanoidi P56717.

    Enzyme and pathway databases

    Reactomei REACT_205260. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
    REACT_209521. G alpha (q) signalling events.

    Family and domain databases

    InterProi IPR001704. Orexin.
    [Graphical view ]
    PANTHERi PTHR15173. PTHR15173. 1 hit.
    Pfami PF02072. Orexin. 1 hit.
    [Graphical view ]
    PRINTSi PR01091. OREXINPP.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: PROTEIN SEQUENCE.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiOREX_BOVIN
    AccessioniPrimary (citable) accession number: P56717
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3