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Protein

Orexin-A

Gene

HCRT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin-A
Alternative name(s):
Hypocretin-1
Short name:
Hcrt1
Gene namesi
Name:HCRT
Synonyms:OX, PPOX
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000447691 – 33Orexin-AAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi6 ↔ 12By similarity
Disulfide bondi7 ↔ 14By similarity
Modified residuei33Leucine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP56717.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000665.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000875.

Structurei

3D structure databases

ProteinModelPortaliP56717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.Curated

Phylogenomic databases

eggNOGiENOG410J4FI. Eukaryota.
ENOG410Y5WS. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR001704. Orexin.
PANTHERiPTHR15173. PTHR15173. 1 hit.
PfamiView protein in Pfam
PF02072. Orexin. 1 hit.
PRINTSiPR01091. OREXINPP.

Sequencei

Sequence statusi: Complete.

P56717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
QPLPDCCRQK TCSCRLYELL HGAGNHAAGI LTL
Length:33
Mass (Da):3,583
Last modified:May 30, 2000 - v1
Checksum:i8C16A02AA7CBFBD5
GO

Sequence databases

UniGeneiBt.13040.

Cross-referencesi

Web resourcesi

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Sequence databases

UniGeneiBt.13040.

3D structure databases

ProteinModelPortaliP56717.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000875.

Proteomic databases

PaxDbiP56717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J4FI. Eukaryota.
ENOG410Y5WS. LUCA.

Gene expression databases

BgeeiENSBTAG00000000665.

Family and domain databases

InterProiView protein in InterPro
IPR001704. Orexin.
PANTHERiPTHR15173. PTHR15173. 1 hit.
PfamiView protein in Pfam
PF02072. Orexin. 1 hit.
PRINTSiPR01091. OREXINPP.
ProtoNetiSearch...

Entry informationi

Entry nameiOREX_BOVIN
AccessioniPrimary (citable) accession number: P56717
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: March 15, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.