Reviewed, UniProtKB/Swiss-Prot P56717 (OREX_BOVIN)

Names and origin

Protein names

Recommended name:
    Orexin-A
Alternative name(s):
    Hypocretin-1
      Short name=Hcrt1

Gene names

Name:	HCRT
Synonyms:	OX, PPOX

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	33 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity By similarity.
Subcellular location	Rough endoplasmic reticulumBy similarity. Cytoplasmic vesicleBy similarity. Cell junction › synapseBy similarity. Note= Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses By similarity.
Sequence similarities	Belongs to the orexin family.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Endoplasmic reticulum Synapse
Molecular function	Neuropeptide
PTM	Amidation Pyrrolidone carboxylic acid
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	feeding behavior Inferred from electronic annotation. Source: InterPro neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW rough endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 33	33	Orexin-A		PRO_0000044769
Amino acid modifications
	Modified residue	1	1	Pyrrolidone carboxylic acid By similarity
	Modified residue	33	1	Leucine amide By similarity
	Disulfide bond	6 ↔ 12		By similarity
	Disulfide bond	7 ↔ 14		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56717-1 [UniParc]. Last modified May 30, 2000. Version 1. Checksum: 8C16A02AA7CBFBD5	FASTA	33	3,583
	10 20 30 QPLPDCCRQK TCSCRLYELL HGAGNHAAGI LTL

References

[1]

"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.-S., Terrett J.A. , Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Cell 92:573-585(1998) [PubMed: 9491897] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Hypothalamus.

Web resources

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Cross-references

Sequence databases
UniGene	Bt.13040
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000000665. Bos taurus. [Contig view]
Phylogenomic databases
HOVERGEN	P56717.
Family and domain databases
InterPro	IPR001704. Orexin. [Graphical view]
PANTHER	PTHR15173. Orexin. 1 hit.
Pfam	PF02072. Orexin. 1 hit. [Graphical view]
PRINTS	PR01091. OREXINPP.
ProtoNet	Search...

Entry information

Entry name

OREX_BOVIN

Accession

Primary (citable) accession number: P56717

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	November 25, 2008
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)