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Reviewed, UniProtKB/Swiss-Prot P56717 (OREX_BOVIN)

Last modified November 25, 2008. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Orexin-A
Alternative name(s):
    Hypocretin-1
      Short name=Hcrt1
Gene names
Name: HCRT
Synonyms: OX, PPOX
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length33 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity By similarity.

Subcellular location

Rough endoplasmic reticulumBy similarity. Cytoplasmic vesicleBy similarity. Cell junctionsynapseBy similarity. Note= Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses By similarity.

Sequence similarities

Belongs to the orexin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3333Orexin-A
PRO_0000044769

Amino acid modifications

Modified residue11Pyrrolidone carboxylic acid By similarity
Modified residue331Leucine amide By similarity
Disulfide bond6 ↔ 12 By similarity
Disulfide bond7 ↔ 14 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56717-1 [UniParc].

Last modified May 30, 2000. Version 1.
Checksum: 8C16A02AA7CBFBD5

FASTA333,583
        10         20         30 
QPLPDCCRQK TCSCRLYELL HGAGNHAAGI LTL 

« Hide

References

[1]"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior."
Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.-S., Terrett J.A. expand/collapse author list , Elshourbagy N.A., Bergsma D.J., Yanagisawa M.
Cell 92:573-585(1998) [PubMed: 9491897] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Hypothalamus.

Web resources

Protein Spotlight

Qui dort dine - Issue 15 of October 2001

Cross-references

Sequence databases

UniGeneBt.13040

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000000665. Bos taurus. [Contig view]

Phylogenomic databases

HOVERGENP56717.

Family and domain databases

InterProIPR001704. Orexin.
[Graphical view]
PANTHERPTHR15173. Orexin. 1 hit.
PfamPF02072. Orexin. 1 hit.
[Graphical view]
PRINTSPR01091. OREXINPP.
ProtoNetSearch...

Entry information

Entry nameOREX_BOVIN
AccessionPrimary (citable) accession number: P56717
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 25, 2008
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents