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Protein

Omega-conotoxin TxVII

Gene
N/A
Organism
Conus textile (Cloth-of-gold cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). Specifically acts on L-type channels. It blocks molluscan dihydropyridine-sensitive calcium channels.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-conotoxin TxVII
OrganismiConus textile (Cloth-of-gold cone)
Taxonomic identifieri6494 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1603. TxVII.
1096. TxVII precursor.
1097. TxVII precursor.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000039270623 – 49Add BLAST27
PeptideiPRO_000004447952 – 77Omega-conotoxin TxVIIAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 671 Publication
Disulfide bondi59 ↔ 711 Publication
Disulfide bondi66 ↔ 751 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi61 – 63Combined sources3
Beta strandi72 – 74Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F3KNMR-A52-77[»]
ProteinModelPortaliP56714.
SMRiP56714.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56714.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214. Conotoxin.
IPR012321. Conotoxin_omega-typ_CS.
PfamiView protein in Pfam
PF02950. Conotoxin. 1 hit.
PROSITEiView protein in PROSITE
PS60004. OMEGA_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTCMMIVA VLFLTAWTFA TADDSGNGLE NLFPKAHHEM KNPEASKLNK
60 70
RCKQADEPCD VFSLDCCTGI CLGVCMW
Length:77
Mass (Da):8,545
Last modified:March 23, 2010 - v2
Checksum:i5A640B4607F38272
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31N → K in AAF07974 (PubMed:11158371).Curated1
Sequence conflicti34 – 35PK → SN in AAF07974 (PubMed:11158371).Curated2

Mass spectrometryi

Molecular mass is 2832.23 Da from positions 52 - 77. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193263 mRNA. Translation: AAF07974.1.
AF193264 mRNA. Translation: AAF07975.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193263 mRNA. Translation: AAF07974.1.
AF193264 mRNA. Translation: AAF07975.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F3KNMR-A52-77[»]
ProteinModelPortaliP56714.
SMRiP56714.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1603. TxVII.
1096. TxVII precursor.
1097. TxVII precursor.

Miscellaneous databases

EvolutionaryTraceiP56714.

Family and domain databases

InterProiView protein in InterPro
IPR004214. Conotoxin.
IPR012321. Conotoxin_omega-typ_CS.
PfamiView protein in Pfam
PF02950. Conotoxin. 1 hit.
PROSITEiView protein in PROSITE
PS60004. OMEGA_CONOTOXIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCO7_CONTE
AccessioniPrimary (citable) accession number: P56714
Secondary accession number(s): Q9U652, Q9U653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 23, 2010
Last modified: November 2, 2016
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.