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Protein

Omega-conotoxin TxVII

Gene
N/A
Organism
Conus textile (Cloth-of-gold cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). Specifically acts on L-type channels. It blocks molluscan dihydropyridine-sensitive calcium channels.

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-conotoxin TxVII1 Publication
OrganismiConus textile (Cloth-of-gold cone)
Taxonomic identifieri6494 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1603. TxVII.
1096. TxVII precursor.
1097. TxVII precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000039270623 – 49Add BLAST27
PeptideiPRO_000004447952 – 77Omega-conotoxin TxVIIAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 671 PublicationImported
Disulfide bondi59 ↔ 711 PublicationImported
Disulfide bondi66 ↔ 751 PublicationImported

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

Secondary structure

177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi61 – 63Combined sources3
Beta strandi72 – 74Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F3KNMR-A52-77[»]
ProteinModelPortaliP56714.
SMRiP56714.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56714.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.1 Publication
The cysteine framework is VI/VII (C-C-CC-C-C).Curated

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214. Conotoxin.
IPR012321. Conotoxin_omega-typ_CS.
PfamiView protein in Pfam
PF02950. Conotoxin. 1 hit.
PROSITEiView protein in PROSITE
PS60004. OMEGA_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTCMMIVA VLFLTAWTFA TADDSGNGLE NLFPKAHHEM KNPEASKLNK
60 70
RCKQADEPCD VFSLDCCTGI CLGVCMW
Length:77
Mass (Da):8,545
Last modified:March 23, 2010 - v2
Checksum:i5A640B4607F38272
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31N → K in AAF07974 (PubMed:11158371).Curated1
Sequence conflicti34 – 35PK → SN in AAF07974 (PubMed:11158371).Curated2

Mass spectrometryi

Molecular mass is 2832.23 Da from positions 52 - 77. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193263 mRNA. Translation: AAF07974.1.
AF193264 mRNA. Translation: AAF07975.1.

Similar proteinsi

Entry informationi

Entry nameiCO7_CONTE
AccessioniPrimary (citable) accession number: P56714
Secondary accession number(s): Q9U652, Q9U653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 23, 2010
Last modified: November 22, 2017
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families