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Protein

Protein Wnt-7b

Gene

WNT7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

  1. frizzled binding Source: GO_Central

GO - Biological processi

  1. activation of JUN kinase activity Source: Ensembl
  2. anatomical structure regression Source: Ensembl
  3. apoptotic process involved in patterning of blood vessels Source: Ensembl
  4. canonical Wnt signaling pathway Source: UniProtKB
  5. cell fate commitment Source: GO_Central
  6. cellular metabolic process Source: UniProtKB
  7. cellular response to retinoic acid Source: UniProtKB
  8. central nervous system vasculogenesis Source: UniProtKB
  9. chorio-allantoic fusion Source: UniProtKB
  10. developmental growth involved in morphogenesis Source: UniProtKB
  11. embryonic organ development Source: UniProtKB
  12. embryonic placenta morphogenesis Source: UniProtKB
  13. establishment or maintenance of polarity of embryonic epithelium Source: UniProtKB
  14. fibroblast proliferation Source: UniProtKB
  15. forebrain regionalization Source: UniProtKB
  16. homeostatic process Source: UniProtKB
  17. inner medullary collecting duct development Source: UniProtKB
  18. in utero embryonic development Source: UniProtKB
  19. lens fiber cell development Source: BHF-UCL
  20. lobar bronchus development Source: UniProtKB
  21. lung-associated mesenchyme development Source: Ensembl
  22. lung development Source: UniProtKB
  23. lung epithelium development Source: UniProtKB
  24. lung morphogenesis Source: UniProtKB
  25. mammary gland epithelium development Source: UniProtKB
  26. metanephric collecting duct development Source: UniProtKB
  27. metanephric epithelium development Source: UniProtKB
  28. metanephric loop of Henle development Source: UniProtKB
  29. metanephros morphogenesis Source: UniProtKB
  30. negative regulation of smoothened signaling pathway Source: Ensembl
  31. neuron differentiation Source: UniProtKB
  32. neuron projection morphogenesis Source: Ensembl
  33. odontogenesis of dentin-containing tooth Source: Ensembl
  34. outer medullary collecting duct development Source: UniProtKB
  35. oxygen homeostasis Source: UniProtKB
  36. positive regulation of cell proliferation Source: Ensembl
  37. positive regulation of gene expression Source: Ensembl
  38. positive regulation of JNK cascade Source: GO_Central
  39. positive regulation of osteoblast differentiation Source: UniProtKB
  40. regulation of cell projection size Source: Ensembl
  41. renal inner medulla development Source: UniProtKB
  42. renal outer medulla development Source: UniProtKB
  43. response to glucocorticoid Source: Ensembl
  44. smooth muscle cell differentiation Source: Ensembl
  45. stem cell proliferation Source: UniProtKB
  46. synapse organization Source: UniProtKB
  47. trachea cartilage morphogenesis Source: UniProtKB
  48. Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-7b
Gene namesi
Name:WNT7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:12787. WNT7B.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Reactome
  2. extracellular region Source: Reactome
  3. extracellular space Source: GO_Central
  4. Golgi lumen Source: Reactome
  5. plasma membrane Source: Reactome
  6. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 349325Protein Wnt-7bPRO_0000041444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 84By similarity
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi123 ↔ 131By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi133 ↔ 152By similarity
Disulfide bondi200 ↔ 214By similarity
Disulfide bondi202 ↔ 209By similarity
Lipidationi206 – 2061O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP56706.
PaxDbiP56706.
PRIDEiP56706.

PTM databases

PhosphoSiteiP56706.

Expressioni

Tissue specificityi

Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate.

Gene expression databases

BgeeiP56706.
CleanExiHS_WNT7B.
ExpressionAtlasiP56706. baseline and differential.
GenevestigatoriP56706.

Organism-specific databases

HPAiCAB025665.

Interactioni

Subunit structurei

Interacts with PORCN.By similarity

Protein-protein interaction databases

BioGridi113314. 4 interactions.
IntActiP56706. 3 interactions.
STRINGi9606.ENSP00000341032.

Structurei

3D structure databases

ProteinModelPortaliP56706.
SMRiP56706. Positions 62-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP56706.
KOiK00572.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP56706.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA
60 70 80 90 100
ICQSRPDAII VIGEGAQMGI NECQYQFRFG RWNCSALGEK TVFGQELRVG
110 120 130 140 150
SREAAFTYAI TAAGVAHAVT AACSQGNLSN CGCDREKQGY YNQAEGWKWG
160 170 180 190 200
GCSADVRYGI DFSRRFVDAR EIKKNARRLM NLHNNEAGRK VLEDRMQLEC
210 220 230 240 250
KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV VRASRLRQPT
260 270 280 290 300
FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG
310 320 330 340
ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK
Length:349
Mass (Da):39,327
Last modified:May 10, 2002 - v2
Checksum:iD114C329118C7CB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti293 – 2931L → I (PubMed:8168088).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062766 mRNA. Translation: BAB68399.1.
AF416743 mRNA. Translation: AAN32640.1.
BX511035, CR536603 Genomic DNA. Translation: CAX15183.1.
CR536603, BX511035 Genomic DNA. Translation: CAX15218.1.
BC034923 mRNA. Translation: AAH34923.1.
CCDSiCCDS33667.1.
RefSeqiNP_478679.1. NM_058238.2.
UniGeneiHs.512714.

Genome annotation databases

EnsembliENST00000339464; ENSP00000341032; ENSG00000188064.
GeneIDi7477.
KEGGihsa:7477.
UCSCiuc003bgo.2. human.

Polymorphism databases

DMDMi20532426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062766 mRNA. Translation: BAB68399.1.
AF416743 mRNA. Translation: AAN32640.1.
BX511035, CR536603 Genomic DNA. Translation: CAX15183.1.
CR536603, BX511035 Genomic DNA. Translation: CAX15218.1.
BC034923 mRNA. Translation: AAH34923.1.
CCDSiCCDS33667.1.
RefSeqiNP_478679.1. NM_058238.2.
UniGeneiHs.512714.

3D structure databases

ProteinModelPortaliP56706.
SMRiP56706. Positions 62-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113314. 4 interactions.
IntActiP56706. 3 interactions.
STRINGi9606.ENSP00000341032.

PTM databases

PhosphoSiteiP56706.

Polymorphism databases

DMDMi20532426.

Proteomic databases

MaxQBiP56706.
PaxDbiP56706.
PRIDEiP56706.

Protocols and materials databases

DNASUi7477.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339464; ENSP00000341032; ENSG00000188064.
GeneIDi7477.
KEGGihsa:7477.
UCSCiuc003bgo.2. human.

Organism-specific databases

CTDi7477.
GeneCardsiGC22M046316.
HGNCiHGNC:12787. WNT7B.
HPAiCAB025665.
MIMi601967. gene.
neXtProtiNX_P56706.
PharmGKBiPA37388.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP56706.
KOiK00572.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP56706.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).

Miscellaneous databases

ChiTaRSiWNT7B. human.
GeneWikiiWNT7B.
GenomeRNAii7477.
NextBioi29288.
PROiP56706.
SOURCEiSearch...

Gene expression databases

BgeeiP56706.
CleanExiHS_WNT7B.
ExpressionAtlasiP56706. baseline and differential.
GenevestigatoriP56706.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of human WNT7B."
    Kirikoshi H., Sekihara H., Katoh M.
    Int. J. Oncol. 19:779-783(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Kim N.-S., Kim J.-M., Oh J.-H., Sohn H.-Y., Hahn Y., Kim Y.S.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  5. "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue."
    Huguet E.L., McMahon J.A., McMahon A.P., Bicknell R., Harris A.L.
    Cancer Res. 54:2615-2621(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 204-327.
    Tissue: Mammary gland.

Entry informationi

Entry nameiWNT7B_HUMAN
AccessioniPrimary (citable) accession number: P56706
Secondary accession number(s): B8A596, Q96Q12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: February 4, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.