P56706 (WNT7B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-7b

Gene names

Name:

WNT7B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.
Subunit structure	Interacts with PORCN By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate.
Post-translational modification	Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-73. Palmitoylation is necessary for proper trafficking to cell surface By similarity.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of JUN kinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome anatomical structure regression Inferred from electronic annotation. Source: Compara anterior/posterior pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome axonogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB cell-cell signaling Non-traceable author statement. Source: UniProtKB cellular response to retinoic acid Inferred from expression pattern PubMed 12239632PubMed 12429992. Source: UniProtKB central nervous system vasculogenesis Inferred from sequence or structural similarity. Source: UniProtKB chorio-allantoic fusion Inferred from sequence or structural similarity. Source: UniProtKB developmental growth involved in morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB establishment or maintenance of polarity of embryonic epithelium Inferred from sequence or structural similarity. Source: UniProtKB fibroblast proliferation Inferred from expression pattern PubMed 19734317. Source: UniProtKB forebrain regionalization Inferred from expression pattern PubMed 15164427. Source: UniProtKB induction of apoptosis Inferred from electronic annotation. Source: Compara inner medullary collecting duct development Inferred from sequence or structural similarity. Source: UniProtKB lens fiber cell development Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL lobar bronchus development Inferred from sequence or structural similarity. Source: UniProtKB lung epithelium development Inferred from sequence or structural similarity. Source: UniProtKB lung morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB lung-associated mesenchyme development Inferred from Biological aspect of Ancestor. Source: RefGenome mammary gland epithelium development Inferred from expression pattern Ref.5. Source: UniProtKB metanephric collecting duct development Inferred from sequence or structural similarity. Source: UniProtKB metanephric loop of Henle development Inferred from sequence or structural similarity. Source: UniProtKB metanephros morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of smoothened signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome odontogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara outer medullary collecting duct development Inferred from sequence or structural similarity. Source: UniProtKB oxygen homeostasis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of JNK cascade Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from sequence or structural similarity. Source: UniProtKB renal inner medulla development Inferred from sequence or structural similarity. Source: UniProtKB renal outer medulla development Inferred from sequence or structural similarity. Source: UniProtKB smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara stem cell proliferation Inferred from expression pattern PubMed 19734317. Source: UniProtKB synapse organization Inferred from sequence or structural similarity. Source: UniProtKB trachea cartilage morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	extracellular matrix structural constituent Non-traceable author statement. Source: UniProtKB frizzled binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 349	325	Protein Wnt-7b		PRO_0000041444
Amino acid modifications
	Lipidation	73	1	S-palmitoyl cysteine By similarity
	Lipidation	206	1	O-palmitoyl serine; by PORCN By similarity
	Glycosylation	83	1	N-linked (GlcNAc...) Potential
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Glycosylation	295	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	293	1	L → I Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P56706 [UniParc]. Last modified May 10, 2002. Version 2. Checksum: D114C329118C7CB1	FASTA	349	39,327
	10 20 30 40 50 60 MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA ICQSRPDAII 70 80 90 100 110 120 VIGEGAQMGI NECQYQFRFG RWNCSALGEK TVFGQELRVG SREAAFTYAI TAAGVAHAVT 130 140 150 160 170 180 AACSQGNLSN CGCDREKQGY YNQAEGWKWG GCSADVRYGI DFSRRFVDAR EIKKNARRLM 190 200 210 220 230 240 NLHNNEAGRK VLEDRMQLEC KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV 250 260 270 280 290 300 VRASRLRQPT FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG 310 320 330 340 ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of human WNT7B." Kirikoshi H., Sekihara H., Katoh M. Int. J. Oncol. 19:779-783(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Kim N.-S., Kim J.-M., Oh J.-H., Sohn H.-Y., Hahn Y., Kim Y.S. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[5]	"Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue." Huguet E.L., McMahon J.A., McMahon A.P., Bicknell R., Harris A.L. Cancer Res. 54:2615-2621(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 204-327. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB062766 mRNA. Translation: BAB68399.1. AF416743 mRNA. Translation: AAN32640.1. BX511035, CR536603 Genomic DNA. Translation: CAX15183.1. CR536603, BX511035 Genomic DNA. Translation: CAX15218.1. BC034923 mRNA. Translation: AAH34923.1.
IPI	IPI00011031.
RefSeq	NP_478679.1. NM_058238.2.
UniGene	Hs.512714.
3D structure databases
ProteinModelPortal	P56706.
ModBase	Search...
Protein-protein interaction databases
IntAct	P56706. 3 interactions.
STRING	9606.ENSP00000341032.
PTM databases
PhosphoSite	P56706.
Polymorphism databases
DMDM	20532426.
Proteomic databases
PaxDb	P56706.
PRIDE	P56706.
Protocols and materials databases
DNASU	7477.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339464; ENSP00000341032; ENSG00000188064.
GeneID	7477.
KEGG	hsa:7477.
UCSC	uc003bgo.2. human.
Organism-specific databases
CTD	7477.
GeneCards	GC22M046316.
HGNC	HGNC:12787. WNT7B.
HPA	CAB025665.
MIM	601967. gene.
neXtProt	NX_P56706.
PharmGKB	PA37388.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284879.
HOGENOM	HOG000039528.
HOVERGEN	HBG001595.
KO	K00572.
OrthoDB	EOG4GXFMZ.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P56706.
Bgee	P56706.
CleanEx	HS_WNT7B.
Genevestigator	P56706.
GermOnline	ENSG00000188064. Homo sapiens.
Family and domain databases
InterPro	IPR005817. Wnt. IPR013300. Wnt7. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF22. PTHR12027:SF22. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01891. WNT7PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7477.
NextBio	29288.
SOURCE	Search...

Entry information

Entry name

WNT7B_HUMAN

Accession

Primary (citable) accession number: P56706
Secondary accession number(s): B8A596, Q96Q12

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 10, 2002
Last modified:	April 3, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.