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P56706

- WNT7B_HUMAN

UniProt

P56706 - WNT7B_HUMAN

Protein

Protein Wnt-7b

Gene

WNT7B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (10 May 2002)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome

    GO - Biological processi

    1. activation of JUN kinase activity Source: Ensembl
    2. anatomical structure regression Source: Ensembl
    3. apoptotic process involved in patterning of blood vessels Source: Ensembl
    4. canonical Wnt signaling pathway Source: UniProtKB
    5. cell fate commitment Source: RefGenome
    6. cellular metabolic process Source: UniProtKB
    7. cellular response to retinoic acid Source: UniProtKB
    8. central nervous system vasculogenesis Source: UniProtKB
    9. chorio-allantoic fusion Source: UniProtKB
    10. developmental growth involved in morphogenesis Source: UniProtKB
    11. embryonic organ development Source: UniProtKB
    12. embryonic placenta morphogenesis Source: UniProtKB
    13. establishment or maintenance of polarity of embryonic epithelium Source: UniProtKB
    14. fibroblast proliferation Source: UniProtKB
    15. forebrain regionalization Source: UniProtKB
    16. homeostatic process Source: UniProtKB
    17. inner medullary collecting duct development Source: UniProtKB
    18. in utero embryonic development Source: UniProtKB
    19. lens fiber cell development Source: BHF-UCL
    20. lobar bronchus development Source: UniProtKB
    21. lung-associated mesenchyme development Source: Ensembl
    22. lung development Source: UniProtKB
    23. lung epithelium development Source: UniProtKB
    24. lung morphogenesis Source: UniProtKB
    25. mammary gland epithelium development Source: UniProtKB
    26. metanephric collecting duct development Source: UniProtKB
    27. metanephric epithelium development Source: UniProtKB
    28. metanephric loop of Henle development Source: UniProtKB
    29. metanephros morphogenesis Source: UniProtKB
    30. negative regulation of smoothened signaling pathway Source: Ensembl
    31. neuron differentiation Source: UniProtKB
    32. neuron projection morphogenesis Source: Ensembl
    33. odontogenesis of dentin-containing tooth Source: Ensembl
    34. outer medullary collecting duct development Source: UniProtKB
    35. oxygen homeostasis Source: UniProtKB
    36. positive regulation of cell proliferation Source: Ensembl
    37. positive regulation of gene expression Source: Ensembl
    38. positive regulation of JNK cascade Source: RefGenome
    39. positive regulation of osteoblast differentiation Source: UniProtKB
    40. regulation of cell projection size Source: Ensembl
    41. renal inner medulla development Source: UniProtKB
    42. renal outer medulla development Source: UniProtKB
    43. response to glucocorticoid Source: Ensembl
    44. smooth muscle cell differentiation Source: Ensembl
    45. stem cell proliferation Source: UniProtKB
    46. synapse organization Source: UniProtKB
    47. trachea cartilage morphogenesis Source: UniProtKB
    48. Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-7b
    Gene namesi
    Name:WNT7B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:12787. WNT7B.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: Reactome
    2. extracellular region Source: Reactome
    3. extracellular space Source: RefGenome
    4. Golgi lumen Source: Reactome
    5. plasma membrane Source: Reactome
    6. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37388.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 349325Protein Wnt-7bPRO_0000041444Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi73 ↔ 84By similarity
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi123 ↔ 131By similarity
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 152By similarity
    Disulfide bondi200 ↔ 214By similarity
    Disulfide bondi202 ↔ 209By similarity
    Lipidationi206 – 2061O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi294 ↔ 309By similarity
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi324 ↔ 339By similarity
    Disulfide bondi326 ↔ 336By similarity
    Disulfide bondi331 ↔ 332By similarity

    Post-translational modificationi

    Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP56706.
    PaxDbiP56706.
    PRIDEiP56706.

    PTM databases

    PhosphoSiteiP56706.

    Expressioni

    Tissue specificityi

    Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate.

    Gene expression databases

    ArrayExpressiP56706.
    BgeeiP56706.
    CleanExiHS_WNT7B.
    GenevestigatoriP56706.

    Organism-specific databases

    HPAiCAB025665.

    Interactioni

    Subunit structurei

    Interacts with PORCN.By similarity

    Protein-protein interaction databases

    BioGridi113314. 3 interactions.
    IntActiP56706. 3 interactions.
    STRINGi9606.ENSP00000341032.

    Structurei

    3D structure databases

    ProteinModelPortaliP56706.
    SMRiP56706. Positions 62-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    HOGENOMiHOG000039528.
    HOVERGENiHBG001595.
    KOiK00572.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiP56706.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013300. Wnt7.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01891. WNT7PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56706-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA    50
    ICQSRPDAII VIGEGAQMGI NECQYQFRFG RWNCSALGEK TVFGQELRVG 100
    SREAAFTYAI TAAGVAHAVT AACSQGNLSN CGCDREKQGY YNQAEGWKWG 150
    GCSADVRYGI DFSRRFVDAR EIKKNARRLM NLHNNEAGRK VLEDRMQLEC 200
    KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV VRASRLRQPT 250
    FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG 300
    ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK 349
    Length:349
    Mass (Da):39,327
    Last modified:May 10, 2002 - v2
    Checksum:iD114C329118C7CB1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti293 – 2931L → I(PubMed:8168088)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB062766 mRNA. Translation: BAB68399.1.
    AF416743 mRNA. Translation: AAN32640.1.
    BX511035, CR536603 Genomic DNA. Translation: CAX15183.1.
    CR536603, BX511035 Genomic DNA. Translation: CAX15218.1.
    BC034923 mRNA. Translation: AAH34923.1.
    CCDSiCCDS33667.1.
    RefSeqiNP_478679.1. NM_058238.2.
    UniGeneiHs.512714.

    Genome annotation databases

    EnsembliENST00000339464; ENSP00000341032; ENSG00000188064.
    GeneIDi7477.
    KEGGihsa:7477.
    UCSCiuc003bgo.2. human.

    Polymorphism databases

    DMDMi20532426.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB062766 mRNA. Translation: BAB68399.1 .
    AF416743 mRNA. Translation: AAN32640.1 .
    BX511035 , CR536603 Genomic DNA. Translation: CAX15183.1 .
    CR536603 , BX511035 Genomic DNA. Translation: CAX15218.1 .
    BC034923 mRNA. Translation: AAH34923.1 .
    CCDSi CCDS33667.1.
    RefSeqi NP_478679.1. NM_058238.2.
    UniGenei Hs.512714.

    3D structure databases

    ProteinModelPortali P56706.
    SMRi P56706. Positions 62-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113314. 3 interactions.
    IntActi P56706. 3 interactions.
    STRINGi 9606.ENSP00000341032.

    PTM databases

    PhosphoSitei P56706.

    Polymorphism databases

    DMDMi 20532426.

    Proteomic databases

    MaxQBi P56706.
    PaxDbi P56706.
    PRIDEi P56706.

    Protocols and materials databases

    DNASUi 7477.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339464 ; ENSP00000341032 ; ENSG00000188064 .
    GeneIDi 7477.
    KEGGi hsa:7477.
    UCSCi uc003bgo.2. human.

    Organism-specific databases

    CTDi 7477.
    GeneCardsi GC22M046316.
    HGNCi HGNC:12787. WNT7B.
    HPAi CAB025665.
    MIMi 601967. gene.
    neXtProti NX_P56706.
    PharmGKBi PA37388.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284879.
    HOGENOMi HOG000039528.
    HOVERGENi HBG001595.
    KOi K00572.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi P56706.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).

    Miscellaneous databases

    GeneWikii WNT7B.
    GenomeRNAii 7477.
    NextBioi 29288.
    PROi P56706.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P56706.
    Bgeei P56706.
    CleanExi HS_WNT7B.
    Genevestigatori P56706.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013300. Wnt7.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01891. WNT7PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of human WNT7B."
      Kirikoshi H., Sekihara H., Katoh M.
      Int. J. Oncol. 19:779-783(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Kim N.-S., Kim J.-M., Oh J.-H., Sohn H.-Y., Hahn Y., Kim Y.S.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    5. "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue."
      Huguet E.L., McMahon J.A., McMahon A.P., Bicknell R., Harris A.L.
      Cancer Res. 54:2615-2621(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 204-327.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiWNT7B_HUMAN
    AccessioniPrimary (citable) accession number: P56706
    Secondary accession number(s): B8A596, Q96Q12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 10, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3