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P56706 (WNT7B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-7b
Gene names
Name:WNT7B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subunit structure

Interacts with PORCN By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate.

Post-translational modification

Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-73. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

activation of JUN kinase activity

Inferred from electronic annotation. Source: Ensembl

anatomical structure regression

Inferred from electronic annotation. Source: Ensembl

apoptotic process involved in patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to retinoic acid

Inferred from expression pattern PubMed 12239632PubMed 12429992. Source: UniProtKB

central nervous system vasculogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

chorio-allantoic fusion

Inferred from sequence or structural similarity. Source: UniProtKB

developmental growth involved in morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

embryonic organ development

Inferred from sequence or structural similarity. Source: UniProtKB

embryonic placenta morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

establishment or maintenance of polarity of embryonic epithelium

Inferred from sequence or structural similarity. Source: UniProtKB

fibroblast proliferation

Inferred from expression pattern PubMed 19734317. Source: UniProtKB

forebrain regionalization

Inferred from expression pattern PubMed 15164427. Source: UniProtKB

homeostatic process

Inferred from sequence or structural similarity. Source: UniProtKB

in utero embryonic development

Inferred from sequence or structural similarity. Source: UniProtKB

inner medullary collecting duct development

Inferred from sequence or structural similarity. Source: UniProtKB

lens fiber cell development

Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL

lobar bronchus development

Inferred from sequence or structural similarity. Source: UniProtKB

lung development

Inferred from sequence or structural similarity. Source: UniProtKB

lung epithelium development

Inferred from sequence or structural similarity. Source: UniProtKB

lung morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

lung-associated mesenchyme development

Inferred from electronic annotation. Source: Ensembl

mammary gland epithelium development

Inferred from expression pattern Ref.5. Source: UniProtKB

metanephric collecting duct development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric epithelium development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephric loop of Henle development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephros morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

neuron differentiation

Inferred from expression pattern PubMed 12429992. Source: UniProtKB

neuron projection morphogenesis

Inferred from electronic annotation. Source: Ensembl

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

outer medullary collecting duct development

Inferred from sequence or structural similarity. Source: UniProtKB

oxygen homeostasis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of JNK cascade

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell projection size

Inferred from electronic annotation. Source: Ensembl

renal inner medulla development

Inferred from sequence or structural similarity. Source: UniProtKB

renal outer medulla development

Inferred from sequence or structural similarity. Source: UniProtKB

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

stem cell proliferation

Inferred from expression pattern PubMed 19734317. Source: UniProtKB

synapse organization

Inferred from sequence or structural similarity. Source: UniProtKB

trachea cartilage morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentGolgi lumen

Traceable author statement. Source: Reactome

endoplasmic reticulum lumen

Traceable author statement. Source: Reactome

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

plasma membrane

Traceable author statement. Source: Reactome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 349325Protein Wnt-7b
PRO_0000041444

Amino acid modifications

Lipidation731S-palmitoyl cysteine By similarity
Lipidation2061O-palmitoyl serine; by PORCN By similarity
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2931L → I Ref.5

Sequences

Sequence LengthMass (Da)Tools
P56706 [UniParc].

Last modified May 10, 2002. Version 2.
Checksum: D114C329118C7CB1

FASTA34939,327
        10         20         30         40         50         60 
MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA ICQSRPDAII 

        70         80         90        100        110        120 
VIGEGAQMGI NECQYQFRFG RWNCSALGEK TVFGQELRVG SREAAFTYAI TAAGVAHAVT 

       130        140        150        160        170        180 
AACSQGNLSN CGCDREKQGY YNQAEGWKWG GCSADVRYGI DFSRRFVDAR EIKKNARRLM 

       190        200        210        220        230        240 
NLHNNEAGRK VLEDRMQLEC KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV 

       250        260        270        280        290        300 
VRASRLRQPT FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG 

       310        320        330        340 
ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of human WNT7B."
Kirikoshi H., Sekihara H., Katoh M.
Int. J. Oncol. 19:779-783(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Kim N.-S., Kim J.-M., Oh J.-H., Sohn H.-Y., Hahn Y., Kim Y.S.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[5]"Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue."
Huguet E.L., McMahon J.A., McMahon A.P., Bicknell R., Harris A.L.
Cancer Res. 54:2615-2621(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 204-327.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB062766 mRNA. Translation: BAB68399.1.
AF416743 mRNA. Translation: AAN32640.1.
BX511035, CR536603 Genomic DNA. Translation: CAX15183.1.
CR536603, BX511035 Genomic DNA. Translation: CAX15218.1.
BC034923 mRNA. Translation: AAH34923.1.
RefSeqNP_478679.1. NM_058238.2.
UniGeneHs.512714.

3D structure databases

ProteinModelPortalP56706.
SMRP56706. Positions 62-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113314. 3 interactions.
IntActP56706. 3 interactions.
STRING9606.ENSP00000341032.

PTM databases

PhosphoSiteP56706.

Polymorphism databases

DMDM20532426.

Proteomic databases

PaxDbP56706.
PRIDEP56706.

Protocols and materials databases

DNASU7477.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339464; ENSP00000341032; ENSG00000188064.
GeneID7477.
KEGGhsa:7477.
UCSCuc003bgo.2. human.

Organism-specific databases

CTD7477.
GeneCardsGC22M046316.
HGNCHGNC:12787. WNT7B.
HPACAB025665.
MIM601967. gene.
neXtProtNX_P56706.
PharmGKBPA37388.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284879.
HOGENOMHOG000039528.
HOVERGENHBG001595.
KOK00572.
OrthoDBEOG7C8GJ8.
PhylomeDBP56706.
TreeFamTF105310.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP56706.
BgeeP56706.
CleanExHS_WNT7B.
GenevestigatorP56706.

Family and domain databases

InterProIPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF22. PTHR12027:SF22. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiWNT7B.
GenomeRNAi7477.
NextBio29288.
PROP56706.
SOURCESearch...

Entry information

Entry nameWNT7B_HUMAN
AccessionPrimary (citable) accession number: P56706
Secondary accession number(s): B8A596, Q96Q12
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM