Reviewed,
UniProtKB/Swiss-Prot P56704 (WNT3A_HUMAN)
Last modified
March 2, 2010.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein Wnt-3a | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 352 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. |
| Subunit structure | Interacts with PORCN By similarity. |
| Subcellular location | |
| Tissue specificity | Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate. |
| Sequence similarities | Belongs to the Wnt family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Wnt signaling pathway |
| Cellular component | Extracellular matrix Secreted |
| Domain | Signal |
| Molecular function | Developmental protein |
| PTM | Glycoprotein Lipoprotein Palmitate |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | Wnt receptor signaling pathway, calcium modulating pathway Inferred from electronic annotation. Source: InterPro cell-cell signalingNon-traceable author statement. Source: UniProtKB |
| Cellular component | proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | extracellular matrix structural constituent Non-traceable author statement. Source: UniProtKB signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | Potential | ||||||
| Chain | 25 – 352 | 328 | Protein Wnt-3a | PRO_0000041418 | |||||
Amino acid modifications | |||||||||
| Lipidation | 77 | 1 | S-palmitoyl cysteine By similarity | ||||||
| Glycosylation | 87 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 298 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region." Saitoh T., Hirai M., Katoh M. Biochem. Biophys. Res. Commun. 284:1168-1175(2001) [PubMed: 11414706] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue." Huguet E.L., McMahon J.A., McMahon A.P., Bicknell R., Harris A.L. Cancer Res. 54:2615-2621(1994) [PubMed: 8168088] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-330. Tissue: Mammary gland. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB060284 mRNA. Translation: BAB61052.1. AK056278 mRNA. Translation: BAB71136.1. AL136379 Genomic DNA. Translation: CAI23122.1. BC103922 mRNA. Translation: AAI03923.1. |
| IPI | IPI00654606. |
| RefSeq | NP_149122.1. |
| UniGene | Hs.336930 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P56704. |
Proteomic databases | |
| PRIDE | P56704. |
Genome annotation databases | |
| Ensembl | ENST00000284523; ENSP00000284523; ENSG00000154342; Homo sapiens. [Genome view] ENST00000366753; ENSP00000355715; ENSG00000154342; Homo sapiens. [Genome view] |
| GeneID | 89780. |
| KEGG | hsa:89780. |
| UCSC | uc001hrq.1. human. |
Organism-specific databases | |
| CTD | 89780. |
| GeneCards | GC01P226261. |
| H-InvDB | HIX0001654. |
| HGNC | HGNC:15983. WNT3A. |
| MIM | 606359. gene. |
| PharmGKB | PA38074. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG13814. |
| HOVERGEN | HBG001595. |
| InParanoid | P56704. |
| OrthoDB | EOG9N5ZGH. |
| PhylomeDB | P56704. |
Gene expression databases | |
| ArrayExpress | P56704. |
| Bgee | P56704. |
| CleanEx | HS_WNT3A. |
| Genevestigator | P56704. |
Family and domain databases | |
| InterPro | IPR009141. Wnt3. IPR005816. Wnt_grthfactor. IPR018161. Wnt_grthfactor_CS. IPR005817. Wnt_SF. [Graphical view] |
| PANTHER | PTHR12027. Wnt. 1 hit. PTHR12027:SF18. Wnt3. 1 hit. |
| Pfam | PF00110. wnt. 1 hit. [Graphical view] |
| PRINTS | PR01843. WNT3PROTEIN. PR01349. WNTPROTEIN. |
| SMART | SM00097. WNT1. 1 hit. [Graphical view] |
| PROSITE | PS00246. WNT1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 76263. |
| SOURCE | Search... |
Entry information
| Entry name | WNT3A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P56704 Secondary accession number(s): Q3SY80, Q969P2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


