ID   WNT3_HUMAN              Reviewed;         355 AA.
AC   P56703; Q2M237; Q9H1J9;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 2.
DT   25-JAN-2012, entry version 96.
DE   RecName: Full=Proto-oncogene Wnt-3;
DE   AltName: Full=Proto-oncogene Int-4 homolog;
DE   Flags: Precursor;
GN   Name=WNT3; Synonyms=INT4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y.,
RA   Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A.,
RA   Culbert A.A., Reith A.D., Barnes M.R.;
RT   "Molecular cloning and characterization of six novel human WNT
RT   genes.";
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=21490205; PubMed=11604997;
RA   Katoh M.;
RT   "Molecular cloning and characterization of human WNT3.";
RL   Int. J. Oncol. 19:977-982(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-333.
RX   MEDLINE=94063935; PubMed=8244403; DOI=10.1006/geno.1993.1412;
RA   Roelink H., Wang J., Black D.M., Solomon E., Nusse R.;
RT   "Molecular cloning and chromosomal localization to 17q21 of the human
RT   WNT3 gene.";
RL   Genomics 17:790-792(1993).
RN   [5]
RP   INVOLVEMENT IN ARTTRA.
RX   PubMed=14872406; DOI=10.1086/382196;
RA   Niemann S., Zhao C., Pascu F., Stahl U., Aulepp U., Niswander L.,
RA   Weber J.L., Mueller U.;
RT   "Homozygous WNT3 mutation causes tetra-amelia in a large
RT   consanguineous family.";
RL   Am. J. Hum. Genet. 74:558-563(2004).
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in
CC       cell-cell signaling during morphogenesis of the developing neural
CC       tube (By similarity).
CC   -!- SUBUNIT: Interacts with PORCN (By similarity). Interacts with WLS
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix.
CC   -!- DISEASE: Defects in WNT3 are the cause of autosomal recessive
CC       tetra-amelia (ARTTRA) [MIM:273395]. Tetra-amelia is a rare human
CC       genetic disorder characterized by complete absence of all four
CC       limbs and other anomalies such as craniofacial, nervous system,
CC       pulmonary, skeletal and urogenital defects.
CC   -!- SIMILARITY: Belongs to the Wnt family.
CC   -!- WEB RESOURCE: Name=GeneReviews;
CC       URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/WNT3";
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AY009397; AAG38657.1; -; mRNA.
DR   EMBL; AB067628; BAB70502.1; -; mRNA.
DR   EMBL; BC112116; AAI12117.1; -; mRNA.
DR   EMBL; BC112118; AAI12119.1; -; mRNA.
DR   EMBL; BC114219; AAI14220.1; -; mRNA.
DR   IPI; IPI00011023; -.
DR   PIR; A47536; A47536.
DR   RefSeq; NP_110380.1; NM_030753.3.
DR   UniGene; Hs.445884; -.
DR   IntAct; P56703; 1.
DR   STRING; P56703; -.
DR   DMDM; 14424477; -.
DR   PRIDE; P56703; -.
DR   Ensembl; ENST00000225512; ENSP00000225512; ENSG00000108379.
DR   GeneID; 7473; -.
DR   KEGG; hsa:7473; -.
DR   UCSC; uc002ikv.1; human.
DR   CTD; 7473; -.
DR   GeneCards; GC17M044839; -.
DR   H-InvDB; HIX0039031; -.
DR   HGNC; HGNC:12782; WNT3.
DR   MIM; 165330; gene.
DR   MIM; 273395; phenotype.
DR   neXtProt; NX_P56703; -.
DR   Orphanet; 1027; Autosomal recessive amelia.
DR   Orphanet; 3301; Tetraamelia - multiple malformations.
DR   PharmGKB; PA37383; -.
DR   eggNOG; prNOG14485; -.
DR   GeneTree; ENSGT00600000084119; -.
DR   HOGENOM; HBG446188; -.
DR   HOVERGEN; HBG001595; -.
DR   InParanoid; P56703; -.
DR   OMA; MCGCDSH; -.
DR   OrthoDB; EOG4XD3R9; -.
DR   PhylomeDB; P56703; -.
DR   Reactome; REACT_111102; Signal Transduction.
DR   NextBio; 29272; -.
DR   ArrayExpress; P56703; -.
DR   Bgee; P56703; -.
DR   CleanEx; HS_WNT3; -.
DR   Genevestigator; P56703; -.
DR   GermOnline; ENSG00000108379; Homo sapiens.
DR   GO; GO:0005769; C:early endosome; IBA:RefGenome.
DR   GO; GO:0005615; C:extracellular space; TAS:BHF-UCL.
DR   GO; GO:0005770; C:late endosome; IBA:RefGenome.
DR   GO; GO:0005624; C:membrane fraction; IDA:BHF-UCL.
DR   GO; GO:0045121; C:membrane raft; IBA:RefGenome.
DR   GO; GO:0005886; C:plasma membrane; IBA:RefGenome.
DR   GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005110; F:frizzled-2 binding; IBA:RefGenome.
DR   GO; GO:0044338; P:canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation; IMP:BHF-UCL.
DR   GO; GO:0044339; P:canonical Wnt receptor signaling pathway involved in osteoblast differentiation; IMP:BHF-UCL.
DR   GO; GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
DR   GO; GO:0009950; P:dorsal/ventral axis specification; IBA:RefGenome.
DR   GO; GO:0035115; P:embryonic forelimb morphogenesis; IBA:RefGenome.
DR   GO; GO:0035116; P:embryonic hindlimb morphogenesis; IBA:RefGenome.
DR   GO; GO:0009880; P:embryonic pattern specification; IBA:RefGenome.
DR   GO; GO:0060323; P:head morphogenesis; IBA:RefGenome.
DR   GO; GO:0071425; P:hemopoietic stem cell proliferation; IBA:RefGenome.
DR   GO; GO:0042472; P:inner ear morphogenesis; IBA:RefGenome.
DR   GO; GO:0060174; P:limb bud formation; IMP:BHF-UCL.
DR   GO; GO:0061180; P:mammary gland epithelium development; IEP:UniProtKB.
DR   GO; GO:0001707; P:mesoderm formation; IBA:RefGenome.
DR   GO; GO:0030917; P:midbrain-hindbrain boundary development; IBA:RefGenome.
DR   GO; GO:0045599; P:negative regulation of fat cell differentiation; IBA:RefGenome.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IBA:RefGenome.
DR   GO; GO:0060064; P:Spemann organizer formation at the anterior end of the primitive streak; IBA:RefGenome.
DR   GO; GO:0007223; P:Wnt receptor signaling pathway, calcium modulating pathway; IBA:RefGenome.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR009141; Wnt3.
DR   InterPro; IPR018161; Wnt_grthfactor_CS.
DR   KO; K00312; -.
DR   PANTHER; PTHR12027; Wnt; 1.
DR   PANTHER; PTHR12027:SF18; Wnt3; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01843; WNT3PROTEIN.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Developmental protein; Extracellular matrix;
KW   Glycoprotein; Proto-oncogene; Reference proteome; Secreted; Signal;
KW   Wnt signaling pathway.
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22    355       Proto-oncogene Wnt-3.
FT                                /FTId=PRO_0000041416.
FT   CARBOHYD     90     90       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    301    301       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   355 AA;  39645 MW;  85D15F2C7884A64F CRC64;
     MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG LVPKQLRFCR
     NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI FGPVLDKATR ESAFVHAIAS
     AGVAFAVTRS CAEGTSTICG CDSHHKGPPG EGWKWGGCSE DADFGVLVSR EFADARENRP
     DARSAMNKHN NEAGRTTILD HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS
     ASEMVVEKHR ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC
     NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD VHTCK
//