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P56703

- WNT3_HUMAN

UniProt

P56703 - WNT3_HUMAN

Protein

Proto-oncogene Wnt-3

Gene

WNT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. receptor agonist activity Source: BHF-UCL

    GO - Biological processi

    1. anterior/posterior axis specification Source: Ensembl
    2. axon guidance Source: Ensembl
    3. canonical Wnt signaling pathway Source: UniProtKB
    4. canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: BHF-UCL
    5. canonical Wnt signaling pathway involved in osteoblast differentiation Source: BHF-UCL
    6. cell fate commitment Source: RefGenome
    7. cell morphogenesis Source: BHF-UCL
    8. cellular response to retinoic acid Source: UniProtKB
    9. dorsal/ventral axis specification Source: Ensembl
    10. embryonic forelimb morphogenesis Source: Ensembl
    11. embryonic hindlimb morphogenesis Source: Ensembl
    12. head morphogenesis Source: Ensembl
    13. limb bud formation Source: BHF-UCL
    14. mammary gland epithelium development Source: UniProtKB
    15. mesoderm formation Source: Ensembl
    16. negative regulation of axon extension involved in axon guidance Source: Ensembl
    17. neuron differentiation Source: UniProtKB
    18. positive regulation of collateral sprouting in absence of injury Source: Ensembl
    19. positive regulation of gene expression Source: Ensembl
    20. Spemann organizer formation at the anterior end of the primitive streak Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200777. TCF dependent signaling in response to WNT.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proto-oncogene Wnt-3
    Alternative name(s):
    Proto-oncogene Int-4 homolog
    Gene namesi
    Name:WNT3
    Synonyms:INT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:12782. WNT3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: Reactome
    2. extracellular region Source: Reactome
    3. extracellular space Source: BHF-UCL
    4. Golgi lumen Source: Reactome
    5. plasma membrane Source: Reactome
    6. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Tetraamelia, autosomal recessive (ARTTRA) [MIM:273395]: A rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    MIMi273395. phenotype.
    Orphaneti3301. Tetraamelia - multiple malformations.
    PharmGKBiPA37383.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 355334Proto-oncogene Wnt-3PRO_0000041416Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi80 ↔ 91By similarity
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi131 ↔ 139By similarity
    Disulfide bondi141 ↔ 158By similarity
    Disulfide bondi206 ↔ 220By similarity
    Disulfide bondi208 ↔ 215By similarity
    Lipidationi212 – 2121O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi300 ↔ 315By similarity
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi330 ↔ 345By similarity
    Disulfide bondi332 ↔ 342By similarity
    Disulfide bondi337 ↔ 338By similarity

    Post-translational modificationi

    Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP56703.
    PRIDEiP56703.

    PTM databases

    PhosphoSiteiP56703.

    Expressioni

    Gene expression databases

    BgeeiP56703.
    CleanExiHS_WNT3.
    GenevestigatoriP56703.

    Interactioni

    Subunit structurei

    Interacts with PORCN. Interacts with WLS.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FZD7O750843EBI-3644922,EBI-746917

    Protein-protein interaction databases

    BioGridi113310. 1 interaction.
    IntActiP56703. 1 interaction.
    STRINGi9606.ENSP00000225512.

    Structurei

    3D structure databases

    ProteinModelPortaliP56703.
    SMRiP56703. Positions 60-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiP56703.
    KOiK00312.
    OMAiMCGCDSH.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiP56703.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009141. Wnt3.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01843. WNT3PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P56703-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG    50
    LVPKQLRFCR NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI 100
    FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGTSTICG CDSHHKGPPG 150
    EGWKWGGCSE DADFGVLVSR EFADARENRP DARSAMNKHN NEAGRTTILD 200
    HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS ASEMVVEKHR 250
    ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC 300
    NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD 350
    VHTCK 355
    Length:355
    Mass (Da):39,645
    Last modified:June 20, 2001 - v2
    Checksum:i85D15F2C7884A64F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009397 mRNA. Translation: AAG38657.1.
    AB067628 mRNA. Translation: BAB70502.1.
    BC112116 mRNA. Translation: AAI12117.1.
    BC112118 mRNA. Translation: AAI12119.1.
    BC114219 mRNA. Translation: AAI14220.1.
    CCDSiCCDS11505.1.
    PIRiA47536.
    RefSeqiNP_110380.1. NM_030753.4.
    UniGeneiHs.445884.
    Hs.745220.

    Genome annotation databases

    EnsembliENST00000225512; ENSP00000225512; ENSG00000108379.
    GeneIDi7473.
    KEGGihsa:7473.
    UCSCiuc002ikv.3. human.

    Polymorphism databases

    DMDMi14424477.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009397 mRNA. Translation: AAG38657.1 .
    AB067628 mRNA. Translation: BAB70502.1 .
    BC112116 mRNA. Translation: AAI12117.1 .
    BC112118 mRNA. Translation: AAI12119.1 .
    BC114219 mRNA. Translation: AAI14220.1 .
    CCDSi CCDS11505.1.
    PIRi A47536.
    RefSeqi NP_110380.1. NM_030753.4.
    UniGenei Hs.445884.
    Hs.745220.

    3D structure databases

    ProteinModelPortali P56703.
    SMRi P56703. Positions 60-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113310. 1 interaction.
    IntActi P56703. 1 interaction.
    STRINGi 9606.ENSP00000225512.

    Chemistry

    BindingDBi P56703.
    ChEMBLi CHEMBL6079.

    PTM databases

    PhosphoSitei P56703.

    Polymorphism databases

    DMDMi 14424477.

    Proteomic databases

    PaxDbi P56703.
    PRIDEi P56703.

    Protocols and materials databases

    DNASUi 7473.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225512 ; ENSP00000225512 ; ENSG00000108379 .
    GeneIDi 7473.
    KEGGi hsa:7473.
    UCSCi uc002ikv.3. human.

    Organism-specific databases

    CTDi 7473.
    GeneCardsi GC17M044839.
    GeneReviewsi WNT3.
    HGNCi HGNC:12782. WNT3.
    MIMi 165330. gene.
    273395. phenotype.
    neXtProti NX_P56703.
    Orphaneti 3301. Tetraamelia - multiple malformations.
    PharmGKBi PA37383.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284879.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi P56703.
    KOi K00312.
    OMAi MCGCDSH.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi P56703.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200777. TCF dependent signaling in response to WNT.

    Miscellaneous databases

    GeneWikii WNT3.
    GenomeRNAii 7473.
    NextBioi 29272.
    PROi P56703.
    SOURCEi Search...

    Gene expression databases

    Bgeei P56703.
    CleanExi HS_WNT3.
    Genevestigatori P56703.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009141. Wnt3.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01843. WNT3PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of six novel human WNT genes."
      Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and characterization of human WNT3."
      Katoh M.
      Int. J. Oncol. 19:977-982(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene."
      Roelink H., Wang J., Black D.M., Solomon E., Nusse R.
      Genomics 17:790-792(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-333.
    5. "Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family."
      Niemann S., Zhao C., Pascu F., Stahl U., Aulepp U., Niswander L., Weber J.L., Mueller U.
      Am. J. Hum. Genet. 74:558-563(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN ARTTRA.

    Entry informationi

    Entry nameiWNT3_HUMAN
    AccessioniPrimary (citable) accession number: P56703
    Secondary accession number(s): Q2M237, Q9H1J9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3