Reviewed,
UniProtKB/Swiss-Prot P56703 (WNT3_HUMAN)
Last modified
November 3, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Proto-oncogene protein Wnt-3 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 355 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube By similarity. |
| Subunit structure | Interacts with PORCN By similarity. |
| Subcellular location | |
| Involvement in disease | Defects in WNT3 are the cause of autosomal recessive tetra-amelia [MIM:273395]. Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. |
| Sequence similarities | Belongs to the Wnt family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Wnt signaling pathway |
| Cellular component | Extracellular matrix Secreted |
| Disease | Proto-oncogene |
| Domain | Signal |
| Molecular function | Developmental protein |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | Wnt receptor signaling pathway, calcium modulating pathway Inferred from electronic annotation. Source: InterPro |
| Cellular component | proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | extracellular matrix structural constituent Non-traceable author statement. Source: UniProtKB signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | ||||||
| Chain | 22 – 355 | 334 | Proto-oncogene protein Wnt-3 | PRO_0000041416 | |||||
Amino acid modifications | |||||||||
| Glycosylation | 90 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 301 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and characterization of six novel human WNT genes." Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Molecular cloning and characterization of human WNT3." Katoh M. Int. J. Oncol. 19:977-982(2001) [PubMed: 11604997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene." Roelink H., Wang J., Black D.M., Solomon E., Nusse R. Genomics 17:790-792(1993) [PubMed: 8244403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-333. |
| [5] | "Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family." Niemann S., Zhao C., Pascu F., Stahl U., Aulepp U., Niswander L., Weber J.L., Mueller U. Am. J. Hum. Genet. 74:558-563(2004) [PubMed: 14872406] [Abstract] Cited for: INVOLVEMENT IN TETRA-AMELIA. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AY009397 mRNA. Translation: AAG38657.1. AB067628 mRNA. Translation: BAB70502.1. BC112116 mRNA. Translation: AAI12117.1. BC112118 mRNA. Translation: AAI12119.1. BC114219 mRNA. Translation: AAI14220.1. | |
| IPI | IPI00011023. |
| PIR | A47536. |
| RefSeq | NP_110380.1. |
| UniGene | Hs.445884 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P56703. |
Proteomic databases | |
| PRIDE | P56703. |
Genome annotation databases | |
| Ensembl | ENST00000225512; ENSP00000225512; ENSG00000108379; Homo sapiens. [Genome view] |
| GeneID | 7473. |
| KEGG | hsa:7473. |
| UCSC | uc002ikv.1. human. |
Organism-specific databases | |
| CTD | 7473. |
| GeneCards | GC17M042196. |
| HGNC | HGNC:12782. WNT3. |
| MIM | 165330. gene. 273395. phenotype. |
| Orphanet | 1027. Amelia, autosomal recessive. 3300. Tetraamelia - pulmonary hypoplasia. |
| PharmGKB | PA37383. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P56703. |
| HOVERGEN | P56703. |
| OMA | NCTTIHD. |
Gene expression databases | |
| ArrayExpress | P56703. |
| Bgee | P56703. |
| CleanEx | HS_WNT3. |
| Genevestigator | P56703. |
| GermOnline | ENSG00000108379. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR009141. Wnt3. IPR005816. Wnt_grthfactor. IPR018161. Wnt_grthfactor_CS. IPR005817. Wnt_SF. [Graphical view] |
| PANTHER | PTHR12027. Wnt. 1 hit. PTHR12027:SF18. Wnt3. 1 hit. |
| Pfam | PF00110. wnt. 1 hit. [Graphical view] |
| PRINTS | PR01843. WNT3PROTEIN. PR01349. WNTPROTEIN. |
| SMART | SM00097. WNT1. 1 hit. [Graphical view] |
| PROSITE | PS00246. WNT1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 29272. |
| SOURCE | Search... |
Entry information
| Entry name | WNT3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P56703 Secondary accession number(s): Q2M237, Q9H1J9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


