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P56703

- WNT3_HUMAN

UniProt

P56703 - WNT3_HUMAN

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Protein
Proto-oncogene Wnt-3
Gene
WNT3, INT4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube By similarity.

GO - Molecular functioni

  1. frizzled binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. receptor agonist activity Source: BHF-UCL

GO - Biological processi

  1. Spemann organizer formation at the anterior end of the primitive streak Source: Ensembl
  2. anterior/posterior axis specification Source: Ensembl
  3. axon guidance Source: Ensembl
  4. canonical Wnt signaling pathway Source: UniProtKB
  5. canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: BHF-UCL
  6. canonical Wnt signaling pathway involved in osteoblast differentiation Source: BHF-UCL
  7. cell fate commitment Source: RefGenome
  8. cell morphogenesis Source: BHF-UCL
  9. cellular response to retinoic acid Source: UniProtKB
  10. dorsal/ventral axis specification Source: Ensembl
  11. embryonic forelimb morphogenesis Source: Ensembl
  12. embryonic hindlimb morphogenesis Source: Ensembl
  13. head morphogenesis Source: Ensembl
  14. limb bud formation Source: BHF-UCL
  15. mammary gland epithelium development Source: UniProtKB
  16. mesoderm formation Source: Ensembl
  17. negative regulation of axon extension involved in axon guidance Source: Ensembl
  18. neuron differentiation Source: UniProtKB
  19. positive regulation of collateral sprouting in absence of injury Source: Ensembl
  20. positive regulation of gene expression Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200777. TCF dependent signaling in response to WNT.

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene Wnt-3
Alternative name(s):
Proto-oncogene Int-4 homolog
Gene namesi
Name:WNT3
Synonyms:INT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:12782. WNT3.

Subcellular locationi

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular region Source: Reactome
  4. extracellular space Source: BHF-UCL
  5. plasma membrane Source: Reactome
  6. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Tetraamelia, autosomal recessive (ARTTRA) [MIM:273395]: A rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi273395. phenotype.
Orphaneti3301. Tetraamelia - multiple malformations.
PharmGKBiPA37383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 355334Proto-oncogene Wnt-3
PRO_0000041416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 91 By similarity
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi131 ↔ 139 By similarity
Disulfide bondi141 ↔ 158 By similarity
Disulfide bondi206 ↔ 220 By similarity
Disulfide bondi208 ↔ 215 By similarity
Lipidationi212 – 2121O-palmitoyl serine; by PORCN By similarity
Disulfide bondi300 ↔ 315 By similarity
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi330 ↔ 345 By similarity
Disulfide bondi332 ↔ 342 By similarity
Disulfide bondi337 ↔ 338 By similarity

Post-translational modificationi

Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP56703.
PRIDEiP56703.

PTM databases

PhosphoSiteiP56703.

Expressioni

Gene expression databases

BgeeiP56703.
CleanExiHS_WNT3.
GenevestigatoriP56703.

Interactioni

Subunit structurei

Interacts with PORCN By similarity. Interacts with WLS By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
FZD7O750843EBI-3644922,EBI-746917

Protein-protein interaction databases

BioGridi113310. 1 interaction.
IntActiP56703. 1 interaction.
STRINGi9606.ENSP00000225512.

Structurei

3D structure databases

ProteinModelPortaliP56703.
SMRiP56703. Positions 60-354.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiP56703.
KOiK00312.
OMAiMCGCDSH.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP56703.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009141. Wnt3.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01843. WNT3PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56703-1 [UniParc]FASTAAdd to Basket

« Hide

MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG    50
LVPKQLRFCR NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI 100
FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGTSTICG CDSHHKGPPG 150
EGWKWGGCSE DADFGVLVSR EFADARENRP DARSAMNKHN NEAGRTTILD 200
HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS ASEMVVEKHR 250
ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC 300
NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD 350
VHTCK 355
Length:355
Mass (Da):39,645
Last modified:June 20, 2001 - v2
Checksum:i85D15F2C7884A64F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY009397 mRNA. Translation: AAG38657.1.
AB067628 mRNA. Translation: BAB70502.1.
BC112116 mRNA. Translation: AAI12117.1.
BC112118 mRNA. Translation: AAI12119.1.
BC114219 mRNA. Translation: AAI14220.1.
CCDSiCCDS11505.1.
PIRiA47536.
RefSeqiNP_110380.1. NM_030753.4.
UniGeneiHs.445884.
Hs.745220.

Genome annotation databases

EnsembliENST00000225512; ENSP00000225512; ENSG00000108379.
GeneIDi7473.
KEGGihsa:7473.
UCSCiuc002ikv.3. human.

Polymorphism databases

DMDMi14424477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY009397 mRNA. Translation: AAG38657.1 .
AB067628 mRNA. Translation: BAB70502.1 .
BC112116 mRNA. Translation: AAI12117.1 .
BC112118 mRNA. Translation: AAI12119.1 .
BC114219 mRNA. Translation: AAI14220.1 .
CCDSi CCDS11505.1.
PIRi A47536.
RefSeqi NP_110380.1. NM_030753.4.
UniGenei Hs.445884.
Hs.745220.

3D structure databases

ProteinModelPortali P56703.
SMRi P56703. Positions 60-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113310. 1 interaction.
IntActi P56703. 1 interaction.
STRINGi 9606.ENSP00000225512.

Chemistry

BindingDBi P56703.
ChEMBLi CHEMBL6079.

PTM databases

PhosphoSitei P56703.

Polymorphism databases

DMDMi 14424477.

Proteomic databases

PaxDbi P56703.
PRIDEi P56703.

Protocols and materials databases

DNASUi 7473.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225512 ; ENSP00000225512 ; ENSG00000108379 .
GeneIDi 7473.
KEGGi hsa:7473.
UCSCi uc002ikv.3. human.

Organism-specific databases

CTDi 7473.
GeneCardsi GC17M044839.
GeneReviewsi WNT3.
HGNCi HGNC:12782. WNT3.
MIMi 165330. gene.
273395. phenotype.
neXtProti NX_P56703.
Orphaneti 3301. Tetraamelia - multiple malformations.
PharmGKBi PA37383.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284879.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi P56703.
KOi K00312.
OMAi MCGCDSH.
OrthoDBi EOG7C8GJ8.
PhylomeDBi P56703.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200777. TCF dependent signaling in response to WNT.

Miscellaneous databases

GeneWikii WNT3.
GenomeRNAii 7473.
NextBioi 29272.
PROi P56703.
SOURCEi Search...

Gene expression databases

Bgeei P56703.
CleanExi HS_WNT3.
Genevestigatori P56703.

Family and domain databases

InterProi IPR005817. Wnt.
IPR009141. Wnt3.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01843. WNT3PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of six novel human WNT genes."
    Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and characterization of human WNT3."
    Katoh M.
    Int. J. Oncol. 19:977-982(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene."
    Roelink H., Wang J., Black D.M., Solomon E., Nusse R.
    Genomics 17:790-792(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-333.
  5. "Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family."
    Niemann S., Zhao C., Pascu F., Stahl U., Aulepp U., Niswander L., Weber J.L., Mueller U.
    Am. J. Hum. Genet. 74:558-563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ARTTRA.

Entry informationi

Entry nameiWNT3_HUMAN
AccessioniPrimary (citable) accession number: P56703
Secondary accession number(s): Q2M237, Q9H1J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 20, 2001
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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