P56703 (WNT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proto-oncogene Wnt-3

Alternative name(s):
Proto-oncogene Int-4 homolog

Gene names

Name:	WNT3
Synonyms:	INT4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube By similarity.
Subunit structure	Interacts with PORCN By similarity. Interacts with WLS By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Involvement in disease	Defects in WNT3 are the cause of autosomal recessive tetra-amelia (ARTTRA) [MIM:273395]. Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. Ref.5
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Disease	Proto-oncogene
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Spemann organizer formation at the anterior end of the primitive streak Inferred from Biological aspect of Ancestor. Source: RefGenome Wnt receptor signaling pathway, calcium modulating pathway Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation Inferred from mutant phenotype. Source: BHF-UCL canonical Wnt receptor signaling pathway involved in osteoblast differentiation Inferred from mutant phenotype. Source: BHF-UCL cellular response to retinoic acid Inferred from sequence or structural similarity. Source: UniProtKB dorsal/ventral axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome embryonic forelimb morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome embryonic hindlimb morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome embryonic pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome head morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome hemopoietic stem cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome inner ear morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome limb bud formation Inferred from mutant phenotype Ref.5. Source: BHF-UCL mammary gland epithelium development Inferred from expression pattern. Source: UniProtKB mesoderm formation Inferred from Biological aspect of Ancestor. Source: RefGenome midbrain-hindbrain boundary development Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of fat cell differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	early endosome Inferred from Biological aspect of Ancestor. Source: RefGenome extracellular space Traceable author statement. Source: BHF-UCL late endosome Inferred from Biological aspect of Ancestor. Source: RefGenome membrane fraction Inferred from direct assay. Source: BHF-UCL membrane raft Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	frizzled-2 binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 355	334	Proto-oncogene Wnt-3		PRO_0000041416
Amino acid modifications
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P56703 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: 85D15F2C7884A64F	FASTA	355	39,645
	10 20 30 40 50 60 MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG LVPKQLRFCR 70 80 90 100 110 120 NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI FGPVLDKATR ESAFVHAIAS 130 140 150 160 170 180 AGVAFAVTRS CAEGTSTICG CDSHHKGPPG EGWKWGGCSE DADFGVLVSR EFADARENRP 190 200 210 220 230 240 DARSAMNKHN NEAGRTTILD HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS 250 260 270 280 290 300 ASEMVVEKHR ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC 310 320 330 340 350 NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD VHTCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of six novel human WNT genes." Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and characterization of human WNT3." Katoh M. Int. J. Oncol. 19:977-982(2001) [PubMed: 11604997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene." Roelink H., Wang J., Black D.M., Solomon E., Nusse R. Genomics 17:790-792(1993) [PubMed: 8244403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-333.
[5]	"Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family." Niemann S., Zhao C., Pascu F., Stahl U., Aulepp U., Niswander L., Weber J.L., Mueller U. Am. J. Hum. Genet. 74:558-563(2004) [PubMed: 14872406] [Abstract] Cited for: INVOLVEMENT IN ARTTRA.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY009397 mRNA. Translation: AAG38657.1. AB067628 mRNA. Translation: BAB70502.1. BC112116 mRNA. Translation: AAI12117.1. BC112118 mRNA. Translation: AAI12119.1. BC114219 mRNA. Translation: AAI14220.1.
IPI	IPI00011023.
PIR	A47536.
RefSeq	NP_110380.1. NM_030753.3.
UniGene	Hs.445884.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P56703. 1 interaction.
STRING	P56703.
Polymorphism databases
DMDM	14424477.
Proteomic databases
PRIDE	P56703.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000225512; ENSP00000225512; ENSG00000108379.
GeneID	7473.
KEGG	hsa:7473.
UCSC	uc002ikv.1. human.
Organism-specific databases
CTD	7473.
GeneCards	GC17M044839.
H-InvDB	HIX0039031.
HGNC	HGNC:12782. WNT3.
MIM	165330. gene. 273395. phenotype.
neXtProt	NX_P56703.
Orphanet	1027. Autosomal recessive amelia. 3301. Tetraamelia - multiple malformations.
PharmGKB	PA37383.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14485.
GeneTree	ENSGT00600000084119.
HOGENOM	HBG446188.
HOVERGEN	HBG001595.
InParanoid	P56703.
OMA	MCGCDSH.
OrthoDB	EOG4XD3R9.
PhylomeDB	P56703.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P56703.
Bgee	P56703.
CleanEx	HS_WNT3.
Genevestigator	P56703.
GermOnline	ENSG00000108379. Homo sapiens.
Family and domain databases
InterPro	IPR005817. Wnt. IPR009141. Wnt3. IPR018161. Wnt_grthfactor_CS. [Graphical view]
KO	K00312.
PANTHER	PTHR12027. Wnt. 1 hit. PTHR12027:SF18. Wnt3. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01843. WNT3PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	29272.
SOURCE	Search...

Entry information

Entry name

WNT3_HUMAN

Accession

Primary (citable) accession number: P56703
Secondary accession number(s): Q2M237, Q9H1J9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	June 20, 2001
Last modified:	January 25, 2012
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.