Reviewed, UniProtKB/Swiss-Prot P56703 (WNT3_HUMAN)

Names and origin

Protein names

Recommended name:
    Proto-oncogene protein Wnt-3

Gene names

Name:	WNT3
Synonyms:	INT4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube By similarity.
Subunit structure	Interacts with PORCN By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Involvement in disease	Defects in WNT3 are the cause of autosomal recessive tetra-amelia [MIM:273395]. Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Disease	Proto-oncogene
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway, calcium modulating pathway Inferred from electronic annotation. Source: InterPro
Cellular component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	extracellular matrix structural constituent Non-traceable author statement. Source: UniProtKB signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 355	334	Proto-oncogene protein Wnt-3		PRO_0000041416
Amino acid modifications
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P56703-1 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: 85D15F2C7884A64F	FASTA	355	39,645
	10 20 30 40 50 60 MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG LVPKQLRFCR 70 80 90 100 110 120 NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI FGPVLDKATR ESAFVHAIAS 130 140 150 160 170 180 AGVAFAVTRS CAEGTSTICG CDSHHKGPPG EGWKWGGCSE DADFGVLVSR EFADARENRP 190 200 210 220 230 240 DARSAMNKHN NEAGRTTILD HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS 250 260 270 280 290 300 ASEMVVEKHR ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC 310 320 330 340 350 NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD VHTCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of six novel human WNT genes." Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and characterization of human WNT3." Katoh M. Int. J. Oncol. 19:977-982(2001) [PubMed: 11604997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene." Roelink H., Wang J., Black D.M., Solomon E., Nusse R. Genomics 17:790-792(1993) [PubMed: 8244403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-333.
[5]	"Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family." Niemann S., Zhao C., Pascu F., Stahl U., Aulepp U., Niswander L., Weber J.L., Mueller U. Am. J. Hum. Genet. 74:558-563(2004) [PubMed: 14872406] [Abstract] Cited for: INVOLVEMENT IN TETRA-AMELIA.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY009397 mRNA. Translation: AAG38657.1. AB067628 mRNA. Translation: BAB70502.1. BC112116 mRNA. Translation: AAI12117.1. BC112118 mRNA. Translation: AAI12119.1. BC114219 mRNA. Translation: AAI14220.1.
IPI	IPI00011023.
PIR	A47536.
RefSeq	NP_110380.1.
UniGene	Hs.445884
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P56703.
Proteomic databases
PRIDE	P56703.
Genome annotation databases
Ensembl	ENST00000225512; ENSP00000225512; ENSG00000108379; Homo sapiens. [Genome view]
GeneID	7473.
KEGG	hsa:7473.
UCSC	uc002ikv.1. human.
Organism-specific databases
CTD	7473.
GeneCards	GC17M042196.
HGNC	HGNC:12782. WNT3.
MIM	165330. gene. 273395. phenotype.
Orphanet	1027. Amelia, autosomal recessive. 3300. Tetraamelia - pulmonary hypoplasia.
PharmGKB	PA37383.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P56703.
HOVERGEN	P56703.
OMA	NCTTIHD.
Gene expression databases
ArrayExpress	P56703.
Bgee	P56703.
CleanEx	HS_WNT3.
Genevestigator	P56703.
GermOnline	ENSG00000108379. Homo sapiens.
Family and domain databases
InterPro	IPR009141. Wnt3. IPR005816. Wnt_grthfactor. IPR018161. Wnt_grthfactor_CS. IPR005817. Wnt_SF. [Graphical view]
PANTHER	PTHR12027. Wnt. 1 hit. PTHR12027:SF18. Wnt3. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01843. WNT3PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	29272.
SOURCE	Search...

Entry information

Entry name

WNT3_HUMAN

Accession

Primary (citable) accession number: P56703
Secondary accession number(s): Q2M237, Q9H1J9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	June 20, 2001
Last modified:	November 3, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.