P56703 (WNT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 96.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Proto-oncogene Wnt-3 Alternative name(s): Proto-oncogene Int-4 homolog | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 355 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube By similarity. |
| Subunit structure | Interacts with PORCN By similarity. Interacts with WLS By similarity. |
| Subcellular location | |
| Involvement in disease | Defects in WNT3 are the cause of autosomal recessive tetra-amelia (ARTTRA) [MIM:273395]. Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. Ref.5 |
| Sequence similarities | Belongs to the Wnt family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and characterization of six novel human WNT genes." Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Molecular cloning and characterization of human WNT3." Katoh M. Int. J. Oncol. 19:977-982(2001) [PubMed: 11604997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene." Roelink H., Wang J., Black D.M., Solomon E., Nusse R. Genomics 17:790-792(1993) [PubMed: 8244403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-333. |
| [5] | "Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family." Niemann S., Zhao C., Pascu F., Stahl U., Aulepp U., Niswander L., Weber J.L., Mueller U. Am. J. Hum. Genet. 74:558-563(2004) [PubMed: 14872406] [Abstract] Cited for: INVOLVEMENT IN ARTTRA. |
| + | Additional computationally mapped references. |
Web resources
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY009397 mRNA. Translation: AAG38657.1. AB067628 mRNA. Translation: BAB70502.1. BC112116 mRNA. Translation: AAI12117.1. BC112118 mRNA. Translation: AAI12119.1. BC114219 mRNA. Translation: AAI14220.1. |
| IPI | IPI00011023. |
| PIR | A47536. |
| RefSeq | NP_110380.1. NM_030753.3. |
| UniGene | Hs.445884. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P56703. 1 interaction. |
| STRING | P56703. |
Polymorphism databases | |
| DMDM | 14424477. |
Proteomic databases | |
| PRIDE | P56703. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000225512; ENSP00000225512; ENSG00000108379. |
| GeneID | 7473. |
| KEGG | hsa:7473. |
| UCSC | uc002ikv.1. human. |
Organism-specific databases | |
| CTD | 7473. |
| GeneCards | GC17M044839. |
| H-InvDB | HIX0039031. |
| HGNC | HGNC:12782. WNT3. |
| MIM | 165330. gene. 273395. phenotype. |
| neXtProt | NX_P56703. |
| Orphanet | 1027. Autosomal recessive amelia. 3301. Tetraamelia - multiple malformations. |
| PharmGKB | PA37383. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG14485. |
| GeneTree | ENSGT00600000084119. |
| HOGENOM | HBG446188. |
| HOVERGEN | HBG001595. |
| InParanoid | P56703. |
| OMA | MCGCDSH. |
| OrthoDB | EOG4XD3R9. |
| PhylomeDB | P56703. |
Enzyme and pathway databases | |
| Reactome | REACT_111102. Signal Transduction. |
Gene expression databases | |
| ArrayExpress | P56703. |
| Bgee | P56703. |
| CleanEx | HS_WNT3. |
| Genevestigator | P56703. |
| GermOnline | ENSG00000108379. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR005817. Wnt. IPR009141. Wnt3. IPR018161. Wnt_grthfactor_CS. [Graphical view] |
| KO | K00312. |
| PANTHER | PTHR12027. Wnt. 1 hit. PTHR12027:SF18. Wnt3. 1 hit. |
| Pfam | PF00110. wnt. 1 hit. [Graphical view] |
| PRINTS | PR01843. WNT3PROTEIN. PR01349. WNTPROTEIN. |
| SMART | SM00097. WNT1. 1 hit. [Graphical view] |
| PROSITE | PS00246. WNT1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 29272. |
| SOURCE | Search... |
Entry information
| Entry name | WNT3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P56703 Secondary accession number(s): Q2M237, Q9H1J9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with