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P56700

- RGS16_RAT

UniProt

P56700 - RGS16_RAT

Protein

Regulator of G-protein signaling 16

Gene

Rgs16

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha.

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 16
    Short name:
    RGS16
    Alternative name(s):
    Retinal-specific RGS
    Short name:
    RGS-r
    Retinally abundant regulator of G-protein signaling
    Gene namesi
    Name:Rgs16
    Synonyms:Rgsr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1589741. Rgs16.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. membrane raft Source: RGD
    3. plasma membrane Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Regulator of G-protein signaling 16PRO_0000204223Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21S-palmitoyl cysteineBy similarity
    Lipidationi12 – 121S-palmitoyl cysteineBy similarity
    Modified residuei167 – 1671PhosphotyrosineBy similarity
    Modified residuei176 – 1761PhosphotyrosineBy similarity

    Post-translational modificationi

    Either Cys-2 or Cys-12 or both are palmitoylated.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiP56700.

    Expressioni

    Tissue specificityi

    Predominantly found in the retina. Some expression has been found in the liver.

    Gene expression databases

    GenevestigatoriP56700.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000029844.

    Structurei

    3D structure databases

    ProteinModelPortaliP56700.
    SMRiP56700. Positions 53-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 180117RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG269229.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiP56700.
    PhylomeDBiP56700.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56700-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCRTIATFPN TCLERAKEFK TRLGIFLHKS ELSSDTGGNG KFEWASKLSK    50
    ERSFSEDVLG WRESFQSLLN SKNGVAAFHA FLKTEFSEEN LEFWLACEEF 100
    KKIRSATKLA SRAHHIFDEY IRSEAPKEVN IDHETRELTK TNLQAATTSC 150
    FDVAQGKTRT LMEKDSYPRF LKSPAYRDLA AQASATSASG SSPAEPSHT 199
    Length:199
    Mass (Da):22,400
    Last modified:July 15, 1999 - v1
    Checksum:i3C5A51E83F3956CC
    GO

    Sequence databases

    UniGeneiRn.202892.

    Genome annotation databases

    UCSCiRGD:1589741. rat.

    Cross-referencesi

    Sequence databases

    UniGenei Rn.202892.

    3D structure databases

    ProteinModelPortali P56700.
    SMRi P56700. Positions 53-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000029844.

    Proteomic databases

    PRIDEi P56700.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:1589741. rat.

    Organism-specific databases

    RGDi 1589741. Rgs16.

    Phylogenomic databases

    eggNOGi NOG269229.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi P56700.
    PhylomeDBi P56700.

    Miscellaneous databases

    PROi P56700.

    Gene expression databases

    Genevestigatori P56700.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling."
      Chen C.-K., Wieland T., Simon M.I.
      Proc. Natl. Acad. Sci. U.S.A. 93:12885-12889(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.

    Entry informationi

    Entry nameiRGS16_RAT
    AccessioniPrimary (citable) accession number: P56700
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3