P56700 (RGS16_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 16
Short name=RGS16

Alternative name(s):
Retinal-specific RGS
Short name=RGS-r
Retinally abundant regulator of G-protein signaling

Gene names

Name:	Rgs16
Synonyms:	Rgsr

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha.
Tissue specificity	Predominantly found in the retina. Some expression has been found in the liver.
Post-translational modification	Either Cys-2 or Cys-12 or both are palmitoylated By similarity.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Molecular function	Signal transduction inhibitor
PTM	Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome membrane raft Inferred from direct assay PubMed 12642593. Source: RGD plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Regulator of G-protein signaling 16		PRO_0000204223
Regions
	Domain	64 – 180	117	RGS
Amino acid modifications
	Modified residue	167	1	Phosphotyrosine By similarity
	Modified residue	176	1	Phosphotyrosine By similarity
	Lipidation	2	1	S-palmitoyl cysteine By similarity
	Lipidation	12	1	S-palmitoyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56700 [UniParc]. Last modified July 15, 1999. Version 1. Checksum: 3C5A51E83F3956CC	FASTA	199	22,400
	10 20 30 40 50 60 MCRTIATFPN TCLERAKEFK TRLGIFLHKS ELSSDTGGNG KFEWASKLSK ERSFSEDVLG 70 80 90 100 110 120 WRESFQSLLN SKNGVAAFHA FLKTEFSEEN LEFWLACEEF KKIRSATKLA SRAHHIFDEY 130 140 150 160 170 180 IRSEAPKEVN IDHETRELTK TNLQAATTSC FDVAQGKTRT LMEKDSYPRF LKSPAYRDLA 190 AQASATSASG SSPAEPSHT

References

[1]	"RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling." Chen C.-K., Wieland T., Simon M.I. Proc. Natl. Acad. Sci. U.S.A. 93:12885-12889(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
IPI	IPI00556938.
UniGene	Rn.202892.
3D structure databases
ProteinModelPortal	P56700.
SMR	P56700. Positions 53-180.
ModBase	Search...
Proteomic databases
PRIDE	P56700.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:1589741. rat.
Organism-specific databases
RGD	1589741. Rgs16.
Phylogenomic databases
eggNOG	NOG269229.
HOGENOM	HOG000233512.
HOVERGEN	HBG013233.
InParanoid	P56700.
OrthoDB	EOG4STS5S.
Gene expression databases
ArrayExpress	P56700.
Genevestigator	P56700.
GermOnline	ENSRNOG00000027024. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.196.10. 2 hits.
InterPro	IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RGS16_RAT

Accession

Primary (citable) accession number: P56700

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program