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Protein

Regulator of G-protein signaling 16

Gene

Rgs16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 16
Short name:
RGS16
Alternative name(s):
Retinal-specific RGS
Short name:
RGS-r
Retinally abundant regulator of G-protein signaling
Gene namesi
Name:Rgs16
Synonyms:Rgsr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1589741. Rgs16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • membrane raft Source: RGD
  • plasma membrane Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Regulator of G-protein signaling 16PRO_0000204223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21S-palmitoyl cysteineBy similarity
Lipidationi12 – 121S-palmitoyl cysteineBy similarity
Modified residuei167 – 1671PhosphotyrosineBy similarity
Modified residuei176 – 1761PhosphotyrosineBy similarity

Post-translational modificationi

Either Cys-2 or Cys-12 or both are palmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP56700.

Expressioni

Tissue specificityi

Predominantly found in the retina. Some expression has been found in the liver.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029844.

Structurei

3D structure databases

ProteinModelPortaliP56700.
SMRiP56700. Positions 53-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 180117RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG269229.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP56700.
PhylomeDBiP56700.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCRTIATFPN TCLERAKEFK TRLGIFLHKS ELSSDTGGNG KFEWASKLSK
60 70 80 90 100
ERSFSEDVLG WRESFQSLLN SKNGVAAFHA FLKTEFSEEN LEFWLACEEF
110 120 130 140 150
KKIRSATKLA SRAHHIFDEY IRSEAPKEVN IDHETRELTK TNLQAATTSC
160 170 180 190
FDVAQGKTRT LMEKDSYPRF LKSPAYRDLA AQASATSASG SSPAEPSHT
Length:199
Mass (Da):22,400
Last modified:July 15, 1999 - v1
Checksum:i3C5A51E83F3956CC
GO

Sequence databases

UniGeneiRn.202892.

Genome annotation databases

UCSCiRGD:1589741. rat.

Cross-referencesi

Sequence databases

UniGeneiRn.202892.

3D structure databases

ProteinModelPortaliP56700.
SMRiP56700. Positions 53-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029844.

Proteomic databases

PRIDEiP56700.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1589741. rat.

Organism-specific databases

RGDi1589741. Rgs16.

Phylogenomic databases

eggNOGiNOG269229.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP56700.
PhylomeDBiP56700.

Miscellaneous databases

PROiP56700.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling."
    Chen C.-K., Wieland T., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 93:12885-12889(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiRGS16_RAT
AccessioniPrimary (citable) accession number: P56700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.