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P56700 (RGS16_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 16

Short name=RGS16
Alternative name(s):
Retinal-specific RGS
Short name=RGS-r
Retinally abundant regulator of G-protein signaling
Gene names
Name:Rgs16
Synonyms:Rgsr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha.

Tissue specificity

Predominantly found in the retina. Some expression has been found in the liver.

Post-translational modification

Either Cys-2 or Cys-12 or both are palmitoylated By similarity.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Regulator of G-protein signaling 16
PRO_0000204223

Regions

Domain64 – 180117RGS

Amino acid modifications

Modified residue1671Phosphotyrosine By similarity
Modified residue1761Phosphotyrosine By similarity
Lipidation21S-palmitoyl cysteine By similarity
Lipidation121S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P56700 [UniParc].

Last modified July 15, 1999. Version 1.
Checksum: 3C5A51E83F3956CC

FASTA19922,400
        10         20         30         40         50         60 
MCRTIATFPN TCLERAKEFK TRLGIFLHKS ELSSDTGGNG KFEWASKLSK ERSFSEDVLG 

        70         80         90        100        110        120 
WRESFQSLLN SKNGVAAFHA FLKTEFSEEN LEFWLACEEF KKIRSATKLA SRAHHIFDEY 

       130        140        150        160        170        180 
IRSEAPKEVN IDHETRELTK TNLQAATTSC FDVAQGKTRT LMEKDSYPRF LKSPAYRDLA 

       190 
AQASATSASG SSPAEPSHT 

« Hide

References

[1]"RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling."
Chen C.-K., Wieland T., Simon M.I.
Proc. Natl. Acad. Sci. U.S.A. 93:12885-12889(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

UniGeneRn.202892.

3D structure databases

ProteinModelPortalP56700.
SMRP56700. Positions 53-180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000029844.

Proteomic databases

PRIDEP56700.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:1589741. rat.

Organism-specific databases

RGD1589741. Rgs16.

Phylogenomic databases

eggNOGNOG269229.
HOGENOMHOG000233512.
HOVERGENHBG013233.
InParanoidP56700.
PhylomeDBP56700.

Gene expression databases

GenevestigatorP56700.

Family and domain databases

Gene3D1.10.196.10. 2 hits.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP56700.

Entry information

Entry nameRGS16_RAT
AccessionPrimary (citable) accession number: P56700
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families