SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P56700

- RGS16_RAT

UniProt

P56700 - RGS16_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Regulator of G-protein signaling 16
Gene
Rgs16, Rgsr
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha.

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 16
Short name:
RGS16
Alternative name(s):
Retinal-specific RGS
Short name:
RGS-r
Retinally abundant regulator of G-protein signaling
Gene namesi
Name:Rgs16
Synonyms:Rgsr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1589741. Rgs16.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. membrane raft Source: RGD
  3. plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Regulator of G-protein signaling 16
PRO_0000204223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21S-palmitoyl cysteine By similarity
Lipidationi12 – 121S-palmitoyl cysteine By similarity
Modified residuei167 – 1671Phosphotyrosine By similarity
Modified residuei176 – 1761Phosphotyrosine By similarity

Post-translational modificationi

Either Cys-2 or Cys-12 or both are palmitoylated By similarity.

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP56700.

Expressioni

Tissue specificityi

Predominantly found in the retina. Some expression has been found in the liver.

Gene expression databases

GenevestigatoriP56700.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029844.

Structurei

3D structure databases

ProteinModelPortaliP56700.
SMRiP56700. Positions 53-180.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 180117RGS
Add
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG269229.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP56700.
PhylomeDBiP56700.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56700-1 [UniParc]FASTAAdd to Basket

« Hide

MCRTIATFPN TCLERAKEFK TRLGIFLHKS ELSSDTGGNG KFEWASKLSK    50
ERSFSEDVLG WRESFQSLLN SKNGVAAFHA FLKTEFSEEN LEFWLACEEF 100
KKIRSATKLA SRAHHIFDEY IRSEAPKEVN IDHETRELTK TNLQAATTSC 150
FDVAQGKTRT LMEKDSYPRF LKSPAYRDLA AQASATSASG SSPAEPSHT 199
Length:199
Mass (Da):22,400
Last modified:July 15, 1999 - v1
Checksum:i3C5A51E83F3956CC
GO

Sequence databases

UniGeneiRn.202892.

Genome annotation databases

UCSCiRGD:1589741. rat.

Cross-referencesi

Sequence databases

UniGenei Rn.202892.

3D structure databases

ProteinModelPortali P56700.
SMRi P56700. Positions 53-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000029844.

Proteomic databases

PRIDEi P56700.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:1589741. rat.

Organism-specific databases

RGDi 1589741. Rgs16.

Phylogenomic databases

eggNOGi NOG269229.
HOGENOMi HOG000233512.
HOVERGENi HBG013233.
InParanoidi P56700.
PhylomeDBi P56700.

Miscellaneous databases

PROi P56700.

Gene expression databases

Genevestigatori P56700.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling."
    Chen C.-K., Wieland T., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 93:12885-12889(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiRGS16_RAT
AccessioniPrimary (citable) accession number: P56700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi