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Protein

Wolframin

Gene

Wfs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the regulation of cellular Ca2+ homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca2+ store.By similarity

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Wolframin
Gene namesi
Name:Wfs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1328355. Wfs1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Transmembranei589 – 609HelicalSequence analysisAdd BLAST21
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 869LumenalSequence analysisAdd BLAST217
Transmembranei870 – 890HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659641 – 890WolframinAdd BLAST890

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei32PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Glycosylationi663N-linked (GlcNAc...)1 Publication1
Glycosylationi748N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP56695.
PaxDbiP56695.
PeptideAtlasiP56695.
PRIDEiP56695.

PTM databases

iPTMnetiP56695.
PhosphoSitePlusiP56695.

Expressioni

Tissue specificityi

Highly expressed in the developing lens.1 Publication

Gene expression databases

BgeeiENSMUSG00000039474.
CleanExiMM_WFS1.
ExpressionAtlasiP56695. baseline and differential.
GenevisibleiP56695. MM.

Interactioni

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

BioGridi204558. 1 interactor.
STRINGi10090.ENSMUSP00000048053.

Structurei

3D structure databases

ProteinModelPortaliP56695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 21Poly-Pro9
Compositional biasi191 – 194Poly-Lys4
Compositional biasi877 – 886Poly-Phe10

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYG. Eukaryota.
ENOG4111MAM. LUCA.
GeneTreeiENSGT00390000016928.
HOGENOMiHOG000132944.
HOVERGENiHBG014957.
InParanoidiP56695.
KOiK14020.
OMAiVNFGWNH.
OrthoDBiEOG091G01MI.
PhylomeDBiP56695.
TreeFamiTF326849.

Family and domain databases

InterProiIPR026208. Wolframin.
IPR026209. Wolframin_fam.
[Graphical view]
PANTHERiPTHR13098. PTHR13098. 1 hit.
PRINTSiPR02060. WOLFFAMILY.
PR02061. WOLFRAMIN.

Sequencei

Sequence statusi: Complete.

P56695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSGTPPPSP SGPPPPPAPQ PQARARLNAT ASLEQDKIEP PRAPRPQADP
60 70 80 90 100
SAGRSAGEAA APEPRAPQTG SREETDRAGP MKADVEIPFE EVLEKAKAGD
110 120 130 140 150
PKAQTEVGKH YLRLANDADE ELNSCSAVAW LILAAKQGRR EAVKLLRRCL
160 170 180 190 200
ADRKGITSEN EAEVKQLSSE TDLERAVRKA ALVMYWKLNP KKKKQVAVSE
210 220 230 240 250
LLENVGQVNE QDGGAQPGPV PKSLQKQRRM LERLVSSESK NYIALDDFVE
260 270 280 290 300
LTKKYAKGII PTNLFLQDED EDEDELAGKS PEDLPLRQKV VKYPLHAIME
310 320 330 340 350
IKEYLIDVAS KAGMHWLSTI VPTHHINALI FFFIISNLTI DFFAFFIPLV
360 370 380 390 400
VFYLSFVSMV ICTLKVFQDS KAWENFRTLT DLLLRFEPNL DVEQAEVNFG
410 420 430 440 450
WNHLEPYIHF LLSVVFVIFS FPLASKDCIP CSELAVISTF FTVTSYMSLS
460 470 480 490 500
SSAEPYTRRA LVTEVAAGLL SLLPTVPVDW RFLKVLGQTF FTVPVGHFII
510 520 530 540 550
LNVSLPCLLY VYLFYLFFRM AQLRNFKGTY CYLVPYLVCF MWCELSVVIL
560 570 580 590 600
LQSTGLGLVR ASIGYFLFLF ALPILVAGLA LMGTVQFARW FLSLDLTKIM
610 620 630 640 650
VTTVICGVPL LFRWWTKANF SVMGMVKSLT KSSMVKLILV WLTAILLFCW
660 670 680 690 700
FYVYRSEGMK VYNSTLTWQQ YGFLCGPRAW KETNMARTQI LCSHLEGHRV
710 720 730 740 750
TWTGRFKYVR VTEIDNSAES AINMLPFFLG DWMRCLYGEA YPSCSSGNTS
760 770 780 790 800
TAEEELCRLK QLAKHPCHIK KFDRYKFEIT VGMPFGTNGN RGHEEDDITK
810 820 830 840 850
DIVLRASSEF KDVLLNLRQG SLIEFSTILE GRLGSKWPVF ELKAISCLNC
860 870 880 890
MTQLSPARRH VKIEQDWRST VHGALKFAFD FFFFPFLSAA
Length:890
Mass (Da):100,579
Last modified:July 15, 1999 - v1
Checksum:iCB6C6CA16171A942
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215A → V in AAC64944 (PubMed:9771706).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011971 mRNA. Translation: CAA09892.1.
AF084482 mRNA. Translation: AAC64944.1.
CCDSiCCDS19245.1.
RefSeqiNP_035846.1. NM_011716.2.
UniGeneiMm.20916.

Genome annotation databases

EnsembliENSMUST00000043964; ENSMUSP00000048053; ENSMUSG00000039474.
GeneIDi22393.
KEGGimmu:22393.
UCSCiuc008xff.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011971 mRNA. Translation: CAA09892.1.
AF084482 mRNA. Translation: AAC64944.1.
CCDSiCCDS19245.1.
RefSeqiNP_035846.1. NM_011716.2.
UniGeneiMm.20916.

3D structure databases

ProteinModelPortaliP56695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204558. 1 interactor.
STRINGi10090.ENSMUSP00000048053.

PTM databases

iPTMnetiP56695.
PhosphoSitePlusiP56695.

Proteomic databases

EPDiP56695.
PaxDbiP56695.
PeptideAtlasiP56695.
PRIDEiP56695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043964; ENSMUSP00000048053; ENSMUSG00000039474.
GeneIDi22393.
KEGGimmu:22393.
UCSCiuc008xff.1. mouse.

Organism-specific databases

CTDi7466.
MGIiMGI:1328355. Wfs1.

Phylogenomic databases

eggNOGiENOG410IDYG. Eukaryota.
ENOG4111MAM. LUCA.
GeneTreeiENSGT00390000016928.
HOGENOMiHOG000132944.
HOVERGENiHBG014957.
InParanoidiP56695.
KOiK14020.
OMAiVNFGWNH.
OrthoDBiEOG091G01MI.
PhylomeDBiP56695.
TreeFamiTF326849.

Miscellaneous databases

ChiTaRSiWfs1. mouse.
PROiP56695.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039474.
CleanExiMM_WFS1.
ExpressionAtlasiP56695. baseline and differential.
GenevisibleiP56695. MM.

Family and domain databases

InterProiIPR026208. Wolframin.
IPR026209. Wolframin_fam.
[Graphical view]
PANTHERiPTHR13098. PTHR13098. 1 hit.
PRINTSiPR02060. WOLFFAMILY.
PR02061. WOLFRAMIN.
ProtoNetiSearch...

Entry informationi

Entry nameiWFS1_MOUSE
AccessioniPrimary (citable) accession number: P56695
Secondary accession number(s): Q9Z276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.